Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1-mediated motor neuron cell death and increase amyotrophic lateral sclerosis-like transgenic mouse survival

Journal of Neurochemistry

Volumn 80, Issue 3, 2002, Pages 488-500

  Liu, Rugao ^a,b   Li, Baolin ^c   Flanagan, Shawn W ^d   Oberley, Larry W ^d   Gozal, David ^a   Qiu, Mengsheng ^b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

ALS; GPX4; Lipid peroxidation; MnSOD; Motor neuron degeneration; SOD1 mutation

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; ADENOVIRUS VECTOR; CYTOCHROME C; GENE PRODUCT; MANGANESE SUPEROXIDE DISMUTASE; MUTANT PROTEIN; OXYGEN RADICAL; POLYUNSATURATED FATTY ACID; PROTEIN GPX4; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME RELEASE; ENZYME STRUCTURE; GENE OVEREXPRESSION; IN VITRO STUDY; LIPID PEROXIDATION; MITOCHONDRION; MOTONEURON; MOUSE; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PARALYSIS; PRIORITY JOURNAL; SPIN TRAPPING; SURVIVAL RATE; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTIOXIDANTS; CELL DEATH; CELLS, CULTURED; CYCLIC N-OXIDES; ELECTRON TRANSPORT COMPLEX IV; GLUTATHIONE PEROXIDASE; LIPID PEROXIDATION; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MOTOR NEURONS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; SURVIVAL RATE;

ADENOVIRIDAE; ANIMALIA; MUS MUSCULUS;

EID: 0036488219     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-3042.2001.00720.x     Document Type: Article

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