메뉴 건너뛰기




Volumn 199, Issue 1, 2004, Pages 20-34

γ-Diketone neuropathy: Axon atrophy and the role of cytoskeletal protein adduction

Author keywords

diketone neuropathy; 2,5 Hexanedione; Axon atrophy; Axon swellings; Distal axonopathy; Neurofilament adduction

Indexed keywords

1,4 DIKETONE; ACETONYLACETONE;

EID: 4143089396     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.03.008     Document Type: Article
Times cited : (31)

References (142)
  • 1
    • 0021193174 scopus 로고
    • Electrophysiological deficits in peripheral nerve as a discriminator of early hexacarbon neurotoxicity
    • Anderson R.J., Dunham C.B. Electrophysiological deficits in peripheral nerve as a discriminator of early hexacarbon neurotoxicity. J. Toxicol. Environ. Health. 13:1984;835-843
    • (1984) J. Toxicol. Environ. Health , vol.13 , pp. 835-843
    • Anderson, R.J.1    Dunham, C.B.2
  • 2
    • 0020578606 scopus 로고
    • The spatio-temporal pattern of the axonopathy associated with the neurotoxicity of 3,4-dimethyl-2,5-hexanedione in the rat
    • Anthony D.C., Giangaspero F., Graham D.G. The spatio-temporal pattern of the axonopathy associated with the neurotoxicity of 3,4-dimethyl-2,5-hexanedione in the rat. J. Neuropathol. Exp. Neurol. 42:1983;548-560
    • (1983) J. Neuropathol. Exp. Neurol. , vol.42 , pp. 548-560
    • Anthony, D.C.1    Giangaspero, F.2    Graham, D.G.3
  • 3
    • 0021027622 scopus 로고
    • The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione: I. Accelerated clinical neuropathy is accompanied by more proximal axonal swellings
    • Anthony D.C., Boekelheide K., Graham D.G. The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione: I. Accelerated clinical neuropathy is accompanied by more proximal axonal swellings. Toxicol. Appl. Pharmacol. 71:1983;362-371
    • (1983) Toxicol. Appl. Pharmacol. , vol.71 , pp. 362-371
    • Anthony, D.C.1    Boekelheide, K.2    Graham, D.G.3
  • 4
    • 0030870708 scopus 로고    scopus 로고
    • Slow axonal transport: The polymer transport model
    • Baas P.W., Brown A. Slow axonal transport: the polymer transport model. Cell Biol. 7:1997;380-384
    • (1997) Cell Biol. , vol.7 , pp. 380-384
    • Baas, P.W.1    Brown, A.2
  • 5
    • 0022494074 scopus 로고
    • Anterograde components of axonal transport in motor and sensory nerves in experimental 2,5-hexanedione neuropathy
    • Braendgaard H., Sidenius P. Anterograde components of axonal transport in motor and sensory nerves in experimental 2,5-hexanedione neuropathy. J. Neurochem. 47:1986;31-37
    • (1986) J. Neurochem. , vol.47 , pp. 31-37
    • Braendgaard, H.1    Sidenius, P.2
  • 6
    • 0030708555 scopus 로고    scopus 로고
    • Entropic exclusion by neurofilament sidearms: A mechanism for maintaining interfilament spacing
    • Brown H.G., Hoh J.H. Entropic exclusion by neurofilament sidearms: a mechanism for maintaining interfilament spacing. Biochemistry. 36:1997;15035-15040
    • (1997) Biochemistry , vol.36 , pp. 15035-15040
    • Brown, H.G.1    Hoh, J.H.2
  • 9
    • 0022758234 scopus 로고
    • 2,5-Hexanedione neuropathy is associated with the covalent crosslinking of neurofilament proteins
    • Carden M.J., Lee V.M.-Y., Schalepfer W.W. 2,5-Hexanedione neuropathy is associated with the covalent crosslinking of neurofilament proteins. Neurochem. Pathol. 5:1986;25-35
    • (1986) Neurochem. Pathol. , vol.5 , pp. 25-35
    • Carden, M.J.1    Lee, V.M.-Y.2    Schalepfer, W.W.3
  • 10
    • 0020472247 scopus 로고
    • The pattern of recovery of axons in the nervous system of rats following 2,5-hexanediol intoxication: A question of rheology?
