-
1
-
-
0032948363
-
Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women
-
Legro RS, Kunselman AR, Dodson WC, Dunaif A 1999 Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 84:165-169
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 165-169
-
-
Legro, R.S.1
Kunselman, A.R.2
Dodson, W.C.3
Dunaif, A.4
-
2
-
-
0033963780
-
The prevalence of polycystic ovaries in women with type 2 diabetes mellitus
-
Oxf
-
Conn JJ, Jacobs HS, Conway GS 2000 The prevalence of polycystic ovaries in women with type 2 diabetes mellitus. Clin Endocrinol (Oxf) 52:81-86
-
(2000)
Clin Endocrinol
, vol.52
, pp. 81-86
-
-
Conn, J.J.1
Jacobs, H.S.2
Conway, G.S.3
-
3
-
-
0031787388
-
A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome
-
Legro RS, Finegood D, Dunaif A 1998 A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 83:2694-2698
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 2694-2698
-
-
Legro, R.S.1
Finegood, D.2
Dunaif, A.3
-
4
-
-
0031790832
-
Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositol glycan mediators as the signal transduction system
-
Nestler JE, Jakubowicz DJ, de Vargas AF, Brik C, Quintero N, Medina F 1998 Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositol glycan mediators as the signal transduction system. J Clin Endocrinol Metab 83:2001-2005
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 2001-2005
-
-
Nestler, J.E.1
Jakubowicz, D.J.2
De Vargas, A.F.3
Brik, C.4
Quintero, N.5
Medina, F.6
-
5
-
-
0029873153
-
Can metformin reduce insulin resistance in polycystic ovary syndrome?
-
Acbay O, Gundogdu S 1996 Can metformin reduce insulin resistance in polycystic ovary syndrome? Fertil Steril 65:946-949
-
(1996)
Fertil Steril
, vol.65
, pp. 946-949
-
-
Acbay, O.1
Gundogdu, S.2
-
6
-
-
0029795871
-
The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome
-
Dunaif A, Scott D, Finegood D, Quintana B, Whitcomb R 1996 The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. J Clin Endocrinol Metab 81:3299-3306
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 3299-3306
-
-
Dunaif, A.1
Scott, D.2
Finegood, D.3
Quintana, B.4
Whitcomb, R.5
-
7
-
-
0032583935
-
Insulin-sensitizing agents in polycystic ovary syndrome
-
Sattar N, Hopkinson ZE, Greer IA 1998 Insulin-sensitizing agents in polycystic ovary syndrome. Lancet 351:305-307
-
(1998)
Lancet
, vol.351
, pp. 305-307
-
-
Sattar, N.1
Hopkinson, Z.E.2
Greer, I.A.3
-
8
-
-
0030783316
-
Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 α activity and serum androgens
-
Nestler JE, Jakubowicz DJ 1997 Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 α activity and serum androgens. J Clin Endocrinol Metab 82:4075-4079
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 4075-4079
-
-
Nestler, J.E.1
Jakubowicz, D.J.2
-
9
-
-
0033963473
-
Metformin treatment reduces ovarian cytochrome P-450c17 response to human chorionic gonadotrophin in woen with insulin resistance-polycystic ovary syndrome
-
La Marca A, Egbe TO, Morgante G, Paglia T, Ciani A, de Leo V 2000 Metformin treatment reduces ovarian cytochrome P-450c17 response to human chorionic gonadotrophin in woen with insulin resistance-polycystic ovary syndrome. Hum Reprod 15:21-23
-
(2000)
Hum Reprod
, vol.15
, pp. 21-23
-
-
La Marca, A.1
Egbe, T.O.2
Morgante, G.3
Paglia, T.4
Ciani, A.5
De Leo, V.6
-
10
-
-
0029995670
-
Thiazolidinediones in the treatment of insulin resistance and type II diabetes
-
Saltiel AR, Olefsky JM 1996 Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 45:1661-1669
-
(1996)
Diabetes
, vol.45
, pp. 1661-1669
-
-
Saltiel, A.R.1
Olefsky, J.M.2
-
11
-
-
0032937815
-
Effect of troglitazone on endocrine and ovulatory performance in women with insulin resistance-related polycystic ovary syndrome
-
Hasegawa I, Murakawa H, Suzuki M, Yamamoto Y, Kurabayashi T, Tanaka K 1999 Effect of troglitazone on endocrine and ovulatory performance in women with insulin resistance-related polycystic ovary syndrome. Fertil Steril 71:323-327
-
(1999)
