메뉴 건너뛰기




Volumn 390, Issue 4, 2005, Pages 333-341

Surgical trauma and immunosuppression: Pathophysiology and potential immunomodulatory approaches

Author keywords

Gender; Immunomodulation; Immunosuppression; Sex steroids; Shock; Surgery

Indexed keywords

ANDROGEN; ANTIANDROGEN; ESTRADIOL; ESTROGEN; FLUTAMIDE; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOMODULATING AGENT; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; INTERLEUKIN 6; PRASTERONE; SEX HORMONE;

EID: 23444457479     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00423-005-0557-4     Document Type: Article
Times cited : (120)

References (76)
  • 3
    • 0002786895 scopus 로고
    • Monocyte and lymphocyte responses following trauma
    • Schlag G, Redl H eds Springer, Berlin Heidelberg New York
    • Stephan RN, Ayala A, Chaudry IH (1993) Monocyte and lymphocyte responses following trauma. In: Schlag G, Redl H (eds) Pathophysiology of shock, sepsis and organ failure. Springer, Berlin Heidelberg New York, pp 131-144
    • (1993) Pathophysiology of Shock, Sepsis and Organ Failure , pp. 131-144
    • Stephan, R.N.1    Ayala, A.2    Chaudry, I.H.3
  • 5
    • 0020517209 scopus 로고
    • Multiple organ failure in polytrauma patients
    • Faist E, Baue AE, Dittmer H (1983) Multiple organ failure in polytrauma patients. J Trauma 23:775-787
    • (1983) J Trauma , vol.23 , pp. 775-787
    • Faist, E.1    Baue, A.E.2    Dittmer, H.3
  • 6
    • 0021266347 scopus 로고
    • Changes in mitogen responsiveness lymphocyte subsets after traumatic injury: Relation to development of sepsis
    • Levy EM, Alharbi SA, Grindlinger G, Black PH (1984) Changes in mitogen responsiveness lymphocyte subsets after traumatic injury: relation to development of sepsis. Clin Immunol Immunopathol 32:224-233
    • (1984) Clin Immunol Immunopathol , vol.32 , pp. 224-233
    • Levy, E.M.1    Alharbi, S.A.2    Grindlinger, G.3    Black, P.H.4
  • 8
    • 0030699110 scopus 로고    scopus 로고
    • Testosterone receptor blockade after hemorrhage in males: Restoration of the depressed immune functions and improved survival following subsequent sepsis
    • Angele MK, Wichmann MW, Ayala A, Cioffi WG, Chaudry IH (1997) Testosterone receptor blockade after hemorrhage in males: restoration of the depressed immune functions and improved survival following subsequent sepsis. Arch Surg 132:1207-1214
    • (1997) Arch Surg , vol.132 , pp. 1207-1214
    • Angele, M.K.1    Wichmann, M.W.2    Ayala, A.3    Cioffi, W.G.4    Chaudry, I.H.5
  • 9
    • 0032407998 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA): An inexpensive steroid hormone which decreases the mortality from sepsis
    • Angele MK, Catania RA, Ayala A, Cioffi WG, Bland K, Chaudry IH (1998) Dehydroepiandrosterone (DHEA): an inexpensive steroid hormone which decreases the mortality from sepsis. Arch Surg 133:1281-1288
    • (1998) Arch Surg , vol.133 , pp. 1281-1288
    • Angele, M.K.1    Catania, R.A.2    Ayala, A.3    Cioffi, W.G.4    Bland, K.5    Chaudry, I.H.6
  • 10
    • 0036144034 scopus 로고    scopus 로고
    • Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis
    • Knoferl MW, Angele MK, Diodato MD, Schwacha MG, Ayala A, Cioffi WG, Bland KI, Chaudry IH (2002) Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis. Ann Surg 235:105-112
    • (2002) Ann Surg , vol.235 , pp. 105-112
    • Knoferl, M.W.1    Angele, M.K.2    Diodato, M.D.3    Schwacha, M.G.4    Ayala, A.5    Cioffi, W.G.6    Bland, K.I.7    Chaudry, I.H.8
  • 11
    • 11144344922 scopus 로고    scopus 로고
    • Surgical trauma: Hyperinflammation vs immunosuppression?
