Differential effects of necrotic or apoptotic cell uptake on antigen presentation by macrophages

Pathobiology

Volumn 67, Issue 5-6, 1999, Pages 302-305

  Barker, Robert N ^a   Erwig, Lars Peter ^b   Pearce, Wayne P ^b   Devine, Anne ^b   Rees, Andrew J ^b  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b NONE

Author keywords

Antigen presentation; Apoptosis; Costimulation; Macrophage; Necrosis; Transforming growth factor 1

Indexed keywords

CD40 ANTIGEN; CONCANAVALIN A; OVALBUMIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; APOPTOSIS; BONE MARROW; CELL METABOLISM; CELL TYPE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

MURINAE;

EID: 0342751267     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028085     Document Type: Conference Paper

References (5)

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2. Goerdt G, Orfanos CE: Other functions, other genes: Alternative activation of antigen-presenting cells. Immunity 1999;10:137.
3. Erwig LP, Kluth DC, Walsh GM, Rees AJ: Initial cytokine exposure determines function of macrophages and renders them unresponsive to other cytokines. J Immunol 1998;161:1983.
4. Reiter I, Krammer B, Schwamberger G: Differential effect of apoptotic versus necrotic tumor cells on macrophage antitumor activities. J Immunol 1999;163:1730.
5. Fadok VA, Bratton DL, Konowal K, Freed PW, Westcott JY, Henson PM: Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2 and PAF. J Clin Invest 1998;101:890.