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Volumn 79, Issue 3, 2006, Pages 616-627

Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1

Author keywords

Flow cytometry; HIV 1 pathogenesis; Immune receptors; Nucleofection; T cell activation

Indexed keywords

ANTIRETROVIRUS AGENT; CELL SURFACE RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NEF PROTEIN; B LYMPHOCYTE ANTIGEN; CD4 ANTIGEN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; IMMUNOLOGIC FACTOR;

EID: 33646082756     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0805461     Document Type: Article
Times cited : (52)

References (79)
  • 2
    • 0028835788 scopus 로고
    • Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
    • Kirchhoff, F., Greenough, T. C., Brettler, D. B., Sullivan, J. L., Desrosiers, R. C. (1995) Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N. Engl. J. Med. 332, 228-232.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 228-232
    • Kirchhoff, F.1    Greenough, T.C.2    Brettler, D.B.3    Sullivan, J.L.4    Desrosiers, R.C.5
  • 4
    • 0029875421 scopus 로고    scopus 로고
    • Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
    • Schwartz, O., Marechal, V., Le Gall, S., Lemonnier, F., Heard, J. M. (1996) Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat. Med. 2, 338-342.
    • (1996) Nat. Med. , vol.2 , pp. 338-342
    • Schwartz, O.1    Marechal, V.2    Le Gall, S.3    Lemonnier, F.4    Heard, J.M.5
  • 5
    • 0035794535 scopus 로고    scopus 로고
    • Mechanism for down-regulation of CD28 by Nef
    • Swigut, T., Shohdy, N., Skowronski, J. (2001) Mechanism for down-regulation of CD28 by Nef. EMBO J. 20, 1593-1604.
    • (2001) EMBO J. , vol.20 , pp. 1593-1604
    • Swigut, T.1    Shohdy, N.2    Skowronski, J.3
  • 6
    • 0025733252 scopus 로고
    • Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
    • Garcia, J. V., Miller, A. D. (1991) Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 350, 508-511.
    • (1991) Nature , vol.350 , pp. 508-511
    • Garcia, J.V.1    Miller, A.D.2
  • 8
    • 0031791917 scopus 로고    scopus 로고
    • Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) ζ chain leads to TCR down-modulation
    • Bell, I., Ashman, C., Maughan, J., Hooker, E., Cook, F., Reinhart, T. A. (1998) Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) ζ chain leads to TCR down-modulation. J. Gen. Virol. 79, 2717-2727.
    • (1998) J. Gen. Virol. , vol.79 , pp. 2717-2727
    • Bell, I.1    Ashman, C.2    Maughan, J.3    Hooker, E.4    Cook, F.5    Reinhart, T.A.6
  • 10
    • 0033529258 scopus 로고    scopus 로고
    • HIV-1 Nef increases T cell activation in a stimulus-dependent manner
    • Schrager, J. A., Marsh, J. W. (1999) HIV-1 Nef increases T cell activation in a stimulus-dependent manner. Proc. Natl. Acad. Sci. USA 96, 8167-8172.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8167-8172
    • Schrager, J.A.1    Marsh, J.W.2
  • 11
    • 0034602776 scopus 로고    scopus 로고
    • The Nef protein of HIV-1 associates with rafts and primes T cells for activation
    • Wang, J. K., Kiyokawa, E., Verdin, E., Trono, D. (2000) The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc. Natl. Acad. Sci. USA 97, 394-399.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 394-399
    • Wang, J.K.1    Kiyokawa, E.2    Verdin, E.3    Trono, D.4
  • 12
    • 0034948709 scopus 로고    scopus 로고
    • Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators
    • Simmons, A., Aluvihare, V., McMichael, A. (2001) Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. Immunity 14, 763-777.
    • (2001) Immunity , vol.14 , pp. 763-777
    • Simmons, A.1    Aluvihare, V.2    McMichael, A.3
  • 13
    • 0028485232 scopus 로고
    • HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization
    • Baur, A. S., Sawai, E. T., Dazin, P., Fantl, W. J., Cheng-Mayer, C., Peterlin, B. M. (1994) HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1, 373-384.
