Arousal and reward: a dichotomy in orexin function

Trends in Neurosciences

Volumn 29, Issue 10, 2006, Pages 571-577

  Harris, Glenda C ^a   Aston Jones, Gary ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; BLOCKING AGENT; CORTICOTROPIN RELEASING FACTOR; OREXIN; OREXIN A; UNCLASSIFIED DRUG;

ADDICTION; AROUSAL; DRUG EFFECT; FEEDING; FOOD INTAKE; GABAERGIC SYSTEM; HORMONAL REGULATION; HUMAN; HYPOTHALAMUS NUCLEUS; LEARNING; MEMORY; MOLECULAR BIOLOGY; NEUROBIOLOGY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; REWARD;

ANIMALS; AROUSAL; BRAIN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEURONS; NEUROPEPTIDES; REWARD;

EID: 33748806552     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tins.2006.08.002     Document Type: Review

References (60)

1. Wallace B.C. Psychological and environmental determinants of relapse in crack cocaine smokers. J. Subst. Abuse Treat. 6 (1989) 95-106
2. Mendelson J.H., and Mello N.K. Management of cocaine abuse and dependence. N. Engl. J. Med. 334 (1996) 965-972
3. O'Brien C.P. A range of research-based pharmacotherapies for addiction. Science 278 (1997) 66-70
4. Shaham Y., et al. The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl.) 168 (2003) 3-20
5. Bossert J.M., et al. Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications. Eur. J. Pharmacol. 526 (2005) 36-50
6. de Lecea L., et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 322-327
7. Sakurai T., et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 (1998) 573-585
8. Peyron C., et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18 (1998) 9996-10015
9. Sakurai T. Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy homeostasis. Sleep Med. Rev. 9 (2005) 231-241
10. de Lecea L., and Sutcliffe J.G. The hypocretins and sleep. FEBS J. 272 (2005) 5675-5688
11. Harris G.C., et al. A novel role for lateral hypothalamic orexin neurons in reward seeking. Nature 437 (2005) 556-559
12. Anand B.K., and Brobeck J.R. Hypothalamic control of food intake in rats and cats. Yale J. Biol. Med. 24 (1951) 123-140
13. Olds J., and Milner P. Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. J. Comp. Physiol. Psychol. 47 (1954) 419-427
14. DiLeone R.J., et al. Lateral hypothalamic neuropeptides in reward and drug addiction. Life Sci. 73 (2003) 759-768
15. Petrovich G.D., and Gallagher M. Amygdala subsystems and control of feeding behavior by learned cues. Ann. N. Y. Acad. Sci. 985 (2003) 251-262
16. Siegel J.M. Hypocretin (orexin): role in normal behavior and neuropathology. Annu. Rev. Psychol. 55 (2004) 125-148
17. Saper C.B., et al. Hypothalamic regulation of sleep and circadian rhythms. Nature 437 (2005) 1257-1263
18. Chemelli R.M., et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98 (1999) 437-451
19. Lin L., et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98 (1999) 365-376
20. Nishino S., and Mignot E. Pharmacological aspects of human and canine narcolepsy. Prog. Neurobiol. 52 (1997) 27-78
21. Akimoto H., et al. Pharmacotherapy in narcolepsy. Dis. Nerv. Syst. 21 (1960) 704-706
22. Guilleminault C., et al. On the treatment of rapid eye movement narcolepsy. Arch. Neurol. 30 (1974) 90-93
23. Georgescu D., et al. Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J. Neurosci. 23 (2003) 3106-3111
24. Estabrooke I.V., et al. Fos expression in orexin neurons varies with behavioral state. J. Neurosci. 21 (2001) 1656-1662
25. Fadel J., et al. Differential activation of orexin neurons by antipsychotic drugs associated with weight gain. J. Neurosci. 22 (2002) 6742-6746
26. Campbell R.E., et al. Orexin neurons express a functional pancreatic polypeptide Y4 receptor. J. Neurosci. 23 (2003) 1487-1497
27. Lu L., et al. Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: a review. Neurosci. Biobehav. Rev. 27 (2003) 457-491
28. Sakamoto F., et al. Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF neurons. Regul. Pept. 118 (2004) 183-191
29. Winsky-Sommerer R., et al. Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J. Neurosci. 24 (2004) 11439-11448
