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Volumn 4, Issue 4, 2005, Pages 669-675

Immunomodulatory effect of morphine: Therapeutic implications

Author keywords

Immunomodulation; Macrophage; Morphine; Opiate; Renal fibrosis; T cell

Indexed keywords

CARBOPLATIN; IMMUNOMODULATING AGENT; KAPPA OPIATE RECEPTOR AGONIST; METENKEPHALIN; MORPHINE; MU OPIATE RECEPTOR; PACLITAXEL;

EID: 21744455746     PISSN: 14740338     EISSN: None     Source Type: Journal    
DOI: 10.1517/14740338.4.4.669     Document Type: Review
Times cited : (27)

References (75)
  • 1
    • 0020331572 scopus 로고
    • History of opiate use in the Orient and the United States
    • WAY EL: History of opiate use in the Orient and the United States. Ann. NY. Acad. Sci. (1982) 398:12-23.
    • (1982) Ann. NY. Acad. Sci. , vol.398 , pp. 12-23
    • Way, E.L.1
  • 4
    • 4644330576 scopus 로고    scopus 로고
    • A cell biologist's perspective on physiological adaptation to opiate drugs
    • VON ZASTROW M: A cell biologist's perspective on physiological adaptation to opiate drugs. Neuropharmacology (2004) 47(Suppl. 1):286-292.
    • (2004) Neuropharmacology , vol.47 , Issue.SUPPL. 1 , pp. 286-292
    • von Zastrow, M.1
  • 5
    • 0037396943 scopus 로고    scopus 로고
    • Microbial infections, immunomodulation, and drugs of abuse
    • FRIEDMAN H, NEWTON C, KLEIN TW: Microbial infections, immunomodulation, and drugs of abuse. Clin. Microbiol. Rev. (2003) 16:209-219.
    • (2003) Clin. Microbiol. Rev. , vol.16 , pp. 209-219
    • Friedman, H.1    Newton, C.2    Klein, T.W.3
  • 7
    • 0032520701 scopus 로고    scopus 로고
    • Evidence for opioid receptors on cells involved in host defense and the immune system
    • SHARP BM, ROY S, BIDLACK JM: Evidence for opioid receptors on cells involved in host defense and the immune system. J. Neuroimmunol. (1998) 83:45-56.
    • (1998) J. Neuroimmunol. , vol.83 , pp. 45-56
    • Sharp, B.M.1    Roy, S.2    Bidlack, J.M.3
  • 8
    • 0031854313 scopus 로고    scopus 로고
    • Opiates transdeactivate chemokine receptors: Delta and mu opiate receptor-mediated heterologous desensitization
    • GRIMM MC, BEN-BARUCH A, TAUB DD et al.: Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization. J. Exp. Med. (1998) 188:317-325.
    • (1998) J. Exp. Med. , vol.188 , pp. 317-325
    • Grimm, M.C.1    Ben-Baruch, A.2    Taub, D.D.3
  • 9
    • 0027229191 scopus 로고
    • Morphine inhibits the release of tumor necrosis factor in human peripheral blood mononuclear cell cultures
    • CHAO CC, MOLITOR TW, CLOSE K et al.: Morphine inhibits the release of tumor necrosis factor in human peripheral blood mononuclear cell cultures. Int. J. Immunopharmacol. (1993) 15:447-453.
    • (1993) Int. J. Immunopharmacol. , vol.15 , pp. 447-453
    • Chao, C.C.1    Molitor, T.W.2    Close, K.3
  • 10
    • 0027433718 scopus 로고
    • Morphine-induced alterations of immune status: Dose dependency, compartment specificity and antagonism by naltrexone
    • LYSLE DT, COUSSON ME, WATTS VJ et al.: Morphine-induced alterations of immune status: dose dependency, compartment specificity and antagonism by naltrexone. J. Pharmacol. Exp. Ther. (1993) 265:1071-1078.
    • (1993) J. Pharmacol. Exp. Ther. , vol.265 , pp. 1071-1078
    • Lysle, D.T.1    Cousson, M.E.2    Watts, V.J.3
  • 11
    • 0032582829 scopus 로고    scopus 로고
    • MU-opioid receptor-knockout mice: Role of mu-opioid receptor in morphine mediated immune functions
    • ROY S, BARKE RA, LOH HH: MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions. Brain Res. Mol. Brain Res. (1998) 61:190-194.
