Hyperthermia-enhanced serotonin (5-HT) depletion resulting from D- fenfluramine (D-Fen) exposure does not evoke a glial-cell response in the central nervous system of rats

Brain Research

Volumn 839, Issue 2, 1999, Pages 279-282

  Stewart, Christopher W ^a,b   Slikker Jr , William ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Body temperature; Fenfluramine; GFAP; Serotonin

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; DEXFENFLURAMINE; GLIAL FIBRILLARY ACIDIC PROTEIN; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EXPOSURE; ENVIRONMENTAL TEMPERATURE; FRONTAL CORTEX; GLIA CELL; HIPPOCAMPUS; HYPERTHERMIA; MALE; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE;

ANIMALS; BRAIN CHEMISTRY; FENFLURAMINE; FEVER; FRONTAL LOBE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; HIPPOCAMPUS; HYDROXYINDOLEACETIC ACID; MALE; NEUROGLIA; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN UPTAKE INHIBITORS;

EID: 0033612960     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01732-1     Document Type: Article

References (14)

1. Bowyer J.F., Davies D.L., Schmued L., Broening H.W., Newport G.D., Slikker W. Jr., Holson R.R. Further studies of the role of hyperthermia in methamphetamine neurotoxicity. J. Pharmacol. Exp. Ther. 268:1994;1571-1580.
2. Broening H.W., Bowyer J.F., Slikker W. Jr. Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (±)-3,4-methylenedioxy- methamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response. J. Pharmacol. Exp. Ther. 275:1995;1-9.
3. Clineschmidt B.V., Zacchei A.G., Totaro J.A., Pflueger A.B., McGuffin J.C., Wishousky T.I. Fenfluramine and brain serotonin. Ann. N.Y. Acad. Sci. 305:1978;222-241.
4. Colado M.I., O'Shea E., Granados R., Murray T.K., Green A.R. In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine. Br. J. Pharmacol. 121:1997;889-900.
5. Duhault J., Boulanger M. Fenfluramine long-term administration and brain serotonin. Eur. J. Pharmacol. 43:1977;203-205.
6. 3H ]-dopa J. Neurochem. 13:1966;655-669.
7. Malberg J.E., Seiden L.S. Administration of fenfluramine at different ambient temperatures produces different core temperature and 5-HT neurotoxicity profiles. Brain Res. 765:1997;101-107.
8. McCann U., Hatzidimitriou G., Ridenour A., Fischer C., Yuan J., Katz J., Ricaurte G. Dexfenfluramine and serotonin neurotoxicity: further preclinical evidence the clinical caution is indicated. J. Pharmacol. Exp. Ther. 269:1994;792-798.
9. Miller D.B., O'Callaghan J.P. Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse. J. Pharmacol. Exp. Ther. 270:1994;752-760.
10. Miller D.B., O'Callaghan J.P. The role of temperature, stress and other factors in the neurotoxicity of the substituted amphetamines 3,4-methylenedioxymethamphetamine and fenfluramine. Mol. Neurobiol. 11:1995;177-192.
11. O'Callaghan J.P. Quantification of glial fibrillary acidic protein: comparison of slot immunobinding assays with a novel sandwich ELISA. Neurotoxicol. Teratol. 13:1991;275-281.
12. Schmued L., Slikker W., Clausing P., Bowyer J. D-Fenfluramine produces neuronal degeneration in localized regions of the cortex, thalamus, and cerebellum of the rat. Toxicol. Sci. 48:1999;100-106.
13. Stewart C.W., Bowyer J.F., Slikker W. Jr. Elevated environmental temperatures can induce hyperthermia during D-fenfluramine exposure and enhance 5-hydroxytryptamine (5-HT) depletion in the brain. J. Pharmacol. Exp. Ther. 283:1997;1144-1150.
14. Westphalen R.I., Dodd P.R. The nature of D,L-fenfluramine-induced 5-HT reuptake transporter loss in rats. Mol. Neurobiol. 11:1995;165-175.