Alloreactive CD4 T Cell Activation In Vivo: An Autonomous Function of the Indirect Pathway of Alloantigen Presentation

Journal of Immunology

Volumn 171, Issue 12, 2003, Pages 6502-6509

  Reed, Amy J ^a   Noorchashm, Hooman ^a   Rostami, Susan Y ^a   Zarrabi, Yasaman ^a   Perate, Alison R ^a   Jeganathan, Arjun N ^a   Caton, Andrew J ^b   Naji, Ali ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD4 ANTIGEN; HLA ANTIGEN CLASS 2; INFLUENZA VIRUS HEMAGGLUTININ; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; ALLOIMMUNITY; ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN FUNCTION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; BIOSYNTHESIS; CELL CLONE; CELL CULTURE; CELL DIFFERENTIATION; CLINICAL PATHWAY; CONTROLLED STUDY; CYTOLOGY; GENETICS; HEART TRANSPLANTATION; IMMUNE RESPONSE; IMMUNOLOGY; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC INFILTRATION; LYMPHOID TISSUE; METABOLISM; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN ALLOGRAFT; SKIN TRANSPLANTATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMUS; TIME SERIES ANALYSIS; TRANSGENIC MOUSE; TRANSPLANTATION; VIROLOGY;

EID: 0345735836     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.12.6502     Document Type: Article

References (32)

1. Gould, D. S., and H. Auchincloss, Jr. 1999. Direct and indirect recognition: the role of MHC antigens in graft rejection. Immunol. Today 20:77.
2. + cells are essential for allorejection. J. Exp. Med. 184:2013.
3. Auchincloss, H., Jr., and H. Sultan. 1996. Antigen processing and presentation in transplantation. Curr. Opin. Immunol. 8:681.
4. Benichou, G., A. Valujskikh, and P. S. Heeger. 1999. Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice. J. Immunol. 162:352.
5. Sayegh, M. H., and C. B. Carpenter. 1996. Role of indirect allorecognition in allograft rejection. Int. Rev. Immunol. 13:221.
6. Song, H. K., H. Noorchashm, Y. K. Lieu, S. Rostami, S. A. Greeley, C. F. Barker, and A. Naji. 1999. Tracking alloreactive cell division in vivo. Transplantation 68:297.
7. + T cell precursor frequency. Transplantation 67:1281.
8. Song, H. K., H. Noorchashm, Y. K. Lieu, S. Rostami, S. A. Greeley, C. F. Barker, and A. Naji. 1999. Cutting edge: alloimmune responses against major and minor histocompatibility antigens: distinct division kinetics and requirement for CD28 costimulation. J. Immunol. 162:2467.
9. + T cell populations. Transplantation 62:300.
10. Fangmann, J., R. Dalchau, and J. W. Fabre. 1992. Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides. J. Exp. Med. 175:1521.
11. Liu, Z., A. I. Colovai, S. Tugulea, E. F. Reed, P. E. Fisher, D. Mancini, E. A. Rose, R. Cortesini, R. E. Michler, and N. Suciu-Foca. 1996. Indirect recognition of donor HLA-DR peptides in organ allograft rejection. J. Clin. Invest. 98:1150.
12. Campos, L., A. Naji, B. C. Deli, J. H. Kern, J. I. Kim, C. F. Barker, and J. F. Markmann. 1995. Survival of MHC-deficient mouse heterotopic cardiac allografts. Transplantation 59:187.
13. 8 single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180:25.
14. Gerhard, W., A. M. Haberman, P. A. Scherle, A. H. Taylor, G. Palladino, and A. J. Caton. 1991. Identification of eight determinants in the hemagglutinin molecule of influenza virus A/PR/8/34 (H1N1) which are recognized by class II-restricted T cells from BALB/c mice. J. Virol. 65:364.
15. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301.
16. Cerasoli, D. M., J. McGrath, S. R. Carding, F. F. Shih, B. B. Knowles, and A. J. Caton. 1995. Low avidity recognition of a class II-restricted neo-self peptide by virus-specific T cells. Int. Immunol. 7:935.
17. Wells, A. D., H. Gudmundsdottir, and L. A. Turka. 1997. Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J. Clin. Invest. 100:3173.
18. Caton, A. J., J. R. Swartzentruber, A. L. Kuhl, S. R. Carding, and S. E. Stark. 1996. Activation and negative selection of functionally distinct subsets of antibody-secreting cells by influenza hemagglutinin as a viral and a neo-self antigen. J. Exp. Med. 183:13.
19. Kouskoff, V., H. J. Fehling, M. Lemeur, C. Benoist, and D. Mathis. 1993. A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice. J. Immunol. Methods 166:28Z
20. Larsen, C. P., P. J. Morris, and J. M. Austyn. 1990. Migration of dendritic leukocytes from cardiac allografts into host spleens: a novel pathway for initiation of rejection. J. Exp. Med. 171:307.
21. Larsen, C. P., R. M. Steinman, M. Witmer-Pack, D. F. Hankins, P. J. Morris, and J. M. Austyn. 1990. Migration and maturation of Langerhans cells in skin transplants and explants. J. Exp. Med. 172:1483.
22. Lakkis, F. G., A. Arakelov, B. T. Konieczny, and Y. Inoue. 2000. Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nat. Med. 6:686.
23. Barker, C. F., and R. E. Billingham. 1968. The role of afferent lymphatics in the rejection of skin homografts. J. Exp. Med. 128:197.
24. Caton, A. J., G. G. Brownlee, J. W. Yewdell, and W. Gerhard. 1982. The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype). Cell 31:417
25. Ron, Y., and J. Sprent. 1987. T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes. J. Immunol. 138:2848.
26. Janeway, C. A. Jr., J. Ron, and M. E. Katz. 1987. The B cell is the initiating antigen presenting cell in peripheral lymph nodes. J. Immunol. 138:1051.
27. + T cell responses to a self peptide. Eur. J. Immunol. 30:136.
28. Azzam H. S., A. Grinberg, K. Lui, H. Shen, E. W. Shores, and P. E. Love. 1998. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 188:2301.
29. Anderson, M. S., E. S. Venanzi, L. Klein, Z. Chen, S. P. Berzins, S. J. Turley, H. von Boehmer, R. Bronson, A. Dierich, C. Benoist, and D. Mathis. 2002. Proqjection of an immunological self shadow within the thymus by the Aire protein. Science 298:1395.
30. Pietra, B. A., A. Wisemanm, A. Bolwerk, M. Rizeq, and R. G. Gill. 2000. CD4 T cell mediated cardiac allograft rejection required donor but not host MHC class II. J. Clin. Invest. 106:1003.
31. + T cells: evidence from a lymphopenic T cell model. Immunity 17:425.
32. Mandelbrot D. A., Y. Furukawa, A. J. McAdam, S. I. Alexander, P. Libby, R. N. Mitchell, and A. H. Sharpe. 1999. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. J. Immunol. 163:3753.