    • (1998) Brain Res. Mol. Brain Res. , vol.61 , pp. 190-194
    • Roy, S.1    Barke, R.A.2    Loh, H.H.3
  • 12
    • 0022749252 scopus 로고
    • Suppression of the induction of delayed hypersensitivity in rats by repetitive morphine treatments
    • PELLIS NR, HARPER C, DAFNY N: Suppression of the induction of delayed hypersensitivity in rats by repetitive morphine treatments. Exp. Neurol. (1986) 93:92-97.
    • (1986) Exp. Neurol. , vol.93 , pp. 92-97
    • Pellis, N.R.1    Harper, C.2    Dafny, N.3
  • 13
    • 0024366947 scopus 로고
    • The periaqueductal gray matter mediates opiate-induced immunosuppression
    • WEBER RJ, PERT A: The periaqueductal gray matter mediates opiate-induced immunosuppression. Science (1989) 245:188-190.
    • (1989) Science , vol.245 , pp. 188-190
    • Weber, R.J.1    Pert, A.2
  • 14
    • 0037217709 scopus 로고    scopus 로고
    • Role of heme oxygenase- 1 in morphine-modulated apoptosis and migration of macrophages
    • PATEL K, BHASKARAN M, DANI D et al.: Role of heme oxygenase- 1 in morphine-modulated apoptosis and migration of macrophages. J. Infect. Dis. (2003) 187:47-54.
    • (2003) J. Infect. Dis. , vol.187 , pp. 47-54
    • Patel, K.1    Bhaskaran, M.2    Dani, D.3
  • 15
    • 0037090092 scopus 로고    scopus 로고
    • Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis
    • SINGHAL PC, BHASKARAN M, PATEL J et al.: Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis. J. Immunol. (2002) 168:4025-4033.
    • (2002) J. Immunol. , vol.168 , pp. 4025-4033
    • Singhal, P.C.1    Bhaskaran, M.2    Patel, J.3
  • 16
    • 0034054677 scopus 로고    scopus 로고
    • Morphine-induced macrophage apoptosis: The role of transforming growth factor-beta
    • SINGHAL PC, KAPASI AA, FRANKI N et al.: Morphine-induced macrophage apoptosis: the role of transforming growth factor-beta. Immunology (2000) 100:57-62.
    • (2000) Immunology , vol.100 , pp. 57-62
    • Singhal, P.C.1    Kapasi, A.A.2    Franki, N.3
  • 17
    • 0032519904 scopus 로고    scopus 로고
    • Morphine enhances macrophage apoptosis
    • SINGHAL PC, SHARMA P, KAPASI AA et al.: Morphine enhances macrophage apoptosis. J. Immunol. (1998) 160:1886-1893.
    • (1998) J. Immunol. , vol.160 , pp. 1886-1893
    • Singhal, P.C.1    Sharma, P.2    Kapasi, A.A.3
  • 18
    • 2642546664 scopus 로고    scopus 로고
    • Morphine-induced macrophage apoptosis: Oxidative stress and strategies for modulation
    • BHAT RS, BHASKARAN M, MONGIA A et al.: Morphine-induced macrophage apoptosis: oxidative stress and strategies for modulation. J. Leukoc. Biol. (2004) 75:1131-1138.
    • (2004) J. Leukoc. Biol. , vol.75 , pp. 1131-1138
    • Bhat, R.S.1    Bhaskaran, M.2    Mongia, A.3
  • 19
    • 0027501801 scopus 로고
    • Suppression of peritoneal macrophage phagocytosis of Candida albicans by opioids
    • SZABO I, ROJAVIN M, BUSSIERE JL et al.: Suppression of peritoneal macrophage phagocytosis of Candida albicans by opioids.J. Pharmacol. Exp. Ther. (1993) 267:703-706.
