Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms

Brazilian Journal of Medical and Biological Research

Volumn 35, Issue 10, 2002, Pages 1221-1228

  Picolo, G ^a   Chacur, M ^a   Gutierrez J M ^b   Teixeira, C F P ^a   Cury, Y ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

Author keywords

Antivenom; Bothrops asper venom; Bothrops jararaca venom; Edema; Hyperalgesia; Neutralization

Indexed keywords

BATROXOBIN; NEUTRALIZING ANTIBODY; SNAKE VENOM; SNAKE VENOM ANTISERUM;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; CONTROLLED STUDY; DOSE RESPONSE; ENVENOMATION; HYPERALGESIA; INCUBATION TIME; MALE; NONHUMAN; PAW EDEMA; RAT; RAT STRAIN; TIME; TREATMENT OUTCOME;

ANIMALIA; BOTHROPS; BOTHROPS ASPER; BOTHROPS JARARACA; PANTHEROPHIS OBSOLETUS; SERPENTES;

EID: 0036817733     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2002001000016     Document Type: Article

References (30)

1. Warrell DA (1992). The global problem of snake bite: its prevention and treatment. In: Gopalakrishnakone P & Tan CR (Editors), Recent Advances in Toxicology Research. National University of Singapore, Singapore, 121-153.
2. Rosenfeld G (1971). Symptomatology, pathology and treatment of snake bites in South America. In: Bucherl W & Buckley E (Editors), Venomous Animals and Their Venoms. Vol. II, Venomous Vertebrates. Academic Press, New York, NY, USA, 345-384.
3. Cardoso JLC, Fan HW, Franca FOS, Jorge MT, Leite RP, Nishioka SA, Avila A, Sano-Martins IS, Tomy SC, Santoro ML, Chudzinski AM, Castro SCB, Kamiguti AS, Kelen EMA, Hirata MH, Mirandola RMS, Theakston RDG & Warrell DA (1993). Randomized comparative trial of three antivenoms in the treatment of envenoming by lance-headed vipers (Bothrops jararaca) in São Paulo, Brazil. Quarterly Journal of Medicine, 86: 315-325.
4. Rojas G, Bogarín G & Gutiérrez JM (1997). Snakebite mortality in Costa Rica. Toxicon, 35: 1639-1643.
5. Otero R, Gutiérrez JM, Núñez V, Robles A, Estrada R, Segura E, Toro MF, Garcia ME, Diaz A, Ramirez EC, Gómez G, Castañeda J & Moreno ME (1996). A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 90: 696-700.
6. Otero R, Gutiérrez JM, Rojas G, Núñez V, Díaz A, Miranda E, Uribe AF, Silva JF, Ospina JG, Medina Y, Toro ME, Garcǐa ME, León G, Garcǐa M, Lizano S, De La Torre J, Márquez J, Mena Y, González N, Arenas LC, Puzón A, Blanco N, Sierra A, Espinal ME, Arboleda M, Jiménez JC, Ramírez P, Díaz M, Guzmán MC, Barros J, Henao S, Ramǐrez A, Macea U & Lozano R (1999). A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid and ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms. Toxicon, 37: 895-908.
7. Otero-Patiño R, Cardoso JLC, Higashi HG, Núñez V, Díaz A, Toro ME, García ME, Sierra A, García LF, Moreno AM, Medina MC, Castañeda N, Silva-Díaz JF, Murcia M, Cárdenas SY, Dias da Silva WD & The Regional Group of Antivenom Therapy Research (REGATHER) (1998). A randomized, blinded, comparative trial of one pepsin-digested and two whole IgG antivenoms for Bothrops snake bites in Urabá, Colombia. American Journal of Tropical Medicine and Hygiene, 58: 183-189.
8. Gutiérrez JM, Chaves F, Bolaños R, Cerdas L, Rojas E, Arroyo O & Portilla E (1981). Neutralización de los efectos locales del veneno de Bothrops asper por un antiveneno polivalente. Toxicon, 19: 493-500.
9. Gutiérrez JM, Gené JA, Rojas G & Cerdas L (1985). Neutralization of proteolytic and hemorrhagic activities of Costa Rica snake venoms by a polyvalent antivenom. Toxicon, 23: 887-893.
10. Gutiérrez JM, León G, Rojas G, Lomonte B, Rucavado A & Chaves F (1998). Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom. Toxicon, 36: 1529-1538.
