Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 2, 2005, Pages 491-499

  Da Settimo, Federico ^a   Primofiore, Giampaolo ^a   La Motta, Concettina ^a   Salerno, Silvia ^a   Novellino, Ettore ^b   Greco, Giovanni ^b   Lavecchia, Antonio ^b   Laneri, Sonia ^b   Boldrini, Enrico ^c  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c Opocrin SpA   (Italy)

Author keywords

Aldose reductase; Cataract; Inhibitors; Spirohydantoin derivatives

Indexed keywords

2,3 DIHYDRO 7 METHYLSPIRO[4H THIOPYRANO[2,3 B]PYRIDIN 4,4' IMIDAZOLIDINE] 2',5' DIONE; 2,3 DIHYDROSPIRO[4H THIOPYRANO[2,3 B]PYRIDIN 4,4' IMIDAZOLIDINE] 2',5' DION 1' YLACETIC ACID; 2,3 DIHYDROSPIRO[4H THIOPYRANO[2,3 B]PYRIDIN 4,4' IMIDAZOLIDINE] 2',5' DIONE; 2,3 DIHYDROSPIRO[4H THIOPYRANO[2,3 B]PYRIDIN 4,4' IMIDAZOLIDINE] 2',5' DIONE 1,1 DIOXIDE; ACETIC ACID DERIVATIVE; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; EYE DROPS; HYDANTOIN DERIVATIVE; PYRIDONE DERIVATIVE; SORBINIL; SULFONE DERIVATIVE; TOLRESTAT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISEASE COURSE; DISEASE SEVERITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; GALACTOSEMIA; IC 50; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; ISOMER; NONHUMAN; PROSPECTIVE STUDY; RAT; SIMULATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALDEHYDE REDUCTASE; ANIMALS; CATARACT; HYDANTOINS; INHIBITORY CONCENTRATION 50; KIDNEY; LENS, CRYSTALLINE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRIDONES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 10444284227     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.10.019     Document Type: Article

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