Importance of sex and relative efficacy at the μ opioid receptor in the development of tolerance and cross-tolerance to the antinociceptive effects of opioids

Psychopharmacology

Volumn 158, Issue 2, 2001, Pages 154-164

  Barrett, Andrew C ^a   Cook, Charles D ^b   Terner, Jolan M ^a   Craft, Rebecca M ^c   Picker, Mitchell J ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Antinociception; Efficacy; Morphine tolerance; Opioid; Sex difference

Indexed keywords

BUPRENORPHINE; DEZOCINE; MORPHINE; MU OPIATE RECEPTOR;

ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CROSS TOLERANCE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SENSITIVITY; DRUG TOLERANCE; FEMALE; MALE; MORPHINE TOLERANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SEX;

ANALGESICS; ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; FEMALE; MALE; MORPHINE; NARCOTICS; PAIN MEASUREMENT; RATS; RATS, INBRED F344; RATS, INBRED LEW; RECEPTORS, OPIOID, MU; SEX CHARACTERISTICS; SEX FACTORS;

EID: 0034749640     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130100821     Document Type: Article

References (33)

1. Tolerance and dependence after continuous morphine infusion from osmotic pumps measured by operant responding in rats
2. Sex differences and the effect of gonadectomy on morphine-induced antinociception and dependence in rats and mice
3. Microinjection of morphine into the rostral ventromedial medulla produces greater antinociception in male compared to female rats
4. Factors affecting restraint stress-induced potentiation of morphine analgesia
5. Gender-related differences in the antinociceptive properties of morphine
6. Sex-related differences in morphine's antinociceptive activity: Relationship to serum and brain morphine concentrations
7. Sex-related differences in the antinociceptive effects of opioids: Importance of rat genotype, nociceptive stimulus intensity and efficacy at the μ opioid receptor
8. Sex differences in development of morphine tolerance and dependence in the rat
9. Adaptations to prolonged or repeated stress - Comparison between rat strains showing intrinsic differences in reactivity to acute stress
10. Differential right shifts in the dose-response curve for intrathecal morphine and sufentanil as a function of stimulus intensity
11. Corticosterone responses of adult Lewis and Fischer rats
12. Genetic differences in morphine sensitivity, tolerance and withdrawal
13. Endocrine influences on the actions of morphine: IV. Effects of sex and strain
14. Roles of gender, gonadectomy and estrous phase in the analgesic effects of intracerebroventricular morphine
15. Gender effects and central opioid analgesia
16. Sex differences in supraspinal morphine analgesia are dependent on genotype
17. A comparison of morphine analgesic tolerance in male and female mice
18. Morphine antinociception elicited from the ventrolateral periaqueductal gray is sensitive to sex and gonadectomy differences in rats
19. Sex differences in thermal nociception and morphine antinociception in rodents depend on genotype
20. An examination of the interactions between the antinociceptive effects of morphine and various mu opioids: Role of intrinsic efficacy and stimulus intensity
21. Opioid antinociception in ovariectomized monkeys: Comparison with antinociception in males and effects of estradiol replacement
22. Development of tolerance to the analgesic activity of mu agonists after continuous infusion of morphine, meperidine or fentanyl in rats
23. Antinociceptive effects of opioids following acute and chronic administration of butorphanol: Influence of stimulus intensity and relative efficacy at the mu receptor
24. Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion
25. Lewis/Fischer rat strain differences in endocrine and behavioral responses to environmental challenge
26. Characterization of neonatal rat fentanyl tolerance and dependence
27. Characterization of neonatal rat morphine tolerance and dependence
28. Cross-tolerance to etorphine differentiates mu-opioid agonists in a rat tail withdrawal assay
29. Differential tolerance to the antinociceptive effects of μ opioids during repeated treatment with etonitazene, morphine, or buprenorphine in rats
30. Rat strain differences in the potentiation of morphine-induced analgesia by stress
31. Reinforcing and discriminative stimulus properties of mixed agonist-antagonist opioids