    • (1993) J. Pharmacol. Exp. Ther. , vol.267 , pp. 703-706
    • Szabo, I.1    Rojavin, M.2    Bussiere, J.L.3
  • 20
    • 0025858255 scopus 로고
    • Role of adrenal cortical activation in the immunosuppressive effects of chronic morphine treatment
    • BRYANT HU, BERNTON EW, KENNER JR et al.: Role of adrenal cortical activation in the immunosuppressive effects of chronic morphine treatment. Endocrinology (1991) 128:3253-3258.
    • (1991) Endocrinology , vol.128 , pp. 3253-3258
    • Bryant, H.U.1    Bernton, E.W.2    Kenner, J.R.3
  • 21
    • 0034793410 scopus 로고    scopus 로고
    • Morphine modulates lymph node-derived T lymphocyte function: Role of caspase-3, -8, and nitric oxide
    • WANG J, CHARBONEAU R, BALASUBRAMANIAN S et al.: Morphine modulates lymph node-derived T lymphocyte function: role of caspase-3, -8, and nitric oxide. J. Leukoc. Biol. (2001) 70:527-536.
    • (2001) J. Leukoc. Biol. , vol.70 , pp. 527-536
    • Wang, J.1    Charboneau, R.2    Balasubramanian, S.3
  • 22
    • 0034905665 scopus 로고    scopus 로고
    • Morphine directs T cells toward T(H2) differentiation
    • ROY S, BALASUBRAMANIAN S, SUMANDEEP S et al.: Morphine directs T cells toward T(H2) differentiation. Surgery (2001) 130:304-309.
    • (2001) Surgery , vol.130 , pp. 304-309
    • Roy, S.1    Balasubramanian, S.2    Sumandeep, S.3
  • 23
    • 0026090264 scopus 로고
    • Clinical pharmacokinetics of morphine
    • GLARE PA, WALSH TD: Clinical pharmacokinetics of morphine. Ther. Drug Monit. (1991) 13(1):1-23.
    • (1991) Ther. Drug Monit. , vol.13 , Issue.1 , pp. 1-23
    • Glare, P.A.1    Walsh, T.D.2
  • 24
    • 0027460865 scopus 로고
    • Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations
    • HASSELSTROM J, SAWE J: Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations. Clin. Pharmacokinet. (1993) 24(4):344-354
    • (1993) Clin. Pharmacokinet. , vol.24 , Issue.4 , pp. 344-354
    • Hasselstrom, J.1    Sawe, J.2
  • 25
    • 0031032492 scopus 로고    scopus 로고
    • Morphine metabolites
    • CHRISTRUP LL: Morphine metabolites. Acta Anaesthesiol. Scand. (1997) 41 (1 Pt 2):116-122.
    • (1997) Acta Anaesthesiol. Scand. , vol.41 , Issue.1 PART 2 , pp. 116-122
    • Christrup, L.L.1
  • 26
  • 27
    • 2542492932 scopus 로고    scopus 로고
    • Practice guidelines for acute pain management in the perioperative setting
    • AMERICAN SOCIETY OF ANESTHESIOLOGISTS TASK FORCE ON ACUTE PAIN MANAGEMENT
    • AMERICAN SOCIETY OF ANESTHESIOLOGISTS TASK FORCE ON ACUTE PAIN MANAGEMENT: Practice guidelines for acute pain management in the perioperative setting. Anesthesiology (2004) 100(6):1573-1581.
    • (2004) Anesthesiology , vol.100 , Issue.6 , pp. 1573-1581
  • 28
    • 21744433254 scopus 로고    scopus 로고
    • Overview of the management of unstable angina and acute non-ST elevation (non-Q wave) myocardial infarction
    • BREALL JA, AROESTY JM, SIMONS M: Overview of the management of unstable angina and acute non-ST elevation (non-Q wave) myocardial infarction. UpToDate online vol.12.3 (2005).
    • (2005) UpToDate Online , vol.12 , Issue.3
    • Breall, J.A.1    Aroesty, J.M.2    Simons, M.3
  • 29
    • 0042377298 scopus 로고    scopus 로고
    • Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea
    • ABERNETHY AP, CURROW DC, FRITH P et al.: Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. BMJ (2003) 327(7414):523-528.
    • (2003) BMJ , vol.327 , Issue.7414 , pp. 523-528
    • Abernethy, A.P.1    Currow, D.C.2    Frith, P.3
  • 30
    • 1242329138 scopus 로고    scopus 로고
    • Nebulized opioids use in COPD
    • FORAL PA, MALESKER MA, HUERTA G et al.: Nebulized opioids use in COPD. Chest (2004) 125(2):691-694.
