The expression of δ- and κ-opioid receptor is enhanced during intestinal inflammation in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 2, 2003, Pages 455-462

  Pol, Olga ^a   Palacio, José R ^b   Puig, Margarita M ^a  

^a INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; MESSENGER RNA; MU OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG EFFECT; ENTERITIS; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; INTESTINE; INTESTINE SECRETION; INTESTINE TRANSIT TIME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; WESTERN BLOTTING;

ANIMALS; INFLAMMATION; INTESTINAL DISEASES; MALE; MICE; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0037622772     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.049346     Document Type: Article

References (39)

1. Bagnol D, Mansour A, Akil H, and Watson SJ (1997) Cellular localization and distribution of the cloned μ and κ opioid receptors in rat gastrointestinal tract. Neuroscience 81:579-591.
2. Bao L, Jin SX, Zhang C, Wang LH, Xu ZZ, Zhang FX, Wang LC, Ning FS, Cai HJ, Guan JS, et al. (2003) Activation of δ opioid receptors induces receptor insertion and neuropeptide secretion. Neuron 37:121-133.
3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. Buzas B and Cox B (1997) Quantitative analysis of the μ and δ opioid receptor gene expression in rat brain and peripheral ganglia using competitive polymerase chain reaction. Neuroscience 76:479-489.
5. Cahill CM, McClellan KA, Morinville A, Hoffert C, Hubatsch D, O'Donnell D, and Beaudet A (2001) Immunohistochemical distribution of δ opioid receptors in the rat central nervous system: evidence for somatodendritic labeling and antigen-specific cellular compartmentalization. J Comp Neurol 440:65-84.
6. Cahill CM, Morinville A, Hoffert C, O'Donnell D, and Beaudet A (2003) Upregulation and trafficking of δ opioid receptor in a model of chronic inflammation: implications for pain control. Pain 101:199-208.
7. Chen Y, Mestek A, Liu J, and Yu L (1993) Molecular cloning of a rat κ-opioid receptor reveals sequence similarities to the μ and δ opioid receptors. Biochem J 295:625-628.
8. 9-tetrahydrocannabinol and morphine. J Pharmacol Exp Ther 297:121-127.
9. Dashwood MR, Sykes RM, and Thompson CS (1986) Autoradiographic localization of opioid receptor types in the rat small intestine. NIDA Res Monogr 75:315-318.
10. Evans CJ, Keith DE, Morrison H, Magendzo K, and Edwards RH (1992) Cloning of a δ opioid receptor by functional expression. Science (Wash DC) 258:1952-1955.
11. Fletcher EL, Clark MJ, Senior P, and Furness JB (2001) Gene expression and localization of GABAc receptors in neurons of the rat gastrointestinal tract. Neuroscience 107:181-189.
12. Gylys KH, Tran N, Magendzo K, Zaki P, and Evans CJ (1997) cAMP decreases steady-state levels of δ-opioid receptor mRNA in NG108-15 cells. Neuroreport 8:2369-2372.
13. Hu X, Bi J, Loh HH, and Wei LN (2002) Regulation of mouse κ opioid receptor gene expression by different 3′-untranslated regions and the effect of retinoic acid. Mol. Pharmacol 62:881-887.
14. Hurley RW and Hammond DL (2000) The analgesic effects of supraspinal μ and δ opioid receptor agonists are potentiated during persistent inflammation. J Neurosci 20:1249-1259.
15. Ji RR, Zhang Q, Law PY, Low HH, Elde R, and Hökfelt T (1995) Expression of μ, δ and κ-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. J Neurosci 15:8156-8166.
16. Joshi SK, Su X, Porreca F, and Gebhart GF (2000) κ-Opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. J Neurosci 20:5874-5879.
