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Volumn 36, Issue 2, 2008, Pages 311-320

Smad signaling in the rat model of monocrotaline pulmonary hypertension

Author keywords

BMP receptors; Monocrotaline; Pulmonary hypertension; Smad signal transduction

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; MONOCROTALINE; SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD4 PROTEIN; SODIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA;

EID: 42149122684     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623307311402     Document Type: Article
Times cited : (27)

References (51)
  • 1
    • 0027295522 scopus 로고
    • Alterations of growth factor transcripts in rat lungs during development of monocrotaline-induced pulmonary hypertension
    • Arcot, S.S., Lipke, D.W., Gillespie, M.N., and Olson, J.W. (1993). Alterations of growth factor transcripts in rat lungs during development of monocrotaline-induced pulmonary hypertension. Biochem Pharmacol 46, 1086-91.
    • (1993) Biochem Pharmacol , vol.46 , pp. 1086-91
    • Arcot, S.S.1    Lipke, D.W.2    Gillespie, M.N.3    Olson, J.W.4
  • 2
    • 0037046175 scopus 로고    scopus 로고
    • Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
    • Atkinson, C., Stewart, S., Upton, P.D., Machado, R., Thomson, J.R., Trembath, R.C., and Morrell, N.W. (2002). Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation 105, 1672-8.
    • (2002) Circulation , vol.105 , pp. 1672-8
    • Atkinson, C.1    Stewart, S.2    Upton, P.D.3    MacHado, R.4    Thomson, J.R.5    Trembath, R.C.6    Morrell, N.W.7
  • 3
    • 0033524945 scopus 로고    scopus 로고
    • Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors
    • Chen, Y.G., and Massague, J. (1999). Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors. J Biol Chem 274, 3672-7.
    • (1999) J Biol Chem , vol.274 , pp. 3672-7
    • Chen, Y.G.1    Massague, J.2
  • 5
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck, R., and Zhang, Y.E. (2003). Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425, 577-84.
    • (2003) Nature , vol.425 , pp. 577-84
    • Derynck, R.1    Zhang, Y.E.2
  • 8
    • 17644442535 scopus 로고
    • Changes in pulmonary structure and function induced by monocrotaline intoxication
    • Ghodsi, F., and Will, J.A. (1981). Changes in pulmonary structure and function induced by monocrotaline intoxication. Am J Physiol 240, H149-55.
    • (1981) Am J Physiol , vol.240 , pp. 149-55
    • Ghodsi, F.1    Will, J.A.2
  • 9
    • 0141428794 scopus 로고    scopus 로고
    • Controlling the angiogenic switch: A balance between two distinct TGF-β receptor signaling pathways
    • Goumans, M.J., Lebrin, F., and Valdimarsdottir, G. (2003). Controlling the angiogenic switch: a balance between two distinct TGF-β receptor signaling pathways. Trends Cardiovasc Med 13, 301-7.
    • (2003) Trends Cardiovasc Med , vol.13 , pp. 301-7
    • Goumans, M.J.1    Lebrin, F.2    Valdimarsdottir, G.3
  • 10
    • 0037007226 scopus 로고    scopus 로고
    • Balancing the activation state of the endothelium via two distinct TGF-β type I receptors
    • Goumans, M.J., Valdimarsdottir, G., Itoh, S., Rosendahl, A., Sideras, P., and ten Dijke, P. (2002). Balancing the activation state of the endothelium via two distinct TGF-β type I receptors. Embo J 21, 1743-53.
    • (2002) Embo J , vol.21 , pp. 1743-53
    • Goumans, M.J.1    Valdimarsdottir, G.2    Itoh, S.3    Rosendahl, A.4    Sideras, P.5    Ten Dijke, P.6
  • 11
    • 0022160411 scopus 로고
    • Antibodies to the autophosphorylation sites of the epidermal growth factor receptor protein-tyrosine kinase as probes of structure and function
    • Gullick, W.J., Downward, J., and Waterfield, M.D. (1985). Antibodies to the autophosphorylation sites of the epidermal growth factor receptor protein-tyrosine kinase as probes of structure and function. Embo J 4, 2869-77.
    • (1985) Embo J , vol.4 , pp. 2869-77
    • Gullick, W.J.1    Downward, J.2    Waterfield, M.D.3
  • 12
    • 0037013859 scopus 로고    scopus 로고
    • Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues
    • He, W., Li, A.G., Wang, D., Han, S., Zheng, B., Goumans, M.J., Ten Dijke, P., and Wang, X.J. (2002). Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues. Embo J 21, 2580-90.
