Distinct regulation of effector and memory T-cell differentiation

Immunology and Cell Biology

Volumn 86, Issue 4, 2008, Pages 325-332

  Kallies, Axel ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Bcl 6; Blimp 1; IL12; IL2; T bet; Transcription factors

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; CYTOKINE; EOMES PROTEIN; INTERLEUKIN 12; INTERLEUKIN 2; PROTEIN BCL 6; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR T BET;

ANTIGEN SPECIFICITY; CELL FATE; CELLULAR IMMUNITY; EFFECTOR CELL; HOMEOSTASIS; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; MEMORY T LYMPHOCYTE; NONHUMAN; REINFECTION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

B-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; IMMUNOLOGIC MEMORY; INTERLEUKINS; TRANSCRIPTION FACTORS;

EID: 43449134355     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2008.16     Document Type: Review

References (95)

1. Jabbari A, Harty JT. The generation and modulation of antigen-specific memory CD8 T cell responses. J Leukoc Biol 2006; 80: 16-23.
2. + T cells in protective immunity to influenza. Immunol Rev 2006; 211: 8-22.
3. + memory T cells: functional differentiation and homeostasis. Immunol Rev 2006; 211: 39-48.
4. Wilson CB, Makar KW, Shnyreva M, Fitzpatrick DR. DNA methylation and the expanding epigenetics of T cell lineage commitment. Semin Immunol 2005; 17: 105-119.
5. Wherry EJ, Teichgraber V, Becker TC, Masopust D, Kaech SM, Antia R et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol 2003; 4: 225-234.
6. Kalia V, Sarkar S, Gourley TS, Rouse BT, Ahmed R. Differentiation of memory B and T cells. Curr Opin Immunol 2006; 18: 255-264.
7. Freitas AA, Rocha B. Population biology of lymphocytes: the flight for survival. Annu Rev Immunol 2000; 18: 83-111.
8. Maris CH, Miller JD, Altman JD, Jacob J. A transgenic mouse model genetically tags all activated CD8 T cells. J Immunol 2003; 171: 2393-2401.
9. + T cell clones. Adv Immunol 2007; 96: 103-139.
10. Lauvau G, Vijh S, Kong P, Horng T, Kerksiek K, Serbina N et al. Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science 2001; 294: 1735-1739.
11. + T cell contraction is controlled by early inflammation. Nat Immunol 2004; 5: 809-817.
12. Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relation. Science 1996; 272: 54-60.
13. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708-712.
14. Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 2004; 22: 745-763.
15. - memory T cells do not differ in immediate effector cell function. J Immunol 2002; 169: 638-641.
16. + memory T cell subsets. Proc Natl Acad Sci USA 2004; 101: 5610-5615.
17. Kaech SM, Tan JT, Wherry EJ, Konieczny BT, Surh CD, Ahmed R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol 2003; 4: 1191-1198.
18. Farber DL. Differential TCR signaling and the generation of memory T cells. J Immunol 1998; 160: 535-539.
19. Sallusto F, Lanzavecchia A. Exploring pathways for memory T cell generation. J Clin Invest 2001; 108: 805-806.
20. Nutt SL, Kee BL. The transcriptional regulation of B cell lineage commitment. Immunity 2007; 26: 715-725.
21. + T cells. Immunol Rev 2006; 211: 81-92.
22. + T-cell memory. Immunol Rev 2006; 211: 67-80.
23. + T cells. J Immunol 2004; 173: 2217-2221.
24. Sprent J, Cho J-H, Boyman O, Surh CD. T cell homeostasis. Immunol Cell Biol 2008; 86: 312-319.
25. + T-cell memory and prime-boost response after dendritic-cell vaccination. Nat Med 2005; 11: 748-756.
26. Boyman O, Purton JF, Surh CD, Sprent J. Cytokines and T-cell homeostasis. Curr Opin Immunol 2007; 19: 320-326.
27. Schluns KS, Kieper WC, Jameson SC, Lefrancois L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat Immunol 2000; 1: 426-432.
28. + T cell subsets identified by expression of IL-7 receptor alpha and CD62L. J Immunol 2005; 175: 4686-4696.
29. + central memory T cells into protective Listeria-specific effector memory T cells. Eur J Immunol 2006; 36: 1453-1464.
