SH3-domain binding function of HIV-1 Nef is required for association with a PAK-related kinase

Virology

Volumn 250, Issue 2, 1998, Pages 273-282

  Manninen, Aki ^a   Hiipakka, Marita ^a   Vihinen, Mauno ^a   Lu, Wange ^b   Mayer, Bruce J ^b   Saksela, Kalle ^a,c  

^a UNIVERSITY OF TAMPERE   (Finland)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

AIDS; cdc42; HIV; NAK; Nck; Nef; PAK; Protein kinase; SH3

Indexed keywords

NEF PROTEIN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN; VIRUS PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; EMBRYO; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VIRUS INFECTION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0032566903     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9381     Document Type: Article

References (30)

1. Arold S., Franken P., Strub M. P., Hoh F., Benichou S., Benarous R., Dumas C. The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure. 5:1997;1361-1372.
2. Briggs S. D., Sharkey M., Stevenson M., Smithgall T. E. SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1. J. Biol. Chem. 272:1997;17899-17902.
3. Collette Y., Dutartre H., Benziane A., Romas M., Benarous R., Harris M., Olive D. Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects. J. Biol. Chem. 271:1996;6333-6341.
4. Feng S., Chen J. K., Yu H., Simon J. A., Schreiber S. L. Two binding orientations for peptides to the Src SH3 domain: Development of a general model for SH3-ligand interactions. Science. 266:1994;1241-1247.
5. Goldsmith M. A., Warmerdam M. T., Atchison R. E., Miller M. D., Greene W. C. Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef. J. Virol. 69:1995;4112-4121.
6. Greenway A., Azad A., Mills J., McPhee D. Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity. J. Virol. 70:1996;6701-6708.
7. Grzesiek S., Bax A., Hu J. S., Kaufman J., Palmer I., Stahl S. J., Tjandra N., Wingfield P. T. Refined solution structure and backbone dynamics of HIV-1 Nef. Protein Sci. 6:1997;1248-1263.
8. Harris M. From negative factor to a critical role in virus pathogenesis: The changing fortunes of Nef. J. Gen. Virol. 77:1996;2379-2392.
9. Iafrate A. J., Bronson S., Skowronski J. Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. EMBO J. 16:1997;673-684.
10. Khan I., Sawai E. T., Antonio E., Luciw P., Weber C. J., Mandell C. P., Montbriand P., Luciw P. A. Role of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques. J. Virol. 72:1998;5820-5830.
11. Lang S. M., Iafrate A. J., Stahl-Hennig C., Kuhn E. M., Nisslein T., Kaup F.-J., Haupt M., Hunsmann G., Skowronski J., Kirchhoff F. Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques. Nature Med. 3:1997;860-865.
12. Lee C. H., Leung B., Lemmon M. A., Zheng J., Cowburn D., Kuriyan J., Saksela K. A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J. 14:1995;5006-5015.
13. Lee C. H., Saksela K., Mirza U. A., Chait B. T., Kuriyan J. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell. 85:1996;931-942.
14. Lim W. A. Reading between the lines: SH3 recognition of an intact protein. Structure. 4:1996;657-659.
15. Lim W. A., Richards F. M., Fox R. O. Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains. Nature. 372:1994;375-379.
16. Lu W., Katz S., Gupta R., Mayer B. J. Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Curr. Biol. 7:1997;85-94.
17. Lu X., Wu X., Plemenitas A., Yu H., Sawai E. T., Abo A., Peterlin B. M. CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1. Curr. Biol. 6:1996;1677-1684.
18. Luo T., Livingston R. A., Garcia J. V. Infectivity enhancement by human immunodeficiency virus type 1 Nef is independent of its association with a cellular serine/threonine kinase. J. Virol. 71:1997;9524-9530.
19. Mayer B. J., Gupta R. Functions of SH2 and SH3 domains. Curr. Top. Microbiol. Immunol. 228:1998;1-22.
20. Moarefi I., LaFevre B. M., Sicheri F., Huse M., Lee C. H., Kuriyan J., Miller W. T. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature. 385:1997;650-653.
21. Nunn M. F., Marsh J. W. Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family. J. Virol. 70:1996;6157-6161.
22. Saksela K. Nef and host cell protein kinases. Front. Biosci. 2:1997;606-618.
23. Saksela K., Cheng G., Baltimore D. Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO J. 14:1995;484-491.
24. Sawai E. T., Baur A. S., Peterlin B. M., Levy J. A., Cheng-Mayer C. A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. J. Biol. Chem. 270:1995;15307-15314.
25. Sawai E. T., Baur A., Struble H., Peterlin B. M., Levy J. A., Cheng-Mayer C. Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. Proc. Natl. Acad. Sci. USA. 91:1994;1539-1543.
26. Sawai E. T., Cheng M. C., Luciw P. A. Nef and the Nef-associated kinase. Res. Virol. 148:1997;47-52.
27. Sawai E. T., Khan I. H., Montbriand P. M., Peterlin B. M., Cheng-Mayer C., Luciw P. A. Activation of PAK by HIV and SIV Nef: Importance for AIDS in rhesus macaques. Curr. Biol. 6:1996;1519-1527.
28. Sells M. A., Chernoff J. Emerging from the Pak: The p21-activated protein kinase family. Trends Cell Biol. 7:1997;162-167.
29. Shugars D. C., Smith M. S., Glueck D. H., Nantermet P. V., Seillier-Moiseiwitsch F., Swanstrom R. Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo. J. Virol. 67:1993;4639-4650.
30. Wiskerchen M., Cheng-Mayer C. HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis. Virology. 224:1996;292-301.