    • (1994) Immunity , vol.1 , pp. 373-384
    • Baur, A.S.1    Sawai, E.T.2    Dazin, P.3    Fantl, W.J.4    Cheng-Mayer, C.5    Peterlin, B.M.6
  • 14
    • 0033827320 scopus 로고    scopus 로고
    • HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line
    • Schibeci, S. D., Clegg, A. O., Biti, R. A., Sagawa, K., Stewart, G. J., Williamson, P. (2000) HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line. AIDS 14, 1701-1707.
    • (2000) AIDS , vol.14 , pp. 1701-1707
    • Schibeci, S.D.1    Clegg, A.O.2    Biti, R.A.3    Sagawa, K.4    Stewart, G.J.5    Williamson, P.6
  • 15
    • 0031039979 scopus 로고    scopus 로고
    • Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling
    • Iafrate, A. J., Bronson, S., Skowronski, J. (1997) Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. EMBO J. 16, 673-684.
    • (1997) EMBO J. , vol.16 , pp. 673-684
    • Iafrate, A.J.1    Bronson, S.2    Skowronski, J.3
  • 16
    • 0026077650 scopus 로고
    • Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA
    • Luria, S., Chambers, I., Berg, P. (1991) Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA. Proc. Natl. Acad. Sci. USA 88, 5326-5330.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5326-5330
    • Luria, S.1    Chambers, I.2    Berg, P.3
  • 17
    • 0030475891 scopus 로고    scopus 로고
    • CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1
    • Lu, X., Wu, X., Plemenitas, A., Yu, H., Sawai, E. T., Abo, A., Peterlin, B. M. (1996) CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1. Curr. Biol. 6, 1677-1684.
    • (1996) Curr. Biol. , vol.6 , pp. 1677-1684
    • Lu, X.1    Wu, X.2    Plemenitas, A.3    Yu, H.4    Sawai, E.T.5    Abo, A.6    Peterlin, B.M.7
  • 19
    • 0029015330 scopus 로고
    • Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis
    • Aiken, C., Trono, D. (1995) Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J. Virol. 69, 5048-5056.
    • (1995) J. Virol. , vol.69 , pp. 5048-5056
    • Aiken, C.1    Trono, D.2
  • 20
    • 0029045360 scopus 로고
    • Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell
    • Schwartz, O., Marechal, V., Danos, O., Heard, J. M. (1995) Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell. J. Virol. 69, 4053-4059.
    • (1995) J. Virol. , vol.69 , pp. 4053-4059
    • Schwartz, O.1    Marechal, V.2    Danos, O.3    Heard, J.M.4
  • 21
    • 0025160079 scopus 로고
    • Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: Evidence for a role in the selective T-cell functional defects observed in infected individuals
    • Schnittman, S. M., Lane, H. C., Greenhouse, J., Justement, J. S., Baseler, M., Fauci, A. S. (1990) Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals. Proc. Natl. Acad. Sci. USA 87, 6058-6062.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6058-6062
    • Schnittman, S.M.1    Lane, H.C.2    Greenhouse, J.3    Justement, J.S.4    Baseler, M.5    Fauci, A.S.6
  • 23
    • 0030968495 scopus 로고    scopus 로고
    • Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro
    • Spina, C. A., Prince, H. E., Richman, D. D. (1997) Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro. J. Clin. Invest. 99, 1774-1785.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1774-1785
    • Spina, C.A.1    Prince, H.E.2    Richman, D.D.3
  • 24
    • 0025342694 scopus 로고
    • HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
    • Zack, J. A., Arrigo, S. J., Weitsman, S. R., Go, A. S., Haislip, A., Chen, I. S. (1990) HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61, 213-222.