    • (2004) Chest , vol.125 , Issue.2 , pp. 691-694
    • Foral, P.A.1    Malesker, M.A.2    Huerta, G.3
  • 32
    • 0033056025 scopus 로고    scopus 로고
    • Influence of central antitussive drugs on the cough motor pattern
    • BOLSER DC, HEY JA, CHAPMAN RW: Influence of central antitussive drugs on the cough motor pattern. J. Appl. Physiol. (1999) 86(3):1017-1024.
    • (1999) J. Appl. Physiol. , vol.86 , Issue.3 , pp. 1017-1024
    • Bolser, D.C.1    Hey, J.A.2    Chapman, R.W.3
  • 33
    • 0036308601 scopus 로고    scopus 로고
    • Therapy for cough: Active agents
    • CHUNG KF, CHANG AB: Therapy for cough: active agents. Pulm. Pharmacol. Ther. (2002) 15(3):335-338.
    • (2002) Pulm. Pharmacol. Ther. , vol.15 , Issue.3 , pp. 335-338
    • Chung, K.F.1    Chang, A.B.2
  • 34
    • 0036277476 scopus 로고    scopus 로고
    • Dramatic response to nebulized morphine in an asthmatic patient with severe chronic cough
    • RUTHERFOLD RM, AZHER T, GILMARTIN JJ: Dramatic response to nebulized morphine in an asthmatic patient with severe chronic cough. Ir. Med. J. (2002) 95(4):113-114.
    • (2002) Ir. Med. J. , vol.95 , Issue.4 , pp. 113-114
    • Rutherfold, R.M.1    Azher, T.2    Gilmartin, J.J.3
  • 35
    • 0033093980 scopus 로고    scopus 로고
    • Role of opioid ligands in the irritable bowel syndrome
    • CORAZZIARI E: Role of opioid ligands in the irritable bowel syndrome. Can. J. Gastroenterol. (1999)13 (Suppl. A):71-75.
    • (1999) Can. J. Gastroenterol. , vol.13 , Issue.SUPPL. A , pp. 71-75
    • Corazziari, E.1
  • 36
    • 0032144529 scopus 로고    scopus 로고
    • Antidiarrheal agents for the management of treatment-related diarrhea in cancer patients
    • IPPOLITI C: Antidiarrheal agents for the management of treatment-related diarrhea in cancer patients. Am. J. Health Syst. Pharm. (1998) 55(15):1573-1580.
    • (1998) Am. J. Health Syst. Pharm. , vol.55 , Issue.15 , pp. 1573-1580
    • Ippoliti, C.1
  • 37
    • 2542520687 scopus 로고    scopus 로고
    • MR cholangiopancreatography: Improved ductal distention with intravenous morphine administration
    • SILVA AC, FRIESE JL, HARA AK et al.: MR cholangiopancreatography: improved ductal distention with intravenous morphine administration. Radiographics (2004) 24(3):677-687.
    • (2004) Radiographics , vol.24 , Issue.3 , pp. 677-687
    • Silva, A.C.1    Friese, J.L.2    Hara, A.K.3
  • 38
    • 0141991261 scopus 로고    scopus 로고
    • Treatment of spasticity in a spinal cord-injured patient wth nitrathecal morphine due to intrathecal baclofen tolerance - A case report and review of literature
    • SONO BM, MANI RM, OO T et al.: Treatment of spasticity in a spinal cord-injured patient wth nitrathecal morphine due to intrathecal baclofen tolerance - a case report and review of literature. Spinal Cord (2003) 41 (10):586-589.
    • (2003) Spinal Cord , vol.41 , Issue.10 , pp. 586-589
    • Sono, B.M.1    Mani, R.M.2    Oo, T.3
  • 40
    • 0032103115 scopus 로고    scopus 로고
    • Enkelytin and opioid peptide association in invertebrates and vertebrates: Immune activation and pain
    • STEFANO GB, SALZET B, FRICCHIONE GL: Enkelytin and opioid peptide association in invertebrates and vertebrates: immune activation and pain. Immunol. Today (1998) 19(6):265-268.
