Chemopreventive effects of Furan-2-yl-3-pyridin-2-yl-propenone against 7,12-dimethylbenz[a]anthracene-inducible genotoxicity

Toxicology and Applied Pharmacology

Volumn 228, Issue 3, 2008, Pages 343-350

  Hwang, Yong Pil ^a   Han, Eun Hee ^a   Choi, Jae Ho ^a   Kim, Hyung Gyun ^a   Lee, Kyung Jin ^a   Jeong, Tae Cheon ^b   Lee, Eung Seok ^b   Jeong, Hye Gwang ^a  

^a Chosun University   (South Korea)

^b Yeungnam University   (South Korea)

Author keywords

1 Furan 2 yl 3 pyridin 2 yl propenone; 7,12 Dimethylbenz a anthracene; Chemoprevention; CYP; Phase II enzymes

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; FURAN 2 YL 3 PYRIDIN 2 YL PROPENONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; PROTEIN INHIBITOR; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR NF E2; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BREAST ADENOCARCINOMA; CELL NUCLEUS; CELL STRAIN MCF 7; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DETOXIFICATION; DNA ADDUCT; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENOTOXICITY; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PHARMACOLOGICAL BLOCKING; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ACTIVE TRANSPORT, CELL NUCLEUS; ANTICARCINOGENIC AGENTS; ARYL HYDROCARBON HYDROXYLASES; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; DNA ADDUCTS; FURANS; GLUTATHIONE TRANSFERASE; HUMANS; MAP KINASE SIGNALING SYSTEM; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; PROPANE; PROTEIN KINASE C; PYRIDINES; RECEPTORS, ARYL HYDROCARBON;

EID: 42049087435     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.12.018     Document Type: Article

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