Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: Implications for amyotrophic lateral sclerosis

Journal of Neurochemistry

Volumn 93, Issue 1, 2005, Pages 38-46

  Cassina, Patricia ^a   Pehar, Mariana ^a,b   Vargas, Marcelo R ^b   Castellanos, Raquel ^a   Barbeito, Ana G ^a   Estévez, Alvaro G ^c   Thompson, John A ^d   Beckman, Joseph S ^e   Barbeito, Luis ^b  

^a DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^b INSTITUTO DE INVESTIGACIONES BIOLÓGICAS CLEMENTE ESTABLE   (Uruguay)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d Kentucky   (United States)

^e OREGON STATE UNIVERSITY   (United States)

Author keywords

Amyotrophic lateral sclerosis; Astrocytes; Fibroblast growth factor receptor 1; Fibroblast growth factor 1; Motor neurons; Nitric oxide

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 1; NERVE GROWTH FACTOR; NEUTRALIZING ANTIBODY; PD 166866; PROTEIN P75; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL NUCLEUS; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; MOTONEURON; MOUSE; NERVE FIBER TRANSECTION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SPINAL CORD INJURY;

EID: 16244389278     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02984.x     Document Type: Article

References (47)

1. Beckman J. S., Estevez A. G., Crow J. P. and Barbeito L. (2001) Superoxide dismutase and the death of motoneurons in ALS. Trends Neurosci. 24, S15-S20.
2. Bruijn L. I., Miller T. M. and Cleveland D. W. (2004) Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu. Rev. Neurosci. 27, 723-749.
3. Burgess W. H. and Maciag T. (1989) The heparin-binding (fibroblast) growth factor family of proteins. Annu. Rev. Biochem. 58, 575-606.
4. Burke D., Wilkes D., Blundell T. L. and Malcolm S. (1998) Fibroblast growth factor receptors: lessons from the genes. Trends Biochem. Sci. 23, 59-62.
5. Cassina P., Peluffo H., Pehar M., Martinez-Palma L., Ressia A., Beckman J. S., Estevez A. G. and Barbeito L. (2002) Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. J. Neurosci. Res. 67, 21-29.
6. Clarke W. E., Berry M., Smith C., Kent A. and Logan A. (2001) Coordination of fibroblast growth factor receptor 1 (FGFR1) and fibroblast growth factor-2 (FGF-2) trafficking to nuclei of reactive astrocytes around cerebral lesions in adult rats. Mol. Cell Neurosci. 17, 17-30.
7. Crow J. P. (2000) Peroxynitrite scavenging by metalloporphyrins and thiolates. Free Radic. Biol. Med. 28, 1487-1494.
8. Cuevas P., Carceller F. and Gimenez-Gallego G. (1995) Acidic fibroblast growth factor prevents death of spinal cord motoneurons in newborn rats after nerve section. Neurol. Res. 17, 396-399.
9. Eckenstein F. P. (1994) Fibroblast growth factors in the nervous system. J. Neurobiol. 25, 1467-1480.
10. Eckenstein F. P., Shipley G. D. and Nishi R. (1991) Acidic and basic fibroblast growth factors in the nervous system: distribution and differential alteration of levels after injury of central versus peripheral nerve. J. Neurosci. 11, 412-419.
11. Elde R., Cao Y. H., Cintra A., Brelje T. C., Pelto-Huikko M., Junttila T., Fuxe K., Pettersson R. F. and Hokfelt T. (1991) Prominent expression of acidic fibroblast growth factor in motor and sensory neurons. Neuron 7, 349-364.
12. Estevez A. G., Spear N., Manuel S. M., Radi R., Henderson C. E., Barbeito L. and Beckman J. S. (1998) Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. J. Neurosci. 18, 923-931.
13. Estevez A. G., Crow J. P., Sampson J. B., Reiter C., Zhuang Y, Richardson G. J., Tarpey M. M., Barbeito L. and Beckman J. S. (1999) Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science 286, 2498-2500.
