Secondary lymphoid organs are important but not absolutely required for allograft responses

American Journal of Transplantation

Volumn 3, Issue 3, 2003, Pages 259-266

  Zhou, Ping ^a   Hwang, Kwang Woo ^a   Palucki, David ^a   Kim, Oliver ^a   Newell, Kenneth A ^b   Fu, Yang Xin ^a   Alegre, Maria Luisa ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute rejection; Secondary lymphoid organs; T cells

Indexed keywords

ACUTE GRAFT REJECTION; ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GRAFT REJECTION; HEART GRAFT; IMMUNE RESPONSE; IMMUNOREACTIVITY; LYMPH NODE; LYMPHOID ORGAN; MOUSE; MOUSE STRAIN; NONHUMAN; ORGAN DONOR; PEYER PATCH; PROVOCATION TEST; RECIPIENT; SKIN GRAFT; SPECIES COMPARISON; SPLENECTOMY; T LYMPHOCYTE; WILD TYPE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; FLOW CYTOMETRY; HEART TRANSPLANTATION; KINETICS; LYMPH NODES; LYMPHATIC SYSTEM; LYMPHOCYTES; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; SKIN TRANSPLANTATION; T-LYMPHOCYTES; TIME FACTORS; TRANSPLANTATION IMMUNOLOGY;

EID: 0037355158     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-6143.2003.00067.x     Document Type: Article

References (34)

1. Pietra BA, Wiseman A, Bolwerk A, Rizeq M, Gill RG. CD4 T cellmediated cardiac allograft rejection requires donor but not host MHC class II. J Clin Invest 2000; 106: 1003-1010.
2. Mandelbrot DA, Kishimoto K, Auchincloss H Jr, Sharpe AH, Sayegh MH. Rejection of mouse cardiac allografts by costimulation in trans. J Immunol 2001; 167: 1174-1178.
3. Kreisel D, Krupnick AS, Gelman AE et al. Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition. Nat Med 2002; 8: 233-239.
4. Miyawaki S, Nakamura Y, Suzuka H et al. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol 1994; 24: 429-434.
5. Shinkura R, Kitada K, Matsuda F et al. Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa binducing kinase. Nat Genet 1999; 22: 74-77.
6. Lakkis FG, Arakelov A, Konieczny BT, Inoue Y. Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nat Med 2000; 6: 686-688.
7. Lin X, Cunningham ET, Mu Y, Geleziunas R, Greene WC. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases. Immunity 1999; 10: 271-280.
8. Fagarasan S, Shinkura R, Kamata T et al. Alymphoplasia (aly) type nuclear factor kappaB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system. J Exp Med 2000; 191: 1477-1486.
9. Yamada T, Mitani T, Yorita K et al. Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kappa B-inducing kinase. J Immunol 2000; 165: 804-812.
10. Karrer U, Althage A, Odermatt B, Hengartner H, Zinkernagel RM. Immunodeficiency of alymphoplasia mice (aly/aly) in vivo: structural defect of secondary lymphoid organs and functional B cell defect. Eur J Immunol 2000; 30: 2799-2807.
11. Hasegawa S, Miura T, Sasaki S, Madarame H, Nakane A. Dysregulation of interleukin-10 and interleukin-12 are involved in the reduced host resistance to Listeria monocytogenes infection in alymphoplastic aly mutant mice. FEMS Immunol Med Microbiol 2002; 32: 111-117.
12. Mori S, Nakano H, Aritomi K, Wang CR, Gunn MD, Kakiuchi T. Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses. J Exp Med 2001; 193: 207-218.
13. Gajewska BU, Alvarez D, Vidric M et al. Generation of experimental allergic airways inflammation in the absence of draining lymph nodes. J Clin Invest 2001; 108: 577-583.
14. Lee BJ, Santee S, Von Gesjen S, Ware CF, Sarawar SR. Lymphotoxin-alpha-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosis. J Virol 2000; 74: 2786-2792.
15. Kumaraguru U, Davis IA, Deshpande S, Tevethia SS, Rouse BT. Lymphotoxin alpha-/- mice develop functionally impaired CD8+ T cell responses and fail to contain virus infection of the central nervous system. J Immunol 2001; 166: 1066-1074.
16. Rennert PD, Hochman PS, Flavell RA et al. Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice. J Exp Med 2001; 193: 1227-1238.
17. Guo Z, Wang J, Meng L et al. Cutting edge: membrane lymphotoxin regulates CD8 (+) T cell-mediated intestinal allograft rejection. J Immunol 2001; 167: 4796-4800.
18. Chin R, Zhou P, Alegre ML, Fu YX. Confounding factors complicate conclusions in aly model. Nat Med 2001; 7: 1165-1166.
19. De Togni P, Goellner J, Ruddle NH et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 1994; 264: 703-707.
20. Fu YX, Huang G, Matsumoto M, Molina H, Chaplin DD. Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node. Proc Natl Acad Sci USA 1997; 94: 5739-5743.
21. Koni PA, Sacca R, Lawton P, Browning JL, Ruddle NH, Flavell RA. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity 1997; 6: 491-500.
22. Futterer A, Mink K, Luz A, Kosco-Vilbois MH, Pfeffer K. The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 1998; 9: 59-70.
23. Corry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973; 16: 343-350.
24. Szot GL, Zhou P, Sharpe AH et al. Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival. Transplantation 2000; 69: 904-909.
25. Szot GL, Zhou P, Rulifson I et al. Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice. Am J Transplant 2001; 1: 38-46.
26. Chalasani G, Dai Z, Konieczny BT, Baddoura FK, Lakkis FG. Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs. Proc Natl Acad Sci USA 2002; 99: 6175-6180.
27. Matsumoto M, Iwamasa K, Rennert PD et al. Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis. J Immunol 1999; 163: 1584-1591.
28. Wu Q, Salomon B, Chen M et al. Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor. J Exp Med 2001; 193: 1327-1332.
29. Ettinger R, Munson SH, Chao CC, Vadeboncoeur M, Toma J, McDevitt HO. A critical role for lymphotoxin-beta receptor in the development of diabetes in nonobese diabetic mice. J Exp Med 2001; 193: 1333-1340.
30. Hasegawa S, Becker G, Nagano H, Libby P, Mitchell RN. Pattern of graft- and host-specific MHC class II expression in long-term murine cardiac allografts: origin of inflammatory and vascular wall cells. Am J Pathol 1998; 153: 69-79.
31. Tamada K, Shimozaki K, Chapoval AI et al. Modulation of T-cellmediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat Med 2000; 6: 283-289.
32. Tamada K, Ni J, Zhu G et al. Cutting edge: selective impairment of CD8 (+) T cell function in mice lacking the TNF superfamily member LIGHT. J Immunol 2002; 168: 4832-4835.
33. YeQ, Fraser CC, Gao W et al. Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival. J Exp Med 2002; 195: 795-800.
34. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708-712.