메뉴 건너뛰기




Volumn 83, Issue 3, 2008, Pages 648-662

Hypoxia transcriptionally induces macrophage-inflammatory protein-3α/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-κB

Author keywords

Chemokines; Gene regulation; Inflammation; Monocytes; Transcription

Indexed keywords

HOMODIMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENTIVIRUS VECTOR; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MESSENGER RNA; SHORT HAIRPIN RNA; CCL20 PROTEIN, HUMAN; MACROPHAGE INFLAMMATORY PROTEIN; PRIMER DNA;

EID: 43349088950     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0607349     Document Type: Conference Paper
Times cited : (47)

References (66)
  • 1
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch, C., Giannoudis, A., Lewis, C. E. (2004) Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 104, 2224-2234.
    • (2004) Blood , vol.104 , pp. 2224-2234
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 3
    • 0342470975 scopus 로고    scopus 로고
    • Regulation of macrophage gene expression by pro- and anti-inflammatory cytokines
    • Hamilton, T. A., Ohmori, Y., Tebo, J. M., Kishore, R. (1999) Regulation of macrophage gene expression by pro- and anti-inflammatory cytokines. Pathobiology 67, 241-244.
    • (1999) Pathobiology , vol.67 , pp. 241-244
    • Hamilton, T.A.1    Ohmori, Y.2    Tebo, J.M.3    Kishore, R.4
  • 5
    • 0034653396 scopus 로고    scopus 로고
    • The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage-inflammatory protein-1α and -1β in macrophages
    • Bosco, M. C., Rapisarda, A., Massazza, S., Melillo, G., Young, H., Varesio, L. (2000) The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage-inflammatory protein-1α and -1β in macrophages. J. Immunol. 164, 3283-3291.
    • (2000) J. Immunol , vol.164 , pp. 3283-3291
    • Bosco, M.C.1    Rapisarda, A.2    Massazza, S.3    Melillo, G.4    Young, H.5    Varesio, L.6
  • 6
    • 21244443731 scopus 로고    scopus 로고
    • Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences
    • Stout, R. D., Jiang, C., Matta, B., Tietzel, I., Watkins, S. K., Suttles, J. (2005) Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J. Immunol. 175, 342-349.
    • (2005) J. Immunol , vol.175 , pp. 342-349
    • Stout, R.D.1    Jiang, C.2    Matta, B.3    Tietzel, I.4    Watkins, S.K.5    Suttles, J.6
  • 7
    • 0034901463 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology
    • Semenza, G. L. (2001) Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol. Med. 7, 345-350.
    • (2001) Trends Mol. Med , vol.7 , pp. 345-350
    • Semenza, G.L.1
  • 9
    • 0345827523 scopus 로고    scopus 로고
    • Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis
    • Distler, J. H., Wenger, R. H., Gassmann, M., Kurowska, M., Hirth, A., Gay, S., Distler, O. (2004) Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 50, 10-23.
    • (2004) Arthritis Rheum , vol.50 , pp. 10-23
    • Distler, J.H.1    Wenger, R.H.2    Gassmann, M.3    Kurowska, M.4    Hirth, A.5    Gay, S.6    Distler, O.7
  • 10
    • 0347123433 scopus 로고    scopus 로고
    • Tumor-educated macrophages promote tumor progression and metastasis
    • Pollard, J. W. (2004) Tumor-educated macrophages promote tumor progression and metastasis. Nat. Rev. Cancer 4, 71-78.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 11
    • 0345118952 scopus 로고    scopus 로고
    • Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis
    • White, J. R., Harris, R. A., Lee, S. R., Craigon, M. H., Binley, K., Price, T., Beard, G. L., Mundy, C. R., Naylor, S. (2004) Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis. Genomics 83, 1-8.
    • (2004) Genomics , vol.83 , pp. 1-8
    • White, J.R.1    Harris, R.A.2    Lee, S.R.3    Craigon, M.H.4    Binley, K.5    Price, T.6    Beard, G.L.7    Mundy, C.R.8    Naylor, S.9
  • 12
    • 0033231301 scopus 로고    scopus 로고
    • Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes
    • Melillo, G., Sausville, E. A., Cloud, K., Lahusen, T., Varesio, L., Senderovicz, A. M. (1999) Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes. Cancer Res. 59, 5433-5437.