    • Cavanagh J.B. The pattern of recovery of axons in the nervous system of rats following 2,5-hexanediol intoxication: a question of rheology? Neuropathol. Appl. Neurobiol. 8:1982;19-34
    • (1982) Neuropathol. Appl. Neurobiol. , vol.8 , pp. 19-34
    • Cavanagh, J.B.1
  • 11
    • 0033677861 scopus 로고    scopus 로고
    • The C-terminal tail domain of neurofilament protein-H NF-H forms the crossbridges and regulates neurofilament bundle formation
    • Chen J., Nakata T., Zhang Z., Hirokawa N. The C-terminal tail domain of neurofilament protein-H NF-H forms the crossbridges and regulates neurofilament bundle formation. J. Cell Sci. 113:2000;3861-3869
    • (2000) J. Cell Sci. , vol.113 , pp. 3861-3869
    • Chen, J.1    Nakata, T.2    Zhang, Z.3    Hirokawa, N.4
  • 12
    • 0033561167 scopus 로고    scopus 로고
    • Overexpression of a-internexin causes abnormal neurofilamentous accumulation and motor coordination deficits in transgenic mice
    • Ching G.Y., Chien C.-L., Flores R., Liem R.K.H. Overexpression of a-internexin causes abnormal neurofilamentous accumulation and motor coordination deficits in transgenic mice. J. Neurosci. 19:1999;2974-2986
    • (1999) J. Neurosci. , vol.19 , pp. 2974-2986
    • Ching, G.Y.1    Chien, C.-L.2    Flores, R.3    Liem, R.K.H.4
  • 14
    • 0020015086 scopus 로고
    • Toxicity and the metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone and 2,5-hexanedione
    • Couri D., Milks M. Toxicity and the metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone and 2,5-hexanedione. Annu. Rev. Pharmacol. Toxicol. 22:1982;145-166
    • (1982) Annu. Rev. Pharmacol. Toxicol. , vol.22 , pp. 145-166
    • Couri, D.1    Milks, M.2
  • 15
    • 0017167733 scopus 로고
    • Giant axonal neuropathy caused by industrial chemicals: Neurofilamentous axonal masses in man
    • Davenport J.G., Farrell D.F., Sumi S.M. Giant axonal neuropathy caused by industrial chemicals: neurofilamentous axonal masses in man. Neurology. 26:1976;919-923
    • (1976) Neurology , vol.26 , pp. 919-923
    • Davenport, J.G.1    Farrell, D.F.2    Sumi, S.M.3
  • 16
    • 0022336953 scopus 로고
    • Molecular mechanisms of diketone neurotoxicity
    • DeCaprio A.P. Molecular mechanisms of diketone neurotoxicity. Chem.-Biol. Interact. 54:1985;257-270
    • (1985) Chem.-Biol. Interact. , vol.54 , pp. 257-270
    • Decaprio, A.P.1
  • 17
    • 0022994922 scopus 로고
    • Mechanisms of in vitro pyrrole adduct autoxidation in 2,5-hexanedione-treated protein
    • DeCaprio A.P. Mechanisms of in vitro pyrrole adduct autoxidation in 2,5-hexanedione-treated protein. Mol. Pharmacol. 30:1986;452-458
    • (1986) Mol. Pharmacol. , vol.30 , pp. 452-458
    • Decaprio, A.P.1
  • 18
    • 0023091351 scopus 로고
    • N-Hexane neurotoxicity. a mechanism involving pyrrole adduct formation in axonal cytoskeletal protein
    • DeCaprio A.P. n-Hexane neurotoxicity. A mechanism involving pyrrole adduct formation in axonal cytoskeletal protein. Neurotoxicology. 8:1987;199-210
    • (1987) Neurotoxicology , vol.8 , pp. 199-210
    • Decaprio, A.P.1
  • 19
    • 0002022283 scopus 로고    scopus 로고
    • N-Hexane, metabolites and derivative
    • P.S. Spencer, & H.H. Schaumburg. New York: Oxford Univ. Press
