Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

European Journal of Immunology

Volumn 28, Issue 8, 1998, Pages 2320-2330

  Avraham, Ayelet ^a   Jung, Steffen ^a   Samuels, Yardena ^a   Seger, Rony ^b   Ben Neriah, Yinon ^a  

^a HEBREW UNIVERSITY   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

c Jun N terminal kinase; CD28; JNK kinase activation; PKC ; T cell co stimulation

Indexed keywords

CALCINEURIN; CD28 ANTIGEN; CELL CYCLE PROTEIN; PROTEIN KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; ONCOGENE C JUN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCINEURIN; CDC42 GTP-BINDING PROTEIN; CELL CYCLE PROTEINS; ENZYME ACTIVATION; GTP-BINDING PROTEINS; HUMANS; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MAP KINASE KINASE 4; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PROTEIN KINASE C; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSFECTION;

EID: 0031903616     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199808)28:08<2320::AID-IMMU2320>3.0.CO;2-K     Document Type: Article

References (37)

1. Schwartz, R. H., T cell clonal anergy. Curr. Opin. Immunol. 1997. 9: 351-357.
2. Jung, S., Yaron, A., Alkalay, I., Hatzubai, A., Avraham, A. and Ben-Neriah, Y., Costimulation requirement for AP-1 and NF-kappa B transcription factor activation in T cells. Annu. N. Y. Acad. Sci. 1995. 766: 245-252.
3. Rao, A., Luo, C. and Hogan, P. G., Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 1997. 15: 707-747.
4. Cantrell, D., T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 1996. 14: 259-274.
5. Lenschow, D. J., Walunas, T. L. and Bluestone, J. A., CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 1996. 14: 233-258.
6. Ward, S. G., CD28: a signaling perspective. Biochem. J. 1996. 318: 361-377.
7. Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M. and Ben-Neriah, Y., JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994. 77: 727-736.
8. Kang, S. M., Beverly, B., Tran, A. C., Brorson, K., Schwartz, R. H. and Lenardo, M. J., Transactivation by AP-1 is a molecular target of T cell clonal anergy. Science 1992. 257: 1134-1138.
9. Li, W., Whaley, C. D., Mondino, A. and Mueller, D. L., Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells [see comments]. Science 1996. 271: 1272-1276.
10. Robinson, M. J. and Cobb, M. H., Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 1997. 9: 180-186.
11. Seger, R. and Krebs, E. G., The MARK signaling cascade. FASEB J. 1995. 9: 726-735.
12. Sanchez, I., Hughes, R. T., Mayer, B. J., Yee, K., Woodgett, J. R., Avruch, J., Kyriakis, J. M. and Zon, L. I., Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 1994. 372: 794-798.
13. Tournier, C., Whitmarsh, A. J., Cavanagh, J., Barrett, T. and Davis, R. J., Mitogen-activated protein kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc. Natl. Acad. Sci. USA 1997. 94: 7337-7342.
14. Fanger, G. R., Gerwins, P., Widmann, C., Jarpe, M. B. and Johnson, G. L., MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun aminoterminal kinases? Curr. Opin. Genet. Dev. 1997. 7: 67-74.
15. Sells, M. A. and Chernoff, J., Emerging from the PAK: the p21-activated protein kinase family. Trends Cell Biol. 1997. 7: 162-167.
16. Minden, A. and Karin, M., Regulation and function of the JNK subgroup of MAP kinases. Biochim. Biophys. Acta 1997. 1333: F85-104.
17. Nishina, H., Bachmann, M., OliveiradosSantos, A. J., Kozieradzki, I., Fischer, K. D., Odermatt, B., Wakeham, A., Shahinian, A., Takimoto, H., Bernstein, A., Mak, T. W., Woodgett, J. R., Ohashi, P. S. and Penninger, J. M., Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J. Exp. Med. 1997. 186: 941-953.
18. Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J. and Davis, R. J., Proinflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 1995. 270: 7420-7426.
19. Baier-Bitterlich, G., Uberall, F., Bauer, B., Fresser, F., Wachter, H., Grunicke, H., Utermann, G., Altman, A. and Baier, G., Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes. Mol. Cell Biol. 1996. 16: 1842-1850.
20. Monks, C. R., Kupfer, H., Tamir, I., Barlow, A. and Kupfer, A., Selective modulation of protein kinase C-theta during T-cell activation. Nature 1997. 385: 83-86.
21. Clipstone, N. A. and Crabtree, G. R., Identification of calcineurin as a key signaling enzyme in T-lymphocyte activation. Nature 1992. 357: 695-697.
22. Stowers, L., Yelon, D., Berg, L. J. and Chant, J., Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc. Natl. Acad. Sci. USA 1995. 92: 5027-5031.
23. Crespo, P., Schuebel, K. E., Ostrom, A. A., Gutkind, J. S. and Bustelo, X. R., Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav protooncogene product. Nature 1997. 385: 169-172.
24. Han, J., Das, B., Wei, W., Van Aelst, L., Mosteller, R. D., Khosravi-Far, R., Westwick, J. K., Der, C. J. and Broek, D., Lck regulates Vav activation of members of the Rho family of GTPases. Mol. Cell Biol. 1997. 17: 1346-1353.
25. Lu, X., Wu, X., Plemenitas, A., Yu, H., Sawai, E. T., Abo, A. and Peterlin, B. M., CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1. Curr. Biol. 1996. 6: 1677-1684.
26. Bretscher, P. and Cohn, M., A theory of self-nonself discrimination. Science 1970. 169: 1042-1049.
27. Healy, J. I., Dolmetsch, R. E., Timmerman, L. A., Cyster, J. G., Thomas, M. L., Crabtree, G. R., Lewis, R. S. and Goodnow, C. C., Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity 1997. 6: 419-428.
28. Jacinto, E., Werlen, G. and Karin, M., Cooperation between Syk and Rad leads to synergistic JNK activation in T lymphocytes. Immunity 1998. 8: 31-41.
29. Collins, T. L., Deckert, M. and Altman, A., Views on Vav. Immunol. Today 1997. 18: 221-225.
30. Genot, E., Cleverley, S., Henning, S. and Cantrell, D., Multiple p21ras effector pathways regulate nuclear factor of activated T cells. EMBO J. 1996. 15: 3923-3933.
31. Symons, M., Derry, J. M., Karlak, B., Jiang, S., Lemahieu, V., McCormick, F., Francke, U. and Abo, A., Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 1996. 84: 723-734.
32. Kupfer, A., Mosmann, T. R. and Kupfer, H., Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells. Proc. Natl. Acad. Sci. USA 1991. 88: 775-779.
33. Kupfer, H., Monks, C. R. and Kupfer, A., Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions. J. Exp. Med. 1994. 179: 1507-1515.
34. Kaga, S., Ragg, S., Rogers, K. A. and Ochi, A., Stimulation of CD28 with B7-2 promotes focal adhesion-like cell contacts where Rho family small G proteins accumulate in T cells. J. Immunol. 1998. 160: 24-27.
35. Weiss, A. and Littman, D. R., signal transduction by lymphocyte antigen receptors. Cell 1994. 76: 263-274.
36. Wu, Z., Wu, J., Jacinto, E. and Karin, M., Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. Mol. Cell Biol. 1997. 17: 7407-7416.
37. Seger, R., Ahn, N. G., Posada, J., Munar, E. S., Jensen, A. J., Cooper, J. A., Cobb, M. H. and Krebs, E. G., Purification and characterization of Mitogen-activated Protein Kinase Activator(s) from Epidermal Growth Factor-stimulated A431 cells. J. Biol. Chem. 1992. 267: 14373-14381.