    • Menger MD, Vollmar B (2004) Surgical trauma: hyperinflammation vs immunosuppression? Langenbecks Arch Surg 389:475-484
    • (2004) Langenbecks Arch Surg , vol.389 , pp. 475-484
    • Menger, M.D.1    Vollmar, B.2
  • 12
    • 0027411590 scopus 로고
    • Trauma-hemorrhage and resuscitation in the mouse: Effects on cardiac output and organ blood flow
    • Wang P, Ba ZF, Burkhardt J, Chaudry IH (1993) Trauma-hemorrhage and resuscitation in the mouse: effects on cardiac output and organ blood flow. Am J Physiol 264:H1166-H1173
    • (1993) Am J Physiol , vol.264
    • Wang, P.1    Ba, Z.F.2    Burkhardt, J.3    Chaudry, I.H.4
  • 14
    • 0027752805 scopus 로고
    • The L-arginine-nitric oxide pathway
    • Moncada S, Higgs EA (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329:2002-2012
    • (1993) N Engl J Med , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, E.A.2
  • 15
    • 0002339907 scopus 로고
    • Evidence supporting the proposal that endothelium-derived relaxing factor is nitric oxide
    • Furchgott RF, Khan MT, Jothianandan D (1987) Evidence supporting the proposal that endothelium-derived relaxing factor is nitric oxide. Thromb Res 7:5
    • (1987) Thromb Res , vol.7 , pp. 5
    • Furchgott, R.F.1    Khan, M.T.2    Jothianandan, D.3
  • 16
    • 0026652468 scopus 로고
    • The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat
    • Weyrich AS, Ma X, Lefer AM (1992) The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat. Circulation 86:279-288
    • (1992) Circulation , vol.86 , pp. 279-288
    • Weyrich, A.S.1    Ma, X.2    Lefer, A.M.3
  • 17
    • 0024311321 scopus 로고
    • Synthesis of nitric oxide from L-arginine by neutrophils: Release and interaction with superoxide anion
    • McCall TB, Broughton-Smith NK, Palmer RM, Whittle BJ, Moncada S (1989) Synthesis of nitric oxide from L-arginine by neutrophils: release and interaction with superoxide anion. Biochem J 261:293-296
    • (1989) Biochem J , vol.261 , pp. 293-296
    • McCall, T.B.1    Broughton-Smith, N.K.2    Palmer, R.M.3    Whittle, B.J.4    Moncada, S.5
  • 18
    • 0032732546 scopus 로고    scopus 로고
    • Role of TNF-alpha in local surgical trauma-induced microvascular dysfunction
    • Yamauchi J, Vollmar B, Wolf B, Menger MD (1999) Role of TNF-alpha in local surgical trauma-induced microvascular dysfunction. Dig Surg 16:400-406
    • (1999) Dig Surg , vol.16 , pp. 400-406
    • Yamauchi, J.1    Vollmar, B.2    Wolf, B.3    Menger, M.D.4
  • 19
    • 0027996241 scopus 로고
    • Mechanism of enhanced susceptibility to sepsis following hemorrhage: Interleukin (IL)-10 suppression of T-cell response is mediated by eicosanoid induced IL-4 release
    • Ayala A, Lehman DL, Herdon CD, Chaudry IH (1994) Mechanism of enhanced susceptibility to sepsis following hemorrhage: interleukin (IL)-10 suppression of T-cell response is mediated by eicosanoid induced IL-4 release. Arch Surg 129:1172-1178
    • (1994) Arch Surg , vol.129 , pp. 1172-1178
    • Ayala, A.1    Lehman, D.L.2    Herdon, C.D.3    Chaudry, I.H.4
  • 20
    • 0029367030 scopus 로고
    • Alterations in alveolar macrophage tumor necrosis factor (TNF) response following trauma-hemorrhagic shock
