Nitric oxide synthase in spinal cord central sensitization following intradermal injection of capsaicin

Pain

Volumn 94, Issue 1, 2001, Pages 47-58

  Wu, J ^a   Fang, L ^a   Lin, Q ^a   Willis, W D ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Allodynia; Capsaicin injection; Central sensitization; Hyperalgesia; Long term changes; Nitric oxide

Indexed keywords

2 AMINO 5,6 DIHYDRO 6 METHYL 4H 1,3 THIAZINE; 7 NITROINDAZOLE; CAPSAICIN; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOPROTEIN; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR SPACE; FORCE; HINDLIMB; HYPERALGESIA; LUMBAR SPINAL CORD; MALE; MECHANICAL STIMULATION; MICRODIALYSIS; NERVE CELL; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSITIZATION; SPINAL CORD DORSAL HORN; WESTERN BLOTTING; WITHDRAWAL REFLEX;

ANIMALS; CAPSAICIN; ENZYME INHIBITORS; INFLAMMATION; INJECTIONS, INTRADERMAL; MALE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; PAIN MEASUREMENT; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 0034814351     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(01)00340-2     Document Type: Article

References (71)

1. Neurogenic hyperalgesia: The search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia
2. Selective neuronal nitric oxide synthase inhibition blocks furosemide-stimulated renin secretion in vivo
3. Nitric oxide protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH-diaphorase
4. Studies on the acute inflammatory response. I. Involvement of the central nervous system in certain models of inflammation
5. Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model
6. Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection
7. Suppression of adjuvant-induced arthritis by selective inhibition of inducible intric oxide synthase
8. Peripheral origins and central modulation of subcutaneous formalin-induced activity of rat dorsal horn neurones
9. Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: Differential response to an intrathecal opiate administered pre or post formalin
10. The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
11. Nitric oxide synthase immunoreactivity in rat spinal cord
12. Nitric oxide synthase: Expression and expressional control of the three isoforms
13. Staining of glial fibrillary acidic protein (GFAP) in lumber spinal cord increase following the sciatic nerve constriction injury
14. Nitric oxide signaling in the central nervous system
15. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intracellular messenger in the brain
16. Electrophysiological evidence for a role of bradykinin in chemical nociception in the rat
17. Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat
18. Handy and Moore reply
19. Treatment of a chonic allodynia-like response in spinally injured rats: Effects of systemically administered nitric oxide synthase inhibitors
20. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
21. Expression of nitric oxide synthase and colocalization with Jun, Fos and Krox transcription factors in spinal cord neurons following noxious stimulation of the rat hindpaw
22. Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein
23. Formalin test in mice, a useful technique for evaluating mild analgesics
24. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase
25. Essential role for nitric oxide in neurogenic inflammation in rat cutaneous microcirculation. Evidence for an endothelium-independent mechanism
26. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole: Effects upon local cerebral blood flow and glucose use in the rat
27. Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse
28. Nitric oxide synthases in mammals
29. Nitric oxide synthase in human and rat lung: Immunocytochemical and histochemical localization
30. Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw
31. Endothelial nitric oxide synthase: Molecular cloning and characterization of a distinct constitutive enzyme isoform
32. Neurogenic hyperalgesia: Psychophysical studies of underlying mechanisms
33. Pain, hyperalgesia and activity in nociceptive-C units in human after intradermal injection of capsaicin
34. Cutaneous sensory receptors in the rat foot
35. Involvement of cGMP in nociceptive processing by and sensitization of spinothalamic neurons in primate
36. Nitric oxide-mediated spinal disinhibition contributes to the sensitization of primate spinothalamic tract neurons
37. Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons
38. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line
39. Changes in amino acid concentration over time and space around an impact injury and their diffusion through the rat spinal cord
40. Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-d-aspartate-produced facilitation of the nociceptive tail flick reflex
41. Nitric oxide (NO) and nociceptive processing in the spinal cord
42. The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat
43. The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat
44. The L-arginine-nitric oxide pathway
45. Selective inhibitors of neuronal nitric oxide synthase - Is no NOS really good for the nervous system?
46. L-N-nitro arginine methyl ester exhibits antinociceptive activity in the mouse
47. Synthesis of L-thiocitrullin, L-homocitrulline, and S-methyl-l-thiocitrulline: A new class of potent nitric oxide synthase inhibitors
48. Regulation of biosynthesis of nitric oxide
49. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase
50. Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan-induced thermal hyperalgesia
51. 2+/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons
52. Expression of nitric oxide synthase in the spinal cord in amyotrophic lateral sclerosis
53. Further evidence for a role of nitric oxide in experimental allergic encephalomyelitis: Aminoguanidine treatment modifies its clinical evolution
54. The formalin test in mice: The influence of ambient temperature
55. Rat spinal cord neurons contain nitric oxide synthase
56. Effect of spinal nitric oxide inhibition on capsaicin-induced nociceptive response
57. Involvement of nitric oxide in acute spinal cord injury: An immunocytochemical study using light and electron microscopy in the rat
58. Extracellular amino acid concentration in the dorsal horn of freely moving rats following veratridine and nociceptive stimulation
59. Behavioral and immunohistochemical changes in an experimental arthritis model in rats
60. The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin
61. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: A FAD- and FMN-containing flavoprotein
62. The formalin test: An evaluation of the method
63. Spinal cord NADPH-diaphorase histochemical staining but not nitric oxide synthase immunoreactivity increases following carrageenan-produced hindpaw inflammation in the rat
64. Immune activation: The role of pro-inflammatory cytokines in inflammation, illness response and pathological pain states
65. Spinal cord evoked potentials and edema in the pathophysiology of rat spinal cord injury. Involvement of nitric oxide
66. Inducible nitric oxide synthase gene expression in the brain during systemic inflammation
67. Contribution of inducible and neuronal nitric oxide synthase to allodynia of rats following intradermal injection of capsaicin
68. Nitric oxide contributes to central sensitization following intradermal injection of capsaicin
69. Contribution of inducible and neuronal nitric oxide synthase to central sensitization in rats following intradermal injection of capsaicin
70. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages