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Volumn 367, Issue 3, 2004, Pages 349-354

Microglial activation is a pharmacologically specific marker for the neurotoxic amphetamines

Author keywords

MDMA; Methamphetamine; Microglia; Neurotoxicity; Striatum

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; AMPHETAMINE; CYTOKINE; DEXAMPHETAMINE; GLIAL FIBRILLARY ACIDIC PROTEIN; METHAMPHETAMINE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

EID: 4444335318     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.06.065     Document Type: Article
Times cited : (172)

References (59)
  • 1
    • 0035152836 scopus 로고    scopus 로고
    • Immune function of microglia
    • F. Aloisi Immune function of microglia Glia 36 2001 165 179
    • (2001) Glia , vol.36 , pp. 165-179
    • Aloisi, F.1
  • 2
    • 1642273736 scopus 로고    scopus 로고
    • Repeated amphetamine treatment causes a persistent elevation of glial fibrillary acidic protein in the caudate-putamen
    • V. Armstrong, C.M. Reichel, J.F. Doti, C.A. Crawford, and S.A. McDougall Repeated amphetamine treatment causes a persistent elevation of glial fibrillary acidic protein in the caudate-putamen Eur. J. Pharmacol. 488 2004 111 115
    • (2004) Eur. J. Pharmacol. , vol.488 , pp. 111-115
    • Armstrong, V.1    Reichel, C.M.2    Doti, J.F.3    Crawford, C.A.4    McDougall, S.A.5
  • 3
    • 0042320662 scopus 로고    scopus 로고
    • Increased morphological diversity of microglia in the activated hypothalamic supraoptic nucleus
    • A.E. Ayoub, and A.K. Salm Increased morphological diversity of microglia in the activated hypothalamic supraoptic nucleus J. Neurosci. 23 2003 7759 7766
    • (2003) J. Neurosci. , vol.23 , pp. 7759-7766
    • Ayoub, A.E.1    Salm, A.K.2
  • 5
    • 0034624295 scopus 로고    scopus 로고
    • Neuronal degeneration in the limbic system of weanling rats exposed to saline, hyperthermia or d-amphetamine
    • J.F. Bowyer Neuronal degeneration in the limbic system of weanling rats exposed to saline, hyperthermia or d-amphetamine Brain Res. 885 2000 166 171
    • (2000) Brain Res. , vol.885 , pp. 166-171
    • Bowyer, J.F.1
  • 7
    • 0141445982 scopus 로고    scopus 로고
    • Speed kills: Cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosis
    • J.L. Cadet, S. Jayanthi, and X. Deng Speed kills: cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosis FASEB J. 17 2003 1775 1788
    • (2003) FASEB J. , vol.17 , pp. 1775-1788
    • Cadet, J.L.1    Jayanthi, S.2    Deng, X.3
  • 8
    • 0030175757 scopus 로고    scopus 로고
    • Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) induced Parkinson's disease mice model
    • A. Czlonkowska, M. Kohutnicka, I. Kurkowska-Jastrzebska, and A. Czlonkowski Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) induced Parkinson's disease mice model Neurodegeneration 5 1996 137 143
    • (1996) Neurodegeneration , vol.5 , pp. 137-143
    • Czlonkowska, A.1    Kohutnicka, M.2    Kurkowska-Jastrzebska, I.3    Czlonkowski, A.4
  • 9
    • 0034882387 scopus 로고    scopus 로고
    • Methamphetamine neurotoxicity: Necrotic and apoptotic mechanisms and relevance to human abuse and treatment
    • C. Davidson, A.J. Gow, T.H. Lee, and E.H. Ellinwood Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment Brain Res. Brain Res. Rev. 36 2001 1 22
    • (2001) Brain Res. Brain Res. Rev. , vol.36 , pp. 1-22
    • Davidson, C.1    Gow, A.J.2    Lee, T.H.3    Ellinwood, E.H.4
  • 13
    • 0036470165 scopus 로고    scopus 로고
    • Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    • H.M. Gao, J.S. Hong, W. Zhang, and B. Liu Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons J. Neurosci. 22 2002 782 790
    • (2002) J. Neurosci. , vol.22 , pp. 782-790
