Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog

Journal of Biological Chemistry

Volumn 283, Issue 8, 2008, Pages 4501-4511

  De Rosa, María Fabiana ^a,b,c   Ackerley, Cameron ^a   Wang, Bernice ^a,c   Ito, Shinya ^a,c   Clarke, David M ^c   Lingwood, Clifford ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; CHEMOTHERAPY; ELECTRIC CURRENTS; ENZYME ACTIVITY; GLYCOPROTEINS; SURFACE RESISTANCE; SURFACE TREATMENT;

ADJACENT SITES; AFTER TREATMENTS; BI LAYERS; BIO AVAILABILITIES; CANCER CHEMOTHERAPIES; CELL SURFACES; CELLULAR EFFLUXES; CHEMOTHERAPEUTIC DRUGS; CYCLOSPORIN A; DRUG RESISTANCES; EXTRACELLULAR; GLOBOTRIAOSYLCERAMIDE; GLYCOSPHINGOLIPID; LONG TERMS; MDCK CELLS; MULTIDRUG RESISTANCES; NO BINDINGS; ORAL BIOAVAILABILITIES; OVEREXPRESSION; PLASMA MEMBRANES; RHODAMINE 123; TRANSLOCASE; TRANSMEMBRANE SEGMENTS; VERAPAMIL; VINBLASTINE;

CELL MEMBRANES;

ADAMANTYLGLOBOTRIAOSYLCERAMIDE; CYCLOSPORIN A; GLOBOTRIAOSYLCERAMIDE; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE; ABCB1 PROTEIN, HUMAN; ADAMANTANE; ADAMANTYL GLOBOTRIAOSYL CERAMIDE; ADAMANTYL-GLOBOTRIAOSYL CERAMIDE; ANTINEOPLASTIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CERAMIDE TRIHEXOSIDE; CYCLOSPORIN; DRUG DERIVATIVE; ENZYME INHIBITOR; FLUORESCENT DYE; GLYCOPROTEIN P; PROTEIN SYNTHESIS INHIBITOR; RHODAMINE 123; SHIGA TOXIN;

ANIMAL CELL; ARTICLE; CELL STRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG BIOAVAILABILITY; DRUG POTENTIATION; DRUG RESISTANCE; DRUG TRANSPORT; ENDOCYTOSIS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; ANIMAL; BIOAVAILABILITY; BIOSYNTHESIS; CELL MEMBRANE; CELL POLARITY; CELL STRAIN CACO 2; DOG; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; GOLGI COMPLEX; INTESTINE MUCOSA; METABOLISM; MULTIDRUG RESISTANCE; NEOPLASM; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; TIME; UPREGULATION;

ADAMANTANE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CALCIUM CHANNEL BLOCKERS; CELL MEMBRANE; CELL POLARITY; CYCLOSPORINE; DOGS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENDOCYTOSIS; ENZYME INHIBITORS; FLUORESCENT DYES; GOLGI APPARATUS; HUMANS; INTESTINAL MUCOSA; NEOPLASMS; P-GLYCOPROTEIN; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN SYNTHESIS INHIBITORS; PROTEIN TRANSPORT; RHODAMINE 123; SHIGA TOXINS; TIME FACTORS; TRIHEXOSYLCERAMIDES; UP-REGULATION; VERAPAMIL; VINBLASTINE;

EID: 41949115343     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705473200     Document Type: Article

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