    • DeCaprio A.P. n-Hexane, metabolites and derivative. Spencer P.S., Schaumburg H.H. Experimental and Clinical Neurotoxicology. 2nd ed.:2000;633-648 Oxford Univ. Press, New York
    • (2000) Experimental and Clinical Neurotoxicology 2nd Ed. , pp. 633-648
    • Decaprio, A.P.1
  • 20
    • 0026779534 scopus 로고
    • Limited and selective adduction of carboxyl-terminal lysines in the high molecular weight neurofilament proteins by 2,5-hexanedione in vitro
    • DeCaprio A.P., Fowke J.H. Limited and selective adduction of carboxyl-terminal lysines in the high molecular weight neurofilament proteins by 2,5-hexanedione in vitro. Brain Res. 586:1992;219-228
    • (1992) Brain Res. , vol.586 , pp. 219-228
    • Decaprio, A.P.1    Fowke, J.H.2
  • 21
    • 0021821585 scopus 로고
    • Alterations in rat axonal cytoskeletal proteins induced by in vitro and in vivo 2,5-hexanedione exposure
    • DeCaprio A.P., O'Neill E.A. Alterations in rat axonal cytoskeletal proteins induced by in vitro and in vivo 2,5-hexanedione exposure. Toxicol. Appl. Pharmacol. 78:1985;235-247
    • (1985) Toxicol. Appl. Pharmacol. , vol.78 , pp. 235-247
    • Decaprio, A.P.1    O'Neill, E.A.2
  • 22
    • 0020384150 scopus 로고
    • Covalent binding of a neurotoxic n-hexane metabolite: Conversion of primary amines to substituted pyrrole adducts by 2,5-hexanedione
    • DeCaprio A.P., Olajos E.J., Weber P. Covalent binding of a neurotoxic n-hexane metabolite: conversion of primary amines to substituted pyrrole adducts by 2,5-hexanedione. Toxicol. Appl. Pharmacol. 65:1982;440-450
    • (1982) Toxicol. Appl. Pharmacol. , vol.65 , pp. 440-450
    • Decaprio, A.P.1    Olajos, E.J.2    Weber, P.3
  • 24
    • 0023483391 scopus 로고
    • Mechanism of formation and quantitation of imines, pyrroles, and stable nonpyrrole adducts in 2,5-hexanedione-treated protein
    • DeCaprio A.P., Jackowski S.J., Regan K.A. Mechanism of formation and quantitation of imines, pyrroles, and stable nonpyrrole adducts in 2,5-hexanedione-treated protein. Mol. Pharmacol. 32:1987;542-548
    • (1987) Mol. Pharmacol. , vol.32 , pp. 542-548
    • Decaprio, A.P.1    Jackowski, S.J.2    Regan, K.A.3
  • 25
    • 0023873976 scopus 로고
    • Comparative neurotoxicity and pyrrole-forming proteins of 2,5-hexanedione and perdeuterio-2,5-hexanedione in the rat
    • DeCaprio A.P., Briggs R.G., Jackowski S.J., Kim J.C.S. Comparative neurotoxicity and pyrrole-forming proteins of 2,5-hexanedione and perdeuterio-2,5-hexanedione in the rat. Toxicol. Appl. Pharmacol. 92:1988;75-85
    • (1988) Toxicol. Appl. Pharmacol. , vol.92 , pp. 75-85
    • Decaprio, A.P.1    Briggs, R.G.2    Jackowski, S.J.3    Kim, J.C.S.4
  • 26
    • 0031194356 scopus 로고    scopus 로고
    • Regioselective binding of 2,5-hexanedione to high-molecular-weight rat neurofilament proteins in vitro
    • DeCaprio A.P., Kinney E.A., Fowke J.H. Regioselective binding of 2,5-hexanedione to high-molecular-weight rat neurofilament proteins in vitro. Toxicol. Appl. Pharmacol. 145:1997;211-217
    • (1997) Toxicol. Appl. Pharmacol. , vol.145 , pp. 211-217
    • Decaprio, A.P.1    Kinney, E.A.2    Fowke, J.H.3
  • 27
    • 0026580004 scopus 로고
    • Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells
    • DeWaegh S.M., Lee V.M.-Y., Brady S.T. Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells. Cell. 68:1992;451-463
    • (1992) Cell , vol.68 , pp. 451-463
    • Dewaegh, S.M.1    Lee, V.M.-Y.2    Brady, S.T.3
  • 28
    • 0014835861 scopus 로고
    • Axon caliber related to neurofilaments and microtubules in sciatic nerve fibers of rats and mice
    • Friede R.L., Samorajski T. Axon caliber related to neurofilaments and microtubules in sciatic nerve fibers of rats and mice. Anat. Rec. 167:1970;379-388
    • (1970) Anat. Rec. , vol.167 , pp. 379-388
    • Friede, R.L.1    Samorajski, T.2
  • 29
    • 0032559341 scopus 로고    scopus 로고
    • A structural scaffolding of intermediate filaments in health and disease
    • Fuchs E., Cleveland D.W. A structural scaffolding of intermediate filaments in health and disease. Science. 279:1998;514-519
    • (1998) Science , vol.279 , pp. 514-519
    • Fuchs, E.1    Cleveland, D.W.2
  • 31
    • 0024909130 scopus 로고
    • Pyrrole oxidation and protein cross-linking as necessary steps in the development of γ-diketone neuropathy
    • Genter St. Clair M.B., Anthony D.C., Wikstrand C.J., Graham D.G. Pyrrole oxidation and protein cross-linking as necessary steps in the development of γ-diketone neuropathy. Neurotoxicology. 10:1989;743-756
    • (1989) Neurotoxicology , vol.10 , pp. 743-756
    • Genter St. Clair, M.B.1    Anthony, D.C.2    Wikstrand, C.J.3    Graham, D.G.4
  • 32
    • 0031452245 scopus 로고    scopus 로고
    • Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit
    • Giasson B.I., Mushynski W.E. Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit. J. Neurosci. 17:1997;9466-9472
    • (1997) J. Neurosci. , vol.17 , pp. 9466-9472
    • Giasson, B.I.1    Mushynski, W.E.2
  • 33
    • 0026092127 scopus 로고
    • Neurofilament redistribution in transected nerves: Evidence for bi-directional transport of neurofilaments
    • Glass J.D., Griffin J.W. Neurofilament redistribution in transected nerves: evidence for bi-directional transport of neurofilaments. J. Neurosci. 11:1991;3154-3164
    • (1991) J. Neurosci. , vol.11 , pp. 3154-3164
    • Glass, J.D.1    Griffin, J.W.2
  • 34
    • 0019965407 scopus 로고
    • Studies of the molecular pathogenesis of hexane neuropathy: II. Evidence that pyrrole derivitization of lysyl residues leads to protein crosslinking
    • Graham D.G., Anthony D.C., Boekelheide K., Maschmann N.A., Richards R.G., Wolfram J.W., Shaw B.R. Studies of the molecular pathogenesis of hexane neuropathy: II. Evidence that pyrrole derivitization of lysyl residues leads to protein crosslinking. Toxicol. Appl. Pharmacol. 64:1982;415-422
    • (1982) Toxicol. Appl. Pharmacol. , vol.64 , pp. 415-422
    • Graham, D.G.1    Anthony, D.C.2    Boekelheide, K.3    Maschmann, N.A.4    Richards, R.G.5    Wolfram, J.W.6    Shaw, B.R.7
  • 35
    • 0021258573 scopus 로고
    • In vitro evidence that covalent crosslinking of neurofilaments occurs in γ-diketone neuropathy
    • Graham D.G., Szakal-Quin G., Priest J.W., Anthony D.C. In vitro evidence that covalent crosslinking of neurofilaments occurs in γ-diketone neuropathy. Proc. Natl. Acad. Sci. 81:1984;4979-4982