    • Gao, H.M.1    Hong, J.S.2    Zhang, W.3    Liu, B.4
  • 14
    • 0035399785 scopus 로고    scopus 로고
    • Microglia in neurodegeneration: Molecular aspects
    • P.J. Gebicke-Haerter Microglia in neurodegeneration: molecular aspects Microsc. Res. Tech. 54 2001 47 58
    • (2001) Microsc. Res. Tech. , vol.54 , pp. 47-58
    • Gebicke-Haerter, P.J.1
  • 17
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • F. Gonzalez-Scarano, and G. Baltuch Microglia as mediators of inflammatory and degenerative diseases Annu. Rev. Neurosci. 22 1999 219 240
    • (1999) Annu. Rev. Neurosci. , vol.22 , pp. 219-240
    • Gonzalez-Scarano, F.1    Baltuch, G.2
  • 18
    • 0242403117 scopus 로고    scopus 로고
    • Methamphetamine-induced deficits of brain monoaminergic neuronal markers: Distal axotomy or neuronal plasticity
    • T.R. Guilarte, M.K. Nihei, J.L. McGlothan, and A.S. Howard Methamphetamine-induced deficits of brain monoaminergic neuronal markers: distal axotomy or neuronal plasticity Neuroscience 122 2003 499 513
    • (2003) Neuroscience , vol.122 , pp. 499-513
    • Guilarte, T.R.1    Nihei, M.K.2    McGlothan, J.L.3    Howard, A.S.4
  • 19
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • U.K. Hanisch Microglia as a source and target of cytokines Glia 40 2002 140 155
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.K.1
  • 20
    • 0035800589 scopus 로고    scopus 로고
    • Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum
    • Y. He, S. Appel, and W. Le Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum Brain Res. 909 2001 187 193
    • (2001) Brain Res. , vol.909 , pp. 187-193
    • He, Y.1    Appel, S.2    Le, W.3
  • 21
    • 0345118971 scopus 로고    scopus 로고
    • Long-lasting behavioral sensitization to psychostimulants following p-chloroamphetamine-induced neurotoxicity in mice
    • Y. Itzhak, C.N. Achat-Mendes, S.F. Ali, and K.L. Anderson Long-lasting behavioral sensitization to psychostimulants following p-chloroamphetamine- induced neurotoxicity in mice Neuropharmacology 46 2004 74 84
    • (2004) Neuropharmacology , vol.46 , pp. 74-84
    • Itzhak, Y.1    Achat-Mendes, C.N.2    Ali, S.F.3    Anderson, K.L.4
  • 22
    • 0037146908 scopus 로고    scopus 로고
    • Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke
    • R.L. Jakab, and J.F. Bowyer Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke Brain Res. 958 2002 52 69
    • (2002) Brain Res. , vol.958 , pp. 52-69
    • Jakab, R.L.1    Bowyer, J.F.2
  • 24
    • 2142650653 scopus 로고    scopus 로고
    • Alterations in vesicular dopamine uptake contribute to tolerance to the neurotoxic effects of methamphetamine
    • K.L. Johnson-Davis, J.G. Truong, A.E. Fleckenstein, and D.G. Wilkins Alterations in vesicular dopamine uptake contribute to tolerance to the neurotoxic effects of methamphetamine J. Pharmacol. Exp. Ther. 309 2004 578 586
    • (2004) J. Pharmacol. Exp. Ther. , vol.309 , pp. 578-586
    • Johnson-Davis, K.L.1    Truong, J.G.2    Fleckenstein, A.E.3    Wilkins, D.G.4
  • 25
    • 0035900604 scopus 로고    scopus 로고
    • Amphetamine-induced toxicity in dopamine terminals in CD-1 and C57BL/6J mice: Complex roles for oxygen-based species and temperature regulation
    • I.N. Krasnova, B. Ladenheim, S. Jayanthi, J. Oyler, T.H. Moran, M.A. Huestis, and J.L. Cadet Amphetamine-induced toxicity in dopamine terminals in CD-1 and C57BL/6J mice: complex roles for oxygen-based species and temperature regulation Neuroscience 107 2001 265 274
    • (2001) Neuroscience , vol.107 , pp. 265-274
    • Krasnova, I.N.1    Ladenheim, B.2    Jayanthi, S.3    Oyler, J.4    Moran, T.H.5    Huestis, M.A.6    Cadet, J.L.7
  • 26
