Polymorphisms of cytokine and innate immunity genes and GVHD

Best Practice and Research: Clinical Haematology

Volumn 21, Issue 2, 2008, Pages 149-164

  Dickinson, A M ^a   Holler, E ^b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b Regensburg University Medical Centre   (Germany)

Author keywords

graft versus host disease; haematopoietic stem cell transplantation; non HLA genetics

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CHEMOKINE RECEPTOR CCR5; GAMMA INTERFERON; GLYCOPROTEIN GP 96; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; HLA A ANTIGEN; HLA ANTIGEN; HLA B8 ANTIGEN; HLA DQ2 ANTIGEN; HLA DR3 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATING AGENT; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ACUTE GRAFT VERSUS HOST DISEASE; ANTIGEN PRESENTING CELL; CELL INTERACTION; CHRONIC GRAFT VERSUS HOST DISEASE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE SEVERITY; DONOR; GENETIC POLYMORPHISM; GENOTYPE; GRAFT INFECTION; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA MATCHING; HUMAN; IMMUNOGENETICS; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; MORTALITY; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE ACTIVATION; TISSUE INJURY; WHOLE BODY RADIATION;

CYTOKINES; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNITY, NATURAL; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 44049088543     PISSN: 15216926     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beha.2008.03.004     Document Type: Review

References (111)

