Signaling by the JNK group of MAP kinases

Journal of Clinical Immunology

Volumn 21, Issue 4, 2001, Pages 253-257

  Dong, C ^a   Davis, R J ^b   Flavell, R A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

C Jun N terminal kinase; T helper 1 (Th1); T lymphocytes; Th2

Indexed keywords

INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE;

CELL DIFFERENTIATION; CYTOKINE PRODUCTION; EFFECTOR CELL; HELPER CELL; LEUKEMIA CELL LINE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

ANIMALS; CELL DIFFERENTIATION; ENZYME ACTIVATION; HUMANS; INTERFERON TYPE II; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYMPHOCYTE ACTIVATION; MAP KINASE KINASE 4; MAP KINASE KINASE 7; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TH1 CELLS;

EID: 0034945723     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010975124110     Document Type: Review

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13. Interferon-γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
14. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
15. Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells
16. The proximal regulatory element of the interferon-γ promoter mediates selective expression in T cells
17. Memory and effector, but not naive t cells, express transcriptional activity under the control of two IFNγ promoter elements
18. Regulation of the activity of IFN-γ promoter elements during Th cell differentiation
19. JNK1 is required for T cell-mediated immunity against Leishmania major infection
20. JNK inhibits targeting of protein phosphatase calcineurin to NFATc1
21. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation
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23. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
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27. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
28. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes
29. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development
30. Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation