Effect of leptin on CYP17 enzymatic activities in human adrenal cells: New insight in the onset of adrenarche

Endocrinology

Volumn 141, Issue 4, 2000, Pages 1446-1454

  Biason Lauber, A ^a   Zachmann, M ^a   Schoenle, E J ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE PRECURSOR; HYDROCORTISONE; LEPTIN; LEPTIN RECEPTOR; MICROSOME ENZYME; PRASTERONE; RECOMBINANT LEPTIN; SEX HORMONE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE;

ADRENAL CELL; ADRENARCHE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; MICROSOME; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034456536     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.141.4.7402     Document Type: Article

References (18)

1. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
2. Leptin is a metabolic signal to the reproductive system
3. Congenital leptin deficiency is associated with severe early-onset obesity in humans
4. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
5. Serum leptin levels in normal children: Relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage
6. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty
7. Leptin, insulin dehydroepiandrosterone and body fat in under and overweight children with Prader-Labhart-Willi syndrome
8. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland
9. Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland
10. Serine phosphorylation of human P450c17 increases 17,20-lyase activity: Implications for adrenarche and polycystic ovary syndrome
11. A single amino acid substitution in the putative redox partner binding site as cause of isolated 17,20-lyase deficiency
12. cAMP-dependent transactivation involving the homeodomain protein Pbx1
13. 5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer
14. 5
15. Identification and expression cloning of a leptin receptor, OB-R
16. Expression of Ob receptor in normal human adrenals: Differential regulation of adrenocortical and adrenomedullary function by leptin
17. Control of adrenal androgen secretion
18. Regulation of the acute production of steroids in steroidogenic cells