    • (1984) Proc. Natl. Acad. Sci. , vol.81 , pp. 4979-4982
    • Graham, D.G.1    Szakal-Quin, G.2    Priest, J.W.3    Anthony, D.C.4
  • 38
    • 0020560249 scopus 로고
    • Cytoskeletal disorganization induced by local application of IDPN and 2,5-hexanedione
    • Griffin J.W., Fahnestock K.E., Price D.L., Cork C. Cytoskeletal disorganization induced by local application of IDPN and 2,5-hexanedione. Ann. Neurol. 14:1983;55-61
    • (1983) Ann. Neurol. , vol.14 , pp. 55-61
    • Griffin, J.W.1    Fahnestock, K.E.2    Price, D.L.3    Cork, C.4
  • 39
  • 40
    • 0032922480 scopus 로고    scopus 로고
    • Distal axonopathy does not occur without neurofilament accumulation in g-diketone neuropathy: Comparative studies of normal and neurofilament-deficient quail
    • Hirai T., Mizutani M., Kimura T., Ochiai K., Umemura T., Itakura C. Distal axonopathy does not occur without neurofilament accumulation in g-diketone neuropathy: comparative studies of normal and neurofilament-deficient quail. Acta Neuropathol. 97:1999;552-556
    • (1999) Acta Neuropathol. , vol.97 , pp. 552-556
    • Hirai, T.1    Mizutani, M.2    Kimura, T.3    Ochiai, K.4    Umemura, T.5    Itakura, C.6
  • 41
    • 0021261943 scopus 로고
    • Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton
    • Hirokawa N., Glickman M.A., Willard M.B. Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton. J. Cell Biol. 98:1984;1523-1536
    • (1984) J. Cell Biol. , vol.98 , pp. 1523-1536
    • Hirokawa, N.1    Glickman, M.A.2    Willard, M.B.3
  • 43
    • 0025836712 scopus 로고
    • Phosphorylation of neurofilament H subunit at the tail domain by CDC2 kinase dissociates the association to microtubules
    • Hisanaga S., Kusubata M., Okumura E., Kishimoto T. Phosphorylation of neurofilament H subunit at the tail domain by CDC2 kinase dissociates the association to microtubules. J. Biol. Chem. 266:1991;21798-21803
    • (1991) J. Biol. Chem. , vol.266 , pp. 21798-21803
    • Hisanaga, S.1    Kusubata, M.2    Okumura, E.3    Kishimoto, T.4
  • 45
    • 0024341559 scopus 로고
    • Hexanedione effects on protein phosphorylation in rat peripheral nerve
    • Horan K.I., Eichberg J., Berti-Mattera L.N., LoPachin R.M. Hexanedione effects on protein phosphorylation in rat peripheral nerve. Brain Res. 491:1989;366-370
    • (1989) Brain Res. , vol.491 , pp. 366-370
    • Horan, K.I.1    Eichberg, J.2    Berti-Mattera, L.N.3    Lopachin, R.M.4
  • 47
    • 0020373030 scopus 로고
    • The early evolution of neurofilamentous accumulations due to 2,5-hexanediol in the optic pathways of the rat
    • Jones H.B., Cavanagh J.B. The early evolution of neurofilamentous accumulations due to 2,5-hexanediol in the optic pathways of the rat. Neuropathol. Appl. Neurobiol. 8:1982;289-301
    • (1982) Neuropathol. Appl. Neurobiol. , vol.8 , pp. 289-301
    • Jones, H.B.1    Cavanagh, J.B.2
  • 48
    • 0020638142 scopus 로고
    • Distortions of the nodes of Ranvier form axonal distension by filamentous masses in hexacarbon intoxication
    • Jones H.B., Cavanagh J.B. Distortions of the nodes of Ranvier form axonal distension by filamentous masses in hexacarbon intoxication. J. Neurocytol. 12:1983;439-458
