Regioselective covalent modification of hemoglobin in search of antisickling agents

Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2003, Pages 936-953

  Park, Soobong ^a,b   Hayes, Brittany L ^a,c   Marankan, Fatima ^a,d   Mulhearn, Debbie C ^a   Wanna, Linda ^a   Mesecar, Andrew D ^a   Santarsiero, Bernard D ^a   Johnson, Michael E ^a   Venton, Duane L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c CEM Corporation   (United States)

^d SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 (N,N DIMETHYLAMINO)ETHYL ISOTHIOCYANATE; 4 (N,N DIETHYLAMINO)BUTYL ISOTHIOCYANATE; 5 (N,N DIETHYLAMINO)PENTYL ISOTHIOCYANATE; ANTISICKLING AGENT; HEMOGLOBIN S; ISOTHIOCYANIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG DETERMINATION; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; ERYTHROCYTE MEMBRANE; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOLECULAR MODEL; OXYGEN AFFINITY; POLYMERIZATION; PROTEIN STRUCTURE; SICKLE CELL ANEMIA; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANEMIA, SICKLE CELL; CELL MEMBRANE PERMEABILITY; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; ERYTHROCYTE MEMBRANE; HEMOGLOBIN A; HEMOGLOBIN, SICKLE; HEMOGLOBINS; HUMANS; ISOTHIOCYANATES; MODELS, MOLECULAR; POLYMERS; SOLUBILITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037435049     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020361k     Document Type: Article

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