DNA ploidy analysis of mucinous cystic tumors of the pancreas: Correlation of aneuploidy with malignancy and poor prognosis

Cancer

Volumn 77, Issue 1, 1996, Pages 58-62

  Southern, James F ^a   Warshaw, Andrew L ^a   Lewandrowski, Kent B ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

cystic tumor; mucinous neoplasm; pancreas; ploidy

Indexed keywords

ADULT; AGED; ANEUPLOIDY; ARTICLE; CANCER MORTALITY; CANCER SURVIVAL; CLINICAL ARTICLE; CYSTADENOCARCINOMA; CYSTADENOMA; DIPLOIDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; MALE; PANCREAS RESECTION; PANCREAS TUMOR; PLOIDY; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADULT; AGED; ANEUPLOIDY; CYSTADENOCARCINOMA; DNA, NEOPLASM; FEMALE; HUMANS; IMAGE CYTOMETRY; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; PLOIDIES; PROGNOSIS; SURVIVAL ANALYSIS;

EID: 0030030396     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19960101)77:1<58::AID-CNCR11>3.0.CO;2-7     Document Type: Article

References (18)

1. Warshaw A, Compton C, Lewandrowski K, Cardenosa G, Mueller P. Cystic tumors of the pancreas: new clinical and pathological observations in 67 patients. Ann Surg 1990;212:432-45.
2. Alles A, Warshaw AL, Southern IF, Compton CC, Lewandrowski KB. Expression of CA 72-4 (TAG 72) in the fluid contents of pancreatic cysts: a new marker to distinguish malignant pancreatic cystic tumors from benign neoplasms and pseudocysts. Ann Surg 1994;219:131-34.
3. Yong WH, Pins MR, Southern JF, Warshaw AL, Compton CC, Lewandrowski KB. Cyst fluid NB/70K concentration and leukocyte esterase: two new markers for differentiating pancreatic serous tumors from pseudocysts. Pancreas 1995;10:342-46.
4. Rubin D, Warshaw AL, Southern JF, Pins MR, Compton CC, Lewandrowski KB. Expression of CA 15.3 protein in the cyst contents distinguishes benign from malignant pancreatic mucinous cystic neoplasms. Surgery 1994;115:52-5.
5. Kirby RE, Lewandrowski KB, Southern JF, Compton CC, Warshaw A. Relation of epidermal growth factor receptor and estrogen receptor-independent pS2 protein to the malignant transformation of mucinous cystic neoplasms of the pancreas. Arch Surg 1995;130:69-72.
6. Weger AR, Graf AH, Askensten U, Schwab G, Bodner E, Auer G, et al. Ploidy as prognostic determinant in pancreatic cancer [letter]. Lancet 1987;2:1031.
7. Suto T, Sasaki K, Sugai T, Kanno S, Saito K. Heterogeneity in the nuclear DNA content of cells in carcinomas of the biliary tract and pancreas. Cancer 1993;72:2920-28.
8. Unger PD, Danque PN, Fuchs A, Kaneko M. DNA flow cytometric evaluation of serous and mucinous cystic neoplasms of the pancreas. Arch Pathol Lab Med 1991;15:563-65.
9. Drescher CW, Flint A, Hopkins MP, Roberts JA. Prognostic significance of DNA content and nuclear morphology in borderline ovarian tumors. Gynecol Oncol 1993;48:242-46.
10. Berchuk A, Boente MP, Kerns BJ, Kinney RB, Soper JT, Clarke-Pearson DL, et al. Ploidy analysis of epithelial ovarian cancers using image cytometry. Gynecol Oncol 1992;44:61-5.
11. Yang JM, Kirby RE, Lewandrowski KB, Laposata M. Markers of cellular proliferation in mucinous cystic tumors of the pancreas. Academy of Clinical Laboratory Physicians and Scientists, Syracuse, N.Y. June 8-10, 1995.
12. Veloso JD, Solis OG, Barada JH, Fisher HA, Ross JS. DNA ploidy of oncocytic granular renal cell carcinomas and renal oncocytomas by image analysis. Arch Pathol Lab Med 1992;116:154-58.
13. Theissig F, Dimmer V, Haroske G, Kunze KD, Meyer W. Use of nuclear image cytometry, histopathological grading, and DNA cytometry to make breast cancer prognosis more objective. Anal Cell Pathol 1991;3:351-60.
14. Bottger T, Storkel S, Stockle M, Wahl W, Heintz A, Jugenheimer M, et al. [Image analysis of DNA cytometry for assessing prognosis after resection of esophageal cancer]. Chirurg 1991;62:467-72; discussion 472-3.
15. Koss LG, Wersto RP, Simmons DA, Deitch D, Herz F, Freed SZ. Predictive value of DNA measurements in bladder washings. Comparison of flow cytometry, image cytophotometry, and cytology in patients with a past history of urothelial tumors. Cancer 1989;64:916-24.
16. Pollack A, Zagers G, El-Naggar AK, Gauwitz MD, Terry NHA. Near-diploidy: a new prognostic factor for clinically localized prostate cancer treated with external beam radiation therapy. Cancer 1994;73:1895-1903.
17. Ghali VS, Liau S, Teplitz C, Prudente R. A comparative study of DNA ploidy in 115 fresh frozen breast carcinomas by image analysis versus flow cytometry. Cancer 1992;70:2668-72.
18. Yuan J, Hennessy C, Givan AL, Corbett IP, Henry JA, Sherbet GV, et al. Predicting outcome for patients with node negative breast cancer: a comparative study of the value of flow cytometry and cell image analysis for determination of DNA ploidy. Br J Cancer 1992;65:461-65.