1. Remberger M., Ringden O., and Markling L. TNF alpha levels are increased during bone marrow transplantation conditioning in patients who develop acute GVHD. Bone Marrow Transplantation 15 (1995) 99-104
2. Xun C.Q., Thompson J.S., Jennings C.D., et al. Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2-incompatible transplanted SCID mice. Blood 83 (1994) 2360-2367
3. Holler E., Ertl B., Hintermeier-Knabe R., et al. Inflammatory reactions induced by pretransplant conditioning-an alternative target for modulation of acute GVHD and complications following allogeneic bone marrow transplantation?. Leukemia and lymphoma 25 (1997) 217-224
4. Cavet J., Middleton P.G., Segall M., et al. Recipient tumor necrosis factor-alpha and interleukin-10 gene polymorphisms associate with early mortality and acute graft-versus-host disease severity in HLA-matched sibling bone marrow transplants. Blood 94 (1999) 3941-3946
5. Middleton P.G., Taylor P.R.A., Jackson G., et al. Cytokine Gene polymorphisms associating with severe acute graft-versus-host disease in HLA-identical sibling transplants. Blood 92 (1998) 3943-3948
6. Abraham L.J., French M.A., and Dawkins R.L. Polymorphic MHC ancestral haplotypes affect the activity of tumour necrosis factor-alpha. Clinical and Experimental Immunology 92 (1993) 14-18
7. Pociot F., Briant L., Jongeneel C.V., et al. Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus. European Journal of Immunology 23 (1993) 224-231
8. Turner D.M., Grant S.C., Lamb W.R., et al. A genetic marker of high TNF-alpha production in heart transplant recipients. Transplantation 60 (1995) 1113-1117
9. Nedospasov S.A., Udalova I.A., Kuprash D.V., et al. DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene. Journal of Immunology (Baltimore, Md. : 1950) 147 (1991) 1053-1059
10. Udalova I.A., Nedospasov S.A., Webb G.C., et al. Highly informative typing of the human TNF locus using six adjacent polymorphic markers. Genomics 16 (1993) 180-186
11. Holzinger I., de Baey A., Messer G., et al. Cloning and genomic characterization of LST1: a new gene in the human TNF region. Immunogenetics 42 (1995) 315-322
12. Turner D., Grant S.C., Yonan N., et al. Cytokine gene polymorphism and heart transplant rejection. Transplantation 64 (1997) 776-779
13. Pociot F., Molvig J., Wogensen L., et al. A tumour necrosis factor beta gene polymorphism in relation to monokine secretion and insulin-dependent diabetes mellitus. Scandinavian Journal of Immunology 33 (1991) 37-49
14. Keen L.J., DeFor T.E., Bidwell J.L., et al. Interleukin-10 and tumor necrosis factor alpha region haplotypes predict transplant-related mortality after unrelated donor stem cell transplantation. Blood 103 (2004) 3599-3602
15. Nordlander A., Uzunel M., Mattsson J., et al. The TNFd4 allele is correlated to moderate-to-severe acute graft-versus-host disease after allogeneic stem cell transplantation. British Journal of Haematology 119 (2002) 1133-1336
16. Bettens F., Passweg J., Gratwohl A., et al. Association of TNFd and IL-10 polymorphisms with mortality in unrelated hematopoietic stem cell transplantation. Transplantation 81 (2006) 1261-1267
17. Bogunia-Kubik K., Polak M., and Lange A. TNF polymorphisms are associated with toxic but not with aGVHD complications in the recipients of allogeneic sibling haematopoietic stem cell transplantation. Bone Marrow Transplantation 32 (2003) 617-622
18. Tambur A.R., Yaniv I., Stein J., et al. Cytokine gene polymorphism in patients with graft-versus-host disease. Transplantation Proceedings 33 (2001) 502-503
19. Rocha V., Franco R.F., Porcher R., et al. Host defence and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplant. Blood 100 (2002) 3908-3918
20. Mullighan C.G., and Bardy P.G. Advances in the genomics of allogeneic haemopoietic stem cell transplantation. Drug Development Research 62 (2004) 273-292
21. Ishikawa Y., Kashiwase K., Akaza K., et al. Polymorphisms in TNFA and TNFR2 affect outcome of unrelated bone marrow transplantation. Bone Marrow Transplantation 29 (2002) 569-575
22. Stark G.L., Dickinson A.M., Jackson G.H., et al. Tumour necrosis factor receptor type II 196M/R genotype correlates with circulating soluble receptor levels in normal subjects and with graft-versus-host disease after sibling allogeneic bone marrow transplantation. Transplantation 76 (2003) 1742-1749
23. Cullup H., and Stark G. Interleukin-1 polymorphisms and graft versus host disease. Leukemia and lymphoma 46 (2005) 517-523
24. Cullup H., Dickinson A.M., Jackson G.H., et al. Donor interleukin-1 receptor antagonist genotype associated with acute graft-versus-host disease in human leukocyte antigen-matched sibling allogeneic transplants. British Journal of Haematology 113 (2001) 807-813
25. Cullup H., Dickinson A.M., Cavet J., et al. Polymorphisms of IL-1alpha constitute independent risk factors for chronic graft versus host disease following allogeneic bone marrow transplantation. British Journal of Haematology 122 (2003) 778-787