    • (1990) Cell , vol.61 , pp. 213-222
    • Zack, J.A.1    Arrigo, S.J.2    Weitsman, S.R.3    Go, A.S.4    Haislip, A.5    Chen, I.S.6
  • 25
    • 0030937092 scopus 로고    scopus 로고
    • HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28
    • Roederer, M., Raju, P. A., Mitra, D. K., Herzenberg, L. A. (1997) HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28. J. Clin. Invest. 99, 1555-1564.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1555-1564
    • Roederer, M.1    Raju, P.A.2    Mitra, D.K.3    Herzenberg, L.A.4
  • 26
    • 0031018697 scopus 로고    scopus 로고
    • Highly purified CD25-resting T cells cannot be infected de novo with HIV-1
    • Chou, C. S., Ramilo, O., Vitetta, E. S. (1997) Highly purified CD25-resting T cells cannot be infected de novo with HIV-1. Proc. Natl. Acad. Sci. USA 94, 1361-1365.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1361-1365
    • Chou, C.S.1    Ramilo, O.2    Vitetta, E.S.3
  • 27
    • 0028958338 scopus 로고
    • Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro
    • Spina, C. A., Guatelli, J. C., Richman, D. D. (1995) Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro. J. Virol. 69, 2977-2988.
    • (1995) J. Virol. , vol.69 , pp. 2977-2988
    • Spina, C.A.1    Guatelli, J.C.2    Richman, D.D.3
  • 28
    • 0029091047 scopus 로고
    • Highly purified quiescent human peripheral blood CD4+ T cells are infectible by human immunodeficiency virus but do not release virus after activation
    • Tang, S., Patterson, B., Levy, J. A. (1995) Highly purified quiescent human peripheral blood CD4+ T cells are infectible by human immunodeficiency virus but do not release virus after activation. J. Virol. 69, 5659-5665.
    • (1995) J. Virol. , vol.69 , pp. 5659-5665
    • Tang, S.1    Patterson, B.2    Levy, J.A.3
  • 29
    • 0033961745 scopus 로고    scopus 로고
    • In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline
    • Blaak, H., van't Wout, A. B., Brouwer, M., Hooibrink, B., Hovenkamp, E., Schuitemaker, H. (2000) In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline. Proc. Natl. Acad. Sci. USA 97, 1269-1274.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1269-1274
    • Blaak, H.1    Van't Wout, A.B.2    Brouwer, M.3    Hooibrink, B.4    Hovenkamp, E.5    Schuitemaker, H.6
  • 32
    • 1842782773 scopus 로고    scopus 로고
    • Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection
    • Zhang, Z. Q., Wietgrefe, S. W., Li, Q., Shore, M. D., Duan, L., Reilly, C., Lifson, J. D., Haase, A. T. (2004) Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection. Proc. Natl. Acad. Sci. USA 101, 5640-5645.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 5640-5645
    • Zhang, Z.Q.1    Wietgrefe, S.W.2    Li, Q.3    Shore, M.D.4    Duan, L.5    Reilly, C.6    Lifson, J.D.7    Haase, A.T.8
  • 35
    • 0242364699 scopus 로고    scopus 로고
    • Productive HIV infection of resting CD4+ T cells: Role of lymphoid tissue microenvironment and effect of immunomodulating agents
    • Kinter, A., Moorthy, A., Jackson, R., Fauci, A. S. (2003) Productive HIV infection of resting CD4+ T cells: role of lymphoid tissue microenvironment and effect of immunomodulating agents. AIDS Res. Hum. Retroviruses 19, 847-856.
    • (2003) AIDS Res. Hum. Retroviruses , vol.19 , pp. 847-856
    • Kinter, A.1    Moorthy, A.2    Jackson, R.3    Fauci, A.S.4
  • 36
    • 0033532628 scopus 로고    scopus 로고
    • Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes
    • Unutmaz, D., KewalRamani, V. N., Marmon, S., Littman, D. R. (1999) Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes. J. Exp. Med. 189, 1735-1746.
    • (1999) J. Exp. Med. , vol.189 , pp. 1735-1746
    • Unutmaz, D.1    Kewalramani, V.N.2    Marmon, S.3    Littman, D.R.4
  • 37
    • 0035943355 scopus 로고    scopus 로고
    • Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA
    • Wu, Y., Marsh, J. W. (2001) Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA. Science 293, 1503-1506.