    • (1998) Immunol. Today , vol.19 , Issue.6 , pp. 265-268
    • Stefano, G.B.1    Salzet, B.2    Fricchione, G.L.3
  • 41
    • 9544233532 scopus 로고    scopus 로고
    • Opioid and opiate immunoregulatory processes
    • STEFANO GB, SCHARRER B, SMITH EM et al.: Opioid and opiate immunoregulatory processes. Crit. Rev. Immunol. (1996) 16(2):109-144.
    • (1996) Crit. Rev. Immunol. , vol.16 , Issue.2 , pp. 109-144
    • Stefano, G.B.1    Scharrer, B.2    Smith, E.M.3
  • 42
    • 0024510967 scopus 로고
    • Characterization of zeta (zeta): A new opioid receptor involved in growth
    • ZAGON IS, GOODMAN SR, McLAUGHLIN PJ: Characterization of zeta (zeta): a new opioid receptor involved in growth. Brain Res. (1989) 482(2):297-305.
    • (1989) Brain Res. , vol.482 , Issue.2 , pp. 297-305
    • Zagon, I.S.1    Goodman, S.R.2    McLaughlin, P.J.3
  • 43
    • 0032746019 scopus 로고    scopus 로고
    • Human renal cell cancer proliferation in tissue culture is tonically inhibited by opioid growth factor
    • BISIGNANI GJ, McLAUGHLIN PJ, ORDILLE SD et al.: Human renal cell cancer proliferation in tissue culture is tonically inhibited by opioid growth factor. J. Urol. (1999) 162(6):2186-2191.
    • (1999) J. Urol. , vol.162 , Issue.6 , pp. 2186-2191
    • Bisignani, G.J.1    McLaughlin, P.J.2    Ordille, S.D.3
  • 44
    • 0033128701 scopus 로고    scopus 로고
    • Regulation of human head and neck squamous cell carcinoma growth in tissue culture by opioid growth factor
    • MCLAUGHLIN PP, LEVIN RJ, ZAGON IS: Regulation of human head and neck squamous cell carcinoma growth in tissue culture by opioid growth factor. Int. J. Oncol. (1999) 14(5):991-998.
    • (1999) Int. J. Oncol. , vol.14 , Issue.5 , pp. 991-998
    • McLaughlin, P.P.1    Levin, R.J.2    Zagon, I.S.3
  • 45
    • 0029840010 scopus 로고    scopus 로고
    • Opioid growth factor ([Met5]enkephalin) prevents the incidence and retards the growth of human colon cancer
    • ZAGON IS, HYTREK SD, LANG CM et al.: Opioid growth factor ([Met5]enkephalin) prevents the incidence and retards the growth of human colon cancer. Am. J. Physiol. (1996) 271(3 Pt 2):R780-R786.
    • (1996) Am. J. Physiol. , vol.271 , Issue.3 PART 2
    • Zagon, I.S.1    Hytrek, S.D.2    Lang, C.M.3
  • 46
    • 0031590965 scopus 로고    scopus 로고
    • Opioid growth factor (OGF) inhibits human pancreatic cancer transplanted into nude mice
    • ZAGON IS, HYTREK SD, SMITH JP et al.: Opioid growth factor (OGF) inhibits human pancreatic cancer transplanted into nude mice. Cancer Lett. (1997) 112(2):167-175.
    • (1997) Cancer Lett. , vol.112 , Issue.2 , pp. 167-175
    • Zagon, I.S.1    Hytrek, S.D.2    Smith, J.P.3
  • 47
  • 48
    • 0033961207 scopus 로고    scopus 로고
    • Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans
    • ZAGON IS, VERDERAME MF, ALLEN SS et al.: Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans. Brain Res. (2000) 856:75-83.
    • (2000) Brain Res. , vol.856 , pp. 75-83
    • Zagon, I.S.1    Verderame, M.F.2    Allen, S.S.3
  • 49
    • 20344390545 scopus 로고    scopus 로고
    • Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of paclitaxel and opioid growth factor
    • MCLAUGHLIN PJ, JAGLOWSKI JR, VERDERAME MF et al.: Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of paclitaxel and opioid growth factor. Int. J. Oncol. (2005) 3:809-816.