30. Boutrel B., et al. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 19168-19173
31. Macey D.J., et al. CRF and urocortin decreased brain stimulation reward in the rat: reversal by a CRF receptor antagonist. Brain Res. 866 (2000) 82-91
32. Shaham Y., et al. Stress-induced relapse to heroin and cocaine seeking in rats: a review. Brain Res. Rev. 33 (2000) 13-33
33. Wang B., et al. Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking. J. Neurosci. 25 (2005) 5389-5396
34. Horvath T.L., et al. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J. Neurosci. 19 (1999) 1072-1087
35. Tebbe J.J., et al. Stimulation of neurons in rat ARC inhibits gastric acid secretion via hypothalamic CRF1/2- and NPY-Y1 receptors. Am. J. Physiol. Gastrointest. Liver Physiol. 285 (2003) G1075-G1083
36. Fadel J., and Deutch A.Y. Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience 111 (2002) 379-387
37. Trivedi P., et al. Distribution of orexin receptor mRNA in the rat brain. FEBS Lett. 438 (1998) 71-75
38. Marcus J.N., et al. Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 435 (2001) 6-25
39. Korotkova T.M., et al. Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexin/hypocretins. J. Neurosci. 23 (2003) 7-11
40. Yoshida K., et al. Afferents to the orexin neurons of the rat brain. J. Comp. Neurol. 494 (2006) 845-861
41. Stratford T.R., and Kelley A.E. Evidence of a functional relationship between the NAc shell and lateral hypothalamus subserving the control of feeding behavior. J. Neurosci. 19 (1999) 11040-11048
42. Kelley A.E., et al. A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward. J. Comp. Neurol. 493 (2005) 72-85
43. Thorpe A.J., and Kotz C.M. Orexin A in the nucleus accumbens stimulates feeding and locomotor activity. Brain Res. 1050 (2005) 156-162
44. A receptor-mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment. Eur. J. Neurosci. 19 (2004) 376-386
45. Horvath T.L., and Gao X.B. Input organization and plasticity of hypocretin neurons: possible clues to obesity's association with insomnia. Cell Metab. 1 (2005) 279-286
46. Carr K.D. Augmentation of drug reward by chronic food restriction: behavioral evidence and underlying mechanisms. Physiol. Behav. 76 (2002) 353-364
47. Shalev U., et al. The role of corticosterone in food deprivation-induced reinstatement of cocaine seeking in the rat. Psychopharmacology (Berl.) 168 (2003) 170-176
48. Kalra S.P., and Kalra P.S. Overlapping and interactive pathways regulating appetite and craving. J. Addict. Dis. 23 (2004) 5-21
49. Di Chiara G. A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use. J. Psychopharmacol. 12 (1998) 54-67
50. Wise R.A. Dopamine, learning and motivation. Nat. Rev. Neurosci. 5 (2004) 483-494
51. Vittoz N.M., and Berridge C.W. Hypocretin/orexin selectively increases dopamine efflux within the prefrontal cortex: involvement of the ventral tegmental area. Neuropsychopharmacology 31 (2006) 384-395
52. Narita M., et al. Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J. Neurosci. 26 (2006) 398-405
53. Zahm D.S. Functional-anatomical implications of the nucleus accumbens core and shell subterritories. Ann. N. Y. Acad. Sci. 877 (1999) 113-128
54. McFarland K., and Kalivas P.W. The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior. J. Neurosci. 21 (2001) 8655-8663
55. Borgland S.L., et al. Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron 49 (2006) 589-601
56. Selbach O., et al. Orexins/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, GABAergic, noradrenergic, and cholinergic signaling. Neuroscience 127 (2004) 519-528
57. Harris G.C., and Aston-Jones G. Critical role for ventral tegmental glutamate in preference for a cocaine-conditioned environment. Neuropsychopharmacology 28 (2003) 73-76
58. Harris G.C., et al. Glutamate-associated plasticity in the ventral tegmental area is necessary for conditioning environmental stimuli with morphine. Neuroscience 129 (2004) 841-847
59. Ungless M.A., et al. Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411 (2001) 583-587
60. Swanson L.W. Brain Maps: Structure Of The Rat Brain (1992), Elsevier