    • (2002) Embo J , vol.21 , pp. 2580-90
    • He, W.1    Li, A.G.2    Wang, D.3    Han, S.4    Zheng, B.5    Goumans, M.J.6    Ten Dijke, P.7    Wang, X.J.8
  • 13
    • 0036670339 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity
    • Inman, G.J., Nicolas, F.J., and Hill, C.S. (2002). Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity. Mol Cell 10, 283-94.
    • (2002) Mol Cell , vol.10 , pp. 283-94
    • Inman, G.J.1    Nicolas, F.J.2    Hill, C.S.3
  • 14
    • 0028866028 scopus 로고
    • Truncated type II receptor for BMP-4 induces secondary axial structures in Xenopus embryos
    • Ishikawa, T., Yoshioka, H., Ohuchi, H., Noji, S., and Nohno, T. (1995). Truncated type II receptor for BMP-4 induces secondary axial structures in Xenopus embryos. Biochem Biophys Res Commun 216, 26-33.
    • (1995) Biochem Biophys Res Commun , vol.216 , pp. 26-33
    • Ishikawa, T.1    Yoshioka, H.2    Ohuchi, H.3    Noji, S.4    Nohno, T.5
  • 16
    • 0034666010 scopus 로고    scopus 로고
    • Protein targets of monocrotaline pyrrole in pulmonary artery endothelial cells
    • Lame, M.W., Jones, A.D., Wilson, D.W., Dunston, S.K., and Segall, H.J. (2000). Protein targets of monocrotaline pyrrole in pulmonary artery endothelial cells. J Biol Chem 275, 29091-9.
    • (2000) J Biol Chem , vol.275 , pp. 29091-9
    • Lame, M.W.1    Jones, A.D.2    Wilson, D.W.3    Dunston, S.K.4    Segall, H.J.5
  • 17
    • 28444450886 scopus 로고    scopus 로고
    • Monocrotaline pyrrole targets proteins with and without cysteine residues in the cytosol and membranes of human pulmonary artery endothelial cells
    • Lame, M.W., Jones, A.D., Wilson, D.W., and Segall, H.J. (2005). Monocrotaline pyrrole targets proteins with and without cysteine residues in the cytosol and membranes of human pulmonary artery endothelial cells. Proteomics 5, 4398-413.
    • (2005) Proteomics , vol.5 , pp. 4398-413
    • Lame, M.W.1    Jones, A.D.2    Wilson, D.W.3    Segall, H.J.4
  • 22
    • 0348013127 scopus 로고    scopus 로고
    • Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension
    • Machado, R.D., Rudarakanchana, N., Atkinson, C., Flanagan, J.A., Harrison, R., Morrell, N.W., and Trembath, R.C. (2003). Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. Hum Mol Genet 12, 3277-86.
    • (2003) Hum Mol Genet , vol.12 , pp. 3277-86
    • MacHado, R.D.1    Rudarakanchana, N.2    Atkinson, C.3    Flanagan, J.A.4    Harrison, R.5    Morrell, N.W.6    Trembath, R.C.7
  • 23
    • 0033643420 scopus 로고    scopus 로고
    • Characterization of SMAD Phosphorylation and SMAD-receptor Interaction
    • P. H. Howe, ed., Vol. 142, pp. Humana Press, Totowa, NJ.
    • Mehra, A., Attisano, L., and Wrana, J.L. (2000). Characterization of SMAD phosphorylation and SMAD-receptor interaction. In Methods in Molecular Biology (P. H. Howe, ed., Vol. 142, pp. 67-78). Humana Press, Totowa, NJ.
    • (2000) Methods in Molecular Biology , pp. 67-78
    • Mehra, A.1    Attisano, L.2    Wrana, J.L.3
  • 24
    • 0032696038 scopus 로고    scopus 로고
    • Regulated migration of epidermal growth factor receptor from caveolae
    • Mineo, C., Gill, G.N., and Anderson, R.G. (1999). Regulated migration of epidermal growth factor receptor from caveolae. J Biol Chem 274, 30636-43.