    • Nwariaku FE, McIntyre KL, Sikes PJ, Mileski WJ (1995) Alterations in alveolar macrophage tumor necrosis factor (TNF) response following trauma-hemorrhagic shock. Shock 4:200-203
    • (1995) Shock , vol.4 , pp. 200-203
    • Nwariaku, F.E.1    McIntyre, K.L.2    Sikes, P.J.3    Mileski, W.J.4
  • 21
    • 0029349007 scopus 로고
    • Trauma-hemorrhage causes prolonged depression in cellular immunity
    • Zellweger R, Ayala A, DeMaso CM, Chaudry IH (1995) Trauma-hemorrhage causes prolonged depression in cellular immunity. Shock 4:149-153
    • (1995) Shock , vol.4 , pp. 149-153
    • Zellweger, R.1    Ayala, A.2    DeMaso, C.M.3    Chaudry, I.H.4
  • 22
    • 0029738469 scopus 로고    scopus 로고
    • Immune function is more compromised following closed bone fracture and hemorrhagic shock than hemorrhage alone
    • Wichmann MW, Zellweger R, Williams C, Ayala A, DeMaso CM, Chaudry IH (1996) Immune function is more compromised following closed bone fracture and hemorrhagic shock than hemorrhage alone. Arch Surg 131: 995-1000
    • (1996) Arch Surg , vol.131 , pp. 995-1000
    • Wichmann, M.W.1    Zellweger, R.2    Williams, C.3    Ayala, A.4    DeMaso, C.M.5    Chaudry, I.H.6
  • 24
    • 0026756528 scopus 로고
    • Functional analysis of monocytes activity through synthesis patterns of proinflammatory cytokines and neopterin in patients in surgical intensive care
    • Faist E, Storck M, Hultner L, Redl H, Ertel W, Walz A, Schildberg FW (1992) Functional analysis of monocytes activity through synthesis patterns of proinflammatory cytokines and neopterin in patients in surgical intensive care. Surgery 112:562-572
    • (1992) Surgery , vol.112 , pp. 562-572
    • Faist, E.1    Storck, M.2    Hultner, L.3    Redl, H.4    Ertel, W.5    Walz, A.6    Schildberg, F.W.7
  • 25
    • 0034131888 scopus 로고    scopus 로고
    • Immune paralysis of T-lymphocytes and monocytes in postoperative abdominal sepsis. Correlation of immune function with survival
    • Heidecke CD, Weighardt H, Hensler T, Bartels H, Holzmann B (2000) Immune paralysis of T-lymphocytes and monocytes in postoperative abdominal sepsis. Correlation of immune function with survival. Chirurg 71:159-165
    • (2000) Chirurg , vol.71 , pp. 159-165
    • Heidecke, C.D.1    Weighardt, H.2    Hensler, T.3    Bartels, H.4    Holzmann, B.5
  • 26
    • 0034093258 scopus 로고    scopus 로고
    • Sepsis after major visceral surgery is associated with sustained and interferon-gamma-resistant defects of monocyte cytokine production
    • Weighardt H, Heidecke CD, Emmanuilidis K, Maier S, Bartels H, Siewert JR, Holzmann B (2000) Sepsis after major visceral surgery is associated with sustained and interferon-gamma-resistant defects of monocyte cytokine production. Surgery 127:309-315
    • (2000) Surgery , vol.127 , pp. 309-315
    • Weighardt, H.1    Heidecke, C.D.2    Emmanuilidis, K.3    Maier, S.4    Bartels, H.5    Siewert, J.R.6    Holzmann, B.7
  • 30
    • 0038468348 scopus 로고    scopus 로고
    • Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients
    • Spolarics Z, Siddiqi M, Siegel JH, Garcia ZC, Stein DS, Denny T, Deitch EA (2003) Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients. Crit Care Med 31:1722-1729
    • (2003) Crit Care Med , vol.31 , pp. 1722-1729