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • G.W. Kreutzberg Microglia: a sensor for pathological events in the CNS Trends Neurosci. 19 1996 312 318
    • (1996) Trends Neurosci. , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 27
    • 1842714217 scopus 로고    scopus 로고
    • Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity
    • M.J. LaVoie, J.P. Card, and T.G. Hastings Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity Exp. Neurol. 187 2004 47 57
    • (2004) Exp. Neurol. , vol.187 , pp. 47-57
    • Lavoie, M.J.1    Card, J.P.2    Hastings, T.G.3
  • 29
    • 0037651952 scopus 로고    scopus 로고
    • Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: Cellular and molecular mechanisms
    • J. Lyles, and J.L. Cadet Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms Brain Res. Brain Res. Rev. 42 2003 155 168
    • (2003) Brain Res. Brain Res. Rev. , vol.42 , pp. 155-168
    • Lyles, J.1    Cadet, J.L.2
  • 30
    • 0032531781 scopus 로고    scopus 로고
    • Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: Evidence from positron emission tomography studies with [11C]WIN-35,428
    • U.D. McCann, D.F. Wong, F. Yokoi, V. Villemagne, R.F. Dannals, and G.A. Ricaurte Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35,428 J. Neurosci. 18 1998 8417 8422
    • (1998) J. Neurosci. , vol.18 , pp. 8417-8422
    • McCann, U.D.1    Wong, D.F.2    Yokoi, F.3    Villemagne, V.4    Dannals, R.F.5    Ricaurte, G.A.6
  • 31
    • 0031595247 scopus 로고    scopus 로고
    • Neurotoxic effects of +/-fenfluramine and phenteramine, alone and in combination, on monoamine neurons in the mouse brain
    • U.D. McCann, J. Yuan, and G.A. Ricaurte Neurotoxic effects of +/-fenfluramine and phenteramine, alone and in combination, on monoamine neurons in the mouse brain Synapse 30 1998 239 246
    • (1998) Synapse , vol.30 , pp. 239-246
    • McCann, U.D.1    Yuan, J.2    Ricaurte, G.A.3
  • 32
    • 0027964301 scopus 로고
    • Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse
    • D.B. Miller, and J.P. O'Callaghan Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse J. Pharmacol. Exp. Ther. 270 1994 752 760
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 752-760
    • Miller, D.B.1    O'Callaghan, J.P.2
  • 33
    • 0029348577 scopus 로고
    • The role of temperature, stress, and other factors in the neurotoxicity of the substituted amphetamines 3,4-methylenedioxymethamphetamine and fenfluramine
    • D.B. Miller, and J.P. O'Callaghan The role of temperature, stress, and other factors in the neurotoxicity of the substituted amphetamines 3,4-methylenedioxymethamphetamine and fenfluramine Mol. Neurobiol. 11 1995 177 192
    • (1995) Mol. Neurobiol. , vol.11 , pp. 177-192
    • Miller, D.B.1    O'Callaghan, J.P.2
  • 34
    • 0030463961 scopus 로고    scopus 로고
    • Neurotoxicity of d-amphetamine in the C57BL/6J and CD-1 mouse. Interactions with stress and the adrenal system
    • D.B. Miller, and J.P. O'Callaghan Neurotoxicity of d-amphetamine in the C57BL/6J and CD-1 mouse. Interactions with stress and the adrenal system Ann. N.Y. Acad. Sci. 801 1996 148 167
    • (1996) Ann. N.Y. Acad. Sci. , vol.801 , pp. 148-167
    • Miller, D.B.1    O'Callaghan, J.P.2
  • 35
    • 0029996739 scopus 로고    scopus 로고
    • The concept of microglia in relation to central nervous system disease and regeneration
    • S. Moore, and S. Thanos The concept of microglia in relation to central nervous system disease and regeneration Prog. Neurobiol. 48 1996 441 460
    • (1996) Prog. Neurobiol. , vol.48 , pp. 441-460
    • Moore, S.1    Thanos, S.2
  • 36
    • 0036518997 scopus 로고    scopus 로고
    • Innate immunity: The missing link in neuroprotection and neurodegeneration?