    • (1999) J Biol Chem , vol.274 , pp. 30636-43
    • Mineo, C.1    Gill, G.N.2    Anderson, R.G.3
  • 26
    • 0032994043 scopus 로고    scopus 로고
    • Signal transduction by bone morphogenetic protein receptors: Functional roles of Smad proteins
    • Miyazono, K. (1999). Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins. Bone 25, 91-3.
    • (1999) Bone , vol.25 , pp. 91-3
    • Miyazono, K.1
  • 27
    • 33644967079 scopus 로고    scopus 로고
    • Monocrotaline pyrrole-induced megalocytosis of lung and breast epithelial cells: Disruption of plasma membrane and Golgi dynamics and an enhanced unfolded protein response
    • Mukhopadhyay, S., Shah, M., Patel, K., and Sehgal, P.B. (2005). Monocrotaline pyrrole-induced megalocytosis of lung and breast epithelial cells: disruption of plasma membrane and Golgi dynamics and an enhanced unfolded protein response. Toxicol Appl Pharmacol 211, 209-20.
    • (2005) Toxicol Appl Pharmacol , vol.211 , pp. 209-20
    • Mukhopadhyay, S.1    Shah, M.2    Patel, K.3    Sehgal, P.B.4
  • 30
    • 0027176133 scopus 로고
    • Biphasic effect of transforming growth factor-beta 1 on in vitro angiogenesis
    • Pepper, M.S., Vassalli, J.D., Orci, L., and Montesano, R. (1993). Biphasic effect of transforming growth factor-beta 1 on in vitro angiogenesis. Exp Cell Res 204, 356-63.
    • (1993) Exp Cell Res , vol.204 , pp. 356-63
    • Pepper, M.S.1    Vassalli, J.D.2    Orci, L.3    Montesano, R.4
  • 31
    • 0034460336 scopus 로고    scopus 로고
    • Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus
    • Pierreux, C.E., Nicolas, F.J., and Hill, C.S. (2000). Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus. Mol Cell Biol 20, 9041-54.
    • (2000) Mol Cell Biol , vol.20 , pp. 9041-54
    • Pierreux, C.E.1    Nicolas, F.J.2    Hill, C.S.3
  • 32
    • 0033586694 scopus 로고    scopus 로고
    • Vascular cell apoptosis: Cell type-specific modulation by transforming growth factor-beta1 in endothelial cells versus smooth muscle cells
    • Pollman, M.J., Naumovski, L., and Gibbons, G.H. (1999). Vascular cell apoptosis: cell type-specific modulation by transforming growth factor-beta1 in endothelial cells versus smooth muscle cells. Circulation 99, 2019-26.
    • (1999) Circulation , vol.99 , pp. 2019-26
    • Pollman, M.J.1    Naumovski, L.2    Gibbons, G.H.3
  • 33
    • 29144475243 scopus 로고    scopus 로고
    • The BMP type II receptor is located in lipid rafts, including caveolae, of pulmonary endothelium in vivo and in vitro
    • Ramos, M., Lame, M.W., Segall, H.J., and Wilson, D.W. (2006). The BMP type II receptor is located in lipid rafts, including caveolae, of pulmonary endothelium in vivo and in vitro. Vascul Pharmacol 44, 50-9.
    • (2006) Vascul Pharmacol , vol.44 , pp. 50-9
    • Ramos, M.1    Lame, M.W.2    Segall, H.J.3    Wilson, D.W.4
  • 34
    • 34147136670 scopus 로고    scopus 로고
    • Monocrotaline pyrrole induces Smad nuclear accumulation and altered signaling expression in human pulmonary arterial endothelial cells
    • Ramos, M., Lame, M.W., Segall, H.J., and Wilson, D.W. (2007). Monocrotaline pyrrole induces Smad nuclear accumulation and altered signaling expression in human pulmonary arterial endothelial cells. Vascul Pharmacol 46, 439-48.
    • (2007) Vascul Pharmacol , vol.46 , pp. 439-48
    • Ramos, M.1    Lame, M.W.2    Segall, H.J.3    Wilson, D.W.4
  • 36
    • 0035794218 scopus 로고    scopus 로고
    • Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor
    • Razani, B., Zhang, X.L., Bitzer, M., von Gersdorff, G., Bottinger, E.P., and Lisanti, M.P. (2001). Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor. J Biol Chem 276, 6727-38.