Fertil Steril
, vol.71
, pp. 323-327
-
-
Hasegawa, I.1
Murakawa, H.2
Suzuki, M.3
Yamamoto, Y.4
Kurabayashi, T.5
Tanaka, K.6
-
12
-
-
0029878178
-
Molecular scanning of the insulin receptor gene in women with polycystic ovarian syndrome
-
Talbot JA, Bicknell EJ, Rajkhowa M, Krook A, O'Rahilly S, Clayton RN 1996 Molecular scanning of the insulin receptor gene in women with polycystic ovarian syndrome. J Clin Endocrinol Metab 81:1979-1983
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 1979-1983
-
-
Talbot, J.A.1
Bicknell, E.J.2
Rajkhowa, M.3
Krook, A.4
O'Rahilly, S.5
Clayton, R.N.6
-
13
-
-
0026756778
-
Cellular mechanisms of insulin resistance in polycystic ovary syndrome
-
Ciaraldi TP, El-Roeiy A, Madar Z, Reichart D, Olefsky JM, Yen SSC 1992 Cellular mechanisms of insulin resistance in polycystic ovary syndrome. J Clin Endocrinol Metab 75:577-583
-
(1992)
J Clin Endocrinol Metab
, vol.75
, pp. 577-583
-
-
Ciaraldi, T.P.1
El-Roeiy, A.2
Madar, Z.3
Reichart, D.4
Olefsky, J.M.5
Yen, S.S.C.6
-
14
-
-
0031880952
-
Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome
-
Ciaraldi TP, Morales AJ, Hickman MG, Odom-Ford R, Yen SSC, Olefsky JM 1998 Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome. Metabolism 47:940-946
-
(1998)
Metabolism
, vol.47
, pp. 940-946
-
-
Ciaraldi, T.P.1
Morales, A.J.2
Hickman, M.G.3
Odom-Ford, R.4
Yen, S.S.C.5
Olefsky, J.M.6
-
15
-
-
0029119085
-
Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle
-
Dunaif A, Xia J, Book C, Schenker E, Tang Z 1995 Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. J Clin Invest 96:801-810
-
(1995)
J Clin Invest
, vol.96
, pp. 801-810
-
-
Dunaif, A.1
Xia, J.2
Book, C.3
Schenker, E.4
Tang, Z.5
-
17
-
-
0033304892
-
Selective insulin resistance in the polycystic ovary syndrome
-
Book CB, Dunaif A 1999 Selective insulin resistance in the polycystic ovary syndrome. J Clin Endocrinol Metab 84:3110-3116
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 3110-3116
-
-
Book, C.B.1
Dunaif, A.2
-
18
-
-
0035051203
-
Luteinizing hormone receptor, steroidogenesis acute regulatory protein and steroidogenic enzyme messenger ribonucleic acids are over-expressed in theca and granulosa cells from polycystic ovaries
-
Jakimiuk AJ, Weitsman SR, Navab A, Magoffin DA 2001 Luteinizing hormone receptor, steroidogenesis acute regulatory protein and steroidogenic enzyme messenger ribonucleic acids are over-expressed in theca and granulosa cells from polycystic ovaries. J Clin Endocrinol Metab 86:1318-1323
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 1318-1323
-
-
Jakimiuk, A.J.1
Weitsman, S.R.2
Navab, A.3
Magoffin, D.A.4
-
19
-
-
0027411120
-
Regulation of androgen production in cultured human thecal cells by insulin-like growth factor 1 and insulin
-
Bergh C, Carlsson B, Olsson J-H, Selleskog U, Hillensjo T 1993 Regulation of androgen production in cultured human thecal cells by insulin-like growth factor 1 and insulin. Fertil Steril 59:323-331
-
(1993)
Fertil Steril
, vol.59
, pp. 323-331
-
-
Bergh, C.1
Carlsson, B.2
Olsson, J.-H.3
Selleskog, U.4
Hillensjo, T.5
-
20
-
-
0028921511
-
Metabolic regulation of androgen production by human thecal cells in vitro
-
Nahum R, Thong KJ, Hillier SG 1995 Metabolic regulation of androgen production by human thecal cells in vitro. Human Reprod 10:75-81
-
(1995)
Human Reprod
, vol.10
, pp. 75-81
-
-
Nahum, R.1
Thong, K.J.2
Hillier, S.G.3
-
21
-
-
0030756092
-
Identification of common ligand binding determinants of the insulin and insulin-like growth factor I receptors. Insights into mechanisms of ligand binding
-
Mynarcik DC, Williams PF, Schaffer L, Yu GQ, Whittaker J 1997 Identification of common ligand binding determinants of the insulin and insulin-like growth factor I receptors. Insights into mechanisms of ligand binding. J Biol Chem 272:18650-18655
-
(1997)
J Biol Chem
, vol.272
, pp. 18650-18655
-
-
Mynarcik, D.C.1
Williams, P.F.2
Schaffer, L.3
Yu, G.Q.4
Whittaker, J.5
-
22
-
-
0023687661
-