    • Spolarics, Z.1    Siddiqi, M.2    Siegel, J.H.3    Garcia, Z.C.4    Stein, D.S.5    Denny, T.6    Deitch, E.A.7
  • 31
    • 0026458809 scopus 로고
    • Differential effects of haemorrhage on Kupffer cells: Decreased antigen presentation despite increased inflammatory cytokine (IL- 1, IL-6 and TNF) release
    • Ayala A, Perrin MM, Ertel W, Chaudry IH (1992) Differential effects of haemorrhage on Kupffer cells: decreased antigen presentation despite increased inflammatory cytokine (IL- 1, IL-6 and TNF) release. Cytokine 4:66-75
    • (1992) Cytokine , vol.4 , pp. 66-75
    • Ayala, A.1    Perrin, M.M.2    Ertel, W.3    Chaudry, I.H.4
  • 32
    • 0026316281 scopus 로고
    • Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity: Involvement of cell-associated TNF and reactive nitrogen
    • Ayala A, Perrin MM, Wang P, Ertel W, Chaudry IH (1991) Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity: involvement of cell-associated TNF and reactive nitrogen. J Immunol 147:4147-4154
    • (1991) J Immunol , vol.147 , pp. 4147-4154
    • Ayala, A.1    Perrin, M.M.2    Wang, P.3    Ertel, W.4    Chaudry, I.H.5
  • 34
    • 0030077878 scopus 로고    scopus 로고
    • Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes
    • Ayala A, Ertel W, Chaudry IH (1996) Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes. Shock 5:79-90
    • (1996) Shock , vol.5 , pp. 79-90
    • Ayala, A.1    Ertel, W.2    Chaudry, I.H.3
  • 35
    • 0031802515 scopus 로고    scopus 로고
    • Functional analysis of monocyte subsets in surgical sepsis
    • Schinkel C, Sendtner R, Zimmer S, Faist E (1998) Functional analysis of monocyte subsets in surgical sepsis. J Trauma 44:743-748
    • (1998) J Trauma , vol.44 , pp. 743-748
    • Schinkel, C.1    Sendtner, R.2    Zimmer, S.3    Faist, E.4
  • 36
    • 0027477817 scopus 로고
    • Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery
    • Wakefield CH, Carey PD, Foulds S, Monson JR, Guillou PJ (1993) Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery. Br J Surg 80:205-209
    • (1993) Br J Surg , vol.80 , pp. 205-209
    • Wakefield, C.H.1    Carey, P.D.2    Foulds, S.3    Monson, J.R.4    Guillou, P.J.5
  • 38
    • 0009948590 scopus 로고
    • The impact of preexisting disease conditions for host defense integrity in traumatized and critically ill patients
    • Faist E, Meakins J, Schildberg FW (eds) Springer, Berlin Heidelberg New York
    • Christou NV, Tellado JM (1993) The impact of preexisting disease conditions for host defense integrity in traumatized and critically ill patients. In: Faist E, Meakins J, Schildberg FW (eds) Host defense dysfunction in trauma, shock and sepsis. Springer, Berlin Heidelberg New York, pp 73-82
    • (1993) Host Defense Dysfunction in Trauma, Shock and Sepsis , pp. 73-82
    • Christou, N.V.1    Tellado, J.M.2
  • 39
    • 0023104270 scopus 로고
    • Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis
    • Stephan RN, Kupper TS, Geha AS, Baue AE, Chaudry IH (1987) Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis. Arch Surg 122:62-68
    • (1987) Arch Surg , vol.122 , pp. 62-68
    • Stephan, R.N.1    Kupper, T.S.2    Geha, A.S.3    Baue, A.E.4    Chaudry, I.H.5
  • 42
    • 0021919472 scopus 로고
    • The effects of hemorrhage on mitogen-induced lymphocyte proliferation
