Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin

Molecular Therapy

Volumn 16, Issue 6, 2008, Pages 1138-1145

  Oosman, Sarah N ^a   Lam, Ada W ^a   Harb, George ^b   Unniappan, Suraj ^a   Lam, Ni T ^b   Webber, Travis ^a   Bruch, Daniel ^a   Zhang, Qiu Xia ^b   Korbutt, Gregory S ^b   Kieffer, Timothy J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINIC ACID; INSULIN; LEPTIN; MIFEPRISTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENGINEERING; CELL BASED GENE THERAPY; CELL ENCAPSULATION; CELL SECRETION; CONTROLLED STUDY; DIABETES MELLITUS; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG RELEASE; FOOD INTAKE; INSULIN BLOOD LEVEL; INTESTINE CELL; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; PROTEIN DEFECT; WEIGHT REDUCTION;

MUS; RODENTIA;

EID: 44349089866     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2008.62     Document Type: Article

References (38)

1. Ahima, RS and Flier, JS (2000). Leptin. Annu Rev Physiol 62: 413-437.
2. Friedman, JM and Halaas, JL (1998). Leptin and the regulation of body weight in mammals. Nature 395: 763-770.
3. Myers, MG Jr. (2004). Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog Horm Res 59: 287-304.
4. Campfield, LA, Smith, FJ, Guisez, Y, Devos, R and Burn, P (1995). Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549.
5. Halaas, JL, Gajiwala, KS, Maffei, M, Cohen, SL, Chait, BT, Rabinowitz, D et al. (1995). Weight-reducing effects of the plasma protein encoded by the obese gene.Science 269: 543-546.
6. Pelleymounter, MA, Cullen, MJ, Baker, MB, Hecht, R, Winters, D, Boone, T et al. (1995). Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543.
7. Weigle, DS, Bukowski, TR, Foster, DC, Holderman, S, Kramer, JM, Lasser, G et al. (1995). Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96: 2065-2070.
8. Farooqi, IS, Jebb, SA, Langmack, G, Lawrence, E, Cheetham, CH, Prentice, AM et al. (1999). Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 341: 879-884.
9. Farooqi, IS, Matarese, G, Lord, GM, Keogh, JM, Lawrence, E, Agwu, C et al. (2002). Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110: 1093-1103.
10. Gibson, WT, Farooqi, IS, Moreau, M, DePaoli, AM, Lawrence, E, O'Rahilly, S et al. (2004). Congenital leptin deficiency due to homozygosity for the delta133G mutation: Report of a further case and evaluation of response to four years of leptin therapy. J Clin Endocrinol Metab 89: 4821-4826.
11. Considine, RV, Sinha, MK, Heiman, ML, Kriauciunas, A, Stephens, TW, Nyce, MR et al. (1996). Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292-295.
12. Havel, PJ, Kasim-Karakas, S, Mueller, W, Johnson, PR, Gingerich, RL and Stern, JS (1996). Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: Effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab 81 4406-4413.
13. Maffei, M, Halaas, J, Ravussin, E, Pratley, RE, Lee, GH, Zhang, Y et al. (1995). Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight reduced subjects. Nat Med 1: 1155-1161.
14. Heymsfield, SB, Greenberg, AS, Fujioka, K, Dixon, RM, Patane, J, Self, B et al. (1999). Recombinant leptin for weight loss in obese and lean adults: A randomised, controlled, dose-dependent trial. J Am Med Assoc 282: 1568-1575.
15. Rosenbaum, M, Murphy, EM, Heymsfield, SB, Matthews, DE and Leibel, RL (2002). Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 87: 2391-2394.
16. Morsy, MA, Gu, MC, Zhao, JZ, Holder, DJ, Rogers, IT, Pouch, WJ et al. (1998). Leptin gene therapy and daily protein administration: A comparative study in the ob/ob mouse. Gene Ther 5: 8-18.