Expression and characterization of a functional human insulin-like growth factor I receptor
-
Steele-Perkins G, Turner J, Edman JC, Hari J, Pierce SB, Stover C, Rutter WJ, Roth RA1988 Expression and characterization of a functional human insulin-like growth factor I receptor. J Biol Chem 263:11486-11492
-
(1988)
J Biol Chem
, vol.263
, pp. 11486-11492
-
-
Steele-Perkins, G.1
Turner, J.2
Edman, J.C.3
Hari, J.4
Pierce, S.B.5
Stover, C.6
Rutter, W.J.7
Roth, R.A.8
-
23
-
-
0020353998
-
Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action
-
Roth RA, Cassell DJ, Wong KY, Maddux BA, Goldfine ID 1982 Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action. Proc Natl Acad Sci USA 79:7312-7316
-
(1982)
Proc Natl Acad Sci USA
, vol.79
, pp. 7312-7316
-
-
Roth, R.A.1
Cassell, D.J.2
Wong, K.Y.3
Maddux, B.A.4
Goldfine, I.D.5
-
24
-
-
0022658554
-
Interaction of the monoclonal antibodies αIR-1 and αIR-3 with insulin and somatomedin-C receptors
-
Jacobs S, Cook S, Svoboda ME, Van Wyk JJ 1986 Interaction of the monoclonal antibodies αIR-1 and αIR-3 with insulin and somatomedin-C receptors. Endocrinology 118:223-226
-
(1986)
Endocrinology
, vol.118
, pp. 223-226
-
-
Jacobs, S.1
Cook, S.2
Svoboda, M.E.3
Van Wyk, J.J.4
-
25
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos CJ, Matter WF, Hui KY, Brown RF 1994 A specific inhibitor of phosphatidylinositol 3-kinase, 2-(morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269:5241-5248
-
(1994)
J Biol Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
26
-
-
0034455274
-
The insulin signaling system - A common link in the pathogenesis of type 2 diabetes
-
Withers DJ, White M 2000 The insulin signaling system - a common link in the pathogenesis of type 2 diabetes. Endocrinology 141:1917-1921
-
(2000)
Endocrinology
, vol.141
, pp. 1917-1921
-
-
Withers, D.J.1
White, M.2
-
27
-
-
0028884033
-
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
-
Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR 1995 PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494
-
(1995)
J Biol Chem
, vol.270
, pp. 27489-27494
-
-
Alessi, D.R.1
Cuenda, A.2
Cohen, P.3
Dudley, D.T.4
Saltiel, A.R.5
-
28
-
-
14444279192
-
Identification of a novel inhibitor of mitogen-activated protein kinase kinase
-
Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM 1998 Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623-18632
-
(1998)
J Biol Chem
, vol.273
, pp. 18623-18632
-
-
Favata, M.F.1
Horiuchi, K.Y.2
Manos, E.J.3
Daulerio, A.J.4
Stradley, D.A.5
Feeser, W.S.6
Van Dyk, D.E.7
Pitts, W.J.8
Earl, R.A.9
Hobbs, F.10
Copeland, R.A.11
Magolda, R.L.12
Scherle, P.A.13
Trzaskos, J.M.14
-
30
-
-
0030693249
-
Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: Quantification of individual receptor species by selective immunoprecipitation and immunoblotting
-
Bailyes EM, Nave BT, Soos MA, Orr SR, Hayward AC, Siddle K 1997 Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting. Biochem J 327(Pt 1):209-215
-
(1997)
Biochem J
, vol.327
, Issue.1 PART
, pp. 209-215
-
-
Bailyes, E.M.1
Nave, B.T.2
Soos, M.A.3
Orr, S.R.4
Hayward, A.C.5
Siddle, K.6
-
31
-
-
0022499671
-
Identification of a monoclonal antibody which can distinguish between two distinct species of the type I receptor for insulin-like growth factor
-
Morgan DO, Roth RA 1986 Identification of a monoclonal antibody which can distinguish between two distinct species of the type I receptor for insulin-like growth factor. Biochem Biophys Res Commun 138:1341-1347
-
(1986)
Biochem Biophys Res Commun
, vol.138
, pp. 1341-1347
-
-
Morgan, D.O.1
Roth, R.A.2
-
32
-
-
0020962492
-
Monoclonal antibodies to receptors for insulin and somatomedin-C
-
Kull FC, Jacobs S, Su YF, Svoboda ME, Van Wyk JJ, Cuatrecasas P 1983 Monoclonal antibodies to receptors for insulin and somatomedin-C. J Biol Chem 258:6561-6566
-
(1983)
J Biol Chem
, vol.258
, pp. 6561-6566
-
-
Kull, F.C.1
Jacobs, S.2
Su, Y.F.3
Svoboda, M.E.4
Van Wyk, J.J.5
Cuatrecasas, P.6
-