    • Abraham E, Chang Y-H (1985) The effects of hemorrhage on mitogen-induced lymphocyte proliferation. Circ Shock 15:141-149
    • (1985) Circ Shock , vol.15 , pp. 141-149
    • Abraham, E.1    Chang, Y.-H.2
  • 43
    • 0031776052 scopus 로고    scopus 로고
    • Testosterone: The culprit for producing splenocyte depression following trauma-hemorrhage
    • Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH (1998) Testosterone: the culprit for producing splenocyte depression following trauma-hemorrhage. Am J Physiol 274: C1530-C1536
    • (1998) Am J Physiol , vol.274
    • Angele, M.K.1    Ayala, A.2    Cioffi, W.G.3    Bland, K.I.4    Chaudry, I.H.5
  • 46
    • 0032713325 scopus 로고    scopus 로고
    • Protective effects of early interleukin 10 antagonism on injury-induced immune dysfunction
    • Lyons A, Goebel A, Mannick JA, Lederer JA (1999) Protective effects of early interleukin 10 antagonism on injury-induced immune dysfunction. Arch Surg 134:1317-1323
    • (1999) Arch Surg , vol.134 , pp. 1317-1323
    • Lyons, A.1    Goebel, A.2    Mannick, J.A.3    Lederer, J.A.4
  • 47
    • 0029916423 scopus 로고    scopus 로고
    • Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma
    • Decker D, Schondorf M, Bidlingmaier F, Hirner A, von Ruecker AA (1996) Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma. Surgery 119:316-325
    • (1996) Surgery , vol.119 , pp. 316-325
    • Decker, D.1    Schondorf, M.2    Bidlingmaier, F.3    Hirner, A.4    Von Ruecker, A.A.5
  • 50
    • 0024835226 scopus 로고    scopus 로고
    • Endogenous release of interferon-gamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation
    • Fuchs D, Malkovsky M, Reibnegger G, Werner ER, Forni G, Wachter H (1998) Endogenous release of interferon-gamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation. Immunol Lett 23:103-108
    • (1998) Immunol Lett , vol.23 , pp. 103-108
    • Fuchs, D.1    Malkovsky, M.2    Reibnegger, G.3    Werner, E.R.4    Forni, G.5    Wachter, H.6
  • 51
    • 0030732877 scopus 로고    scopus 로고
    • Patterns of cytokine evolution (tumor necrosis factor-α and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma
    • Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL (1997) Patterns of cytokine evolution (tumor necrosis factor-α and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med 25:1813-1819
    • (1997) Crit Care Med , vol.25 , pp. 1813-1819
    • Martin, C.1    Boisson, C.2    Haccoun, M.3    Thomachot, L.4    Mege, J.L.5
  • 52
    • 0032518415 scopus 로고    scopus 로고
    • IL-6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses
    • Xing Z, Gauldie J, Cox G, Baumann H, Jordana M, Lei XF, Achong MK (1998) IL-6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 101:311-320
    • (1998) J Clin Invest , vol.101 , pp. 311-320
    • Xing, Z.1    Gauldie, J.2    Cox, G.3    Baumann, H.4    Jordana, M.5    Lei, X.F.6    Achong, M.K.7
  • 53
    • 0028031990 scopus 로고
    • Interleukin-6 (IL-6) as an anti-inflammatory cytokine: Induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55
    • Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW (1994) Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood 83:113-118
    • (1994) Blood , vol.83 , pp. 113-118
