-
1
-
-
0032488646
-
Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: Analogues of FTY720
-
Kiuchi M, Adachi K, Kohara T et al. Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720. Bioorg Med Chem Lett 1998; 8: 101-6.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 101-106
-
-
Kiuchi, M.1
Adachi, K.2
Kohara, T.3
-
2
-
-
0035884709
-
FTY720: Altered lymphocyte traffic results in allograft protection
-
Brinkmann V, Pinschewer DD, Feng L, Chen S. FTY720: Altered lymphocyte traffic results in allograft protection. Transplantation 2001; 72: 764-769.
-
(2001)
Transplantation
, vol.72
, pp. 764-769
-
-
Brinkmann, V.1
Pinschewer, D.D.2
Feng, L.3
Chen, S.4
-
3
-
-
0036755270
-
FTY720 alters the composition of T-lymphocyte subpopulations in the peripheral blood compartment of renal transplant patients
-
Boehler T, Schuetz M, Budde K, Neumayer H, Waiser J. FTY720 alters the composition of T-lymphocyte subpopulations in the peripheral blood compartment of renal transplant patients. Transplant Proc 2002; 34: 2242-2243.
-
(2002)
Transplant Proc
, vol.34
, pp. 2242-2243
-
-
Boehler, T.1
Schuetz, M.2
Budde, K.3
Neumayer, H.4
Waiser, J.5
-
4
-
-
0036205659
-
First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients
-
Budde K, Schmouder RL, Brunkhorst R et al. First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients. J Am Soc Nephrol 2002; 13: 1073-1083.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 1073-1083
-
-
Budde, K.1
Schmouder, R.L.2
Brunkhorst, R.3
-
5
-
-
0034120178
-
FTY720 immunosuppression impairs effector T-cell peripheral homing without affecting induction, expansion, and memory
-
Pinschewer DD, Ochsenbein AF, Odermatt B, Brinkmann V, Hengartner H, Zinkernagel RM. FTY720 immunosuppression impairs effector T-cell peripheral homing without affecting induction, expansion, and memory. J Immunol 2000; 164: 5761-5770.
-
(2000)
J Immunol
, vol.164
, pp. 5761-5770
-
-
Pinschewer, D.D.1
Ochsenbein, A.F.2
Odermatt, B.3
Brinkmann, V.4
Hengartner, H.5
Zinkernagel, R.M.6
-
6
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
-
Mandala S, Hajdu R, Bergstrom J et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 2002; 296: 346-349.
-
(2002)
Science
, vol.296
, pp. 346-349
-
-
Mandala, S.1
Hajdu, R.2
Bergstrom, J.3
-
7
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
Brinkmann V, Davis MD, Heise CE et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 2002; 277: 21453-21457.
-
(2002)
J Biol Chem
, vol.277
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
-
8
-
-
0032103938
-
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo
-
Yanagawa Y, Sugahara K, Kataoka H, Kawaguchi T, Masubuchi Y, Chiba K. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo. J Immunol 1998; 160: 5493-5499.
-
(1998)
J Immunol
, vol.160
, pp. 5493-5499
-
-
Yanagawa, Y.1
Sugahara, K.2
Kataoka, H.3
Kawaguchi, T.4
Masubuchi, Y.5
Chiba, K.6
-
9
-
-
0033592304
-
FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation
-
Hwang MW, Matsumori A, Furukawa Y et al. FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation. Circulation 1999; 100: 1322-1329.
-
(1999)
Circulation
, vol.100
, pp. 1322-1329
-
-
Hwang, M.W.1
Matsumori, A.2
Furukawa, Y.3
-
10
-
-
0344806941
-
FTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine A
-
Koshiba T, Van Damme B, Rutgeerts O, Waer M, Pirenne J. FTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine A. Transplantation 2003; 75: 945-952.
-
(2003)
Transplantation
, vol.75
, pp. 945-952
-
-
Koshiba, T.1
Van Damme, B.2
Rutgeerts, O.3
Waer, M.4
Pirenne, J.5
-
11
-
-
0037108893
-
Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD
-
Schuurman HJ, Menninger K, Audet M et al. Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD. Transplantation 2002; 74: 951-960.
-
(2002)
Transplantation
, vol.74
, pp. 951-960
-
-
Schuurman, H.J.1
Menninger, K.2
Audet, M.3
-
12
-
-
0030776195
-
Induction of tolerance toward rat cardiac allografts by treatment with allochimeric class I MHC antigen and FTY720
-
Chueh SC, Tian L, Wang M, Wang ME, Stepkowski SM, Kahan BD. Induction of tolerance toward rat cardiac allografts by treatment with allochimeric class I MHC antigen and FTY720. Transplantation 1997; 64: 1407-1414.