    • (2001) Science , vol.293 , pp. 1503-1506
    • Wu, Y.1    Marsh, J.W.2
  • 38
    • 0035873713 scopus 로고    scopus 로고
    • Nonproliferating bystander CD4+ T cells lacking activation markers support HIV replication during immune activation
    • Scales, D., Ni, H., Shaheen, F., Capodici, J., Cannon, G., Weissman, D. (2001) Nonproliferating bystander CD4+ T cells lacking activation markers support HIV replication during immune activation. J. Immunol. 166, 6437-6443.
    • (2001) J. Immunol. , vol.166 , pp. 6437-6443
    • Scales, D.1    Ni, H.2    Shaheen, F.3    Capodici, J.4    Cannon, G.5    Weissman, D.6
  • 39
    • 0032897974 scopus 로고    scopus 로고
    • Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo
    • Glushakova, S., Grivel, J. C., Suryanarayana, K., Meylan, P., Lifson, J. D., Desrosiers, R., Margolis, L. (1999) Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo. J. Virol. 73, 3968-3974.
    • (1999) J. Virol. , vol.73 , pp. 3968-3974
    • Glushakova, S.1    Grivel, J.C.2    Suryanarayana, K.3    Meylan, P.4    Lifson, J.D.5    Desrosiers, R.6    Margolis, L.7
  • 40
    • 0034795885 scopus 로고    scopus 로고
    • CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo
    • Glushakova, S., Munch, J., Carl, S., Greenough, T. C., Sullivan, J. L., Margolis, L., Kirchhoff, F. (2001) CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo. J. Virol. 75, 10113-10117.
    • (2001) J. Virol. , vol.75 , pp. 10113-10117
    • Glushakova, S.1    Munch, J.2    Carl, S.3    Greenough, T.C.4    Sullivan, J.L.5    Margolis, L.6    Kirchhoff, F.7
  • 41
    • 0033962413 scopus 로고    scopus 로고
    • The decreased replicative capacity of simian immunodeficiency virus SIVmac239Δ(nef) is manifest in cultures of immature dendritic cells and T cells
    • Messmer, D., Ignatius, R., Santisteban, C., Steinman, R. M., Pope, M. (2000) The decreased replicative capacity of simian immunodeficiency virus SIVmac239Δ(nef) is manifest in cultures of immature dendritic cells and T cells. J. Virol. 74, 2406-2413.
    • (2000) J. Virol. , vol.74 , pp. 2406-2413
    • Messmer, D.1    Ignatius, R.2    Santisteban, C.3    Steinman, R.M.4    Pope, M.5
  • 42
    • 0035919709 scopus 로고    scopus 로고
    • Nef is required for efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes
    • Petit, C., Buseyne, F., Boccaccio, C., Abastado, J. P., Heard, J. M., Schwartz, O. (2001) Nef is required for efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes. Virology 286, 225-236.
    • (2001) Virology , vol.286 , pp. 225-236
    • Petit, C.1    Buseyne, F.2    Boccaccio, C.3    Abastado, J.P.4    Heard, J.M.5    Schwartz, O.6
  • 43
    • 10644267545 scopus 로고    scopus 로고
    • Human endothelial cells enhance human immunodeficiency virus type 1 replication in CD4+ T cells in a Nef-dependent manner in vitro and in vivo
    • Choi, J., Walker, J., Boichuk, S., Kirkiles-Smith, N., Torpey, N., Pober, J. S., Alexander, L. (2005) Human endothelial cells enhance human immunodeficiency virus type 1 replication in CD4+ T cells in a Nef-dependent manner in vitro and in vivo. J. Virol. 79, 264-276.
    • (2005) J. Virol. , vol.79 , pp. 264-276
    • Choi, J.1    Walker, J.2    Boichuk, S.3    Kirkiles-Smith, N.4    Torpey, N.5    Pober, J.S.6    Alexander, L.7
  • 45
    • 12144291075 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts
    • Krautkramer, E., Giese, S. I., Gasteier, J. E., Muranyi, W., Fackler, O. T. (2004) Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts. J. Virol. 78, 4085-4097.
    • (2004) J. Virol. , vol.78 , pp. 4085-4097
    • Krautkramer, E.1    Giese, S.I.2    Gasteier, J.E.3    Muranyi, W.4    Fackler, O.T.5
  • 46
    • 18044378256 scopus 로고    scopus 로고
    • The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4
    • Michel, N., Allespach, I., Venzke, S., Fackler, O. T., Keppler, O. T. (2005) The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4. Curr. Biol. 15, 714-723.