14. Estevez A. G., Kamaid A., Thompson J. A., Cornwell T. L., Radi R., Barbeito L. and Beckman J. S. (2002) Cyclic guanosine 5′ monophosphate (GMP) prevents expression of neuronal nitric oxide synthase and apoptosis in motor neurons deprived of trophic factors in rats. Neurosci. Lett. 326, 201-205.
15. Faulkner K. M., Liochev S. I. and Fridovich I. (1994) Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J. Biol. Chem. 269, 23 471-23 476.
16. Figueiredo B. C., Pluss K., Skup M., Otten U. and Cuello A. C. (1995) Acidic FGF induces NGF and its mRNA in the injured neocortex of adult animals. Brain Res. Mol Brain Res. 33, 1-6.
17. Gonzalez A. M., Berry M., Maher P. A., Logan A. and Baird A. (1995) A comprehensive analysis of the distribution of FGF-2 and FGFR1 in the rat brain. Brain Res. 701, 201-226.
18. Gurney M. E., Pu H., Chiu A. Y. et al. (1994) Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264, 1772-1775.
19. Henderson C. E., Bloch-Gallego E. and Camu W. (1995) Purification and culture of embryonic motorneurons, in Neural Cell Culture: a Practical Approach (Cohen, J. and Wilkin, G., eds), pp. 61-81. IRL Press, Oxford, England.
20. Hooper D. C., Spitsin S., Kean R. B., Champion J. M., Dickson G. M., Chaudhry I. and Koprowski H. (1998) Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl Acad. Sci. USA 95, 675-680.
21. Kage M., Yang Q., Sato H., Matsumoto S., Kaji R., Akiguchi I., Kimura H. and Tooyama I. (2001) Acidic fibroblast growth factor (FGF-1) in the anterior horn cells of ALS and control cases. Neuroreport 12, 3799-3803.
22. Kresse A., Pettersson R. and Hokfelt T. (1995) Distribution of acidic fibroblast growth factor mRNA-expressing neurons in the adult mouse central nervous system. J. Comp. Neurol. 359, 323-339.
23. Laird J. M., Mason G. S., Thomas K. A., Hargreaves R. J. and Hill R. G. (1995) Acidic fibroblast growth factor stimulates motor and sensory axon regeneration after sciatic nerve crush in the rat. Neuroscience 65, 209-216.
24. Landriscina M., Bagala C., Mandinova A., Soldi R., Micucci I., Bellum S., Prudovsky I. and Maciag T. (2001) Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor I in response to stress. J. Biol. Chem. 276, 25 549-25 557.
25. Liu X. and Zhu X. Z. (1999) Increased expression and nuclear accumulation of basic fibroblast growth factor in primary cultured astrocytes following ischemic-like insults. Brain Res. Mol Brain Res. 71, 171-177.
26. Mandinov L., Mandinova A., Kyurkchiev S. et al. (2003) Copper chelation represses the vascular response to injury. Proc. Natl Acad. Sci. USA 100, 6700-6705.
27. Mouta Carreira C., Landriscina M., Bellum S., Prudovsky I. and Maciag T. (2001) The comparative release of FGF1 by hypoxia and temperature stress. Growth Factors 18, 277-285.
28. Ono T., Saito H., Kishimoto T., Okumoto T. and Miyamoto K. (1991) Stimulation of biosynthesis of nerve growth factor by acidic fibroblast growth factor in cultured mouse astrocytes. Neurosci. Lett. 126, 18-20.
29. Opalenik S. R., Ding Q., Mallery S. R. and Thompson J. A. (1998) Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor. Arch. Biochem. Biophys. 351, 17-26.
30. Panek R. L., Lu G. H., Dahring T. K., Batley B. L., Connolly C., Hamby J. M. and Brown K. J. (1998) In vitro biological characterization and anti-angiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J. Pharmacol. Exp. Ther. 286, 569-577.