17. Bado, A, Levasseur, S, Attoub, S, Kermorqant, S, Laigneau, JP, Bortoluzzi, MN et al. (1998). The stomach is a source of leptin. Nature 394: 790-793.
18. Wang, Y, O'Malley, BW Jr., Tsai, SY and O'Malley, BW (1994). A regulatory system for use in gene transfer. Proc Natl Acad Sci USA 91: 8180-8184.
19. Cheung, AT, Dayanandan, B, Lewis, JT, Korbutt, GS, Rajotte, RV, Bryer-Ash, M et al. (2000). Glucose-dependent insulin release from genetically engineered K cells. Science 290: 1959-1962.
20. Fujita, Y, Cheung, AT and Kieffer, TJ (2004). Harnessing the gut to treat diabetes. Pediatr Diabetes 5(suppl. 2): 57-69.
21. Omer, A, Duvivier-Kali, VF, Trivedi, N, Wilmot, K, Bonner-Weir, S and Weir, GC (2003). Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. Diabetes 52: 69-75.
22. Duvivier-Kali, VF, Omer, A, Parent, RJ, O'Neil, JJ and Weir, GC (2001). Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane. Diabetes 50: 1698-1705.
23. Javor, ED, Cochran, EK, Musso, C, Young, JR, DePaoli, AM and Gorden, P (2005). Long-term efficacy of leptin replacement in patients with generalized lipodystrophy. Diabetes 54: 1994-2002.
24. Oral, EA, Simha, V, Ruiz, E, Andewelt, A, Premkumar, A, Snell, P et al. (2002). Leptin-replacement therapy for lipodystrophy. N Engl J Med 346: 570-578.
25. Petersen, KF, Oral, EA, Dufour, S, Befroy, D, Ariyan, C, Yu, C et al. (2002). Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest 109: 1345-1350.
26. Kamohara, S, Burcelin, R, Halaas, JL, Friedman, JM and Charron, MJ (1997). Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389: 374-377.
27. Minokoshi, Y, Kim, YB, Peroni, OD, Fryer, LG, Muller, C, Carling, D et al. (2002). Leptin stimulates fatty-acid oxidation by activation of AMP-activated protein kinase. Nature 415: 339-343.
28. Cohen, B, Novick, D and Rubinstein, M (1996). Modulation of insulin activities by leptin. Science 274: 1185-1188.
29. Muoio, DM, Dohm, GL, Fiedorek, F Jr., Tapscott, EB and Coleman, RA (1997). Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46: 1360-1363.
30. Siegrist-Kaiser, CA, Pauli, V, Juge-Aubry, CE, Boss, O, Pernin, A, Chin, WW et al. (1997). Direct effects of leptin on brown and white adipose tissue. J Clin Invest 100: 2858-2864.
31. Unger, RH (2003). The physiology of cellular liporegulation. Annu Rev Physiol 65: 333-347.
32. Unger, RH, Zhou, YT and Orci, L (1999). Regulation of fatty acid homeostasis in cells: Novel role of leptin. Proc Natl Acad Sci USA 96: 2327-2332.
33. Lam, NT, Lewis, JT, Cheung, AT, Luk, CT, Tse, J, Wang, J et al. (2004). Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression. Mol Endocrinol 18: 1333-1345.
34. Covey, SD, Wideman, RD, McDonald, C, Unniappan, S, Huynh, F, Asadi, A et al. (2006). The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metab 4: 291-302.
35. Kieffer, TJ and Habener, JF (2000). The adipoinsular axis: Effects of leptin on pancreatic -cells. Am J Physiol Endocrinol Metab 278: E1-E14.
36. Van Heek, M, Compton, DS, France, CF, Tedesco, RP, Fawzi, AB, Graziano, MP et al. (1997). Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 99: 385-390.
37. Rosenbaum, M, Goldsmith, R, Bloomfield, D, Magnano, A, Weimer, L, Heymsfield, S et al. (2005). Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 115: 3579-3586.
38. Leibel, RL (2002). The role of leptin in the control of body weight. Nutr Rev 60: S15-S19.