Alvimopan and COX-2 inhibition reverse opioid and inflammatory components of postoperative ileus

Neurogastroenterology and Motility

Volumn 20, Issue 6, 2008, Pages 689-699

  Schmidt, J ^a   Stoffels, B ^a   Nazir, A ^a   Dehaven Hudkins, D L ^b   Bauer, A J ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b ADOLOR CORPORATION   (United States)

Author keywords

Alvimopan; COX 2; Gastrointestinal motility; Morphine; Nitric oxide; Postoperative ileus

Indexed keywords

3 (3 FLUOROPHENYL) 5,5 DIMETHYL 4 (4 METHYLSULFONYLPHENYL) 2(5H) FURANONE; ALVIMOPAN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DEXTRAN; FLUORESCEIN; MORPHINE SULFATE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL MODEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; DRUG MEGADOSE; GASTROINTESTINAL TRANSIT; ILEUS; IMMUNOMODULATION; INFLAMMATION; LOW DRUG DOSE; MOUSE; NONHUMAN; POSTOPERATIVE CARE; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RAT; STOMACH FUNCTION; STOMACH MOTILITY;

ANALGESICS, OPIOID; ANIMALS; CYCLOOXYGENASE 2 INHIBITORS; ILEUS; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED C57BL; ORGAN CULTURE TECHNIQUES; PIPERIDINES; POSTOPERATIVE COMPLICATIONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU;

EID: 43549095469     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2007.01078.x     Document Type: Article

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