    • (2005) Curr. Biol. , vol.15 , pp. 714-723
    • Michel, N.1    Allespach, I.2    Venzke, S.3    Fackler, O.T.4    Keppler, O.T.5
  • 47
    • 0141521574 scopus 로고    scopus 로고
    • Downmodulation of mature major histocompatibility complex class II and upregulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles
    • Schindler, M., Wurfl, S., Benaroch, P., Greenough, T. C., Daniels, R., Easterbrook, P., Brenner, M., Munch, J., Kirchhoff, F. (2003) Downmodulation of mature major histocompatibility complex class II and upregulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J. Virol. 77, 10548-10556.
    • (2003) J. Virol. , vol.77 , pp. 10548-10556
    • Schindler, M.1    Wurfl, S.2    Benaroch, P.3    Greenough, T.C.4    Daniels, R.5    Easterbrook, P.6    Brenner, M.7    Munch, J.8    Kirchhoff, F.9
  • 48
    • 13744259226 scopus 로고    scopus 로고
    • Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef
    • Keppler, O. T., Allespach, I., Schuller, L., Fenard, D., Greene, W. C., Fackler, O. T. (2005) Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef. J. Virol. 79, 1655-1665.
    • (2005) J. Virol. , vol.79 , pp. 1655-1665
    • Keppler, O.T.1    Allespach, I.2    Schuller, L.3    Fenard, D.4    Greene, W.C.5    Fackler, O.T.6
  • 50
    • 19344363916 scopus 로고    scopus 로고
    • HIV-1 Nef binds the DOCK2-ELMO1 complex to activate Rac and inhibit lymphocyte chemotaxis
    • Janardhan, A., Swigut, T., Hill, B., Myers, M. P., Skowronski, J. (2004) HIV-1 Nef binds the DOCK2-ELMO1 complex to activate Rac and inhibit lymphocyte chemotaxis. PLoS Biol. 2, E6.
    • (2004) PLoS Biol. , vol.2
    • Janardhan, A.1    Swigut, T.2    Hill, B.3    Myers, M.P.4    Skowronski, J.5
  • 51
    • 0035980010 scopus 로고    scopus 로고
    • HIV Nef-mediated cellular phenotypes are differentially expressed as a function of intracellular Nef concentrations
    • Liu, X., Schrager, J. A., Lange, G. D., Marsh, J. W. (2001) HIV Nef-mediated cellular phenotypes are differentially expressed as a function of intracellular Nef concentrations. J. Biol. Chem. 276, 32763-32770.
    • (2001) J. Biol. Chem. , vol.276 , pp. 32763-32770
    • Liu, X.1    Schrager, J.A.2    Lange, G.D.3    Marsh, J.W.4
  • 52
    • 0032076086 scopus 로고    scopus 로고
    • Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4
    • Lu, X., Yu, H., Liu, S. H., Brodsky, F. M., Peterlin, B. M. (1998) Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity 8, 647-656.
    • (1998) Immunity , vol.8 , pp. 647-656
    • Lu, X.1    Yu, H.2    Liu, S.H.3    Brodsky, F.M.4    Peterlin, B.M.5
  • 53
    • 0032525137 scopus 로고    scopus 로고
    • The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
    • Greenberg, M. E., Iafrate, A. J., Skowronski, J. (1998) The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J. 17, 2777-2789.
    • (1998) EMBO J. , vol.17 , pp. 2777-2789
    • Greenberg, M.E.1    Iafrate, A.J.2    Skowronski, J.3
  • 54
    • 0036435652 scopus 로고    scopus 로고
    • The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs
    • Schaefer, T. M., Bell, I., Pfeifer, M. E., Ghosh, M., Trible, R. P., Fuller, C. L., Ashman, C., Reinhart, T. A. (2002) The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs. Virology 302, 106-122.
