Therapeutic manipulation of T cell chemotaxis in transplantation

Current Opinion in Immunology

Volumn 16, Issue 5, 2004, Pages 571-577

  Yopp, Adam C ^a   Krieger, Nancy R ^a   Ochando, Jordi C ^a   Bromberg, Jonathan S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 2; SELECTIN; SPHINGOSINE 1 PHOSPHATE;

CELL ACTIVATION; CELL MIGRATION; CELL TRANSPLANTATION; CHEMOTAXIS; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MOLECULAR BIOLOGY; REGULATORY MECHANISM; REVIEW; T LYMPHOCYTE;

ANIMALS; ANTIGEN-PRESENTING CELLS; CELL ADHESION MOLECULES; CHEMOKINES; CHEMOTAXIS, LEUKOCYTE; HUMANS; LYMPHOCYTE ACTIVATION; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HOMOLOGOUS;

EID: 4444362843     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.07.003     Document Type: Review

References (48)

1. U.H. von Andrian, and T.R. Mempel Homing and cellular traffic in lymph nodes Nat Rev Immunol 3 2003 867 878
2. H. Kobayashi, S. Koga, A.C. Novick, H. Toma, and R.L. Fairchild T-cell mediated induction of allogeneic endothelial cell chemokine expression Transplantation 75 2003 529 536
3. W.W. Hancock, B. Lu, W. Gao, V. Csizmadia, K. Faia, J.A. King, S.T. Smiley, M. Ling, N.P. Gerard, and C. Gerard Requirement of the chemokine receptor CXCR3 for acute allograft rejection J Exp Med 192 2000 1515 1520
4. W.W. Hancock, W. Gao, V. Csizmadia, K.L. Faia, N. Shemmeri, and A.D. Luster Donor-derived IP-10 initiates development of acute allograft rejection J Exp Med 193 2001 975 980
5. W. Gao, P.S. Topham, J.A. King, S.T. Smiley, V. Csizmadia, B. Lu, C.J. Gerard, and W.W. Hancock Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection J Clin Invest 105 2000 35 44
6. - recipients have a twofold prolongation of islet allograft survival as compared with controls.
7. W. Gao, K.L. Faia, V. Csizmadia, S.T. Smiley, D. Soler, J.A. King, T.M. Danoff, and W.W. Hancock Beneficial effects of targeting CCR5 in allograft recipients Transplantation 72 2001 1199 1205
8. 3CR1 reveals a role for fractalkine in cardiac allograft rejection J Clin Invest 108 2001 679 688
9. M. Jiankuo, W. Xingbing, H. Baojun, W. Xiongwin, L. Zhuoya, X. Ping, X. Yong, L. Anting, H. Chunsong, and G. Feili Peptide nucleic acid antisense prolongs skin allograft survival by means of blockade of CXCR3 expression directing T cells into graft J Immunol 170 2003 1556 1565
10. S. Fu, D. Chen, X. Mao, N. Zhang, Y. Ding, and J.S. Bromberg Feline immunodeficiency virus-mediated viral interleukin-10 gene transfer prolongs non-vascularized cardiac allograft survival Am J Transplant 3 2003 552 561
11. R. Abdi, R.N. Smith, L. Makhlouf, N. Najafian, A.D. Luster, H. Auchincloss Jr., and M.H. Sayegh The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection Diabetes 51 2002 2489 2495
12. I. Lee, L. Wang, A.D. Wells, Q. Ye, R. Han, M.E. Dorf, W.A. Kuziel, B.J. Rollins, L. Chen, and W.W. Hancock Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism J Immunol 171 2003 6929 6935
13. M.S. Baker, X. Chen, A.R. Rotramel, J.J. Nelson, B. Lu, C. Gerard, Y. Kanwar, and D.B. Kaufman Genetic deletion of chemokine receptor CXCR3 or antibody blockade of its ligand IP-10 modulates posttransplantation graft-site lymphocytic infiltrates and prolongs functional graft survival in pancreatic islet allograft recipients Surgery 134 2003 126 133
14. Q.W. Zhang, D.D. Kish, and R.L. Fairchild Absence of allograft ICAM-1 attenuates alloantigen-specific T cell priming, but not primed T cell trafficking into the graft, to mediate acute rejection J Immunol 170 2003 5530 5537