31. Pechan P. A., Chowdhury K., Gerdes W. and Seifert W. (1993) Glutamate induces the growth factors NGF, bFGF, the receptor FGF-R1 and c-fos mRNA expression in rat astrocyte culture. Neurosci. Lett. 153, 111-114.
32. Pehar M., Cassina P., Vargas M. R., Castellanos R., Viera L., Beckman J. S., Estevez A. G. and Barbeito L. (2004) Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis. J. Neurochem. 89, 464-473.
33. Raoul C., Pettmann B. and Henderson C. E. (2000) Active killing of neurons during development and following stress: a role for p75 (NTR) and Fas? Curr. Opin. Neurobiol. 10, 111-117.
34. Raoul C., Estevez A. G., Nishimune H., Cleveland D. W., deLapeyriere O., Henderson C. E., Haase G. and Pettmann B. (2002) Motoneuron death triggered by a specific pathway downstream of Fas: potentiation by ALS-linked SOD1 mutations. Neuron 35, 1067-1083.
35. Ryken T. C., Traynelis V. C. and Lim R. (1992) Interaction of acidic fibroblast growth factor and transforming growth factor-β in normal and transformed glia in vitro. J. Neurosurg. 76, 850-855.
36. Shin J. T., Barbeito L., MacMillan-Crow L. A., Beckman J. S. and Thompson J. A. (1996a) Acidic fibroblast growth factor enhances peroxynitrite-induced apoptosis in primary murine fibroblasts. Arch. Biochem. Biophys. 335, 32-41.
37. Shin J. T., Opalenik S. R., Wehby J. N., Mahesh V. K., Jackson A., Tarantini F., Maciag T. and Thompson J. A. (1996b) Serum-starvation induces the extracellular appearance of FGF-1. Biochim. Biophys. Acta 1312, 27-38.
38. Stachowiak M. K., Maher P. A., Joy A., Mordechai E. and Stachowiak E. K. (1996) Nuclear localization of functional FGF receptor 1 in human astrocytes suggests a novel mechanism for growth factor action. Brain Res. Mol Brain Res. 38, 161-165.
39. Stachowiak E. K., Maher P. A., Tucholski J., Mordechai E., Joy A., Moffett J., Coons S. and Stachowiak M. K. (1997) Nuclear accumulation of fibroblast growth factor receptors in human glial cells - association with cell proliferation. Oncogene 14, 2201-2211.
40. Stachowiak M. K., Fang X., Myers J. M., Dunham S. M., Berezney R., Maher P. A. and Stachowiak E. K. (2003) Integrative nuclear FGFR1 signaling (INFS) as a part of a universal 'feed-forward-and-gate' signaling module that controls cell growth and differentiation. J. Cell Biochem. 90, 662-691.
41. Szebenyi G. and Fallon J. F. (1999) Fibroblast growth factors as multifunctional signaling factors. Int. Rev. Cytol. 185, 45-106.
42. Teng Y. D., Mocchetti I. and Wrathall J. R. (1998) Basic and acidic fibroblast growth factors protect spinal motor neurones in vivo after experimental spinal cord injury. Eur. J. Neurosci. 10, 798-802.
43. Teng Y. D., Mocchetti I., Taveira-DaSilva A. M., Gillis R. A. and Wrathall J. R. (1999) Basic fibroblast growth factor increases long-term survival of spinal motor neurons and improves respiratory function after experimental spinal cord injury. J. Neurosci. 19, 7037-7047.
44. Vige X., Costa E. and Wise B. C. (1991) Mechanism of nerve growth factor mRNA regulation by interleukin-1 and basic fibroblast growth factor in primary cultures of rat astrocytes. Mol. Pharmacol. 40, 186-192.
45. Walicke P. A. (1988) Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions. J. Neurosci. 8, 2618-2627.
46. Wu A. S., Kiaei M., Aguirre N., Crow J. P., Calingasan N. Y., Browne S. E. and Beal M. F. (2003) Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis. J. Neurochem. 85, 142-150.
47. Yoshida K. and Gage F. H. (1991) Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes. Brain Res. 538, 118-126.