CRF 1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: Implications for irritable bowel syndrome

British Journal of Pharmacology

Volumn 141, Issue 8, 2004, Pages 1321-1330

  Tache Y ^a   Martinez, V ^a,b   Wang, L ^a   Million, M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Colonic motility; Corticotropin releasing factor; CRF; CRF antagonists; CRF receptors; Enteric nervous system; Irritable bowel syndrome; Stress; Urocortin

Indexed keywords

3 (6 DIMETHYLAMINO 4 METHYL 3 PYRIDINYL) 7 DIPROPYLAMINO 2,5 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDINE; 4 [4 (3 FLUOROPHENYL) 1,2,3,6 TETRAHYDRO 1 PYRIDINYL] 2 [N ETHYL N (4 ISOPROPYL 2 METHYLTHIOPHENYL)AMINO] 6 METHYLPYRIMIDINE; 5 CHLORO 4 [N (CYCLOPROPYLMETHYL) N PROPYLAMINO] 2 METHYL 6 (2,4,6 TRICHLOROANILINO)PYRIMIDINE; ANTALARMIN; ANTISAUVAGINE 30; ASTRESSIN; ATROPINE; AZASETRON; BRETYLIUM; BUTYL[2,5 DIMETHYL 7 (2,4,6 TRIMETHYLPHENYL) 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL]ETHYLAMINE; CORTICOTROPIN RELEASE FACTOR 1; CORTICOTROPIN RELEASE FACTOR 2; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR DERIVATIVE; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CORTICOTROPIN RELEASING FACTOR[12-41][12 DEXTRO PHENYLALANINE]; CORTICOTROPIN RELEASING FACTOR[9-41]; INDOMETACIN; NALOXONE; NBI 35965; NEUROKININ 1 RECEPTOR AGONIST; PSYCHOTROPIC AGENT; RAMASETRON; SEROTONIN 3 ANTAGONIST; TAK 637; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; UROCORTIN; UROCORTIN 1; UROCORTIN 2; UROCORTIN III; CRF RECEPTOR TYPE 1;

ABDOMINAL PAIN; ALPHA HELIX; ANXIETY DISORDER; BLOOD BRAIN BARRIER; BRAIN; COLON DISEASE; COLON MOTILITY; DEFECATION; DIARRHEA; GANGLION BLOCK; GENE EXPRESSION; HUMAN; HYPERSENSITIVITY REACTION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INTESTINE DISTENSION; INTESTINE FUNCTION; INTESTINE INNERVATION; IRRITABLE COLON; LOCUS CERULEUS; MENTAL DISEASE; MOOD DISORDER; NEUROPSYCHIATRY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STRESS; VAGOTOMY; VISCERAL PAIN; ANIMAL; COLON; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SENSORY NERVE;

ANIMALS; COLON; HUMANS; IRRITABLE BOWEL SYNDROME; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SIGNAL TRANSDUCTION; STRESS; VISCERAL AFFERENTS;

EID: 2442539352     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705760     Document Type: Review

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