Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720

Transplantation

Volumn 73, Issue 9, 2002, Pages 1425-1430

  Fu, Fumin ^a   Hu, Shiling ^a   Deleo, Jeffrey ^a   Li, Shu ^a   Hopf, Christine ^a   Hoover, Jennifer ^a   Wang, Shuya ^a   Brinkmann, Volker ^a   Lake, Philip ^a   Shi, Victor C ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FINGOLIMOD; STREPTOZOCIN; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; GRAFT REJECTION; GRAFT SURVIVAL; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; STREPTOZOCIN DIABETES;

EID: 0037093385     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200205150-00011     Document Type: Article

References (31)

1. Islet transplantation: Present and future perspectives
2. Islet transplantation
3. The NOD mouse model of type 1 diabetes: As good as it gets?
4. Clinical islet transplantation: A review
5. Clinical experience with autologous and allogeneic pancreatic islet transplantation
6. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
7. In vitro effects of FK-506 on human and rat islets
8. Islet toxicity of FK506 measured in canine autografts
9. FTY720: A novel transplantation drug that modulates lymphocyte traffic rather than activation
10. Human safety and pharmacology of FTY720
11. Enhanced chemokine-dependent lymphocyte chemotaxis by FTY720 results in immunosuppression
12. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing
13. FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation
14. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo
15. FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory
16. The NOD mouse: A model for insulin-dependent diabetes mellitus
17. Kinetic analysis of inositol trisphosphate binding to pure inositol trisphosphate receptors using scintillation proximity assay
18. Immunosuppressive effects of FTY720 alone or in combination with cyclosporine and/or sirolimus
19. Xenoislet transplantation: Experimental and clinical aspects
20. Islet autoimmunity before and after pancreas transplantation in patients with Type I diabetes mellitus
21. Recurrence of autoimmune diabetes mellitus in recipients of cadaveric pancreatic grafts
22. Recurrence of disease in pancreas transplants
23. Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse
24. Autoimmune diabetes: How many steps for one disease?
25. The effect of H-2 compatibility on pancreatic beta cell survival in the nonobese diabetic mouse
26. Islet transplantation for patients with type 1 diabetes
27. Effect of cyclosporin A on glucose-induced insulin secretion by isolated human islets of Langerhans
28. In vitro effects of FK-506 on human and rat islets
29. Effect of FK506 on insulin secretion in normal dogs
30. Human islet allotransplantation under FK 506
31. Effect of FK 506 on function of human islets of Langerhans