17. Kromer W (1988) Endogenous and exogenous opioids in the control of gastrointestinal motility and secretion. Pharmacol Rev 40:121-162.
18. Li J, Park SW, Loh HH, and Wei LN (2002) Induction of the mouse κ-opioid receptor gene by retinoic acid in P19 cells. J Biol Chem 277:39967-39972.
19. Li S, Zhu J, Chen C, Chen YW, Deriel JK, Ashby B, and Liu-Chen LY (1993) Molecular cloning and expression of a rat κ opioid receptor. Biochem J 295:629-633.
20. Maekawa K, Minami M, Masuda T, and Satoh M (1995) Expression of μ and κ but not δ opioid receptor mRNAs is enhanced in the spinal dorsal horn of the arthritic rats. Pain 64:365-371.
21. Mansour A, Fox CA, Burke S, Meng F, Thompson RC, Akil H, and Watson SJ (1994) μ, δ and κ opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. J Com Neurol 350:412-438.
22. Mollereau C, Parmentier M, Mailleux P, Butour JL, Moisand C, Chalon P, Caput D, Vassart G, and Meunier JC (1994) ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. FEBS Lett 341:33-38.
23. Nano JL, Fournel S, and Rampal P (2000) Characterization of δ-opioid receptors and effect of enkephalins on IRD 98 rat epithelial intestinal cell line. Pflueg Arch 439:547-554.
24. Park SW, Li J, Loh HH, and Wei LN (2002) A novel signaling pathway of nitric oxide on transcriptional regulation of mouse κ opioid receptor gene. J Neurosci 22:7941-7947.
25. Pol O, Alameda F, and Puig MM (2001) Inflammation enhances μ-opioid receptor transcription and expression in mice intestine. Mol Pharmacol 60:894-899.
26. Poonyachoti S and Brown DR (2001) δ-Opioid receptors inhibit neurogenic intestinal secretion evoked by mast cell degranulation and type I hypersensitivity. J Neuro-Immunol 112:89-96.
27. Puig MM and Pol O (1998) Peripheral effects of opioids in a model of chronic intestinal inflammation in mice. J Pharmacol Exp Ther 287:1068-1075.
28. Richardson JD and Vasko MR (2002) Cellular mechanisms of neurogenic inflammation. J Pharmacol Exp Ther 302:839-845.
29. 2 opioid receptors. J Pharmacol Exp Ther 280:1423-1431.
30. Sengupta JN, Snider A, Su X, and Gebhart GF (1999) Effects of κ opioids in the inflamed rat colon. Pain 79:175-185.
31. Stein C (1995) The control of pain in peripheral tissue by opioids. N Engl J Med 332:1685-1690.
32. Sun P and Loh HH (2002) Transcriptional regulation of mouse δ-opioid receptor gene. Role of Ikaros in the stimulated transcription of mouse δ-opioid receptor gene in activated T cells. J Biol Chem 277:12854-12860.
33. Townsend D and Brown DR (2002) Predominance of δ-opioid-binding sites in the porcine enteric nervous system. J Pharmacol Exp Ther 300:900-909.
34. Valle II, Pol O, and Puig MM (2001) Intestinal inflammation enhances the inhibitory effects of opioids on intestinal permeability in mice. J Pharmacol Exp Ther 296: 378-387.
35. Wei LN, Hu X, Bi J, and Loh HH (2000) Post-transcriptional regulation of mouse κ opioid receptor expression. Mol Pharmacol 57:401-408.
36. Wei LN and Loh HH (2002) Regulation of opioid expression. Curr Opin Pharmacol 2:69-75.
37. Winkler A and Spanagel R (1998) Differences in the κ opioid receptor mRNA content in distinct brain regions of two inbred mice strains. Neuroreport 9:1459-1464.
38. Woltje M, Kraus J, and Hollt V (2000) Regulation of mouse δ-opioid receptor gene transcription: involvement of the transcription factors AP-1 and AP-2. J Neurochem 74:1355-1362.
39. Zhang Q, Schäfer M, Elde R, and Stein C (1998) Effects of neurotoxins and hindpaw inflammation on opioid receptor immunoreactivities in dorsal root ganglia. Neuroscience 85:281-291.