Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins

Molecular Therapy

Volumn 13, Issue 3, 2006, Pages 517-527

  Klein, Ronald L ^a   Dayton, Robert D ^a   Leidenheimer, Nancy J ^a   Jansen, Karen ^b   Golde, Todd E ^b   Zweig, Richard M ^c  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b MAYO CLINIC   (United States)

^c Louisiana State University School of Medicine Shreveport   (United States)

Author keywords

Adeno associated virus; Gene therapy; Gene transfer; Green fluorescent protein; Hippocampus; Neurodegeneration; Neurodegenerative disease; Neurotoxicity; Substantia nigra; Tau

Indexed keywords

AMPHETAMINE; GREEN FLUORESCENT PROTEIN; TAU PROTEIN;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN DISEASE; BRAIN NERVE CELL; CELL LOSS; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOPAMINERGIC NERVE CELL; EMBRYO; GENE EXPRESSION; GENE VECTOR; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMAGING SYSTEM; LOW DRUG DOSE; MALE; METHODOLOGY; NEUROTOXICITY; NONHUMAN; RAT; SEROTYPE; SUBSTANTIA NIGRA; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; CELL LINE; CELLS, CULTURED; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; HUMANS; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SEROTYPING; SUBSTANTIA NIGRA; TAU PROTEINS;

ADENO-ASSOCIATED VIRUS; ANIMALIA;

EID: 32944471565     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.10.008     Document Type: Article

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