    • (2005) Int. J. Oncol. , vol.3 , pp. 809-816
    • McLaughlin, P.J.1    Jaglowski, J.R.2    Verderame, M.F.3
  • 50
    • 0027264039 scopus 로고
    • Morphine attenuates surgery-induced enhancement of metastatic colonization in rats
    • PAGE GG, BEN-ELIYAHU S, YIRMIYA R et al.: Morphine attenuates surgery-induced enhancement of metastatic colonization in rats. Pain (1993) 54(1):21-28.
    • (1993) Pain , vol.54 , Issue.1 , pp. 21-28
    • Page, G.G.1    Ben-Eliyahu, S.2    Yirmiya, R.3
  • 51
    • 0031873014 scopus 로고    scopus 로고
    • Pre-operative versus postoperative administration of morphine: Impact on the neuroendocrine, behavioural, and metastatic-enhancing effects of surgery
    • PAGE GG, McDONDALD JS, BEN-ELIYAHU S: Pre-operative versus postoperative administration of morphine: impact on the neuroendocrine, behavioural, and metastatic-enhancing effects of surgery. Br. J. Anaesth. (1998) 81(2):216-23.
    • (1998) Br. J. Anaesth. , vol.81 , Issue.2 , pp. 216-223
    • Page, G.G.1    McDondald, J.S.2    Ben-Eliyahu, S.3
  • 53
    • 0032573361 scopus 로고    scopus 로고
    • Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-kappaB activation
    • SUEOKA E, SUEOKA N, KAI Y et al.: Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-kappaB activation. Biochem. Biophys. Res. Commun. (1998) 252(3):566-570.
    • (1998) Biochem. Biophys. Res. Commun. , vol.252 , Issue.3 , pp. 566-570
    • Sueoka, E.1    Sueoka, N.2    Kai, Y.3
  • 54
    • 0033625740 scopus 로고    scopus 로고
    • NF-kappaB, nitric oxide and opiate signaling
    • WELTERS ID, FIMIANI C, BILFINGER TV et al.: NF-kappaB, nitric oxide and opiate signaling. Med. Hypotheses (2000) 54(2):263-268.
    • (2000) Med. Hypotheses , vol.54 , Issue.2 , pp. 263-268
    • Welters, I.D.1    Fimiani, C.2    Bilfinger, T.V.3
  • 55
    • 0028060140 scopus 로고
    • Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells
    • BARG J, BELCHEVA MM, ZIMLICHMAN R et al.: Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells. J. Neurosci. (1994) 14(10):5858-5864.
    • (1994) J. Neurosci. , vol.14 , Issue.10 , pp. 5858-5864
    • Barg, J.1    Belcheva, M.M.2    Zimlichman, R.3
  • 56
    • 0037446984 scopus 로고    scopus 로고
    • G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: Involvement of p53 phosphorylation
    • TEGEDER I, GROSCH S, SCHMIDTKO A et al.: G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation. Cancer Res. (2003) 63(8):1846-1852.
    • (2003) Cancer Res. , vol.63 , Issue.8 , pp. 1846-1852
    • Tegeder, I.1    Grosch, S.2    Schmidtko, A.3
  • 57
    • 0026182077 scopus 로고
    • Evaluation of NK and LAK cell activities in neoplastic patients during treatment with morphine
    • PROVINCIALI M, DiSTEFANO G, RAFFAELI W et al.: Evaluation of NK and LAK cell activities in neoplastic patients during treatment with morphine. Int. J. Neurosci. (1991) 59(1-3):127-133.
    • (1991) Int. J. Neurosci. , vol.59 , Issue.1-3 , pp. 127-133
    • Provinciali, M.1    DiStefano, G.2    Raffaeli, W.3
  • 58
    • 16544378494 scopus 로고    scopus 로고
    • Opioid therapy and immunosuppression: A review
    • VALLEJO R, de LEON-CASASOLA O, BENYAMIN R: Opioid therapy and immunosuppression: a review. Am. J. Ther. (2004) 11(5):354-365.
