Molecular modeling studies of the binding modes of aldose reductase inhibitors at the active site of human aldose reductase

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 10, 1998, Pages 1811-1819

  Lee, Yong S ^a   Chen, Zhou ^a   Kador, Peter F ^a  

^a NATIONAL EYE INSTITUTE   (United States)

Author keywords

Aldose reductase inhibitors; Aromatic aromatic interaction; Charge interaction; Hydrogen bond; Pharmacophore requirements

Indexed keywords

2,7 DIFLUORO 9 FLUORENACETIC ACID; 9 FLUORENACETIC ACID; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; IMIRESTAT; SPIROFLUORENE 9,5 IMIDAZOLIDINE 2,4 DIONE; UNCLASSIFIED DRUG; ZENARESTAT;

ARTICLE; BINDING SITE; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME BINDING; HYDROGEN BOND; MOLECULAR MODEL; STEREOCHEMISTRY;

ACETIC ACIDS; ALDEHYDE REDUCTASE; BINDING SITES; ENZYME INHIBITORS; FLUORENES; GLYCERALDEHYDE; HUMANS; IMIDAZOLES; IMIDAZOLIDINES; MODELS, MOLECULAR; QUINAZOLINES; RHODANINE; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 0031727488     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00139-4     Document Type: Article

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