    • (1983) J. Neurocytol. , vol.12 , pp. 439-458
    • Jones, H.B.1    Cavanagh, J.B.2
  • 49
    • 0027267825 scopus 로고
    • Comparison of toxicities of acrylamide and 2,5-hexanedione in hens and rats on 3-week dosing regimens
    • Jortner B.S., Ehrich M. Comparison of toxicities of acrylamide and 2,5-hexanedione in hens and rats on 3-week dosing regimens. J. Toxicol. Environ. Health. 39:1993;417-428
    • (1993) J. Toxicol. Environ. Health , vol.39 , pp. 417-428
    • Jortner, B.S.1    Ehrich, M.2
  • 50
    • 0032998158 scopus 로고    scopus 로고
    • Regulation of neurofilament axonal transport by phosphorylation in optic axons in situ
    • Jung C., Shea T.B. Regulation of neurofilament axonal transport by phosphorylation in optic axons in situ. Cell Motil. Cytoskeleton. 42:1999;230-240
    • (1999) Cell Motil. Cytoskeleton , vol.42 , pp. 230-240
    • Jung, C.1    Shea, T.B.2
  • 51
    • 0031968643 scopus 로고    scopus 로고
    • Neurofilament subunits can undergo axonal transport without incorporation into triton-insoluble structures
    • Jung C., Yabe J.T., Wang F.-S., Shea T.B. Neurofilament subunits can undergo axonal transport without incorporation into triton-insoluble structures. Cell Motil. Cytoskeleton. 40:1998;44-58
    • (1998) Cell Motil. Cytoskeleton , vol.40 , pp. 44-58
    • Jung, C.1    Yabe, J.T.2    Wang, F.-S.3    Shea, T.B.4
  • 52
    • 0033977488 scopus 로고    scopus 로고
    • C-terminal phosphorylation of the high molecular weight neurofilament subunit correlates with decreased neurofilament axonal transport velocity
    • Jung C., Yabe J.T., Shea T.B. C-terminal phosphorylation of the high molecular weight neurofilament subunit correlates with decreased neurofilament axonal transport velocity. Brain Res. 856:2000;12-19
    • (2000) Brain Res. , vol.856 , pp. 12-19
    • Jung, C.1    Yabe, J.T.2    Shea, T.B.3
  • 53
    • 0033810408 scopus 로고    scopus 로고
    • Hypophosphorylated neurofilament subunits undergo axonal transport more rapidly than more extensively phosphorylated subunits in situ
    • Jung C., Yabe J.T., Lee S., Shea T.B. Hypophosphorylated neurofilament subunits undergo axonal transport more rapidly than more extensively phosphorylated subunits in situ. Cell Motil. Cytoskeleton. 47:2000;120-129
    • (2000) Cell Motil. Cytoskeleton , vol.47 , pp. 120-129
    • Jung, C.1    Yabe, J.T.2    Lee, S.3    Shea, T.B.4
  • 54
    • 0026044111 scopus 로고
    • Quantitative and qualitative alterations of neuronal and glial intermediate filaments in rat nervous system after exposure to 2,5-hexanedione
    • Karlsson J.-E., Rosengren L.E., Haglid K.G. Quantitative and qualitative alterations of neuronal and glial intermediate filaments in rat nervous system after exposure to 2,5-hexanedione. J. Neurochem. 57:1991;1437-1444
    • (1991) J. Neurochem. , vol.57 , pp. 1437-1444
    • Karlsson, J.-E.1    Rosengren, L.E.2    Haglid, K.G.3
  • 55
    • 4143114272 scopus 로고    scopus 로고
    • Comparative neurotoxicity and protein binding of 2,5-hexanedione and 3-acetyl-2,5-hexanedione in the rat
    • Kinney E.A., DeCaprio A.P. Comparative neurotoxicity and protein binding of 2,5-hexanedione and 3-acetyl-2,5-hexanedione in the rat. Toxicol. Sci. 60:2001;366
    • (2001) Toxicol. Sci. , vol.60 , pp. 366
    • Kinney, E.A.1    Decaprio, A.P.2
  • 56
    • 0000701757 scopus 로고    scopus 로고
    • Weaving a tangled web: The interconnected cytoskeleton
    • Klymkowsky M.W. Weaving a tangled web: the interconnected cytoskeleton. Nat. Cell Biol. 1:1999;E1212-E1223
    • (1999) Nat. Cell Biol. , vol.1
    • Klymkowsky, M.W.1
  • 59
    • 0036226094 scopus 로고    scopus 로고
    • Relating interactions between neurofilaments to the structure of axonal neurofilament distributions through polymer brush models
    • Kumar S., Yin X., Trapp B.D., Hoh J.H., Paulaitis M.E. Relating interactions between neurofilaments to the structure of axonal neurofilament distributions through polymer brush models. Biophys. J. 82:2002;2360-2372
    • (2002) Biophys. J. , vol.82 , pp. 2360-2372
    • Kumar, S.1    Yin, X.2    Trapp, B.D.3    Hoh, J.H.4    Paulaitis, M.E.5
  • 60
    • 84961047051 scopus 로고
    • Effects of acrylamide on the central nervous system of the cat
    • Kuperman A.S. Effects of acrylamide on the central nervous system of the cat. J. Pharmacol. Exp. Ther. 123:1958;180-192
    • (1958) J. Pharmacol. Exp. Ther. , vol.123 , pp. 180-192
    • Kuperman, A.S.1
  • 61
    • 85007912770 scopus 로고
    • Experimental studies of n-hexane administration to albino rats
    • Kurita H. Experimental studies of n-hexane administration to albino rats. Jpn. J. Ind. Health. 9:1967;672-677
    • (1967) Jpn. J. Ind. Health , vol.9 , pp. 672-677
    • Kurita, H.1
  • 62
    • 0022651739 scopus 로고
    • Cross-linking of neurofilament proteins of rat spinal cord in vivo after administration of 2,5-hexanedione
    • Lapadula D.M., Irwin R.D., Suwita E., Abou-Donia M.B. Cross-linking of neurofilament proteins of rat spinal cord in vivo after administration of 2,5-hexanedione. J. Neurochem. 46:1986;1843-1850
    • (1986) J. Neurochem. , vol.46 , pp. 1843-1850
    • Lapadula, D.M.1    Irwin, R.D.2    Suwita, E.3    Abou-Donia, M.B.4
  • 63
    • 0023789510 scopus 로고
    • Evidence for multiple mechanisms responsible for 2,5-hexanedione-induced neuropathy
    • Lapadula D.M., Suwita E., Abou-Donia M.B. Evidence for multiple mechanisms responsible for 2,5-hexanedione-induced neuropathy. Brain Res. 458:1988;123-131
    • (1988) Brain Res. , vol.458 , pp. 123-131
    • Lapadula, D.M.1    Suwita, E.2    Abou-Donia, M.B.3
  • 67
    • 0024242689 scopus 로고
    • Multiple phosphorylated variants of the high molecular mass subunit of neurofilaments in axons of retinal cell neurons: Characterization and evidence for their differential association with stationary and moving neurofilaments
    • Lewis S.E., Nixon R.A. Multiple phosphorylated variants of the high molecular mass subunit of neurofilaments in axons of retinal cell neurons: characterization and evidence for their differential association with stationary and moving neurofilaments. J. Cell Biol. 107:1988;2689-2701
    • (1988) J. Cell Biol. , vol.107 , pp. 2689-2701
    • Lewis, S.E.1    Nixon, R.A.2
  • 68
    • 0033563176 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinases (Erk1 and Erk2) cascade results in phosphorylation of NF-M tail domains in transfected NIH 3T3 cells