    • (2002) Virology , vol.302 , pp. 106-122
    • Schaefer, T.M.1    Bell, I.2    Pfeifer, M.E.3    Ghosh, M.4    Trible, R.P.5    Fuller, C.L.6    Ashman, C.7    Reinhart, T.A.8
  • 55
    • 11844255388 scopus 로고    scopus 로고
    • Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities
    • Madrid, R., Gasteier, J. E., Bouchet, J., Schroder, S., Geyer, M., Benichou, S., Fackler, O. T. (2005) Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities. FEBS Lett. 579, 441-448.
    • (2005) FEBS Lett. , vol.579 , pp. 441-448
    • Madrid, R.1    Gasteier, J.E.2    Bouchet, J.3    Schroder, S.4    Geyer, M.5    Benichou, S.6    Fackler, O.T.7
  • 56
    • 0038758782 scopus 로고    scopus 로고
    • Cooperative interactions of simian immunodeficiency virus Nef, AP-2, and CD3-ζ mediate the selective induction of T-cell receptor-CD3 endocytosis
    • Swigut, T., Greenberg, M., Skowronski, J. (2003) Cooperative interactions of simian immunodeficiency virus Nef, AP-2, and CD3-ζ mediate the selective induction of T-cell receptor-CD3 endocytosis. J. Virol. 77, 8116-8126.
    • (2003) J. Virol. , vol.77 , pp. 8116-8126
    • Swigut, T.1    Greenberg, M.2    Skowronski, J.3
  • 57
    • 0029793620 scopus 로고    scopus 로고
    • CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef
    • Chen, B. K., Gandhi, R. T., Baltimore, D. (1996) CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef. J. Virol. 70, 6044-6053.
    • (1996) J. Virol. , vol.70 , pp. 6044-6053
    • Chen, B.K.1    Gandhi, R.T.2    Baltimore, D.3
  • 58
    • 3843114507 scopus 로고    scopus 로고
    • The effects of HIV-1 Nef on CD4 surface expression and viral infectivity in lymphoid cells are independent of rafts
    • Sol-Foulon, N., Esnault, C., Percherancier, Y., Porrot, F., Metais-Cunha, P., Bachelerie, F., Schwartz, O. (2004) The effects of HIV-1 Nef on CD4 surface expression and viral infectivity in lymphoid cells are independent of rafts. J. Biol. Chem. 279, 31398-31408.
    • (2004) J. Biol. Chem. , vol.279 , pp. 31398-31408
    • Sol-Foulon, N.1    Esnault, C.2    Percherancier, Y.3    Porrot, F.4    Metais-Cunha, P.5    Bachelerie, F.6    Schwartz, O.7
  • 59
    • 0037127303 scopus 로고    scopus 로고
    • Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells
    • Cortes, M. J., Wong-Staal, F., Lama, J. (2002) Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells. J. Biol. Chem. 277, 1770-1779.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1770-1779
    • Cortes, M.J.1    Wong-Staal, F.2    Lama, J.3
  • 60
    • 0036231461 scopus 로고    scopus 로고
    • Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes
    • Lundquist, C. A., Tobiume, M., Zhou, J., Unutmaz, D., Aiken, C. (2002) Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J. Virol. 76, 4625-4633.
    • (2002) J. Virol. , vol.76 , pp. 4625-4633
    • Lundquist, C.A.1    Tobiume, M.2    Zhou, J.3    Unutmaz, D.4    Aiken, C.5
  • 61
    • 0033775488 scopus 로고    scopus 로고
    • Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo
    • Iafrate, A. J., Carl, S., Bronson, S., Stahl-Hennig, C., Swigut, T., Skowronski, J., Kirchhoff, F. (2000) Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo. J. Virol. 74, 9836-9844.
    • (2000) J. Virol. , vol.74 , pp. 9836-9844
    • Iafrate, A.J.1    Carl, S.2    Bronson, S.3    Stahl-Hennig, C.4    Swigut, T.5    Skowronski, J.6    Kirchhoff, F.7
  • 62
    • 0033578072 scopus 로고    scopus 로고
    • Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner
    • Lama, J., Mangasarian, A., Trono, D. (1999) Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner. Curr. Biol. 9, 622-631.
