Feline immunodeficiency virus-mediated viral interleukin-10 gene transfer prolongs non-vascularized cardiac allograft survival

American Journal of Transplantation

Volumn 3, Issue 5, 2003, Pages 552-561

  Fu, Shuang ^a   Chen, Dongmei ^a   Mao, Xia ^b   Zhang, Nan ^a   Ding, Yaozhong ^a   Bromberg, Jonathan S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Columbia Univ Coll of Phys/Surgs ^*  (United States)

Author keywords

Allograft; Lentivirus; Viral IL 10

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; CD40 LIGAND MONOCLONAL ANTIBODY; CHEMOKINE; CHEMOKINE RECEPTOR; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; MONOCLONAL ANTIBODY CD3; VIRUS VECTOR;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DNA TRANSFER; FELINE IMMUNODEFICIENCY VIRUS VECTOR; FEMALE; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; HEART GRAFT; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; ISCHEMIA; ISOGRAFT; MOUSE; NONHUMAN; REPERFUSION INJURY; REPORTER GENE; VIRUS GENE;

ADENOVIRIDAE; ANIMALS; ANTIGENS, CD3; BETA-GALACTOSIDASE; CHEMOKINES; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; GRAFT ENHANCEMENT, IMMUNOLOGIC; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNODEFICIENCY VIRUS, FELINE; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-10; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLASMIDS; RECEPTORS, CHEMOKINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TRANSGENES;

EID: 0037908907     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-6143.2003.00076.x     Document Type: Article

References (50)