15. J. Lacha, A. Bushell, K. Smetana, P. Rossmann, P. Pribylova, K. Wood, and P. Maly Intercellular cell adhesion molecule-1 and selectin ligands in acute cardiac allograft rejection: a study on gene-deficient mouse models J Leukoc Biol 71 2002 311 318
16. K.O. Schowengerdt, J.Y. Zhu, S.M. Stepkowski, Y. Tu, M.L. Entman, and C.M. Ballantyne Cardiac allograft survival in mice deficient in intercellular adhesion molecule-1 Circulation 92 1995 82 87
17. M.E. Reinders, M. Sho, A. Izawa, P. Wang, D. Mukhopadhyay, K.E. Koss, C.S. Geehan, A.D. Luster, M.H. Sayegh, and D.M. Briscoe Proinflammatory functions of vascular endothelial growth factor in alloimmunity J Clin Invest 112 2003 1655 1665 This study demonstrates that VEGF enhances allograft endothelial production of CCL2 and IL-8, and together with interferon-γ produces CXCL10. The authors show that blockade of VEGF with monoclonal antibodies prolongs vascularized murine cardiac allografts by preventing T cell infiltration of the allograft.
18. K. Budde, R.L. Schmouder, R. Brunkhorst, B. Nashan, P.W. Lucker, T. Mayer, S. Choudhury, A. Skerjanec, G. Kraus, and H.H. Neumayer First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients J Am Soc Nephrol 13 2002 1073 1083
19. F. Fu, S. Hu, J. Deleo, S. Li, C. Hopf, J. Hoover, S. Wang, V. Brinkmann, P. Lake, and V.C. Shi Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720 Transplantation 73 2002 1425 1430
20. Y. Nagahara, M. Ikekita, and T. Shinomiya T cell selective apoptosis by a novel immunosuppressant, FTY720, is closely regulated with Bcl-2 Br J Pharmacol 137 2002 953 962
21. S. Mandala, R. Hajdu, J. Bergstrom, E. Quackenbush, J. Xie, J. Milligan, R. Thornton, G.J. Shei, D. Card, and C. Keohane Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists Science 296 2002 346 349
22. S.M. Honig, S. Fu, X. Mao, A. Yopp, M.D. Gunn, G.J. Randolph, and J.S. Bromberg FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes J Clin Invest 111 2003 627 637 FTY720 is shown to stimulate sequential activation of the multidrug transporters Abcb1 and Abcc1, and to sensitize the CCR7 chemokine receptor to promote T cell migration to LNs.
23. + T cells J Immunol 170 2003 3662 3670
24. A. Billich, F. Bornancin, P. Devay, D. Mechtcheriakova, N. Urtz, and T. Baumruker Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases J Biol Chem 278 2003 47408 47415
25. V. Brinkmann, M.D. Davis, C.E. Heise, R. Albert, S. Cottens, R. Hof, C. Bruns, E. Prieschl, T. Baumruker, and P. Hiestand The immune modulator FTY720 targets sphingosine 1-phosphate receptors J Biol Chem 277 2002 21453 21457
26. A.C. Yopp, G.J. Randolph, and J.S. Bromberg Leukotrienes, sphingolipids, and leukocyte trafficking J Immunol 171 2003 5 10
27. M.G. Sanna, J. Liao, E. Jo, C. Alfonso, M.Y. Ahn, M.S. Peterson, B. Webb, S. Lefebvre, J. Chun, N. Gray, and H. Rosen Distinct S1P receptor subtypes S1P1 and S1P3 respectively regulate lymphocyte recirculation and heart rate J Biol Chem 279 2004 13839 13848
28. M.H. Graler, and E.J. Goetzl The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors FASEB J 18 2004 551 553 The authors demonstrate that administration of FTY720 and S1P causes a dose- and time-dependent downregulation of S1PR on the T cell.
29. M. Matloubian, C.G. Lo, G. Cinamon, M.J. Lesneski, Y. Xu, V. Brinkmann, M.L. Allende, R.L. Proia, and J.G. Cyster Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 Nature 427 2004 355 360 An excellent paper demonstrating that, in a chimeric model, an absence of S1PR on thymocytes and T cells prevents their egress from the thymus and LNs, respectively.
