Clinical relevance of internal tandem duplication of the FLT3 gene in childhood acute myeloid leukemia

Cancer

Volumn 94, Issue 12, 2002, Pages 3292-3298

  Liang, Der Cherng ^a   Shih, Lee Yung ^b,e   Hung, Iou Jih ^c   Yang, Chao Ping ^c   Chen, Shu Huey ^a   Jaing, Tang Her ^c   Liu, Hsi Che ^a   Chang, Wan Hui ^d  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c CHANG GUNG CHILDREN S HOSPITAL   (Taiwan)

^d Childhood Cancer Foundation   (Taiwan)

^e CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Childhood acute myeloid leukemia; FLT3 internal tandem duplication; French American British subtype; Fusion transcript

Indexed keywords

AMSACRINE; CD135 ANTIGEN; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; EPIRUBICIN; ETOPOSIDE; GENE PRODUCT; HYDROCORTISONE; IDARUBICIN; MERCAPTOPURINE; METHOTREXATE; MITOXANTRONE; RETINOIC ACID; TIOGUANINE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ARTICLE; CHILDHOOD LEUKEMIA; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CYTOGENETICS; FEMALE; GENE DUPLICATION; GENE FREQUENCY; GENE FUSION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROMYELOCYTIC LEUKEMIA; RISK ASSESSMENT; SCHOOL CHILD; TREATMENT OUTCOME;

ADOLESCENT; CHILD; FEMALE; FMS-LIKE TYROSINE KINASE 3; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; MUTATION; PROGNOSIS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; TANDEM REPEAT SEQUENCES;

EID: 0037096857     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.10598     Document Type: Article

References (27)

1. Fifty years of studies of the biology and therapy of childhood leukemia
2. Clinical and prognostic significance of chromosomal abnormalities in childhood acute myeloid leukemia de novo
3. The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1612 patients entered into the MRC AML 10 trial
4. Internal tandem duplication of the FLT3 gene found in acute myeloid leukemia
5. Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: A study on a large series of patients and cell lines
6. Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia
7. Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia
8. Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells
9. Close physical linkage of the FLT1 and FLT3 genes on chromosome 13 in man and chromosome 5 in mouse
10. Expression of FLT3 receptor and FLT3-ligand in human leukemia-lymphoma cell lines
11. Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells
12. Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia
13. Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia
14. Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children
15. Prevalence and prognostic significance of FLT3 internal tandem duplication in pediatric acute myeloid leukemia
16. Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7): A report of the French-American-British Cooperative Group
17. Proposed revised criteria for the classification of acute myeloid leukemia: A report of the French-American-British Cooperative Group
18. Proposal for the recognition of minimally differentiated acute myeloid leukaemia (AML-M0)
19. Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukemia. Results of the medical Research Council's 10th AML Trial (MRC AML 10)
20. Molecular analysis of fusion transcripts in childhood acute myeloid leukemia in Taiwan
21. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
22. Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the flt 3 gene
23. FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group
24. FLT3 length mutation in AML: Correlation to cytogenetics, FAB-subtype, and prognosis in 652 patients
25. A modified AIDA protocol with anthracycline-based consolidation results in high antileukemic efficacy and reduced toxicity in newly diagnosed PML/RARalpha-positive acute promyelocytic leukemia
26. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study