30. Joshi NS, Cui W, Chandele A, Lee HK, Urso DR, Hagman J et al. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 2007; 27: 281-295.
31. + memory T lymphocyte precursors following peptide immunization. J Immunol 2005; 175: 4400-4407.
32. Hand TW, Morre M, Kaech SM. Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. Proc Natl Acad Sci USA 2007; 104: 11730-11735.
33. + T cell responses. J Immunol 2007; 178: 4027-4031.
34. Kaech SM, Hemby S, Kersh E, Ahmed R. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 2002; 111: 837-851.
35. Chao CC, Jensen R, Dailey MO. Mechanisms of L-selectin regulation by activated T cells. J Immunol 1997; 159: 1686-1694.
36. + T cell lineage commitment. Nat Immunol 2005; 6: 793-799.
37. Lanzavecchia A, Sallusto F. Progressive differentiation and selection of the fittest in the immune response. Nat Rev Immunol 2002; 2: 982-987.
38. Gett AV, Sallusto F, Lanzavecchia A, Geginat J. T cell fitness determined by signal strength. Nat Immunol 2003; 4: 355-360.
39. + T cell response. Immunity 2006; 25: 19-29.
40. Mullen AC, High FA, Hutchins AS, Lee HW, Villarino AV, Livingston DM et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 2001; 292: 1907-1910.
41. Ouyang W, Ranganath SH, Weindel K, Bhattacharya D, Murphy TL, Sha WC et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 1998; 9: 745-755.
42. Pearce EL, Shen H. Generation of CD8 T cell memory is regulated by IL-12. J Immunol 2007; 179: 2074-2081.
43. + T cell fate coupled by T-bet and eomesodermin. Nat Immunol 2005; 6: 1236-1244.
44. + T cell function by the transcription factor eomesodermin. Science 2003; 302: 1041-1043.
45. Szabo SJ, Sullivan BM, Peng SL, Glimcher LH. Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol 2003; 21: 713-758.
46. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100: 655-669.
47. Glimcher LH, Townsend MJ, Sullivan BM, Lord GM. Recent developments in the transcriptional regulation of cytolytic effector cells. Nat Rev Immunol 2004; 4: 900-911.
48. Hwang ES, Hong JH, Glimcher LH. IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J Exp Med 2005; 202: 1289-1300.
49. Sullivan BM, Juedes A, Szabo SJ, von Herrath M, Glimcher LH. Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci USA 2003; 100: 15818-15823.
50. Way SS, Wilson CB. Cutting edge: immunity and IFN-gamma production during Listeria monocytogenes infection in the absence of T-bet. J Immunol 2004; 173: 5918-5922.
51. + T cell differentiation. J Immunol 2006; 177: 7515-7519.
52. + Tcells. J Exp Med 2007; 204: 2015-2021.
53. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993; 75: 253-261.
54. Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995; 3: 521-530.
55. Suzuki H, Kundig TM, Furlonger C, Wakeham A, Timms E, Matsuyama T et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 1995; 268: 1472-1476.
56. Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005; 6: 1142-1151.
57. + regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 2005; 6: 1152-1159.
58. D'Souza WN, Lefrancois L. IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J Immunol 2003; 171: 5727-5735.
59. D'Souza WN, Schluns KS, Masopust D, Lefrancois L. Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses. J Immunol 2002; 168: 5566-5572.
60. Yu A, Zhou J, Marten N, Bergmann CC, Mammolenti M, Levy RB et al. Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors. J Immunol 2003; 170: 236-242.
61. Kramer S, Mamalaki C, Horak I, Schimpl A, Kioussis D, Hung T. Thymic selection and peptide-induced activation of T cell receptor-transgenic CD8 T cells in interleukin-2-deficient mice. Eur J Immunol 1994; 24: 2317-2322.
62. Dooms H, Kahn E, Knoechel B, Abbas AK. IL-2 induces a competitive survival advantage in T lymphocytes. J Immunol 2004; 172: 5973-5979.
63. + T cell memory by promoting the generation of IL-7R alpha-expressing cells. J Exp Med 2007; 204: 547-557.
64. Malek TR. The biology of interleukin-2. Annu Rev Immunol 2008; 26: 453-479.
65. Williams MA, Bevan MJ. Effector and memory CTL differentiation. Annu Rev Immunol 2007; 25: 171-192.
