Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 18, 2008, Pages 6782-6786

  Sirikantaramas, Supaart ^a   Yamazaki, Mami ^a,b   Saito, Kazuki ^a,c  

^a CHIBA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c RIKEN Plant Science Center   (Japan)

Author keywords

Camptotheca acuminata; Evolution; Ophiorrhiza pumila

Indexed keywords

ALKALOID; CAMPTOTHECIN; DNA TOPOISOMERASE; ANTINEOPLASTIC AGENT;

ARTICLE; CAMPTOTHECA; CANCER CELL; CONTROLLED STUDY; GENE MUTATION; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; OPHIORRHIZA; PLANT; PRIORITY JOURNAL; RUBIACEAE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECT; DRUG RESISTANCE; ENZYMOLOGY; EVOLUTION; GENETICS; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS; MUTATION; PHYLOGENY; SACCHAROMYCES CEREVISIAE;

CAMPTOTHECA ACUMINATA; OPHIORRHIZA LIUKIUENSIS; OPHIORRHIZA PUMILA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BINDING SITES; CAMPTOTHECIN; DNA TOPOISOMERASES, TYPE I; DRUG RESISTANCE; EVOLUTION; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; PLANTS; SACCHAROMYCES CEREVISIAE;

EID: 44349191391     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801038105     Document Type: Article

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