26. MacMillan M.L., Radloff G.A., DeFor T.E., et al. Interleukin-1 genotype and outcome of unrelated donor bone marrow transplantation. British Journal of Haematology 121 (2003) 597-604
27. Antin J.H., Weinstein H.J., Guinan E.C., et al. Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease. Blood 84 (1994) 1342-1348
28. Antin J.H., Weisdorf D., Neuberg D., et al. Interleukin-1 blockade does not prevent acute graft-versus-host disease: results of a randomized, double-blind, placebo-controlled trial of interleukin-1 receptor antagonist in allogeneic bone marrow transplantation. Blood 100 (2002) 3479-3482
29. Ferrari S.L., Ahn-Luong L., Garnero P., et al. Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women. The Journal of Clinical Endocrinology and Metabolism 88 (2003) 255-259
30. Terry C.F., Loukaci V., and Green F.R. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. The Journal of Biological Chemistry 275 (2000) 18138-18144
31. Fishman D., Faulds G., Jeffery R., et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. The Journal of Clinical Investigation 102 (1998) 1369-1376
32. Karabon L., Wysoczanska B., Bogunia-Kubik K., et al. IL-6 and IL-10 promoter gene polymorphisms of patients and donors of allogeneic sibling hematopoietic stem cell transplants associate with the risk of acute graft-versus-host disease. Human Immunology 66 (2005) 700-710
33. Cavet J., Dickinson A.M., Norden J., et al. Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation. Blood 98 (2001) 1594-1600
34. Socié G., Loiseau P., Tamouza R., et al. Both genetic and clinical factors predict the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Transplantation 72 (2001) 699-706
35. Janeway Jr. C.A. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunology Today 13 (1992) 11-16
36. Janeway Jr. C.A., and Medzhitov R. Innate immune recognition. Annual Review of Immunology 20 (2002) 197-216
37. Matzinger P. Tolerance, danger, and the extended family. Annual Review of Immunology 12 (1994) 991-1045
38. Iwasaki A., and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nature immunology 5 (2004) 987-995
39. Takeda K., and Akira S. Toll-like receptors in innate immunity. International Immunology 17 (2005) 1-14
40. Martinon F., and Tschopp J. NLRs join TLRs as innate sensors of pathogens. Trends in Immunology 26 (2005) 447-454
41. Inohara, Chamaillard, McDonald C., et al. NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annual Review of Biochemistry 74 (2005) 355-383
42. Ku C.L., Yang K., Bustamante J., et al. Inherited disorders of human Toll-like receptor signaling: immunological implications. Immunological Reviews 203 (2005) 10-20
43. Kobayashi K.S., Chamaillard M., Ogura Y., et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 (2005) 731-734
44. Watanabe T., Kitani A., Murray P.J., et al. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nature Immunology 5 (2004) 800-808
45. Inohara N., and Nunez G. NODs: intracellular proteins involved in inflammation and apoptosis. Nature Reviews. Immunology 3 (2003) 371-382
46. Martinon F., Burns K., and Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Molecular Cell 10 (2002) 417-426
47. Kabelitz D. Expression and function of Toll-like receptors in T lymphocytes. Current Opinion in Immunology 19 (2007) 39-45
48. Schnare M., Barton G.M., Holt A.C., et al. Toll-like receptors control activation of adaptive immune responses. Nature Immunology 2 (2001) 947-950
49. Andonegui G., Bonder C.S., Green F., et al. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. The Journal of Clinical Investigation 111 (2003) 1011-1020
50. Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
51. Shen X.D., Ke B., Zhai Y., et al. Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. American Journal of Transplantation 5 (2005) 1793-1800
52. Zhai Y., Shen X.D., O'Connell R., et al. Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. Journal of Immunology (Baltimore, Md. : 1950) 173 (2004) 7115-7119
53. Ohashi K., Burkart V., Flohe S., et al. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. Journal of Immunology (Baltimore, Md. : 1950) 164 (2000) 558-561
54. Vabulas R.M., Ahmad-Nejad P., Ghose S., et al. HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. The Journal of Biological Chemistry 277 (2002) 15107-15112
55. Vabulas R.M., Braedel S., Hilf N., et al. The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. The Journal of Biological Chemistry 277 (2002) 20847-20853
56. Yu M., Wang H., Ding A., et al. HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock (Augusta, Ga.) 26 (2006) 174-179
57. Elmaagacli A.H., Koldehoff M., Hindahl H., et al. Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation. Transplantation 81 (2006) 247-254
58. Lorenz E., Schwartz D.A., Martin P.J., et al. Association of TLR4 mutations and the risk for acute GVHD after HLA-matched-sibling hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation 7 (2001) 384-387