-
(1997)
Transplantation
, vol.64
, pp. 1407-1414
-
-
Chueh, S.C.1
Tian, L.2
Wang, M.3
Wang, M.E.4
Stepkowski, S.M.5
Kahan, B.D.6
-
13
-
-
0037083360
-
L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance
-
Bai Y, Liu J, Wang Y et al. L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance. J Immunol 2002; 168: 1579-1589.
-
(2002)
J Immunol
, vol.168
, pp. 1579-1589
-
-
Bai, Y.1
Liu, J.2
Wang, Y.3
-
14
-
-
0027076727
-
Induction of long-term survival of rat skin allografts by a novel, highly efficient anti-CD4 monoclonal antibody
-
Lehmann M, Sternkopf F, Metz F et al. Induction of long-term survival of rat skin allografts by a novel, highly efficient anti-CD4 monoclonal antibody. Transplantation 1992; 54: 959-962.
-
(1992)
Transplantation
, vol.54
, pp. 959-962
-
-
Lehmann, M.1
Sternkopf, F.2
Metz, F.3
-
15
-
-
0028567115
-
Tolerance induction by anti-CD4 mab treatment in a rat kidney transplantation model
-
Volk HD, Siegling A, Platzer C, Brock J, Emmrich F, Lehmann M. Tolerance induction by anti-CD4 mab treatment in a rat kidney transplantation model. Transplant Proc 1994; 26: 3155-3156.
-
(1994)
Transplant Proc
, vol.26
, pp. 3155-3156
-
-
Volk, H.D.1
Siegling, A.2
Platzer, C.3
Brock, J.4
Emmrich, F.5
Lehmann, M.6
-
16
-
-
0014089108
-
An improved technique of renal transplantation in the rat
-
Lee S. An improved technique of renal transplantation in the rat. Surgery 1967; 61: 771-773.
-
(1967)
Surgery
, vol.61
, pp. 771-773
-
-
Lee, S.1
-
17
-
-
0342647314
-
Immune response after adenoviral gene transfer in syngeneic heart transplants: Effects of anti-CD4 monoclonal antibody therapy
-
Schröder G, Risch K, Nizze H et al. Immune response after adenoviral gene transfer in syngeneic heart transplants: effects of anti-CD4 monoclonal antibody therapy. Transplantation 2000; 70: 191-198.
-
(2000)
Transplantation
, vol.70
, pp. 191-198
-
-
Schröder, G.1
Risch, K.2
Nizze, H.3
-
18
-
-
10744230932
-
Interferon-gamma regulation in anti-CD4 antibody induced T cell unresponsiveness
-
Sawitzki B, Kieselbach B, Fisser M et al. Interferon-gamma regulation in anti-CD4 antibody induced T cell unresponsiveness. J Am Soc Nephrol 2004; 15: 695-703.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 695-703
-
-
Sawitzki, B.1
Kieselbach, B.2
Fisser, M.3
-
19
-
-
10744232130
-
Alterations of the immune response with increasing recipient age are associated with reduced long-term organ graft function of rat kidney allografts
-
Pascher A, Reutzel-Selke A, Jurisch A et al. Alterations of the immune response with increasing recipient age are associated with reduced long-term organ graft function of rat kidney allografts. Transplantation 2003; 76: 1560-1568.
-
(2003)
Transplantation
, vol.76
, pp. 1560-1568
-
-
Pascher, A.1
Reutzel-Selke, A.2
Jurisch, A.3
-
20
-
-
0033670568
-
Rescuing acute rejection of rat cardiac allografts with FTY720
-
Chueh SC, Tsai CC, Chiu B, Li YC, Lai MK. Rescuing acute rejection of rat cardiac allografts with FTY720, Transplant Proc 2000; 32: 1629-1630.
-
(2000)
Transplant Proc
, vol.32
, pp. 1629-1630
-
-
Chueh, S.C.1
Tsai, C.C.2
Chiu, B.3
Li, Y.C.4
Lai, M.K.5
-
21
-
-
0032996025
-
Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
-
Kirk AD, Burkly LC, Batty DS et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999; 5: 686-693.
-
(1999)
Nat Med
, vol.5
, pp. 686-693
-
-
Kirk, A.D.1
Burkly, L.C.2
Batty, D.S.3
-
22
-
-
0344613988
-
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
-
Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999; 5: 1298-1302.
-
(1999)
Nat Med
, vol.5
, pp. 1298-1302
-
-
Li, Y.1
Li, X.C.2
Zheng, X.X.3
Wells, A.D.4
Turka, L.A.5
Strom, T.B.6
-
23
-
-
0036829074
-
New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs
-
Sho M, Sandner SE, Najafian N et al. New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs. Ann Surg 2002; 236: 667-675.
-
(2002)
Ann Surg
, vol.236
, pp. 667-675
-
-
Sho, M.1
Sandner, S.E.2
Najafian, N.3
-
24
-
-
0036820441
-
FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration
-
Anselmo DM, Amersi FF, Shen XD et al. FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration. Am J Transplant 2002; 2: 843-849.