    • M.D. Nguyen, J.P. Julien, and S. Rivest Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat. Rev. Neurosci. 3 2002 216 227
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 216-227
    • Nguyen, M.D.1    Julien, J.P.2    Rivest, S.3
  • 37
    • 0027786985 scopus 로고
    • Quantification of reactive gliosis as an approach to neurotoxicity assessment
    • J.P. O'Callaghan, and D.B. Miller Quantification of reactive gliosis as an approach to neurotoxicity assessment NIDA Res. Monogr. 136 1993 188 212
    • (1993) NIDA Res. Monogr. , vol.136 , pp. 188-212
    • O'Callaghan, J.P.1    Miller, D.B.2
  • 38
    • 0027931499 scopus 로고
    • Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse
    • J.P. O'Callaghan, and D.B. Miller Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse J. Pharmacol. Exp. Ther. 270 1994 741 751
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 741-751
    • O'Callaghan, J.P.1    Miller, D.B.2
  • 39
    • 0031585659 scopus 로고    scopus 로고
    • Brain serotonin neurotoxicity and fenfluramine and dexfenfluramine [letter; Comment]
    • J.P. O'Callaghan, and D.B. Miller Brain serotonin neurotoxicity and fenfluramine and dexfenfluramine [letter; comment] J. Am. Med. Assoc. 278 1997 2141 2142 (discussion 2142)
    • (1997) J. Am. Med. Assoc. , vol.278 , pp. 2141-2142
    • O'Callaghan, J.P.1    Miller, D.B.2
  • 40
    • 0035783914 scopus 로고    scopus 로고
    • Microglial signalling cascades in neurodegenerative disease
    • J.M. Pocock, and A.C. Liddle Microglial signalling cascades in neurodegenerative disease Prog. Brain Res. 132 2001 555 565
    • (2001) Prog. Brain Res. , vol.132 , pp. 555-565
    • Pocock, J.M.1    Liddle, A.C.2
  • 41
    • 0029836623 scopus 로고    scopus 로고
    • Effect of methamphetamine on glutamate-positive neurons in the adult and developing rat somatosensory cortex
    • C. Pu, H.W. Broening, and C.V. Vorhees Effect of methamphetamine on glutamate-positive neurons in the adult and developing rat somatosensory cortex Synapse 23 1996 328 334
    • (1996) Synapse , vol.23 , pp. 328-334
    • Pu, C.1    Broening, H.W.2    Vorhees, C.V.3
  • 42
    • 0027403536 scopus 로고
    • Developmental dissociation of methamphetamine-induced depletion of dopaminergic terminals and astrocyte reaction in rat striatum
    • C. Pu, and C.V. Vorhees Developmental dissociation of methamphetamine-induced depletion of dopaminergic terminals and astrocyte reaction in rat striatum Brain Res. Dev. Brain Res. 72 1993 325 328
    • (1993) Brain Res. Dev. Brain Res. , vol.72 , pp. 325-328
    • Pu, C.1    Vorhees, C.V.2
  • 45
    • 0030175520 scopus 로고    scopus 로고
    • Repeated administration of escalating high doses of dexfenfluramine does not produce morphological evidence for neurotoxicity in the cortex of rats
    • S. Rose, S. Hunt, P. Collins, J.G. Hindmarsh, and P. Jenner Repeated administration of escalating high doses of dexfenfluramine does not produce morphological evidence for neurotoxicity in the cortex of rats Neurodegeneration 5 1996 145 152
    • (1996) Neurodegeneration , vol.5 , pp. 145-152
    • Rose, S.1    Hunt, S.2    Collins, P.3    Hindmarsh, J.G.4    Jenner, P.5
  • 46
    • 0142139173 scopus 로고    scopus 로고
    • High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain
    • R.B. Rothman, S. Jayanthi, X. Wang, C.M. Dersch, J.L. Cadet, T. Prisinzano, K.C. Rice, and M.H. Baumann High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain Synapse 50 2003 233 239
    • (2003) Synapse , vol.50 , pp. 233-239
    • Rothman, R.B.1    Jayanthi, S.2    Wang, X.3    Dersch, C.M.4    Cadet, J.L.5    Prisinzano, T.6    Rice, K.C.7    Baumann, M.H.8
  • 47
    • 0027204246 scopus 로고
    • Loss of serotonin uptake sites and immunoreactivity in rat cortex after dexfenfluramine occur without parallel glial cell reactions
    • N.E. Rowland, A.N. Kalehua, B.H. Li, S.L. Semple-Rowland, and W.J. Streit Loss of serotonin uptake sites and immunoreactivity in rat cortex after dexfenfluramine occur without parallel glial cell reactions Brain Res. 624 1993 35 43
    • (1993) Brain Res. , vol.624 , pp. 35-43
    • Rowland, N.E.1    Kalehua, A.N.2    Li, B.H.3    Semple-Rowland, S.L.4    Streit, W.J.5
  • 49
    • 0037402801 scopus 로고    scopus 로고
    • Selective microglial activation in the rat rotenone model of Parkinson's disease