59. Kesh S., Mensah N.Y., Peterlongo P., et al. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Annals of the New York Academy of Sciences 1062 (2005) 95-103
60. Palmer S.M., Burch L.H., Davis R.D., et al. The role of innate immunity in acute allograft rejection after lung transplantation. American Journal of Respiratory and Critical Care Medicine 168 (2003) 628-632
61. Palmer S.M., Burch L.H., Trindade A.J., et al. Innate immunity influences long-term outcomes after human lung transplant. American Journal of Respiratory and Critical Care Medicine 171 (2005) 780-785
62. Ducloux D., Deschamps M., Yannaraki M., et al. Relevance of Toll-like receptor-4 polymorphisms in renal transplantation. Kidney International 67 (2005) 2454-2461
63. Walker W.E., Nasr I.W., Camirand G., et al. Absence of innate MyD88 signaling promotes inducible allograft acceptance. Journal of Immunology (Baltimore, Md. : 1950) 177 (2006) 5307-5316
64. Pasare C., and Medzhitov R. Toll pathway-dependent blockade of CD4 + CD25 + T cell-mediated suppression by dendritic cells. Science 299 (2003) 1033-1036
65. Asea A., Kraeft S.K., Kurt-Jones E.A., et al. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nature Medicine 6 (2000) 435-442
66. Basu S., Binder R.J., Suto R., et al. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. International Immunology 12 (2000) 1539-1546
67. Holler E., Rogler G., Herfarth H., et al. Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GVHD following allogeneic stem cell transplantation. Blood 104 (2004) 889-894
68. Holler E., Rogler G., Brenmoehl J., et al. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood 107 (2006) 4189-4193
69. Granell M., Urbano-Ispizua A., Arostegui J.I., et al. Detrimental effect of NOD2/CARD15 polymorphisms in T-cell depleted allogeneic stem cell transplantation. Bone Marrow Transplantation 37 (2006) S79 P431
70. Hildebrandt G.C., Granell M., Urbano-Ispizua A., et al. Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation. Biology of Blood and Marrow Transplantation 14 (2008) 67-74
71. MacMillan M.L., Radloff G.A., Kiffmeyer W.R., et al. High-producer interleukin-2 genotype increases risk for acute graft-versus-host disease after unrelated donor bone marrow transplantation. Transplantation 76 (2003) 1758-1762
72. Yang Y.G., Wang H., Asavaroengchai W., et al. Role of Interferon-gamma in GVHD and GvL. Cellular and Molecular Immunology 2 (2005) 323-329
73. Bogunia-Kubik K., Mlynarczewska A., Wysoczanska B., et al. Recipient interferon-gamma 3/3 genotype contributes to the development of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Haematologica 90 (2005) 425-426
74. Mlynarczewska A., Wysoczanska B., Karabon L., et al. Lack of IFN-gamma 2/2 homozygous genotype independently of recipient age and intensity of conditioning regimen influences the risk of aGVHD manifestation after HLA-matched sibling haematopoietic stem cell transplantation. Bone Marrow Transplantation 34 (2004) 339-344
75. Brok H.P., Heidt P.J., van der Meide P.H., et al. Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice. Journal of Immunology (Baltimore, Md. : 1950) 151 (1993) 6451-6459
76. Turner D.M., Williams D.M., Sankaran D., et al. An investigation of polymorphism in the interleukin-10 gene promoter. European Journal of Immunogenetics 24 (1997) 1-8
77. Edwards-Smith C.J., Jonsson J.R., Purdie D.M., et al. Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa. Hepatology (Baltimore, Md.) 30 (1999) 526-530
78. Lin M.T., Storer B., Martin P.J., et al. Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. The New England Journal of Medicine 349 (2003) 2201-2210
79. Lin M.T., Storer B., Martin P.J., et al. Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between IL-10 genotype of patient and IL-10 receptor beta genotype of donor. Blood 106 (2005) 3995-4001
80. Seo K.W., Kim D.H., Sohn S.K., et al. Protective role of interleukin-10 promoter gene polymorphism in the pathogenesis of invasive pulmonary aspergillosis after allogeneic stem cell transplantation. Bone Marrow Transplantation 36 (2005) 1089-1095
81. Takahashi H., Furukawa T., Hashimoto S., et al. Contribution of TNF-alpha and IL-10 gene polymorphisms to graft-versus-host disease following allo-hematopoietic stem cell transplantation. Bone Marrow Transplantation 26 (2000) 1317-1323
82. Banovic T., MacDonald K.P., Morris E.S., et al. TGF-beta in allogeneic stem cell transplantation: friend or foe?. Blood 106 (2005) 2206-2214
83. Grainger D.J., Heathcote K., Chiano M., et al. Genetic control of the circulating concentration of transforming growth factor type beta 1. Human Molecular Genetics 8 (1999) 93-97
84. Leffell M.S., Vogelsang G.B., Lucas D.P., et al. Association between TGF-beta expression and severe GVHD in allogeneic bone marrow transplantation. Transplantation Proceedings 33 (2001) 485-486