    • (1999) Cancer Res , vol.59 , pp. 5433-5437
    • Melillo, G.1    Sausville, E.A.2    Cloud, K.3    Lahusen, T.4    Varesio, L.5    Senderovicz, A.M.6
  • 13
    • 0028786601 scopus 로고
    • A hypoxia responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo, G., Musso, T., Sica, A., Taylor, L. S., Cox, G., Varesio, L. (1995) A hypoxia responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J. Exp. Med. 182, 1683-1693.
    • (1995) J. Exp. Med , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3    Taylor, L.S.4    Cox, G.5    Varesio, L.6
  • 14
    • 33746215136 scopus 로고    scopus 로고
    • Hypoxia modifies the transcriptome of primary human monocytes: Modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene
    • Bosco, M. C., Puppo, M., Santangelo, C., Anfosso, L., Pfeffer, U., Fardin, P., Battaglia, F., Varesio, L. (2006) Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene. J. Immunol. 177, 1941-1955.
    • (2006) J. Immunol , vol.177 , pp. 1941-1955
    • Bosco, M.C.1    Puppo, M.2    Santangelo, C.3    Anfosso, L.4    Pfeffer, U.5    Fardin, P.6    Battaglia, F.7    Varesio, L.8
  • 15
    • 0035174962 scopus 로고    scopus 로고
    • The regulation of interleukin-8 by hypoxia in human macrophages. A potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)
    • Hirani, N., Antonicelli, F., Strieter, R. M., Wiesener, M. S., Haslett, C., Donnelly, S. C. (2001) The regulation of interleukin-8 by hypoxia in human macrophages. A potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS). Mol. Med. 7, 685-697.
    • (2001) Mol. Med , vol.7 , pp. 685-697
    • Hirani, N.1    Antonicelli, F.2    Strieter, R.M.3    Wiesener, M.S.4    Haslett, C.5    Donnelly, S.C.6
  • 17
    • 2942620525 scopus 로고    scopus 로고
    • Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophages
    • Bosco, M. C., Reffo, G., Puppo, M., Varesio, L. (2004) Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophages. Cell. Immunol. 228, 1-7.
    • (2004) Cell. Immunol , vol.228 , pp. 1-7
    • Bosco, M.C.1    Reffo, G.2    Puppo, M.3    Varesio, L.4
  • 19
    • 9444252869 scopus 로고    scopus 로고
    • Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-κB: The prominent role of p42/p44 and PI3 kinase pathways
    • Zampetaki, A., Mitsialis, S. A., Pfeilschifter, J., Kourembanas, S. (2004) Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-κB: the prominent role of p42/p44 and PI3 kinase pathways. FASEB J. 18, 1090-1092.
    • (2004) FASEB J , vol.18 , pp. 1090-1092
    • Zampetaki, A.1    Mitsialis, S.A.2    Pfeilschifter, J.3    Kourembanas, S.4
  • 20
    • 31444444162 scopus 로고    scopus 로고
    • Integration of oxygen signaling at the consensus HRE
    • Wenger, R. H., Stiehl, D. P., Camenisch, G. (2005) Integration of oxygen signaling at the consensus HRE. Sci. STKE 2005, re12.
    • (2005) Sci. STKE , vol.2005
    • Wenger, R.H.1    Stiehl, D.P.2    Camenisch, G.3
  • 21
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxiainducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
    • Talks, K. L., Turley, H., Gatter, K. C., Maxwell, P. H., Pugh, C. W., Ratcliffe, P. J. (2000) The expression and distribution of the hypoxiainducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157, 411-421.
    • (2000) Am. J. Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6
  • 22
    • 0141988698 scopus 로고    scopus 로고
    • Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxia
    • Sowter, H. M., Raval, R. R., Moore, J. W., Ratcliffe, P. J., Harris, A. L. (2003) Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxia. Cancer Res. 63, 6130-6134.