    • Tilg, H.1    Trehu, E.2    Atkins, M.B.3    Dinarello, C.A.4    Mier, J.W.5
  • 54
    • 0031052969 scopus 로고    scopus 로고
    • Cytokines in anaesthesia
    • Sheeran P, Hall GM (1997) Cytokines in anaesthesia. Br J Anaesth 78:201-219
    • (1997) Br J Anaesth , vol.78 , pp. 201-219
    • Sheeran, P.1    Hall, G.M.2
  • 56
    • 0034243510 scopus 로고    scopus 로고
    • Effect of gender and sex on immune responses following shock
    • Angele MK, Ayala A, Schwacha MG, Chaudry IH (2000) Effect of gender and sex on immune responses following shock. Shock 14:81-90
    • (2000) Shock , vol.14 , pp. 81-90
    • Angele, M.K.1    Ayala, A.2    Schwacha, M.G.3    Chaudry, I.H.4
  • 57
    • 0030295033 scopus 로고    scopus 로고
    • Enhanced immune responses in females as opposed to decreased responses in males following hemorrhagic shock
    • Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH (1996) Enhanced immune responses in females as opposed to decreased responses in males following hemorrhagic shock. Cytokine 8:853-863
    • (1996) Cytokine , vol.8 , pp. 853-863
    • Wichmann, M.W.1    Zellweger, R.2    DeMaso, C.M.3    Ayala, A.4    Chaudry, I.H.5
  • 59
    • 0035820617 scopus 로고    scopus 로고
    • Gender differences in the inflammatory response and survival following hemorrhage and subsequent sepsis
    • Diodato M, Knoferl MW, Angele MK, Schwacha MG, Bland KI, Chaudry IH (2001) Gender differences in the inflammatory response and survival following hemorrhage and subsequent sepsis. Cytokine 14:162-168
    • (2001) Cytokine , vol.14 , pp. 162-168
    • Diodato, M.1    Knoferl, M.W.2    Angele, M.K.3    Schwacha, M.G.4    Bland, K.I.5    Chaudry, I.H.6
  • 60
    • 0031906592 scopus 로고    scopus 로고
    • Testosterone and/or low estradiol: Normally required but harmful immunologically for males after trauma-hemorrhage
    • Angele MK, Ayala A, Monfils BA, Cioffi WG, Bland KI, Chaudry IH (1998) Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage. J Trauma 44:78-85
    • (1998) J Trauma , vol.44 , pp. 78-85
    • Angele, M.K.1    Ayala, A.2    Monfils, B.A.3    Cioffi, W.G.4    Bland, K.I.5    Chaudry, I.H.6
  • 62
    • 0030662536 scopus 로고    scopus 로고
    • Male sex steroids are responsible for depressing macrophage immune function after trauma-hemorrhage
    • Wichmann MW, Ayala A, Chaudry I (1997) Male sex steroids are responsible for depressing macrophage immune function after trauma-hemorrhage. Am J Physiol 273:C1335-C1340
    • (1997) Am J Physiol , vol.273
    • Wichmann, M.W.1    Ayala, A.2    Chaudry, I.3
  • 63
    • 0002077385 scopus 로고    scopus 로고
    • Male and female sex steroids: Do they produce deleterious or beneficial effects on immune responses following trauma-hemorrhage?
    • Angele MK, Knoferl MW, Ayala A, Cioffi WG, Bland K, Chaudry IH (1998) Male and female sex steroids: do they produce deleterious or beneficial effects on immune responses following trauma-hemorrhage? Surg Forum 49:43-45
    • (1998) Surg Forum , vol.49 , pp. 43-45
    • Angele, M.K.1    Knoferl, M.W.2    Ayala, A.3    Cioffi, W.G.4    Bland, K.5    Chaudry, I.H.6
  • 65
    • 0037854548 scopus 로고    scopus 로고
    • Do female sex steroids adversely or beneficially affect the depressed immune responses in males after trauma-hemorrhage?