66. Santer-Nanan B, Berberich-Siebelt F, Xiao Z, Poser N, Sennefelder H, Rauthe S et al. Blimp-1 is expressed in human and mouse T cell subsets and leads to loss of IL-2 production and to defective proliferation. Signal Transduct 2006; 6: 268-279.
67. Gong D, Malek TR. Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production. J Immunol 2007; 178: 242-252.
68. Kallies A, Hasbold J, Tarlinton DM, Dietrich W, Corcoran LM, Hodgkin PD et al. Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med 2004; 200: 967-977.
69. Shapiro-Shelef M, Lin KI, McHeyzer-Williams LJ, Liao J, McHeyzer-Williams MG, Calame K. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 2003; 19: 607-620.
70. Yu J, Angelin-Duclos C, Greenwood J, Liao J, Calame K. Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. Mol Cell Biol 2000; 20: 2592-2603.
71. Shapiro-Shelef M, Calame K. Regulation of plasma-cell development. Nat Rev Immunol 2005; 5: 230-242.
72. Kallies A, Nutt SL. Terminal differentiation of lymphocytes depends on Blimp-1. Curr Opin Immunol 2007; 19: 156-162.
73. Kallies A, Hawkins ED, Belz GT, Metcalf D, Hommel M, Corcoran LM et al. Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat Immunol 2006; 7: 466-474.
74. Martins GA, Cimmino L, Shapiro-Shelef M, Szabolcs M, Herron A, Magnusdottir E et al. Transcriptional repressor Blimp-1 regulates T cell homeostasis and function. Nat Immunol 2006; 7: 457-465.
75. Fukuda T, Yoshida T, Okada S, Hatano M, Miki T, Ishibashi K et al. Disruption of the Bcl6 gene results in an impaired germinal center formation. J Exp Med 1997; 186: 439-448.
76. Kuo TC, Shaffer AL, Haddad Jr J, Choi YS, Staudt LM, Calame K. Repression of BCL-6 is required for the formation of human memory B cells in vitro. J Exp Med 2007; 204: 819-830.
77. Scheeren FA, Naspetti M, Diehl S, Schotte R, Nagasawa M, Wijnands E et al. STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression. Nat Immunol 2005; 6: 303-313.
78. + T cells. J Immunol 2004; 173: 883-891.
79. + T cells. Nat Immunol 2002; 3: 558-563.
80. + T cells. Eur J Immunol 2006; 36: 3146-3156.
81. + T cells. Int Immunol 2007; 19: 427-433.
82. + T lymphocytes. Proc Natl Acad Sci USA 2005; 102: 7418-7425.
83. Klein U, Dalla-Favera R. Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol 2008; 8: 22-33.
84. Nutt SL, Fairfax KA, Kallies A. BLIMP1 guides the fate of effector B and T cells. Nat Rev Immunol 2007; 7: 923-927.
85. + T cell immunity. Nat Immunol 2006; 7: 1317-1325.
86. Mittrucker HW, Matsuyama T, Grossman A, Kundig TM, Potter J, Shahinian A et al. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 1997; 275: 540-543.
87. Brustle A, Heink S, Huber M, Rosenplanter C, Stadelmann C, Yu P et al. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol 2007; 8: 958-966.
88. Ozaki K, Spolski R, Ettinger R, Kim HP, Wang G, Qi CF et al. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol 2004; 173: 5361-5371.
89. Kallies A, Hasbold J, Fairfax K, Pridans C, Emslie D, McKenzie BS et al. Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1. Immunity 2007; 26: 555-566.
90. Zeng R, Spolski R, Finkelstein SE, Oh S, Kovanen PE, Hinrichs CS et al. Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J Exp Med 2005; 201: 139-148.
91. Jelley-Gibbs DM, Brown DM, Dibble JP, Haynes L, Eaton SM, Swain SL. Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation. J Exp Med 2005; 202: 697-706.
92. D'Souza WN, Hedrick SM. Cutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program. J Immunol 2006; 177: 777-781.
93. + T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central-memory cells. J Exp Med 2006; 203: 1045-1054.
94. Chang JT, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, Banerjee A et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 2007; 315: 1687-1691.
95. Russell SM. Determination of T cell fate by dendritic cells: a new role for asymmetric cell division? Immunol Cell Biol 2008 (in press).