    • (2003) Cancer Res , vol.63 , pp. 6130-6134
    • Sowter, H.M.1    Raval, R.R.2    Moore, J.W.3    Ratcliffe, P.J.4    Harris, A.L.5
  • 23
    • 2442502748 scopus 로고    scopus 로고
    • Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor α4 gene by an interaction between hypoxia-inducible factor-1 and Sp1
    • Miki, N., Ikuta, M., Matsui, T. (2004) Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor α4 gene by an interaction between hypoxia-inducible factor-1 and Sp1. J. Biol. Chem. 279, 15025-15031.
    • (2004) J. Biol. Chem , vol.279 , pp. 15025-15031
    • Miki, N.1    Ikuta, M.2    Matsui, T.3
  • 25
    • 0037470245 scopus 로고    scopus 로고
    • Cooperative interaction of hypoxia-inducible factor-2α (HIF-2α) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)
    • Elvert, G., Kappel, A., Heidenreich, R., Englmeier, U., Lanz, S., Acker, T., Rauter, M., Plate, K., Sieweke, M., Breier, G., Flamme, I. (2003) Cooperative interaction of hypoxia-inducible factor-2α (HIF-2α) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1). J. Biol. Chem. 278, 7520-7530.
    • (2003) J. Biol. Chem , vol.278 , pp. 7520-7530
    • Elvert, G.1    Kappel, A.2    Heidenreich, R.3    Englmeier, U.4    Lanz, S.5    Acker, T.6    Rauter, M.7    Plate, K.8    Sieweke, M.9    Breier, G.10    Flamme, I.11
  • 26
    • 25644446823 scopus 로고    scopus 로고
    • Hypoxia-responsive transcription factors
    • Cummins, E. P., Taylor, C. T. (2005) Hypoxia-responsive transcription factors. Pflugers Arch. 450, 363-371.
    • (2005) Pflugers Arch , vol.450 , pp. 363-371
    • Cummins, E.P.1    Taylor, C.T.2
  • 27
    • 0033403652 scopus 로고    scopus 로고
    • Cooperation between transcription factor AP-1 and NF-κB in the induction of interleukin-8 in human pancreatic adenocarcinoma cells by hypoxia
    • Shi, Q., Le, X., Abbruzzese, J. L., Wang, B., Mujaida, N., Matsushima, K., Huang, S., Xiong, Q., Xie, K. (1999) Cooperation between transcription factor AP-1 and NF-κB in the induction of interleukin-8 in human pancreatic adenocarcinoma cells by hypoxia. J. Interferon Cytokine Res. 19, 1363-1371.
    • (1999) J. Interferon Cytokine Res , vol.19 , pp. 1363-1371
    • Shi, Q.1    Le, X.2    Abbruzzese, J.L.3    Wang, B.4    Mujaida, N.5    Matsushima, K.6    Huang, S.7    Xiong, Q.8    Xie, K.9
  • 28
    • 0032920658 scopus 로고    scopus 로고
    • Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-κ B and NF-IL6 in cardiac myocytes
    • Matsui, H., Ihara, Y., Fujio, Y., Kunisada, K., Akira, S., Kishimoto, T., Yamauchi-Takihara, K. (1999) Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-κ B and NF-IL6 in cardiac myocytes. Cardiovasc. Res. 42, 104-112.
    • (1999) Cardiovasc. Res , vol.42 , pp. 104-112
    • Matsui, H.1    Ihara, Y.2    Fujio, Y.3    Kunisada, K.4    Akira, S.5    Kishimoto, T.6    Yamauchi-Takihara, K.7
  • 29
    • 0036007293 scopus 로고    scopus 로고
    • Expression of HIF-1α by human macrophages: Implications for the use of macrophages in hypoxia-regulated cancer gene therapy
    • Burke, B., Tang, N., Corke, K. P., Tazzyman, D., Ameri, K., Wells, M., Lewis, C. E. (2002) Expression of HIF-1α by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J. Pathol. 196, 204-212.