33
-
-
0026699302
-
Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome
-
Dunaif A, Segal KR, Shelley DR, Green G, Dobrjansky A, Licholai T 1992 Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes 41:1257-1266
-
(1992)
Diabetes
, vol.41
, pp. 1257-1266
-
-
Dunaif, A.1
Segal, K.R.2
Shelley, D.R.3
Green, G.4
Dobrjansky, A.5
Licholai, T.6
-
34
-
-
0033913213
-
Signaling pathways in insulin action: Molecular targets of insulin resistance
-
Pessin JE, Saltiel AR 2000 Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest 106:165-169
-
(2000)
J Clin Invest
, vol.106
, pp. 165-169
-
-
Pessin, J.E.1
Saltiel, A.R.2
-
35
-
-
0042570843
-
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
-
Virkamaki A, Ueki K, Kahn CR 1999 Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103:931-943
-
(1999)
J Clin Invest
, vol.103
, pp. 931-943
-
-
Virkamaki, A.1
Ueki, K.2
Kahn, C.R.3
-
36
-
-
0035896580
-
Insulin suppresses transactivation by CAAT/enhancer-binding proteins β (C/EPBβ). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPβ
-
Guo S, Cichy SB, He X, Yang Q, Ragland M, Ghosh AK, Johnson PF, Unterman TG 2001 Insulin suppresses transactivation by CAAT/enhancer-binding proteins β (C/EPBβ). signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPβ. J Biol Chem 276:8516-8523
-
(2001)
J Biol Chem
, vol.276
, pp. 8516-8523
-
-
Guo, S.1
Cichy, S.B.2
He, X.3
Yang, Q.4
Ragland, M.5
Ghosh, A.K.6
Johnson, P.F.7
Unterman, T.G.8
-
37
-
-
0037144496
-
Protein kinase C-ζ regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-α in glioma cells via NF-κB
-
Esteve PO, Chicoine E, Robledo O, Van Themsche C, Potworowski EF, St-Pierre Y 2002 Protein kinase C-ζ regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-α in glioma cells via NF-κB. J Biol Chem 277:35150-35155
-
(2002)
J Biol Chem
, vol.277
, pp. 35150-35155
-
-
Esteve, P.O.1
Chicoine, E.2
Robledo, O.3
Van Themsche, C.4
Potworowski, E.F.5
St-Pierre, Y.6
-
38
-
-
0032718056
-
Signal transduction pathways that regulate eukaryotic protein synthesis
-
Rhoads RE 1999 Signal transduction pathways that regulate eukaryotic protein synthesis. J Biol Chem 274:30337-30340
-
(1999)
J Biol Chem
, vol.274
, pp. 30337-30340
-
-
Rhoads, R.E.1
-
39
-
-
0035958046
-
The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis
-
Seger R, Hanoch T, Rosenberg R, Dantes A, Merz WE, Strauss 3rd JF, Amsterdam A 2001 The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis. J Biol Chem 276:13957-13964
-
(2001)
J Biol Chem
, vol.276
, pp. 13957-13964
-
-
Seger, R.1
Hanoch, T.2
Rosenberg, R.3
Dantes, A.4
Merz, W.E.5
Strauss III, J.F.6
Amsterdam, A.7
-
40
-
-
0037424532
-
cAMP-Dependent protein kinase enhances CYP17 transcription via MKP-1 activation in H295R human adrenocortical cells
-
Sewer MB, Waterman MR 2003 cAMP-Dependent protein kinase enhances CYP17 transcription via MKP-1 activation in H295R human adrenocortical cells. J Biol Chem 278:8106-8111
-
(2003)
J Biol Chem
, vol.278
, pp. 8106-8111
-
-
Sewer, M.B.1
Waterman, M.R.2
-
41
-
-
0035907330
-
Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta-hydroxysteroid dehydrogenase
-
Arlt W, Auchus RJ, Miller WL 2001 Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta-hydroxysteroid dehydrogenase. J Biol Chem 276:16767-16771
-
(2001)
J Biol Chem
, vol.276
, pp. 16767-16771
-
-
Arlt, W.1
Auchus, R.J.2
Miller, W.L.3
-
42
-
-
0028032417
-
Potentiation of insulin stimulation of PI3-kinase by thiazolidinedione- derived antidiabetic agents in Chinese hamster ovary cells expressing human insulin receptors and L6 myotubes
-
Zhang B, Szalkowski D, Diaz E, Hayes N, Smith R, Berger J 1994 Potentiation of insulin stimulation of PI3-kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human insulin receptors and L6 myotubes. J Biol Chem 269:25735-25741
-
(1994)
J Biol Chem
, vol.269
, pp. 25735-25741
-
-
Zhang, B.1
Szalkowski, D.2
Diaz, E.3
Hayes, N.4
Smith, R.5
Berger, J.6
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