1. Mosmann TR, Moore KW. The role of IL-10 in crossregulation of TH1 and TH2 responses Immunol Today 1991; 12: A49-53.
2. Rousset F, Garcia E, Defrance T et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 1992; 89: 1890-1893.
3. Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science 1990; 248: 1230-1234.
4. Suzuki T, Tahara H, Narula S, Moore KW, Robbins PD, Lotze MT. Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors. J Exp Med 1995; 182: 477-486.
5. Takayama T, Tahara H, Thomson AW. Differential effects of myeloid dendritic cells retrovirally transduced to express mammalian or viral interleukin-10 on cytotoxic T lymphocyte and natural killer cell functions and resistance to tumor growth. Transplantation 2001; 71: 1334-1340.
6. Qin L, Chavin KD, Ding Y et al. Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival. J Immunol 1996; 156: 2316-2323.
7. Ding Y, Qin L, Kotenko SV, Pestka S, Bromberg JS. A single amino acid determines the immunostimulatory activity of interleukin 10. J Exp Med 2000; 191: 213-224.
8. Acsadi G, Jiao SS, Jani A et al. Direct gene transfer and expression into rat heart in vivo. New Biol 1991; 3: 71-81.
9. Gojo S, Kitamura S, Germeraad WT, Yoshida Y, Niwaya K, Kawachi K. Ex vivo gene transfer into myocardium using replication-defective retrovirus. Cell Transplant 1996; 5 (Suppl. 1): S81-S84.
10. Wang J, Ma Y, Knechtle SJ. Adenovirus-mediated gene transfer into rat cardiac allografts. Comparison of direct injection and perfusion. Transplantation 1996; 61: 1726-1729.
11. Maeda Y, Ikeda U, Shimpo M et al. Efficient gene transfer into cardiac myocytes using adeno-associated virus (AAV) vectors. J Mol Cell Cardiol 1998; 30: 1341-1348.
12. Qin L, Chavin KD, Ding Y et al. Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model: immunosuppression with TGF-β1 or vIL-10. Transplantation 1995; 59: 809-816.
13. Zuo Z, Wang C, Carpenter D et al. Prolongation of allograft survival with viral IL-10 transfection in a highly histoincompatible model of rat heart allograft rejection. Transplantation 2001; 71: 686-691.
14. Qin L, Ding Y, Pahud DR, Robson ND, Shaked A, Bromberg JS. Adenovirus-mediated gene transfer of viral interleukin-10 inhibits the immune response to both alloantigen and adenoviral antigen. Hum Gene Ther 1997; 8: 1365-1374.
15. Olthoff KM, Judge TA, Gelman AE et al. Adenovirus-mediated gene transfer into cold-preserved liver allografts, survival pattern and unresponsiveness following transduction with CTLA4lg. Nat Med 1998; 4: 194-200.
16. Guillot C, Mathieu P, Coathalem H et al. Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus-mediated CTLA4lg expression. J Immunol 2000; 164: 5258-5268.
17. Jones ND, Van Maurik A, Hara M et al. CD40-CD40 ligand- independent activation of CD8+ T cells can trigger allograft rejection. J Immunol 2000; 165: 1111-1118.
18. Guillot C, Guilonneau C, Mathieu P et al. Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40lg results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chronic rejection. J Immunol 2002; 168: 1600-1609.
19. Girod A, Ried M, Wobus C et al. Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2. Nat Med 1999; 5: 1052-1056.
20. Poeschla EM, Wong-Staal F, Looney DJ. Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors. Nat Med 1998; 4: 354-357.
21. Johnston JC, Gasmi M, Lim LE et al. Minimum requirements for efficient transduction of dividing and nondividing cells by feline immunodeficiency virus vectors. J Virol 1999; 73: 4991-5000.
22. Curran MA, Kaiser SM, Achacoso PL, Nolan GP. Efficient transduction of nondividing cells by optimized feline immunodeficiency virus vectors. Mol Ther 2000; 1: 31-38.
23. Leo O, Foo M, Sachs DH, Samelson LE, Bluestone JA. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci USA 1987; 84: 1374-1378.
24. Taylor PA, Panoskaltsis-Mortari A, Noelle RJ, Blazar BR. Analysis of the requirements for the induction of CD4+ T cell alloantigen hyporesponsiveness by ex vivo anti-CD40 ligand antibody. J Immunol 2000; 164: 612-622.
25. Suzuki T, Tahara H, Narula S, Moore KW, Robbins PD, Lotze MT. Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors. J Exp Med 1995; 182: 477-486.
26. Addison CL, Hitt M, Kunsken D, Graham FL. Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors. J Gen Virol 1997; 78: 1653-1661.
27. Csete ME, Drazan KE, Bree MV, Shaked A. Adenovirus-mediated gene transfer in the transplant setting. Part I. Conditions for expression of transferred genes in cold preserved hepatocytes. Transplantation 1994; 57: 1502-1507.
28. Dong H, Morral N, McEvoy R, Meseck M, Thung SN, Woo SL. Hepatic insulin expression improves glycemic control in type 1 diabetic rats. Diabetes Res Clin Pract 2001; 52: 153-163.
29. Crandell RA, Fabricant CG, Nelson-Rees WA. Development, characterization, and viral susceptibility of a feline (Felis catus) renal cell line (CRFK). In Vitro 1973; 9: 176-185.
30. Qin L, Pahud DR, Ding Y et al. Efficient transfer of genes into murine cardiac grafts by Starburst polyamidoamine dendrimers. Hum Gene Ther 1998; 9: 553-560.
31. Qin L, Ding Y, Pahud DR, Chang E, Imperiale MJ, Bromberg JS. Promoter attenuation in gene therapy: interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression. Hum Gene Ther 1997; 8: 2019-2029.
32. Worgall S, Wolff G, Falck-Pedersen E, Crystal RG. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Hum Gene Ther 1997; 8: 37.
33. Burns JC, Friedmann T, Driever W, Burrascano M, Yee JK. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc Natl Acad Sci USA 1993; 90: 8033-8037.
34. Pierson RN, Crowe JE, Pfeiffer S, Atkinson J, Azimzadeh A, Miller GG. CD40-ligand in primate cardiac allograft and viral immunity. Immunol Res 2001; 23: 253-262.
35. Brinkmann V, Pinschewer DD, Feng L, Chen S. FTY720: altered lymphocyte traffic results in allograft protection. Transplantation 2001; 72: 764-769.
36. Chavin KD, Qin L, Lin J, Kaplan AJ, Bromberg JS. Anti-CD2 and anti-CD3 monoclonal antibodies synergize to prolong allograft survival with decreased side effects. Transplantation 1993; 55: 901-908.
37. Enk AH, Angeloni VL, Udey MC, Katz SI. Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance. J Immunol 1993; 151: 2390-2398.
38. Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 1993; 151: 1224-1234.
39. Zlotnik A, Yoshie O. Chemokines. a new classification system and their role in immunity. Immunity 2000; 12: 121-127.
40. Rossi D, Zlotnik A. The biology of chemokines and their receptors. Annu Rev Immunol 2000; 18: 217-242.
41. Hancock WW, Gao W, Faia KL, Csizmadia V. Chemokines and their receptors in allograft rejection. Curr Opin Immunol 2000; 12: 511.
42. Nelson PJ, Krensky AM. Chemokines, chemokine receptors, and allograft rejection. Immunity 2001; 14: 377.
43. Grone HJ, Weber C, Weber KS et al. Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: blocking monocyte arrest and recruitment. FASEB J 1999; 13: 1371-1383.
44. Pattison J, Nelson PJ, Huie P et al. RANTES chemokine expression in cell-mediated transplant rejection of the kidney. Lancet 1994; 343: 209-211.
45. Hancock WW, Lu B, Gao W et al. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med 2000; 192: 1515-1520.
46. von Hundelshausen P, Weber KSC, Huo Y et al. RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium. Circulation 2001; 103: 1772-1777.
47. Koga S, Auerbach MB, Engeman TM, Novick AC, Toma H, Fairchild RL. T cell infiltration into class II MHC-disparate allografts and acute rejection is dependent on the IFN-induced chemokine Mig. J Immunol 1999; 163: 4878.
48. Hosie MJ, Jarrett O. Analysis of the protective immunity induced by feline immunodeficiency virus vaccination. Adv Vet Med 1999; 41: 325-332.
49. Zaiss AK, Liu Q, Bowen GP, Wong NC, Bartlett JS, Muruve DA. Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors. J Virol 2002; 76: 4580-4590.
50. Higginbotham JN, Seth P, Blaese RM, Ramsey WJ. The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid. Hum Gene Ther 2002; 13: 129-141.