85. Hattori H., Matsuzaki A., Suminoe A., et al. Polymorphisms of transforming growth factor-beta1 and transforming growth factor-beta1 type II receptor genes are associated with acute graft-versus-host disease in children with HLA-matched sibling bone marrow transplantation. Bone Marrow Transplantation 30 (2002) 665-671
86. Jordan W.J., Brookes P.A., Szydlo R.M., et al. IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation. Blood 103 (2004) 717-724
87. Joshi B.H., Hogaboam C., Dover P., et al. Role of interleukin-13 in cancer, pulmonary fibrosis, and other T(H)2-type diseases. Vitamins and Hormones 74 (2006) 479-504
88. Ohashi J., Naka I., Patarapotikul J., et al. A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand. Genes and Immunity 4 (2003) 528-531
89. Steck A.K., Bugawan T.L., Valdes A.M., et al. Association of non-HLA genes with type 1 diabetes autoimmunity. Diabetes 54 (2005) 2482-2486
90. Yigit B., Bozkurt N., Berber I., et al. Analysis of CC chemokine receptor 5 and 2 polymorphisms and renal transplant survival. Cell Biochemistry and Function (2006)
91. Bogunia-Kubik K., Duda D., Suchnicki K., et al. CCR5 deletion mutation and its association with the risk of developing acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Haematologica 91 (2006) 1628-1634
92. Welniak L.A., Wang Z., Sun K., et al. An absence of CCR5 on donor cells results in acceleration of acute graft-vs-host disease. Experimental Hematology 32 (2004) 318-324
93. Wysocki C.A., Burkett S.B., Panoskaltsis-Mortari A., et al. Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioning. Journal of Immunology (Baltimore, Md. : 1950) 173 (2004) 845-854
94. Terwey T.H., Kim T.D., Kochman A.A., et al. CCR2 is required for CD8-induced graft-versus-host disease. Blood 106 (2005) 3322-3330
95. Faaij C.M., Lankester A.C., Spierings E., et al. A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4 T cells to skin in human graft-versus-host disease. British Journal of Haematology 133 (2006) 538-549
96. Jaksch M., Remberger M., and Mattsson J. Increased gene expression of chemokine receptors is correlated with acute graft-versus-host disease after allogeneic stem cell transplantation. Biology of Blood and Marrow Transplantation 11 (2005) 280-287
97. Duffner U., Lu B., Hildebrandt G.C., et al. Role of CXCR3-induced donor T-cell migration in acute GVHD. Experimental Hematology 31 (2003) 897-902
98. Varona R., Cadenas V., Gomez L., et al. CCR6 regulates CD4 + T-cell-mediated acute graft-versus-host disease responses. Blood 106 (2005) 18-26
99. Loeffler J., Steffens M., Arlt E.M., et al. Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation. Journal of Clinical Microbiology 44 (2006) 1847-1850
100. Maeda Y., Reddy P., Lowler K.P., et al. Critical role of host T gamma delta cells in experimental acute graft-versus-host disease. Blood 106 (2005) 749-755
101. Lue H., Kleemann R., Calandra T., et al. Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease. Microbes and Infection/Institut Pasteur 4 (2002) 449-460
102. Choi S.W., Hildebrandt G.C., Olkiewicz K.M., et al. CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation. Blood 110 (2007) 3447-3455
103. Yang J., Qiao H.L., and Dong Z.M. Polymorphisms of IL-13 and IL-4-IL-13-SNPs in patients with penicillin allergies. European Journal of Clinical Pharmacology 61 (2005) 803-809
104. Cardoso S.M., DeFor T.E., Tilley L.A., et al. Patient interleukin-18 GCG haplotype associates with improved survival and decreased transplant-related mortality after unrelated-donor bone marrow transplantation. British Journal of Haematology 126 (2004) 704-710
105. Reddy P., Teshima T., Hildebrandt G., et al. Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects. Blood 101 (2003) 2877-2885
106. Mullighan C., Heatley S., Doherty K., et al. Non-HLA immunogenetic polymorphisms and the risk of complications after allogeneic hemopoietic stem-cell transplantation. Transplantation 77 (2004) 587-596
107. Shamim Z., Ryder L.P., Heilmann C., et al. Genetic polymorphisms in the genes encoding human interleukin-7 receptor-alpha: prognostic significance in allogeneic stem cell transplantation. Bone Marrow Transplantation 37 (2006) 485-491
108. Middleton P.G., Cullup H., Cavet J., et al. Oestrogen receptor alpha gene polymorphism associates with occurrence of graft-versus-host disease and reduced survival in HLA-matched sib-allo BMT. Bone Marrow Transplantation 32 (2003) 41-47
109. Middleton P.G., Cullup H., Dickinson A.M., et al. Vitamin D receptor gene polymorphism associates with graft-versus-host disease and survival in HLA-matched sibling allogeneic bone marrow transplantation. Bone Marrow Transplantation 30 (2002) 223-228
110. Dickinson A.M., Harrold J.L., and Cullup H. Haematopoietic stem cell transplantation: can our genes predict clinical outcome?. Expert Reviews in Molecular Medicine 9 (2007) 1-19
111. Hansen JA, Petersdorf EW, Lin MT, et-al. Genetics of allogeneic hematopoietic cell transplantation. Role of HLA matching, functional variation in immune response genes. Immunologic research; in press.