30. M.L. Allende, J.L. Dreier, S. Mandala, and R.L. Proia Expression of the sphingosine-1-phosphate receptor, S1P1, on T-cells controls thymic emigration J Biol Chem 279 2004 15396 15401
31. T. Sanchez, T. Estrada-Hernandez, J.H. Paik, M.T. Wu, K. Venkataraman, V. Brinkmann, K. Claffey, and T. Hla Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability J Biol Chem 278 2003 47281 47290 The authors show that phosphorylated-FTY720 inhibits inflammation-induced vascular permeability of endothelial cells through formation of the adherens junction component VE-cadherin.
32. F.G. Lakkis, A. Arakelov, B.T. Konieczny, and Y. Inoue Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue Nat Med 6 2000 686 688
33. Y. Bai, J. Liu, Y. Wang, S. Honig, L. Qin, P. Boros, and J.S. Bromberg L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance J Immunol 168 2002 1579 1589
34. P. Zhou, K.W. Hwang, D. Palucki, O. Kim, K.A. Newell, Y.X. Fu, and M.L. Alegre Secondary lymphoid organs are important but not absolutely required for allograft responses Am J Transplant 3 2003 259 266
35. M. Falcone, and N. Sarvetnick The effect of local production of cytokines in the pathogenesis of insulin-dependent diabetes mellitus Clin Immunol 90 1999 2 9
36. C.A. Cuff, J. Schwartz, C.M. Bergman, K.S. Russell, J.R. Bender, and N.H. Ruddle Lymphotoxin α3 induces chemokines and adhesion molecules: insight into the role of LTα in inflammation and lymphoid organ development J Immunol 161 1998 6853 6860
37. + T cell peripheral tolerance in nonobese diabetic mice J Immunol 167 2001 1112 1117
38. S.V. Pakala, M.O. Kurrer, and J.D. Katz T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice J Exp Med 186 1997 299 306
39. + T-regulatory cell subset has optimal suppressive and proliferative potential Am J Transplant 4 2004 65 78
40. A.J. Reed, H. Noorchashm, S.Y. Rostami, Y. Zarrabi, A.R. Perate, A.N. Jeganathan, A.J. Caton, and A. Naji Alloreactive CD4 T cell activation in vivo: an autonomous function of the indirect pathway of alloantigen presentation J Immunol 171 2003 6502 6509
41. S.E. Sandner, A.D. Salama, S.L. Houser, E. Palmer, L.A. Turka, and M.H. Sayegh New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo Am J Transplant 10 2003 1242 1250
42. + T cells through the indirect presentation pathway in vivo J Immunol 171 2003 6510 6518
43. + T cells that cause obliterative airways disease J Immunol 172 2004 3469 3479
44. K. Goodarzi, M. Goodarzi, A.M. Tager, A.D. Luster, and U.H. von Andrian Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues Nat Immunol 4 2003 965 973
45. A. Ariel, N. Chiang, M. Arita, N.A. Petasis, and C.N. Serhan Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-α secretion from human T cells J Immunol 170 2003 6266 6272
46. A.M. Tager, S.K. Bromley, B.D. Medoff, S.A. Islam, S.D. Bercury, E.B. Friedrich, A.D. Carafone, R.E. Gerszten, and A.D. Luster Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment Nat Immunol 4 2003 982 990
47. G. Cinamon, M. Matloubian, M.J. Lesneski, Y. Xu, C. Low, T. Lu, R.L. Proia, and J.G. Cyster Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone Nat Immunol 5 2004 713 720
48. G. Schroeder, K. Risch, K. Kotsch, A. Siepert, J. Brock, P. Nickel, P. Reinke, T. Ritter, H.D. Volk, and M. Lehmann FTY720 prevents anti-CD4 mAb-induced tolerance but cannot reverse established tolerance in a rat kidney transplantation model Am J Transplant 4 2004 863 871