    • (2004) Am. J. Ther. , vol.11 , Issue.5 , pp. 354-365
    • Vallejo, R.1    de Leon-Casasola, O.2    Benyamin, R.3
  • 59
    • 0031436405 scopus 로고    scopus 로고
    • Attenuation of neutrophil and endothelial activation by intravenous morphine in patients with acute myocardial infarction
    • WANG TL, CHANG H, HUNG CR et al.: Attenuation of neutrophil and endothelial activation by intravenous morphine in patients with acute myocardial infarction. Am. J. Cardiol. (1997) 80(12):1532-1535.
    • (1997) Am. J. Cardiol. , vol.80 , Issue.12 , pp. 1532-1535
    • Wang, T.L.1    Chang, H.2    Hung, C.R.3
  • 60
    • 0032402711 scopus 로고    scopus 로고
    • Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction
    • WANG TL, CHANG H, HUNG CR et al.: Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction. Cardiovasc. Res. (1998) 40(3):557-563.
    • (1998) Cardiovasc. Res. , vol.40 , Issue.3 , pp. 557-563
    • Wang, T.L.1    Chang, H.2    Hung, C.R.3
  • 61
    • 1642326902 scopus 로고    scopus 로고
    • Morphine-tolerant mice exhibit a profound and persistent cardioprotective phenotype
    • PEART JN, GROSS GJ. Morphine-tolerant mice exhibit a profound and persistent cardioprotective phenotype. Circulation (2004) 109(10):1219-1222.
    • (2004) Circulation , vol.109 , Issue.10 , pp. 1219-1222
    • Peart, J.N.1    Gross, G.J.2
  • 62
    • 0035676919 scopus 로고    scopus 로고
    • Opiates promote T cell apoptosis through JNK and caspase pathway
    • SINGHAL P, KAPASI A, REDDY K et al.: Opiates promote T cell apoptosis through JNK and caspase pathway. Adv. Exp. Med. Biol. (2001) 493:127-135.
    • (2001) Adv. Exp. Med. Biol. , vol.493 , pp. 127-135
    • Singhal, P.1    Kapasi, A.2    Reddy, K.3
  • 63
    • 1642493592 scopus 로고    scopus 로고
    • Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet
    • ROY S, WANG J, GUPTA S et al.: Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet. J. Neuroimmunol. (2004) 147(1-2):78-81.
    • (2004) J. Neuroimmunol. , vol.147 , Issue.1-2 , pp. 78-81
    • Roy, S.1    Wang, J.2    Gupta, S.3
  • 64
    • 0030828902 scopus 로고    scopus 로고
    • Comparison of the time course of morphine's analgesic and immunologic effects
    • NELSON CJ, DYKSTRA LA, LYSLE DT: Comparison of the time course of morphine's analgesic and immunologic effects. Anesth. Analg. (1997) 85(3):620-626.
    • (1997) Anesth. Analg. , vol.85 , Issue.3 , pp. 620-626
    • Nelson, C.J.1    Dykstra, L.A.2    Lysle, D.T.3
  • 65
    • 0037112041 scopus 로고    scopus 로고
    • The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats
    • RAGHAVENDRA V, RUTKOWSKI MD, DELEO JA: The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats. J. Neurosci. (2002) 22:9980-9989.
    • (2002) J. Neurosci. , vol.22 , pp. 9980-9989
    • Raghavendra, V.1    Rutkowski, M.D.2    Deleo, J.A.3
  • 66
    • 0142210211 scopus 로고    scopus 로고
    • Antagonism of N-methyl-D-aspartate receptors reduces the vulnerability of the immune system to stress after chronic morphine
    • ALONZO NC, BAYER BM: Antagonism of N-methyl-D-aspartate receptors reduces the vulnerability of the immune system to stress after chronic morphine. J. Pharmacol. Exp. Ther. (2003) 307(2):793-800.
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , Issue.2 , pp. 793-800
    • Alonzo, N.C.1    Bayer, B.M.2
  • 67
    • 0023102653 scopus 로고
    • Effect of oral morphine and naloxone on pituitary-adrenal response in man induced by human corticotropin-releasing hormone
    • ALLOLIO B, SCHULTE HM, SCHULTE U et al.: Effect of oral morphine and naloxone on pituitary-adrenal response in man induced by human corticotropin-releasing hormone. Acta. Endocrinol. (Copenhagen) (1987)114:509-514.