    • (2002) J. Pathol , vol.196 , pp. 204-212
    • Burke, B.1    Tang, N.2    Corke, K.P.3    Tazzyman, D.4    Ameri, K.5    Wells, M.6    Lewis, C.E.7
  • 30
    • 0036493984 scopus 로고    scopus 로고
    • Relation of hypoxia-inducible factor-2 α (HIF-2 α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer
    • Leek, R. D., Talks, K. L., Pezzella, F., Turley, H., Campo, L., Brown, N. S., Bicknell, R., Taylor, M., Gatter, K. C., Harris, A. L. (2002) Relation of hypoxia-inducible factor-2 α (HIF-2 α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer. Cancer Res. 62, 1326-1329.
    • (2002) Cancer Res , vol.62 , pp. 1326-1329
    • Leek, R.D.1    Talks, K.L.2    Pezzella, F.3    Turley, H.4    Campo, L.5    Brown, N.S.6    Bicknell, R.7    Taylor, M.8    Gatter, K.C.9    Harris, A.L.10
  • 33
    • 0034661990 scopus 로고    scopus 로고
    • Role of oxidants in NF-κ B activation and TNF-α gene transcription induced by hypoxia and endotoxin
    • Chandel, N. S., Trzyna, W. C., McClintock, D. S., Schumacker, P. T. (2000) Role of oxidants in NF-κ B activation and TNF-α gene transcription induced by hypoxia and endotoxin. J. Immunol. 165, 1013-1021.
    • (2000) J. Immunol , vol.165 , pp. 1013-1021
    • Chandel, N.S.1    Trzyna, W.C.2    McClintock, D.S.3    Schumacker, P.T.4
  • 35
    • 1842483281 scopus 로고    scopus 로고
    • Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper - Excel-based tool using pairwise correlations
    • Pfaffl, M. W., Tichopad, A., Prgomet, C., Neuvians, T. P. (2004) Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper - Excel-based tool using pairwise correlations. Biotechnol. Lett. 26, 509-515.
    • (2004) Biotechnol. Lett , vol.26 , pp. 509-515
    • Pfaffl, M.W.1    Tichopad, A.2    Prgomet, C.3    Neuvians, T.P.4
  • 36
    • 0036281211 scopus 로고    scopus 로고
    • Processing of gene expression data generated by quantitative real-time RT-PCR
    • Muller, P. Y., Janovjak, H., Miserez, A. R., Dobbie, Z. (2002) Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32, 1372-1379.
    • (2002) Biotechniques , vol.32 , pp. 1372-1379
    • Muller, P.Y.1    Janovjak, H.2    Miserez, A.R.3    Dobbie, Z.4
  • 37
    • 0036604077 scopus 로고    scopus 로고
    • Induction of macrophage-inflammatory protein-3α gene expression by TNF-dependent NF-κB activation
    • Sugita, S., Kohno, T., Yamamoto, K., Imaizumi, Y., Nakajima, H., Ishimaru, T., Matsuyama, T. (2002) Induction of macrophage-inflammatory protein-3α gene expression by TNF-dependent NF-κB activation. J. Immunol. 168, 5621-5628.
    • (2002) J. Immunol , vol.168 , pp. 5621-5628
    • Sugita, S.1    Kohno, T.2    Yamamoto, K.3    Imaizumi, Y.4    Nakajima, H.5    Ishimaru, T.6    Matsuyama, T.7
  • 38
    • 0036160992 scopus 로고    scopus 로고
    • Human T cell leukemia virus type-I Tax activates human macrophage inflammatory protein-3 α/CCL20 gene transcription via the NF-κ B pathway
    • Imaizumi, Y., Sugita, S., Yamamoto, K., Imanishi, D., Kohno, T., Tomonaga, M., Matsuyama, T. (2002) Human T cell leukemia virus type-I Tax activates human macrophage inflammatory protein-3 α/CCL20 gene transcription via the NF-κ B pathway. Int. Immunol. 14, 147-155.