11. León G, Rojas G, Lomonte B & Gutiérrez JM (1997). IgG and F(ab')2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom. Toxicon, 35: 1627-1637.
12. León G, Valverde JM, Rojas G, Lomonte B & Gutiérrez JM (2000). Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom. Toxicon, 38: 233-244.
13. Otero R, Tobón GS, Gómez LF, Osorio RG, Valderrama R, Hoyos D, Urreta JE, Molina S & Arboleda JJ (1992). Accidente ofídico en Antioquia y Chocó. Aspectos clínicos y epidemiológicos (marzo de 1989-febrero de 1990). Acta Médica Colombiana, 17: 229-249.
14. Arroyo O, Rojas G & Gutiérrez JM (1999). Envenenamiento por mordedura de serpiente en Costa Rica en 1996: epidemiología y consideraciones clínicas. Acta Médica Costarricense, 41: 23-29.
15. Teixeira CFP, Cury Y, Oga S & Jancar S (1994). Hyperalgesia induced by Bothrops jararaca venom in rats: role of eicosanoids and platelet activating factor (PAF). Toxicon, 32: 419-426.
16. Chacur M, Picolo G, Gutiérrez JM, Teixeira CFP & Cury Y (2001). Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom. Toxicon, 39: 1173-101181.
17. Raw I, Guidolin R, Higashi HG & Kelen EMA (1991). Antivenins in Brazil: preparation. In: Tu AT (Editor), Handbook of Natural Toxins. Vol. 5. Marcel Dekker, New York, NY, USA, 557-581.
18. Angulo Y, Estrada R & Gutiérrez JM (1997). Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom. Toxicon, 35: 81-90.
19. Randall LO & Selitto JJ (1957). A method for measurement of analgesia activity on inflammed tissue. Archives Internationales de Pharmacodynamie, 111: 209-219.
20. Van Arman CG, Begany AJ, Miller JM & Pless HH (1965). Some details of the inflammation caused by yeast and carrageenin. Journal of Pharmacology and Experimental Therapeutics, 150: 328-333.
21. Gad SC & Weil CS (1989). Statistics for toxicologists. In: Hayer AW (Editor), Principles and Methods of Toxicology. 2nd edn. Raven Press, New York, NY, USA, 435-483.
22. Bolaños R & Cerdas L (1980). Producción y control de sueros antiofídicos en Costa Rica. Boletin de la Oficina Sanitaria Panamericana, 88: 184-196.
23. Gutiérrez JM (1995). Clinical toxicology of snakebite in Central America. In: Meier J & White J (Editors), Handbook of Clinical Toxicology of Animal Venoms and Poisons. CRC Press, Boca Raton, FL, USA, 645-665.
24. Rucavado A & Lomonte B (1996). Neutralization of myonecrosis, hemorrhage and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice. Toxicon, 34: 567-577.
25. Trebien HA & Calixto JB (1989). Pharmacological evaluation of rat paw edema induced by Bothrops jararaca venom. Agents and Actions, 26: 292-300.
26. Chaves F, Barboza M & Gutiérrez JM (1995). Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo). Toxicon, 33: 31-39.
27. Dias da Silva W, Guidolin R, Raw I, Higashi HG, Caricati CP, Morais JF, Lima MLSR, Yamaguchi IK, Nishikawa AK, Stephano MA, Marcelino JR, Pinto JR & Santos MJ (1989). Cross-reactivity of horse monovalent antivenoms to venoms of ten Bothrops species. Memórias do Instituto Butantan, 51: 153-168.
28. Ferreira ML, Moura-da-Silva AM & Mota I (1992). Neutralization of different activities of venoms from nine species of Bothrops snakes by Bothrops jararaca antivenom. Toxicon, 30: 1591-1602.
29. Bogarín G, Morais JF, Yamaguchi IK, Stephano MA, Marcelino JR, Nishikawa AK, Guidolin R, Rojas G, Higashi HG & Gutiérrez JM (2000). Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica. Toxicon, 38: 1429-1441.
30. Fernandes I, Lima EX, Takehara HA, Moura-da-Silva AM, Tanjoni I & Gutiérrez JM (2000). Horse IgG isotypes and cross-neutralization of two snake antivenoms produced in Brazil and Costa Rica. Toxicon, 38: 633-644.