    • T.B. Sherer, R. Betarbet, J.H. Kim, and J.T. Greenamyre Selective microglial activation in the rat rotenone model of Parkinson's disease Neurosci. Lett. 341 2003 87 90
    • (2003) Neurosci. Lett. , vol.341 , pp. 87-90
    • Sherer, T.B.1    Betarbet, R.2    Kim, J.H.3    Greenamyre, J.T.4
  • 50
    • 0033612960 scopus 로고    scopus 로고
    • Hyperthermia-enhanced serotonin (5-HT) depletion resulting from d-fenfluramine (d-Fen) exposure does not evoke a glial-cell response in the central nervous system of rats
    • C.W. Stewart, and W. Slikker Jr. Hyperthermia-enhanced serotonin (5-HT) depletion resulting from d-fenfluramine (d-Fen) exposure does not evoke a glial-cell response in the central nervous system of rats Brain Res. 839 1999 279 282
    • (1999) Brain Res. , vol.839 , pp. 279-282
    • Stewart, C.W.1    Slikker Jr., W.2
  • 51
    • 0025132453 scopus 로고
    • An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4)
    • W.J. Streit An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4) J. Histochem. Cytochem. 38 1990 1683 1686
    • (1990) J. Histochem. Cytochem. , vol.38 , pp. 1683-1686
    • Streit, W.J.1
  • 52
    • 0036847816 scopus 로고    scopus 로고
    • Microglia as neuroprotective, immunocompetent cells of the CNS
    • W.J. Streit Microglia as neuroprotective, immunocompetent cells of the CNS Glia 40 2002 133 139
    • (2002) Glia , vol.40 , pp. 133-139
    • Streit, W.J.1
  • 53
    • 0347087356 scopus 로고    scopus 로고
    • Identification of differentially regulated transcripts in mouse striatum following methamphetamine treatment - An oligonucleotide microarray approach
    • D.M. Thomas, D.M. Francescutti-Verbeem, X. Liu, and D.M. Kuhn Identification of differentially regulated transcripts in mouse striatum following methamphetamine treatment - an oligonucleotide microarray approach J. Neurochem. 88 2004 380 393
    • (2004) J. Neurochem. , vol.88 , pp. 380-393
    • Thomas, D.M.1    Francescutti-Verbeem, D.M.2    Liu, X.3    Kuhn, D.M.4
  • 54
    • 4444243788 scopus 로고    scopus 로고
    • Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation
    • (Epub ahead of print as DOI: 10.1124/jpet.104.070961).
    • D.M. Thomas, P.D. Walker, J.A. Benjamins, T.J. Geddes, D.M. Kuhn, Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation, J. Pharmacol. Exp. Ther. (2004) (Epub ahead of print as DOI: 10.1124/jpet.104.070961).
    • (2004) J. Pharmacol. Exp. Ther.
    • Thomas, D.M.1    Walker, P.D.2    Benjamins, J.A.3    Geddes, T.J.4    Kuhn, D.M.5
  • 56
    • 0035077867 scopus 로고    scopus 로고
    • Elevations in plasmatic titers of corticosterone and aldosterone, in the absence of changes in ACTH, testosterone, or glial fibrillary acidic protein, 72 h following d,l-fenfluramine or d-fenfluramine administration to rats
    • M.T. Williams, L.L. Morford, A.E. McCrea, S.L. Inman-Wood, and C.V. Vorhees Elevations in plasmatic titers of corticosterone and aldosterone, in the absence of changes in ACTH, testosterone, or glial fibrillary acidic protein, 72 h following d,l-fenfluramine or d-fenfluramine administration to rats Neurotoxicol. Teratol. 23 2001 23 32
    • (2001) Neurotoxicol. Teratol. , vol.23 , pp. 23-32
    • Williams, M.T.1    Morford, L.L.2    McCrea, A.E.3    Inman-Wood, S.L.4    Vorhees, C.V.5
  • 57
    • 0028428908 scopus 로고
    • Microglial response to degeneration of serotonergic axon terminals
    • M.A. Wilson, and M.E. Molliver Microglial response to degeneration of serotonergic axon terminals Glia 11 1994 18 34
    • (1994) Glia , vol.11 , pp. 18-34
    • Wilson, M.A.1    Molliver, M.E.2
  • 58
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    • D.C. Wu, V. Jackson-Lewis, M. Vila, K. Tieu, P. Teismann, C. Vadseth, D.K. Choi, H. Ischiropoulos, and S. Przedborski Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model of Parkinson disease J. Neurosci. 22 2002 1763 1771
    • (2002) J. Neurosci. , vol.22 , pp. 1763-1771
    • Wu, D.C.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6    Choi, D.K.7    Ischiropoulos, H.8    Przedborski, S.9
  • 59
    • 0036685522 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative disease - A double-edged sword
    • T. Wyss-Coray, and L. Mucke Inflammation in neurodegenerative disease - a double-edged sword Neuron 35 2002 419 432
    • (2002) Neuron , vol.35 , pp. 419-432
    • Wyss-Coray, T.1    Mucke, L.2


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