    • (2002) Int. Immunol , vol.14 , pp. 147-155
    • Imaizumi, Y.1    Sugita, S.2    Yamamoto, K.3    Imanishi, D.4    Kohno, T.5    Tomonaga, M.6    Matsuyama, T.7
  • 39
    • 0027406040 scopus 로고
    • Dimerization of NF-κB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I κ B-α (MAD-3)
    • Duckett, C. S., Perkins, N. D., Kowalik, T. F., Schmid, R. M., Huang, E. S., Baldwin Jr., A. S., Nabel, G. J. (1993) Dimerization of NF-κB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I κ B-α (MAD-3). Mol. Cell. Biol. 13, 1315-1322.
    • (1993) Mol. Cell. Biol , vol.13 , pp. 1315-1322
    • Duckett, C.S.1    Perkins, N.D.2    Kowalik, T.F.3    Schmid, R.M.4    Huang, E.S.5    Baldwin Jr., A.S.6    Nabel, G.J.7
  • 40
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe, J. A., Jiang, B. H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., Semenza, G. L. (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16, 4604-4613.
    • (1996) Mol. Cell. Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6    Semenza, G.L.7
  • 43
    • 33846670516 scopus 로고    scopus 로고
    • Hypoxia inhibits Moloney murine leukemia virus expression in activated macrophages
    • Puppo, M., Bosco, M. C., Federico, M., Pastorino, S., Varesio, L. (2007) Hypoxia inhibits Moloney murine leukemia virus expression in activated macrophages. J. Leukoc. Biol. 81, 528-538.
    • (2007) J. Leukoc. Biol , vol.81 , pp. 528-538
    • Puppo, M.1    Bosco, M.C.2    Federico, M.3    Pastorino, S.4    Varesio, L.5
  • 44
    • 0034782208 scopus 로고    scopus 로고
    • Proinflammatory cytokines induce liver and activation-regulated chemokine/macrophage inflammatory protein-3(/CCL20 in mucosal epithelial cells through NF-(B
    • Fujiie, S., Hieshima, K., Izawa, D., Nakayama, T., Fujisawa, R., Ohyanagi, H., Yoshie, O. (2001) Proinflammatory cytokines induce liver and activation-regulated chemokine/macrophage inflammatory protein-3(/CCL20 in mucosal epithelial cells through NF-(B. Int. Immunol. 13, 1255-1263.
    • (2001) Int. Immunol , vol.13 , pp. 1255-1263
    • Fujiie, S.1    Hieshima, K.2    Izawa, D.3    Nakayama, T.4    Fujisawa, R.5    Ohyanagi, H.6    Yoshie, O.7
  • 45
    • 0037428512 scopus 로고    scopus 로고
    • ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3( gene expression in Caco-2 human colonic epithelial cells
    • Kwon, J. H., Keates, S., Simeonidis, S., Grall, F., Libermann, T. A., Keates, A. C. (2003) ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3( gene expression in Caco-2 human colonic epithelial cells. J. Biol. Chem. 278, 875-884.
    • (2003) J. Biol. Chem , vol.278 , pp. 875-884
    • Kwon, J.H.1    Keates, S.2    Simeonidis, S.3    Grall, F.4    Libermann, T.A.5    Keates, A.C.6
  • 46
    • 0028854272 scopus 로고
    • Differential transcriptional activation in vitro by NF-κ B/Rel proteins
    • Lin, R., Gewert, D., Hiscott, J. (1995) Differential transcriptional activation in vitro by NF-κ B/Rel proteins. J. Biol. Chem. 270, 3123-3131.
    • (1995) J. Biol. Chem , vol.270 , pp. 3123-3131
    • Lin, R.1    Gewert, D.2    Hiscott, J.3
  • 47
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-κB puzzle
    • Ghosh, S., Karin, M. (2002) Missing pieces in the NF-κB puzzle. Cell 109 (Suppl.), S81-S96.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ghosh, S.1    Karin, M.2
  • 48
    • 0034667898 scopus 로고    scopus 로고
    • Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 α from normal and transformed cells
    • Schutyser, E., Struyf, S., Menten, P., Lenaerts, J. P., Conings, R., Put, W., Wuyts, A., Proost, P., Van Damme, J. (2000) Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 α from normal and transformed cells. J. Immunol. 165, 4470-4477.
