High concentrations of clavulanic acid but not of its degradation products decrease glycerol consumption and oxygen uptake rates in cultures of Streptomyces clavuligerus

Biotechnology and Bioengineering

Volumn 100, Issue 3, 2008, Pages 439-447

  Brethauer, Simone ^a   Held, Martin ^a   Panke, Sven ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Clavulanic acid; Product decomposition; Product inhibition; Pyrazines; Streptomyces clavuligerus

Indexed keywords

AEROSPACE APPLICATIONS; ARCHITECTURAL DESIGN; CALCIUM; CARBON; CARBOXYLIC ACIDS; CULTIVATION; DEGRADATION; FOOD PRODUCTS; GLYCEROL; MICROFLUIDICS; NONMETALS; OPTIMIZATION; PHOTOACOUSTIC EFFECT; PRODUCT DESIGN; SULFATE MINERALS; TELLURIUM COMPOUNDS;

(E ,3E) PROCESS; (I ,J) CONDITIONS; BIOLOGICAL PRODUCTION; CARBON SOURCES; CLAVULANIC ACID (CA); CULTURES (TRADITIONAL); DEGRADATION PRODUCTS; GAS TRANSFER; GLOBAL PERFORMANCE; H IGH CONCENTRATIONS; IN ORDER; LABORATORY SCALE; LACTAMASE; OXYGEN CONSUMPTIONS; OXYGEN UPTAKE RATE (OUR); PRODUCT INHIBITION; STIRRED TANK REACTOR (STR); STREPTOMYCES CLAVULIGERUS;

OXYGEN;

CLAVULANIC ACID; GLYCEROL; OXYGEN;

ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; CARBON SOURCE; DRUG DECOMPOSITION; DRUG STRUCTURE; ESCHERICHIA COLI; FERMENTATION; GAS DIFFUSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; OXYGEN CONSUMPTION; STREPTOMYCES CLAVULIGERUS; BIOREACTOR; BIOSYNTHESIS; CULTURE TECHNIQUE; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HYDROLYSIS; METABOLISM; MICROBIOLOGY; STREPTOMYCES;

STREPTOMYCES CLAVULIGERUS;

BIOREACTORS; CELL CULTURE TECHNIQUES; CLAVULANIC ACID; GLYCEROL; HYDROLYSIS; OXYGEN; STREPTOMYCES;

EID: 44049100006     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21783     Document Type: Article

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