    • (1999) Curr. Biol. , vol.9 , pp. 622-631
    • Lama, J.1    Mangasarian, A.2    Trono, D.3
  • 63
    • 0033578016 scopus 로고    scopus 로고
    • Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
    • Ross, T. M., Oran, A. E., Cullen, B. R. (1999) Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein. Curr. Biol. 9, 613-621.
    • (1999) Curr. Biol. , vol.9 , pp. 613-621
    • Ross, T.M.1    Oran, A.E.2    Cullen, B.R.3
  • 64
    • 0027158904 scopus 로고
    • Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection
    • Benson, R. E., Sanfridson, A., Ottinger, J. S., Doyle, C., Cullen, B. R. (1993) Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. J. Exp. Med. 177, 1561-1566.
    • (1993) J. Exp. Med. , vol.177 , pp. 1561-1566
    • Benson, R.E.1    Sanfridson, A.2    Ottinger, J.S.3    Doyle, C.4    Cullen, B.R.5
  • 65
    • 0346601814 scopus 로고    scopus 로고
    • The physiological relevance of CD4 receptor downmodulation during HIV infection
    • Lama, J. (2003) The physiological relevance of CD4 receptor downmodulation during HIV infection. Curr. HIV Res. 1, 167-184.
    • (2003) Curr. HIV Res. , vol.1 , pp. 167-184
    • Lama, J.1
  • 66
    • 0035887446 scopus 로고    scopus 로고
    • Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation
    • Castedo, M., Ferri, K. F., Blanco, J., Roumier, T., Larochette, N., Barretina, J., Amendola, A., Nardacci, R., Metivier, D., Este, J. A., Piacentini, M., Kroemer, G. (2001) Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation. J. Exp. Med. 194, 1097-1110.
    • (2001) J. Exp. Med. , vol.194 , pp. 1097-1110
    • Castedo, M.1    Ferri, K.F.2    Blanco, J.3    Roumier, T.4    Larochette, N.5    Barretina, J.6    Amendola, A.7    Nardacci, R.8    Metivier, D.9    Este, J.A.10    Piacentini, M.11    Kroemer, G.12
  • 67
    • 4644277015 scopus 로고    scopus 로고
    • Apoptosis of bystander T cells induced by human immunodeficiency virus type 1 with increased envelope/receptor affinity and coreceptor binding site exposure
    • Holm, G. H., Zhang, C., Gorry, P. R., Peden, K., Schols, D., De Clercq, E., Gabuzda, D. (2004) Apoptosis of bystander T cells induced by human immunodeficiency virus type 1 with increased envelope/receptor affinity and coreceptor binding site exposure. J. Virol. 78, 4541-4551.
    • (2004) J. Virol. , vol.78 , pp. 4541-4551
    • Holm, G.H.1    Zhang, C.2    Gorry, P.R.3    Peden, K.4    Schols, D.5    De Clercq, E.6    Gabuzda, D.7
  • 68
    • 10844279128 scopus 로고    scopus 로고
    • Cutting edge: Epitope-dependent effect of Nef-mediated HLA class I down-regulation on ability of HIV-1-specific CTLs to suppress HIV-1 replication
    • Tomiyama, H., Fujiwara, M., Oka, S., Takiguchi, M. (2005) Cutting edge: epitope-dependent effect of Nef-mediated HLA class I down-regulation on ability of HIV-1-specific CTLs to suppress HIV-1 replication. J. Immunol. 174, 36-40.
    • (2005) J. Immunol. , vol.174 , pp. 36-40
    • Tomiyama, H.1    Fujiwara, M.2    Oka, S.3    Takiguchi, M.4
  • 69
    • 0032556872 scopus 로고    scopus 로고
    • HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
    • Collins, K. L., Chen, B. K., Kalams, S. A., Walker, B. D., Baltimore, D. (1998) HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391, 397-401.
