AAV vector-mediated RNAi of mutant Huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease

Molecular Therapy

Volumn 16, Issue 5, 2008, Pages 947-956

  Franich, Nicholas R ^a   Fitzsimons, Helen L ^b   Fong, Dahna M ^a   Klugmann, Matthias ^c   During, Matthew J ^a,d   Young, Deborah ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b Neurologix Inc   (United States)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN; MESSENGER RNA; MUTANT PROTEIN; PARVOVIRUS VECTOR; SHORT HAIRPIN RNA;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE COURSE; DRUG MECHANISM; EXON; GENE TRANSFER; GENETIC MODEL; GENETIC TRANSDUCTION; GLOBUS PALLIDUS; HUNTINGTON CHOREA; IMMUNOHISTOCHEMISTRY; MALE; MOTOR DYSFUNCTION; NERVE CELL NECROSIS; NERVE DEGENERATION; NERVE FIBER TRANSPORT; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SUBSTANTIA NIGRA; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS RECOMBINANT;

ADENO-ASSOCIATED VIRUS; MUS MUSCULUS; RATTUS;

EID: 42549134402     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2008.50     Document Type: Article

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