    • (1987) Acta Endocrinol. (Copenhagen) , vol.114 , pp. 509-514
    • Allolio, B.1    Schulte, H.M.2    Schulte, U.3
  • 68
    • 0027433763 scopus 로고
    • Glucocorticoid therapy for immune-mediated diseases: Basic and clinical correlates
    • BOUMPAS DT, CHROUSOS GP, WILDER RL et al.: Glucocorticoid therapy for immune-mediated diseases: basic and clinical correlates. Ann. Intern. Med. (1993) 119:1198-1208.
    • (1993) Ann. Intern. Med. , vol.119 , pp. 1198-1208
    • Boumpas, D.T.1    Chrousos, G.P.2    Wilder, R.L.3
  • 69
    • 0029149074 scopus 로고
    • Suppressive effects of central opioids on delayed type hypersensitivity to trinitrochlorobenzene: Comparative study with morphine and electroacupuncture
    • KASAHARA T, SAKURAI Y, AMEMIYA M et al.: Suppressive effects of central opioids on delayed type hypersensitivity to trinitrochlorobenzene: comparative study with morphine and electroacupuncture. In vivo (1995) 9(3):177-181.
    • (1995) In Vivo , vol.9 , Issue.3 , pp. 177-181
    • Kasahara, T.1    Sakurai, Y.2    Amemiya, M.3
  • 70
    • 0038414661 scopus 로고    scopus 로고
    • Anti-inflammatory effects of opioids
    • WALKER JS: Anti-inflammatory effects of opioids. Adv. Exp. Med. Biol. (2003) 521:148-160.
    • (2003) Adv. Exp. Med. Biol. , vol.521 , pp. 148-160
    • Walker, J.S.1
  • 71
    • 0038071833 scopus 로고    scopus 로고
    • Morphological correlates of immune-mediated peripheral opioid analgesia
    • MOUSA SA: Morphological correlates of immune-mediated peripheral opioid analgesia. Adv. Exp. Med. Biol. (2003)521:77-87.
    • (2003) Adv. Exp. Med. Biol. , vol.521 , pp. 77-87
    • Mousa, S.A.1
  • 72
    • 4143066901 scopus 로고    scopus 로고
    • Opioids as modulators of cell death and survival-unraveling mechanisms and revealing new indications
    • TEGEDER I, GEISSLINGER G: Opioids as modulators of cell death and survival-unraveling mechanisms and revealing new indications. Pharmacol. Rev. (2004) 56(3):351-369.
    • (2004) Pharmacol. Rev. , vol.56 , Issue.3 , pp. 351-369
    • Tegeder, I.1    Geisslinger, G.2
  • 73
    • 0031885104 scopus 로고    scopus 로고
    • Morphine modulates proliferation of kidney fibroblasts
    • SINGHAL PC, SHARMA P, SANWAL V et al.: Morphine modulates proliferation of kidney fibroblasts. Kidney Int. (1998) 53(2):350-357.
    • (1998) Kidney Int. , vol.53 , Issue.2 , pp. 350-357
    • Singhal, P.C.1    Sharma, P.2    Sanwal, V.3
  • 74
    • 12244271045 scopus 로고    scopus 로고
    • Morphine as a drug for stress ulcer prevention and healing in the stomach
    • CHO CH, WU KK, WU S et al.: Morphine as a drug for stress ulcer prevention and healing in the stomach. Eur. J. Pharmacol. (2003) 460(2-3):177-182.
    • (2003) Eur. J. Pharmacol. , vol.460 , Issue.2-3 , pp. 177-182
    • Cho, C.H.1    Wu, K.K.2    Wu, S.3
  • 75
    • 21744462832 scopus 로고    scopus 로고
    • Morphine Modulates Renal Interstitial Fibrosis: A Pharmacologically Modified UUO Model
    • SEMERDZHIEV Y, UPADHYA P, FRANKI N et al.: Morphine Modulates Renal Interstitial Fibrosis: A Pharmacologically Modified UUO Model. J. Am. Soc. Nephrol. (2004) 15:696A.
    • (2004) J. Am. Soc. Nephrol. , vol.15
    • Semerdzhiev, Y.1    Upadhya, P.2    Franki, N.3


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