    • (2000) J. Immunol , vol.165 , pp. 4470-4477
    • Schutyser, E.1    Struyf, S.2    Menten, P.3    Lenaerts, J.P.4    Conings, R.5    Put, W.6    Wuyts, A.7    Proost, P.8    Van Damme, J.9
  • 49
    • 0034798178 scopus 로고    scopus 로고
    • Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation
    • Evans, S. M., Hahn, S. M., Magarelli, D. P., Koch, C. J. (2001) Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation. Am. J. Clin. Oncol. 24, 467-472.
    • (2001) Am. J. Clin. Oncol , vol.24 , pp. 467-472
    • Evans, S.M.1    Hahn, S.M.2    Magarelli, D.P.3    Koch, C.J.4
  • 52
    • 0031034814 scopus 로고    scopus 로고
    • Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells
    • Schmedtje Jr., J. F., Ji, Y. S., Liu, W. L., DuBois, R. N., Runge, M. S. (1997) Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells. J. Biol. Chem. 272, 601-608.
    • (1997) J. Biol. Chem , vol.272 , pp. 601-608
    • Schmedtje Jr., J.F.1    Ji, Y.S.2    Liu, W.L.3    DuBois, R.N.4    Runge, M.S.5
  • 53
    • 33750435582 scopus 로고    scopus 로고
    • NF-κB and the immune response
    • Hayden, M. S., West, A. P., Ghosh, S. (2006) NF-κB and the immune response. Oncogene 25, 6758-6780.
    • (2006) Oncogene , vol.25 , pp. 6758-6780
    • Hayden, M.S.1    West, A.P.2    Ghosh, S.3
  • 54
    • 0026755744 scopus 로고
    • Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-κ B is differentially regulated in human monocytic cells
    • Kaufman, P. A., Weinberg, J. B., Greene, W. C. (1992) Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-κ B is differentially regulated in human monocytic cells. J. Clin. Invest. 90, 121-129.
    • (1992) J. Clin. Invest , vol.90 , pp. 121-129
    • Kaufman, P.A.1    Weinberg, J.B.2    Greene, W.C.3
  • 55
    • 0033596120 scopus 로고    scopus 로고
    • Regulation of DNA binding by Rel/NF-κB transcription factors: Structural views
    • Chen, F. E., Ghosh, G. (1999) Regulation of DNA binding by Rel/NF-κB transcription factors: structural views. Oncogene 18, 6845-6852.
    • (1999) Oncogene , vol.18 , pp. 6845-6852
    • Chen, F.E.1    Ghosh, G.2
  • 56
    • 0033030090 scopus 로고    scopus 로고
    • Acute hypoxia increases alveolar macrophage tumor necrosis factor activity and alters NF-κB expression
    • Leeper-Woodford, S. K., Detmer, K. (1999) Acute hypoxia increases alveolar macrophage tumor necrosis factor activity and alters NF-κB expression. Am. J. Physiol. 276, L909-L916.
    • (1999) Am. J. Physiol , vol.276
    • Leeper-Woodford, S.K.1    Detmer, K.2
  • 58
    • 33845752914 scopus 로고    scopus 로고
    • p50 Nuclear factor-κB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance
    • Saccani, A., Schioppa, T., Porta, C., Biswas, S. K., Nebuloni, M., Vago, L., Bottazzi, B., Colombo, M. P., Mantovani, A., Sica, A. (2006) p50 Nuclear factor-κB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res. 66, 11432-11440.
    • (2006) Cancer Res , vol.66 , pp. 11432-11440
    • Saccani, A.1    Schioppa, T.2    Porta, C.3    Biswas, S.K.4    Nebuloni, M.5    Vago, L.6    Bottazzi, B.7    Colombo, M.P.8    Mantovani, A.9    Sica, A.10
  • 59
    • 0030988261 scopus 로고    scopus 로고
    • Regulation of NFκB1 proteins by the candidate oncoprotein BCL-3: Generation of NF-κB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation
    • Watanabe, N., Iwamura, T., Shinoda, T., Fujita, T. (1997) Regulation of NFκB1 proteins by the candidate oncoprotein BCL-3: generation of NF-κB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation. EMBO J. 16, 3609-3620.
