Structure-based design and synthesis of the first weak non-phosphate inhibitors for IspF, an enzyme in the non-mevalonate pathway of isoprenoid biosynthesis

Helvetica Chimica Acta

Volumn 90, Issue 6, 2007, Pages 1043-1068

  Baumgartner, Corinne ^a   Eberle, Christian ^a   Diederich, François ^a   Lauw, Susan ^b   Rohdich, Felix ^b   Eisenreich, Wolfgang ^b   Bacher, Adelbert ^b  

^a ETH ZURICH   (Switzerland)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; ISOPRENOID; MEVALONATE; PARASITES; RIBOSE;

BIOSYNTHESIS; CARBOHYDRATES; METABOLISM; MOLECULAR STRUCTURE; NITROGEN COMPOUNDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTOZOA; X RAY CRYSTALLOGRAPHY;

ENZYME INHIBITION;

1 (3 METHYL 4 NITROPHENYL)METHANAMINE; 1 (4 NITROPHENYL)METHANAMINE; 2 (3 METHYL 4 NITROBENZYL) 1H ISOINDOLE 1,3(2H)DIONE; 2 METHYL 4 [[(TRIISOPROPYLSILYL)OXY]METHYL]ANILINE; 4 METHOXY N(3 METHYL 4 NITROBENZYL)BENZAMIDE; 4 METHOXY N[3 METHYL 4 [(6 NITROPYRIDIN 3 YL)AMINO]BENZYL]BENZAMIDE; [3 METHYL 4 [(6 NITROPYRIDIN 3 YL)AMINO]PHENYL]METHANOL; CYTOSINE DERIVATIVE; DIMETHYLALLYL DIPHOSPHATE; ENZYME INHIBITOR; ISOPENTENYL DIPHOSPHATE; ISOPRENOID PHOSPHATE; ISPF ENZYME; MEVALONIC ACID; N(3 METHYL 4 NITROBENZYL)BENZAMIDE; N(4 AMINO 3 METHYLBENZYL) 4 METHOXYBENZAMIDE; N(4 AMINO 3 METHYLBENZYL)BENZAMIDE; N(4 AMINOBENZYL)BENZAMIDE; N(4 NITROBENZYL) 1H ISOINDOLE 1,3(2H)DIONE; N(4 NITROBENZYL)BENZAMIDE; N[2 METHYL 4 [[(TRIISOPROPYLSILYL)OXY]METHYL]PHENYL] 6 NITROPYRIDIN 3 AMINE; N[3 METHYL 4 [(6 NITROPYRIDIN 3 YL)AMINO]BENZYL] 4 (TRIFLUOROMETHYL)BENZAMIDE; N[3 METHYL 4 [(6 NITROPYRIDIN 3 YL)AMINO]BENZYL]BENZAMIDE; N[4 (AMINOMETHYL) 2 METHYLPHENYL] 6 NITROPYRIDIN 3 AMINE; N[4 (AZIDOMETHYL) 2 METHYLPHENYL] 6 NITROPYRIDIN 3 AMINE; N[4 [(6 AMINOPYRIDIN 3 YL)AMINO] 3 METHYLBENZYL] 4 METHOXYBENZAMIDE; N[4 [(6 AMINOPYRIDIN 3 YL)AMINO]BENZYL]BENZAMIDE; N[4 [(6 NITROPYRIDIN 3 YL)AMINO]BENZYL]BENZAMIDE; PHTHALIMIDE; TRIISOPROPYL[(3 METHYL 4 NITROBENZYL)OXY]SILANE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COMPUTER MODEL; DRUG TARGETING; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SYNTHESIS; MALARIA; PLASMODIUM; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

EID: 34447338637     PISSN: 0018019X     EISSN: None     Source Type: Journal    
DOI: 10.1002/hlca.200790105     Document Type: Article

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