Targeted deletion of CX3CR1 reveals a role for fractalkine in cardiac allograft rejection

Journal of Clinical Investigation

Volumn 108, Issue 5, 2001, Pages 679-688

  Haskell, Christopher A ^a,e   Hancock, Wayne W ^b   Salant, David J ^c   Gao, Wei ^b   Csizmadia, Vilmos ^b   Peters, Wendy ^a   Faia, Kerrie ^b   Fituri, Omar ^c   Rottman, James B ^b   Charo, Israel F ^a,d  

^a GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR1; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT;

ALLERGIC ENCEPHALOMYELITIS; ALLOGRAFT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLOMERULONEPHRITIS; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY FUNCTION; LEUKOCYTE ADHERENCE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0034800041     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI12976     Document Type: Article

References (43)

1. 3C motif
2. 1, which mediates both leukocyte migration and adhesion
3. 3CR1-expressing cells is independent of G-protein activation
4. 3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow
5. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo
6. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia
7. Inflammatory agents regulate in vivo expression of fractalkine in endothelial cells of the rat heart
8. Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage
9. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation
10. 3CR1
11. NF-κB-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1β, TNF-α, and LPS
12. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
13. Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals
14. Polymerase chain reaction-based method for quantifying recruitment of monocytes to mouse atherosclerotic lesions in vivo. Enhancement by tumor necrosis factor-α and interleukin-1β
15. Unique role of the chemokine domain of fractalkine in cell capture. Kinetics of receptor dissociation correlate with cell adhesion
16. Experimental glomerulonephritis
17. Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis
18. Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent
19. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes
20. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
21. Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection
22. Requirement of the chemokine receptor CXCR3 for acute allograft rejection
23. 3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
24. Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human
25. 3C chemokine-induced leukocyte infiltration and attenuation of glomerulonephritis in Wistar-Kyoto (WKY) rats by vMIP-II
26. Modulation of experimental autoimmune encephalomyelitis: Effect of altered peptide ligand on chemokine and chemokine receptor expression
27. 3CR1 mRNAs in rat brain: Does fractalkine play a role in signaling from neuron to microglia?
28. 3C-chemokine, fractalkine-enhanced adhesion of THP-1 cells to endothelial cells through integrin-dependent and -independent mechanisms
29. Neuronal expression of fractalkine in the presence and absence of inflammation
30. Chemokines and their receptors in allograft rejection
31. Expression of chemokines and their receptors in nephrotoxic serum nephritis
32. RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis
33. Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis
34. Increased severity of glomerulonephritis in C-C chemokine receptor 2 knockout mice
35. The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia
36. 3CR1 chemokine receptors on neurons and their role in neuronal survival
37. Fractalkine modulates TNF-α secretion and neurotoxicity induced by microglial activation
38. Neuronal fractalkine expression in HIV-1 encephalitis: Roles for macrophage recruitment and neuroprotection in the central nervous system
39. Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis
40. Role of Rantes in experimental cardiac allograft rejection
41. A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection
42. 3CR1) in cardiac allograft rejection
43. -/- mice