Facile synthesis of some new pyrazolo [3,4-b] pyrazines and their antifungal activity

Farmaco

Volumn 53, Issue 6, 1998, Pages 383-388

  El Emary, T I ^a   Kamal El Dean, A M ^a   El Kashef, H S ^a  

^a Assiut University   (Egypt)

Author keywords

Antifungal activity; Pyrazine; Pyrazole; Pyrazolopyrazine

Indexed keywords

ANTIFUNGAL AGENT; PYRAZINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRAZOLO[3,4 B]PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS TERREUS; DRUG SYNTHESIS; FUSARIUM MONILIFORME; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PENICILLIUM CHRYSOGENUM; REACTION ANALYSIS; RHIZOPUS;

EID: 0032580915     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(98)00014-7     Document Type: Article

References (19)

1. [1] K. Imaizumi, T. Sado, Bone metabolism improvers containing pyrazolopyrazine, Jpn. Kokai Tokkyo Koho JP 06 80 570 [9480 570] (Cl. AG1K31/495) (22 Mar. 1994) [Chem. Abstr. 121 (1994) 91797w].
2. [1] K. Imaizumi, T. Sado, Bone metabolism improvers containing pyrazolopyrazine, Jpn. Kokai Tokkyo Koho JP 06 80 570 [9480 570] (Cl. AG1K31/495) (22 Mar. 1994) [Chem. Abstr. 121 (1994) 91797w].
3. [2] T. Sado, A. Inoue, Preparation of 1H-pyrazolo[3,4-b]pyrazines as blood platelet aggregation inhibitors and anti-inflammatories, Jpn. Kokai Tokkyo Koho JP 02 101 078 [90 101 78] (Cl. C07D487/04) (12 Apr. 1990) [Chem. Abstr. 113 (1990) 78422k].
4. [2] T. Sado, A. Inoue, Preparation of 1H-pyrazolo[3,4-b]pyrazines as blood platelet aggregation inhibitors and anti-inflammatories, Jpn. Kokai Tokkyo Koho JP 02 101 078 [90 101 78] (Cl. C07D487/04) (12 Apr. 1990) [Chem. Abstr. 113 (1990) 78422k].
5. [3] S. Suzuki, A. Inoue, Anticancer agents containing 1H-pyrazolo[3,4-b]pyrazines, Jpn. Kokai Tokkyo Koho JP 02 172 988 [90 172 988] (Cl. C07D487/04) (4 Jul. 1990) [Chem. Abstr. 113 (1990) 218276t].
6. [3] S. Suzuki, A. Inoue, Anticancer agents containing 1H-pyrazolo[3,4-b]pyrazines, Jpn. Kokai Tokkyo Koho JP 02 172 988 [90 172 988] (Cl. C07D487/04) (4 Jul. 1990) [Chem. Abstr. 113 (1990) 218276t].
7. [4] S. Suzuki, Preparation of 1,5-disubstituted 1H-pyrazolo[3,4-b]-pyrazines as anticancer agents, Jpn. Kokai Tokkyo Koho, JP 02 240 084 [90 240 84] (Cl. C07D487/04) (25 Sep. 1990) [Chem. Abstr. 114 (1991) 178382m].
8. [4] S. Suzuki, Preparation of 1,5-disubstituted 1H-pyrazolo[3,4-b]-pyrazines as anticancer agents, Jpn. Kokai Tokkyo Koho, JP 02 240 084 [90 240 84] (Cl. C07D487/04) (25 Sep. 1990) [Chem. Abstr. 114 (1991) 178382m].
9. [5] J. Hofmann, D. Sickerand, G. Mann, Preparation of 1,3,5-trisubstituted 6-hydroxypyrazolo[3,4-b]pyrazines, Ger. (East) DD 276688 (Cl. C07 D487/04) (7 Mar. 1990) [Chem. Abstr. 113 (1990) 231409h].
10. [5] J. Hofmann, D. Sickerand, G. Mann, Preparation of 1,3,5-trisubstituted 6-hydroxypyrazolo[3,4-b]pyrazines, Ger. (East) DD 276688 (Cl. C07 D487/04) (7 Mar. 1990) [Chem. Abstr. 113 (1990) 231409h].
11. [6] D.W. Rangnekar, S.V. Dhamnaskar, Synthesis of pyrazolo[4′,3′: 5,6]pyrazino[2,3-c]pyrazoles and pyrazolo[4′,3′:5,6]pyrazino[2,3-d]pyrimidines and their application to polyester fibres, J. Chem. Technol. Biotechnol. 49 (1990) 311.
12. [7] M. de Sévricourt, H. El-Kashef, S. Rault, M. Robba, Synthesis of tetracyclic systems: a convenient route to [1]benzothieno[2,3-e]-pyrrolo[1,2-a]pyrazine and [1]benzofuro[2,3-e]pyrrolo[1,2-a]-pyrazine derivatives, Synthesis 9 (1981) 710-711.
13. [8] H. El-Kashef, S. Rault, J.C. Lancelot, M. Robba, Synthesis of [1]-benzothieno[2,3-e]pyrrolo[1,2-a]pyrazines and related compounds, J. Heterocycl. Chem. 23 (1986) 161-167.
14. [9] Sh. Radwan, M.S. Abbady, H.S. El-Kashef, Synthesis of pyrrolo-[1″,2″,1′,2′]pyrazino[6′,5′:4,5]thieno[2,3-c]pyridazine derivatives and related pentacyclic heterocycles, Phosphorus, Sulfur and Silicon 89 (1994) 193-198.
15. [10] E.A. Bakhite, A.A. Gies, A.M. Kamal El-Dean, H.S. El-Kashef, Synthesis and some reactions of pyrrolo[1″,2″:1,6]pyrazino-[2′,3′:4,5]thieno[2,3-b]quinolines; a new fused pyrazine ring system, Phosphorus, Sulfur and Silicon 104 (1995) 143-149.
16. [11] A.M. Kamal El-Dean, H.S. El-Kashef, Synthesis of some imidazopyrazolopyrimidines, Pharmazie 51 (1995) 155-158.
17. [12] E. Mohr, Über 4-alkyl-5-aminopyrazole, J. Prakt. Chem. 79 (1909) 1-49.
18. [13] L.P. Carrod, F.D. Grady, Antibiotic and Chemotherapy, 3rd ed., Churchill Livingstone, Edinburgh, 1972, p. 477.
19. [14] A. Cremer, Antibiotic Sensitivity and Assay Tests, 4th ed., Butterworth, London, 1980, p. 521.