-
(2002)
Am J Transplant
, vol.2
, pp. 843-849
-
-
Anselmo, D.M.1
Amersi, F.F.2
Shen, X.D.3
-
25
-
-
0034120177
-
Regulatory cells potentiate the efficacy of IL-4 gene transfer by up-regulating Th2-dependent expression of protective molecules in the infectious tolerance pathway in transplant recipients
-
Ke B, Ritter T, Kato H et al. Regulatory cells potentiate the efficacy of IL-4 gene transfer by up-regulating Th2-dependent expression of protective molecules in the infectious tolerance pathway in transplant recipients. J Immunol 2001; 164: 5739-5745.
-
(2001)
J Immunol
, vol.164
, pp. 5739-5745
-
-
Ke, B.1
Ritter, T.2
Kato, H.3
-
26
-
-
17144450671
-
Anti-CD4 monoclonal antibody-induced allograft tolerance in rats despite persistence of donor-reactive T cells
-
Lehmann M, Graser E, Risch K et al. Anti-CD4 monoclonal antibody-induced allograft tolerance in rats despite persistence of donor-reactive T cells. Transplantation 1997; 64: 1181-1187.
-
(1997)
Transplantation
, vol.64
, pp. 1181-1187
-
-
Lehmann, M.1
Graser, E.2
Risch, K.3
-
27
-
-
0031945499
-
How do monoclonal antibodies induce tolerance? A role for infectious tolerance?
-
Waldmann H, Cobbold S. How do monoclonal antibodies induce tolerance? A role for infectious tolerance? Annu Rev Immunol 1998; 16: 619-644.
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 619-644
-
-
Waldmann, H.1
Cobbold, S.2
-
28
-
-
0030240965
-
Induction of 'infectious' tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients
-
Onodera K, Lehmann M, Akalin E, Volk HD, Sayegh MH, Kupiec-Weglinski JW. Induction of 'infectious' tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients. J Immunol 1996; 157: 1944-1950.
-
(1996)
J Immunol
, vol.157
, pp. 1944-1950
-
-
Onodera, K.1
Lehmann, M.2
Akalin, E.3
Volk, H.D.4
Sayegh, M.H.5
Kupiec-Weglinski, J.W.6
-
29
-
-
0036207582
-
Bag-1 up-regulation in anti-CD4 mAb treated allo-activated T cells confers resistance to apoptosis
-
Sawitzki B, Lehmann M, Vogt K et al. Bag-1 up-regulation in anti-CD4 mAb treated allo-activated T cells confers resistance to apoptosis. Eur J Immunol 2002; 32: 800-809.
-
(2002)
Eur J Immunol
, vol.32
, pp. 800-809
-
-
Sawitzki, B.1
Lehmann, M.2
Vogt, K.3
-
30
-
-
0035347514
-
Regulatory tolerance-mediating T cells in transplantation tolerance
-
Sawitzki B, Lehmann M, Ritter T, Graser E, Kupiec-Weglinski JW, Volk HD. Regulatory tolerance-mediating T cells in transplantation tolerance. Transplant Proc 2001; 33: 2092-2093.
-
(2001)
Transplant Proc
, vol.33
, pp. 2092-2093
-
-
Sawitzki, B.1
Lehmann, M.2
Ritter, T.3
Graser, E.4
Kupiec-Weglinski, J.W.5
Volk, H.D.6
-
31
-
-
0032526605
-
Thymus requirement and antigen dependency in the 'infectious' tolerance pathway in transplant recipients
-
Onodera K, Volk HD, Ritter T, Kupiec-Weglinski JW. Thymus requirement and antigen dependency in the 'infectious' tolerance pathway in transplant recipients. J Immunol 1998; 160: 5765-5772.
-
(1998)
J Immunol
, vol.160
, pp. 5765-5772
-
-
Onodera, K.1
Volk, H.D.2
Ritter, T.3
Kupiec-Weglinski, J.W.4
-
32
-
-
10744230053
-
Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients
-
Budde K, Schmouder RL, Nashan B et al. Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients. Am J Transplant 2003; 3: 846-854.
-
(2003)
Am J Transplant
, vol.3
, pp. 846-854
-
-
Budde, K.1
Schmouder, R.L.2
Nashan, B.3
-
33
-
-
0037385330
-
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
-
Fontenot JD, Gavin MA, Rudenski AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330-336.
-
(2003)
Nat Immunol
, vol.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudenski, A.Y.3
-
34
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-1061.
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
35
-
-
0038687708
-
The effect of FTY720 on engraftment in a model of spontaneous allograft acceptance
-
Koshiba T, Van Damme B, Ji P et al. The effect of FTY720 on engraftment in a model of spontaneous allograft acceptance. Transpl Int 2003; 16: 383-390.
-
(2003)
Transpl Int
, vol.16
, pp. 383-390
-
-
Koshiba, T.1
Van Damme, B.2
Ji, P.3
|