    • (1998) Nature , vol.391 , pp. 397-401
    • Collins, K.L.1    Chen, B.K.2    Kalams, S.A.3    Walker, B.D.4    Baltimore, D.5
  • 70
    • 10644261241 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef domains required for disruption of major histocompatibility complex class I trafficking are also necessary for coprecipitation of Nef with HLA-A2
    • Williams, M., Roeth, J. F., Kasper, M. R., Filzen, T. M., Collins, K. L. (2005) Human immunodeficiency virus type 1 Nef domains required for disruption of major histocompatibility complex class I trafficking are also necessary for coprecipitation of Nef with HLA-A2. J. Virol. 79, 632-636.
    • (2005) J. Virol. , vol.79 , pp. 632-636
    • Williams, M.1    Roeth, J.F.2    Kasper, M.R.3    Filzen, T.M.4    Collins, K.L.5
  • 71
    • 0344875506 scopus 로고    scopus 로고
    • Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: Potential role of phosphatidylinositol 3-kinase
    • Stumptner-Cuvelette, P., Jouve, M., Helft, J., Dugast, M., Glouzman, A. S., Jooss, K., Raposo, G., Benaroch, P. (2003) Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase. Mol. Biol. Cell 14, 4857-4870.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 4857-4870
    • Stumptner-Cuvelette, P.1    Jouve, M.2    Helft, J.3    Dugast, M.4    Glouzman, A.S.5    Jooss, K.6    Raposo, G.7    Benaroch, P.8
  • 72
    • 0036230879 scopus 로고    scopus 로고
    • Live and let die: Nef functions beyond HIV replication
    • Fackler, O. T., Baur, A. S. (2002) Live and let die: Nef functions beyond HIV replication. Immunity 16, 493-497.
    • (2002) Immunity , vol.16 , pp. 493-497
    • Fackler, O.T.1    Baur, A.S.2
  • 73
    • 4544288671 scopus 로고    scopus 로고
    • Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-κB, and AP-1 induction
    • Fortin, J. F., Barat, C., Beausejour, Y., Barbeau, B., Tremblay, M. J. (2004) Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-κB, and AP-1 induction. J. Biol. Chem. 279, 39520-39531.
    • (2004) J. Biol. Chem. , vol.279 , pp. 39520-39531
    • Fortin, J.F.1    Barat, C.2    Beausejour, Y.3    Barbeau, B.4    Tremblay, M.J.5
  • 74
    • 0034595806 scopus 로고    scopus 로고
    • Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway
    • Manninen, A., Renkema, G. H., Saksela, K. (2000) Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway. J. Biol. Chem. 275, 16513-16517.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16513-16517
    • Manninen, A.1    Renkema, G.H.2    Saksela, K.3
  • 77
    • 0032567042 scopus 로고    scopus 로고
    • Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells
    • Kinoshita, S., Chen, B. K., Kaneshima, H., Nolan, G. P. (1998) Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells. Cell 95, 595-604.
    • (1998) Cell , vol.95 , pp. 595-604
    • Kinoshita, S.1    Chen, B.K.2    Kaneshima, H.3    Nolan, G.P.4
  • 78
    • 0030939152 scopus 로고    scopus 로고
    • The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells
    • Kinoshita, S., Su, L., Amano, M., Timmerman, L. A., Kaneshima, H., Nolan, G. P. (1997) The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells. Immunity 6, 235-244.
    • (1997) Immunity , vol.6 , pp. 235-244
    • Kinoshita, S.1    Su, L.2    Amano, M.3    Timmerman, L.A.4    Kaneshima, H.5    Nolan, G.P.6
  • 79
    • 23844505206 scopus 로고    scopus 로고
    • Endothelial cells promote human immunodeficiency virus replication in nondividing memory T cells via Nef-, Vpr-, and T-cell receptor-dependent activation of NFAT
    • Choi, J., Walker, J., Talbert-Slagle, K., Wright, P., Pober, J. S., Alexander, L. (2005) Endothelial cells promote human immunodeficiency virus replication in nondividing memory T cells via Nef-, Vpr-, and T-cell receptor-dependent activation of NFAT. J. Virol. 79, 11194-11204.
    • (2005) J. Virol. , vol.79 , pp. 11194-11204
    • Choi, J.1    Walker, J.2    Talbert-Slagle, K.3    Wright, P.4    Pober, J.S.5    Alexander, L.6


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