Leptin gene therapy and daily protein administration: A comparative study in the ob/ob mouse

Gene Therapy

Volumn 5, Issue 1, 1998, Pages 8-18

  Morsy, Ma ^a   Gu, M C ^a   Zhao, J Z ^a   Holder, D J ^a   Rogers, I T ^a   Pouch, W J ^a   Motzel, S L ^a   Klein, H J ^a   Gupta, S K ^a   Liang, X ^a   Tota, M R ^a   Rosenblum, C I ^a   Caskey, C T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Adenovirus; Diabetes; Glucose; Obesity; Recombinant leptin

Indexed keywords

LEPTIN; RECOMBINANT PROTEIN;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; GENE THERAPY; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SATIETY; WEIGHT REDUCTION;

ADENOVIRIDAE; ANIMALIA; MURINAE;

EID: 6844237682     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300565     Document Type: Article

References (35)

1. Glaum SR et al. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol Pharmacol 1996; 50: 230-235.
2. Hassink SG et at. Serum leptin in children with obesity -relationship to gender and development. Pediatrics 1996; 98: 201-203.
3. Caro JF et al Decreased cerebrospinal-fluid/serum leptin ratio in obesity - a possible mechanism for leptin resistance. Lancet 1996; 48: 159-161
4. Schwartz MW et al. Cerebrospinal-fluid leptin levels - relationship to plasma levels and to adiposity in humans. Nature Med 1996; 2: 589-593.
5. Considine RV et al. The hypothalamic leptin receptor in humans - identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 1996; 45: 992-994
6. Klein SS, Coppack W, Mohamedali V, Landt M. Adipose-tissue leptin production and plasma leptin kinetics in humans Diabetes 1996; 45: 984-987.
7. Lee GH et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-635.
8. Chen H et al. Evidence that the diabetes gene encodes the leptin receptor - identification of a mutation in the leptin receptor gene in db/db mice Cell 1996; 84. 491-495.
9. Tartaglia LA et al. Identification and expression cloning of a leptin receptor, ob-r. Cell 1995; 83: 1263-1271.
10. Keiffer TJ, Heller RS, Habener JF. Leptin receptors expressed on pancreatic beta cells. Biochem Biophys Res Commun 1996; 224: 522-527.
11. Cohen BD, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996; 274: 1185-1188.
12. Halaas JL et al. Weight-reducing effects of the plasma-protein encoded by the obese gene. Science 1995; 269: 543-546.
13. Ingalls A, Dickie M, Snell G. Obese, a new mutation in the house mouse. J Hered 1950; 41: 317-318.
14. Charlton H. Mouse mutants as models in endocrine research. QJ Exp Physiol 1984; 69: 655-676.
15. Campfield LA et al. Recombinant mouse ob protein - evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269: 546-549.
16. Rentsch J, Levens N, Chiesi M. Recombinant ob-gene product reduces food intake in fasted mice. Biochem Biophys Res Commun 1995; 214: 131-136.
17. Weigle DS et al. Recombinant ob protein reduces feeding and body-weight in the ob/ob mouse. J Clin Invest 1995; 96: 2065-2070.
18. Pelleymounter MA et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-543.
19. Morsy MA et al. Efficient adenovirus-mediated OTC expression in deficient mouse and human hepatocytes. J Clin Invest 1993; 92: 1580-1586.
20. Morsy MA et al. Patient selection may affect gene therapy success: dominant negative effects observed for ornithine transcarbamylase in mouse and human hepatocytes. J Clin Invest 1996; 97: 826-832.
21. Herz J, Gerard RD. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci USA 1993; 90: 2812-2816.
22. Muzzin P, Eisensmith RC, Copeland KC, Woo SL. Correction of obesity and diabetes in genetically obese mice by leptin gene therapy. Proc Natl Acad Sci USA 1996; 93: 14804-14808.
23. Yang Y et al. Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues. J Virol 1996; 70: 6370-6377.
24. Chen G et al. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci USA 1996; 93. 14795-14799.
25. Shimabukuro M et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 1997; 94: 4637-4641.
26. Cohen SL et al. Human leptin characterization. Nature 1996; 382: 589.
27. Walter J et al. Successful expression of human factor IX following repeat administration of adenoviral vector in mice. Proc Natl Acad Sci USA 1996; 93: 3056-3061.
28. Tripathy SK, Black HB, Goldwasser E, Leiden JM. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nature Med 1996; 2: 545-550.
29. Kochanek S et al. A new adenoviral vector: replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase Proc Natl Acad Sci USA 1996; 93: 5731-5736.
30. Parks RJ et al. A helper-dependent adenoviral system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci USA 1996; 93: 13565-13570.
31. Graham FL, Prevec L. Gene transfer and expression protocols. In: Murray EJ (ed). Methods in Molecular Biology. The Humana Press: Clinton, NJ, 1991, pp 109-128.
32. Graham FL, Smiley J, Russell WC, Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus 5. J Gen Virol 1977; 36: 59-72.
33. Rosenblum CI et al. Functional stat-1 and stat-3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells. Endocrinology 1996; 137: 5178-5181.
34. Southern PJ, Berg P. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under the control of the SV40 early region promoter. J Mol Appl Genet 1982; 1: 327-334.
35. Rosenblatt N (ed). Guide for the Care and Usage of Laboratory Animals. Natl Acad Press: Washington DC, 1996.