    • (1997) EMBO J , vol.16 , pp. 3609-3620
    • Watanabe, N.1    Iwamura, T.2    Shinoda, T.3    Fujita, T.4
  • 60
    • 0346996870 scopus 로고    scopus 로고
    • Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation
    • Deng, W. G., Wu, K. K. (2003) Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation. J. Immunol. 171, 6581-6588.
    • (2003) J. Immunol , vol.171 , pp. 6581-6588
    • Deng, W.G.1    Wu, K.K.2
  • 61
    • 0035865062 scopus 로고    scopus 로고
    • Transactivation of C-reactive protein by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein β (C/EBP β) and Rel p50
    • Agrawal, A., Cha-Molstad, H., Samols, D., Kushner, I. (2001) Transactivation of C-reactive protein by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein β (C/EBP β) and Rel p50. J. Immunol. 166, 2378-2384.
    • (2001) J. Immunol , vol.166 , pp. 2378-2384
    • Agrawal, A.1    Cha-Molstad, H.2    Samols, D.3    Kushner, I.4
  • 62
    • 33748756806 scopus 로고    scopus 로고
    • NF-κB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages
    • Cao, S., Zhang, X., Edwards, J. P., Mosser, D. M. (2006) NF-κB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages. J. Biol. Chem. 281, 26041-26050.
    • (2006) J. Biol. Chem , vol.281 , pp. 26041-26050
    • Cao, S.1    Zhang, X.2    Edwards, J.P.3    Mosser, D.M.4
  • 63
    • 0347949510 scopus 로고    scopus 로고
    • Molecular mechanisms of interleukin-10-mediated inhibition of NF-κB activity: A role for p50
    • Driessler, F., Venstrom, K., Sabat, R., Asadullah, K., Schottelius, A. J. (2004) Molecular mechanisms of interleukin-10-mediated inhibition of NF-κB activity: a role for p50. Clin. Exp. Immunol. 135, 64-73.
    • (2004) Clin. Exp. Immunol , vol.135 , pp. 64-73
    • Driessler, F.1    Venstrom, K.2    Sabat, R.3    Asadullah, K.4    Schottelius, A.J.5
  • 64
    • 0035793609 scopus 로고    scopus 로고
    • ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-κ B to regulate the inducible nitric-oxide synthase gene
    • Rudders, S., Gaspar, J., Madore, R., Voland, C., Grall, F., Patel, A., Pellacani, A., Perrella, M. A., Libermann, T. A., Oettgen, P. (2001) ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-κ B to regulate the inducible nitric-oxide synthase gene. J. Biol. Chem. 276, 3302-3309.
    • (2001) J. Biol. Chem , vol.276 , pp. 3302-3309
    • Rudders, S.1    Gaspar, J.2    Madore, R.3    Voland, C.4    Grall, F.5    Patel, A.6    Pellacani, A.7    Perrella, M.A.8    Libermann, T.A.9    Oettgen, P.10
  • 65
    • 31344442461 scopus 로고    scopus 로고
    • Inflammation-associated immune suppression in cancer: The roles played by cytokines, chemokines and additional mediators
    • Ben Baruch, A. (2006) Inflammation-associated immune suppression in cancer: the roles played by cytokines, chemokines and additional mediators. Semin. Cancer Biol. 16, 38-52.
    • (2006) Semin. Cancer Biol , vol.16 , pp. 38-52
    • Ben Baruch, A.1
  • 66
    • 34247261528 scopus 로고    scopus 로고
    • Chemokine receptor CCR6 expression in colorectal liver metastasis
    • Rubie, C., Oliveira-Frick, V., Rau, B., Schilling, M., Wagner, M. (2006) Chemokine receptor CCR6 expression in colorectal liver metastasis. J. Clin. Oncol. 24, 5173-5174.
    • (2006) J. Clin. Oncol , vol.24 , pp. 5173-5174
    • Rubie, C.1    Oliveira-Frick, V.2    Rau, B.3    Schilling, M.4    Wagner, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.