High-Dose Fenfluramine Administration Decreases Serotonin Transporter Binding, but Not Serotonin Transporter Protein Levels, in Rat Forebrain

Synapse

Volumn 50, Issue 3, 2003, Pages 233-239

  Rothman, Richard B ^a,c   Jayanthi, Subramaniam ^a   Wang, Xiaoying ^a   Dersch, Christina M ^a   Cadet, Jean L ^a   Prisinzano, Thomas ^b   Rice, Kenner C ^b   Baumann, Michael H ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NIH ^*  (United States)

Author keywords

Amphetamine; Fenfluramine; Neurotoxicity; Parachloroamphetamine; Serotonin transporter

Indexed keywords

CHLORAMPHETAMINE; FENFLURAMINE; GLIAL FIBRILLARY ACIDIC PROTEIN; SEROTONIN; SEROTONIN TRANSPORTER;

ADAPTATION; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CAUDATE NUCLEUS; CONTROLLED STUDY; DISEASE MARKER; DRUG EFFECT; DRUG MEGADOSE; FOREBRAIN; FRONTAL CORTEX; LIGAND BINDING; MALE; NERVE CELL LESION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SEROTONIN BRAIN LEVEL; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; FENFLURAMINE; HYDROXYINDOLEACETIC ACID; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; P-CHLOROAMPHETAMINE; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN AGENTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0142139173     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.10266     Document Type: Article

References (23)

1. Appel NM, Mitchell WM, Contrera JF, De Souza EB. 1990. Effects of high-dose fenfluramine treatment on monoamine uptake sites in rat brain: assessment using quantitative autoradiography. Synapse 6:33-44.
2. Bauman AL, Apparsundaram S, Ramamoorthy S, Wadzinski BE, Vaughan RA, Blakely RD. 2000. Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. J Neurosci 20:7571-7578.
3. Baumann MH, Ayestas MA, Rothman RB. 1998. Functional consequences of central serotonin depletion produced by repeated fenfluramine administration in rats. J Neurosci 18:9069-9077.
4. Baumann MH, Ayestas MA, Dersch CM, Partilla JS, Rothman RB. 2000. Serotonin transporters, serotonin release, and the mechanism of fenfluramine neurotoxicity. Ann NY Acad Sci 914:172-186.
5. Blakely RD, Bauman AL. 2000. Biogenic amine transporters: regulation in flux. Curr Opin Neurobiol 10:328-336.
6. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
7. 3H]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment. J Neurochem 58:250-257.
8. Fasciano J, Hatzidimitriou G, Yuan J, Katz JL, Ricaurte GA. 1997. N-methylation dissociates methamphetamine's neurotoxic and behavioral pharmacologic effects. Brain Res 771:115-120.
9. Greiner E, Prisinzano T, Johnson IE, Dersch CM, Marcus J, Partilla JS, Rothman RB, Jacobson AE, Rice KC. 2003. Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine. J Med Chem 46:1465-1469.
10. Haring JH, Meyerson L, Hoffman TL. 1992. Effects of para-chloroamphetamine upon the serotonergic innervation of the rat hippocampus. Brain Res 577:253-260.
11. Huether G, Zhou D, Ruther E. 1997. Long-term modulation of presynaptic 5-HT-output: experimentally induced changes in cortical 5-HT-transporter density, tryptophan hydroxylase content and 5-HT innervation density. J Neural Transm 104:993-1004.
12. Jayanthi S, McCoy MT, Ladenheim B, Cadet JL. 2002. Methamphetamine causes coordinate regulation of Src, Cas, Crk, and the Jun N-terminal kinase-Jun pathway. Mol Pharmacol 61:1124-1131.
13. Mamounas LA, Blue ME, Siuciak JA, Altar CA. 1995. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J Neurosci 15:7929-7939.
14. McCann UD, Seiden LS, Rubin LJ, Ricaurte GA. 1997. Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the literature. JAMA 278:666-672.
15. Molliver DC, Molliver ME. 1990. Anatomic evidence for a neurotoxic effect of (+/-)-fenfluramine upon serotonergic projections in the rat. Brain Res 511:165-168.
16. O'Callaghan JP, Miller DB. 1994. Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse. J Pharmacol Exp Ther 270:741-751.
17. Ramamoorthy S, Blakely RD. 1999. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science 285:763-766.
18. Ridet JL, Geffard M, Privat A. 1994. Light and electron microscopic studies of the effects of p-chloroamphetamine on the monoaminergic innervation of the rat spinal cord. J Comp Neurol 343:281-296.
19. Rothman RB. 1986. Binding surface analysis: an intuitive yet quantitative method for the design and analysis of ligand binding studies. Alcohol Drug Res 6:309-325.
20. 125I]RTI-55. J Pharmacol Exp Ther 270:296-309.
21. Rowland NE, Kalehua AN, Li BH, Semple-Rowland SL, Streit WJ. 1993. Loss of serotonin uptake sites and immunoreactivity in rat cortex after dexfenfluramine occur without parallel glial cell reactions. Brain Res 624:35-43.
22. Zaczek R, Battaglia G, Culp S, Appel NM, Contrera JF, De Souza EB. 1990. Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: pharmacokinetic, dose response, regional specificity and time course data. J Pharmacol Exp Ther 253:104-112.
23. Zhou D, Schreinert M, Pilz J, Huether G. 1996. Rat strain differences in the vulnerability of serotonergic nerve endings to neurotoxic damage by p-chloroamphetamine. J Neural Transm 103: 1381-1395.