Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells

Journal of Biological Chemistry

Volumn 279, Issue 39, 2004, Pages 40412-40418

  Norris Cervetto, Edward ^a,b   Callaghan, Richard ^b   Platt, Frances M ^a   Dwek, Raymond A ^a   Butters, Terry D ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELLS; CYTOLOGY; DRUG DOSAGE; ENZYME INHIBITION; TUMORS;

CHEMOSENSITIZATION; DRUG RESISTANCE; GLYCOLIPIDS;

ENZYMES;

CERAMIDE; CERAMIDE GLUCOSYLTRANSFERASE; DEXTRO 1 PHENYL 2 DECANOYLAMINO 3 MORPHOLINO 1 PROPANOL; DOXORUBICIN; ENZYME INHIBITOR; GLYCOLIPID; GLYCOPROTEIN P; N BUTYLDEOXYGALACTONOJIRIMYCIN; N NONYLDEOXYGALACTONOJIRIMYCIN; NOJIRIMYCIN; TARIQUIDAR; TRITIUM; UNCLASSIFIED DRUG; VINBLASTINE SULFATE;

ARTICLE; BIOSYNTHESIS; CANCER CELL; CELL STRAIN MCF 7; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY;

1-DEOXYNOJIRIMYCIN; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CERAMIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; FLOW CYTOMETRY; GLUCOSAMINE; GLUCOSYLCERAMIDES; GLUCOSYLTRANSFERASES; GLYCOLIPIDS; HUMANS; IMINO SUGARS; LIPIDS; MORPHOLINES; P-GLYCOPROTEIN; P-GLYCOPROTEINS; QUINOLINES; TIME FACTORS; VINBLASTINE;

MINK CELL FOCUS-FORMING VIRUS;

EID: 4644333556     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404466200     Document Type: Article

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