    • Knoferl MW, Diodato MD, Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH (2000) Do female sex steroids adversely or beneficially affect the depressed immune responses in males after trauma-hemorrhage? Arch Surg 135:426-433
    • (2000) Arch Surg , vol.135 , pp. 426-433
    • Knoferl, M.W.1    Diodato, M.D.2    Angele, M.K.3    Ayala, A.4    Cioffi, W.G.5    Bland, K.I.6    Chaudry, I.H.7
  • 66
    • 0036213046 scopus 로고    scopus 로고
    • Preservation of splenic immune functions by female sex hormones after trauma-hemorrhage
    • Knoferl MW, Angele MK, Schwacha MG, Bland KI, Chaudry IH (2002) Preservation of splenic immune functions by female sex hormones after trauma-hemorrhage. Crit Care Med 30:888-893
    • (2002) Crit Care Med , vol.30 , pp. 888-893
    • Knoferl, M.W.1    Angele, M.K.2    Schwacha, M.G.3    Bland, K.I.4    Chaudry, I.H.5
  • 68
    • 0032843844 scopus 로고    scopus 로고
    • Male gender is a risk factor for major infections after surgery
    • Offner PJ, Moore EE, Biffl WL (1999) Male gender is a risk factor for major infections after surgery. Arch Surg 134:935-940
    • (1999) Arch Surg , vol.134 , pp. 935-940
    • Offner, P.J.1    Moore, E.E.2    Biffl, W.L.3
  • 69
    • 0033945528 scopus 로고    scopus 로고
    • Incidence of septic complications and multiple organ failure in severely injured patients is sex-specific
    • Oberholzer A, Keel M, Zellweger R, Steckholzer U, Trentz O, Ertel W (2000) Incidence of septic complications and multiple organ failure in severely injured patients is sex-specific. J Trauma 48:932-937
    • (2000) J Trauma , vol.48 , pp. 932-937
    • Oberholzer, A.1    Keel, M.2    Zellweger, R.3    Steckholzer, U.4    Trentz, O.5    Ertel, W.6
  • 70
    • 0031255106 scopus 로고    scopus 로고
    • Flutamide: A novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock
    • Wichmann MW, Angele MK, Ayala A, Cioffi WG, Chaudry I (1997) Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. Shock 8:1-7
    • (1997) Shock , vol.8 , pp. 1-7
    • Wichmann, M.W.1    Angele, M.K.2    Ayala, A.3    Cioffi, W.G.4    Chaudry, I.5
  • 72
    • 0033152402 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA) restores immune function following trauma-hemorrhage by a direct effect on T-lymphocytes
    • Catania RA, Angele MK, Ayala A, Cioffi WG, Bland K, Chaudry IH (1998) Dehydroepiandrosterone (DHEA) restores immune function following trauma-hemorrhage by a direct effect on T-lymphocytes. Cytokine 11:443-450
    • (1998) Cytokine , vol.11 , pp. 443-450
    • Catania, R.A.1    Angele, M.K.2    Ayala, A.3    Cioffi, W.G.4    Bland, K.5    Chaudry, I.H.6
  • 74
    • 0842305744 scopus 로고    scopus 로고
    • Perioperative recombinant human granulocyte colony-stimulating factor (Filgrastim) treatment prevents immunoinflammatory dysfunction associated with major surgery
    • Schneider C, von Aulock S, Zedler S, Schinkel C, Hartung T, Faist E (2004) Perioperative recombinant human granulocyte colony-stimulating factor (Filgrastim) treatment prevents immunoinflammatory dysfunction associated with major surgery. Ann Surg 239:75-81
    • (2004) Ann Surg , vol.239 , pp. 75-81
    • Schneider, C.1    Von Aulock, S.2    Zedler, S.3    Schinkel, C.4    Hartung, T.5    Faist, E.6
  • 75
    • 0037251467 scopus 로고    scopus 로고
    • How to leverage an endogenous immune defense mechanism: The example of granulocyte colony-stimulating factor
    • Hartung T, von Aulock S, Schneider C, Faist E (2003) How to leverage an endogenous immune defense mechanism: the example of granulocyte colony-stimulating factor. Crit Care Med 31:S65-S75
    • (2003) Crit Care Med , vol.31
    • Hartung, T.1    Von Aulock, S.2    Schneider, C.3    Faist, E.4
  • 76
    • 0031606321 scopus 로고    scopus 로고
    • Animal models of sepsis and shock: A review and lessons learned
    • Deitch EA (1998) Animal models of sepsis and shock: a review and lessons learned. Shock 9:1-11
    • (1998) Shock , vol.9 , pp. 1-11
    • Deitch, E.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.