    • (2001) J Biol Chem , vol.276 , pp. 6727-38
    • Razani, B.1    Zhang, X.L.2    Bitzer, M.3    Von Gersdorff, G.4    Bottinger, E.P.5    Lisanti, M.P.6
  • 37
    • 0038801663 scopus 로고    scopus 로고
    • Functional cooperation between Smad proteins and activator protein-1 regulates transforming growth factor-beta-mediated induction of endothelin-1 expression
    • Rodriguez-Pascual, F., Redondo-Horcajo, M., and Lamas, S. (2003). Functional cooperation between Smad proteins and activator protein-1 regulates transforming growth factor-beta-mediated induction of endothelin-1 expression. Circ Res 92, 1288-95.
    • (2003) Circ Res , vol.92 , pp. 1288-95
    • Rodriguez-Pascual, F.1    Redondo-Horcajo, M.2    Lamas, S.3
  • 39
    • 0035069676 scopus 로고    scopus 로고
    • The caveolin triad: Caveolae biogenesis, cholesterol trafficking, and signal transduction
    • Schlegel, A., and Lisanti, M.P. (2001). The caveolin triad: caveolae biogenesis, cholesterol trafficking, and signal transduction. Cytokine Growth Factor Rev 12, 41-51.
    • (2001) Cytokine Growth Factor Rev , vol.12 , pp. 41-51
    • Schlegel, A.1    Lisanti, M.P.2
  • 40
    • 0032186324 scopus 로고    scopus 로고
    • Chronic pulmonary hypertension-the monocrotaline model and involvement of the hemostatic system
    • Schultze, A.E., and Roth, R.A. (1998). Chronic pulmonary hypertension-the monocrotaline model and involvement of the hemostatic system. J Toxicol Environ Health B Crit Rev 1, 271-346.
    • (1998) J Toxicol Environ Health B Crit Rev , vol.1 , pp. 271-346
    • Schultze, A.E.1    Roth, R.A.2
  • 41
    • 30344437854 scopus 로고    scopus 로고
    • Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness
    • Sotgia, F., Williams, T.M., Schubert, W., Medina, F., Minetti, C., Pestell, R.G., and Lisanti, M.P. (2006). Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness. Am J Pathol 168, 292-309.
    • (2006) Am J Pathol , vol.168 , pp. 292-309
    • Sotgia, F.1    Williams, T.M.2    Schubert, W.3    Medina, F.4    Minetti, C.5    Pestell, R.G.6    Lisanti, M.P.7
  • 42
    • 0030296590 scopus 로고    scopus 로고
    • Cell cycle alterations associated with covalent binding of monocrotaline pyrrole to pulmonary artery endothelial cell DNA
    • Thomas, H.C., Lame, M.W., Wilson, D.W., and Segall, H.J. (1996). Cell cycle alterations associated with covalent binding of monocrotaline pyrrole to pulmonary artery endothelial cell DNA. Toxicol Appl Pharmacol 141, 319-29.
    • (1996) Toxicol Appl Pharmacol , vol.141 , pp. 319-29
    • Thomas, H.C.1    Lame, M.W.2    Wilson, D.W.3    Segall, H.J.4
  • 44
    • 0037401059 scopus 로고    scopus 로고
    • Hereditary hemorrhagic telangiectasia: An update on transforming growth factor beta signaling in vasculogenesis and angiogenesis
    • van den Driesche, S., Mummery, C.L., and Westermann, C.J. (2003). Hereditary hemorrhagic telangiectasia: an update on transforming growth factor beta signaling in vasculogenesis and angiogenesis. Cardiovasc Res 58, 20-31.
    • (2003) Cardiovasc Res , vol.58 , pp. 20-31
    • Van Den Driesche, S.1    Mummery, C.L.2    Westermann, C.J.3
  • 45
    • 13644266312 scopus 로고    scopus 로고
    • Caveolin-1 in oncogenic transformation, cancer, and metastasis
    • Williams, T.M., and Lisanti, M.P. (2005). Caveolin-1 in oncogenic transformation, cancer, and metastasis. Am J Physiol Cell Physiol 288, C494-506.
    • (2005) Am J Physiol Cell Physiol , vol.288 , pp. 494-506
    • Williams, T.M.1    Lisanti, M.P.2
  • 48
    • 0347664883 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals
    • Xiao, Z., Watson, N., Rodriguez, C., and Lodish, H.F. (2001). Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals. J Biol Chem 276, 39404-10.
    • (2001) J Biol Chem , vol.276 , pp. 39404-10
    • Xiao, Z.1    Watson, N.2    Rodriguez, C.3    Lodish, H.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.