    • Li B.-S., Veeranna, Gu J., Grant P., Pant H.C. Activation of mitogen-activated protein kinases (Erk1 and Erk2) cascade results in phosphorylation of NF-M tail domains in transfected NIH 3T3 cells. Eur. J. Biochem. 262:1999;211-217
    • (1999) Eur. J. Biochem. , vol.262 , pp. 211-217
    • Li, B.-S.1    Veeranna2    Gu, J.3    Grant, P.4    Pant, H.C.5
  • 69
    • 0030959155 scopus 로고    scopus 로고
    • The relevance of axonal swelling and atrophy to γ-diketone neurotoxicity
    • LoPachin R.M., Lehning E.J. The relevance of axonal swelling and atrophy to γ-diketone neurotoxicity. Neurotoxicology. 18:1997;7-22
    • (1997) Neurotoxicology , vol.18 , pp. 7-22
    • Lopachin, R.M.1    Lehning, E.J.2
  • 70
    • 0027946631 scopus 로고
    • 2,5-Hexanedione alters elemental composition and water content of rat peripheral nerve myelinated axons
    • LoPachin R.M., Lehning E.J., Stack E.C., Hussein S.J., Saubermann A.J. 2,5-Hexanedione alters elemental composition and water content of rat peripheral nerve myelinated axons. J. Neurochem. 63:1994;2266-2278
    • (1994) J. Neurochem. , vol.63 , pp. 2266-2278
    • Lopachin, R.M.1    Lehning, E.J.2    Stack, E.C.3    Hussein, S.J.4    Saubermann, A.J.5
  • 73
    • 0036562871 scopus 로고    scopus 로고
    • Nerve terminals as the primary site of acrylamide action: A hypothesis
    • LoPachin R.M., Ross J.F., Lehning E.J. Nerve terminals as the primary site of acrylamide action: a hypothesis. Neurotoxicology. 23:2002;43-59
    • (2002) Neurotoxicology , vol.23 , pp. 43-59
    • Lopachin, R.M.1    Ross, J.F.2    Lehning, E.J.3
  • 74
    • 0242677820 scopus 로고    scopus 로고
    • γ-Diketone central neuropathy: Quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots
    • LoPachin R.M., Jortner B.S., Reid M.L., Das S. γ-Diketone central neuropathy: quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots. Toxicol. Appl. Pharmacol. 193:2003;29-46
    • (2003) Toxicol. Appl. Pharmacol. , vol.193 , pp. 29-46
    • Lopachin, R.M.1    Jortner, B.S.2    Reid, M.L.3    Das, S.4
  • 75
    • 2942739141 scopus 로고    scopus 로고
    • 2,5-Hexanedione-induced changes in the monomeric neurofilament protein content of rat spinal cord fractions
    • (in press)
    • LoPachin R.M., He D., Reid M.L., Opanashuk L.A. 2,5-Hexanedione-induced changes in the monomeric neurofilament protein content of rat spinal cord fractions. Toxicol. Appl. Pharmacol. 2003;. (in press)
    • (2003) Toxicol. Appl. Pharmacol.
    • Lopachin, R.M.1    He, D.2    Reid, M.L.3    Opanashuk, L.A.4
  • 78
    • 0030752893 scopus 로고    scopus 로고
    • A mechanistic analysis of nondisruptive axonal injury: A review
    • Maxwell W.L., Povlishock J.T., Graham D.L. A mechanistic analysis of nondisruptive axonal injury: a review. J. Neurotrauma. 14:1997;419-440
    • (1997) J. Neurotrauma , vol.14 , pp. 419-440
    • Maxwell, W.L.1    Povlishock, J.T.2    Graham, D.L.3
  • 79
    • 85007927065 scopus 로고
    • An electrophysiological study on the toxicity of n-hexane on the peripheral nerve
    • Miyagaki H. An electrophysiological study on the toxicity of n-hexane on the peripheral nerve. Jpn. J. Ind. Health. 9:1967;660-671
    • (1967) Jpn. J. Ind. Health , vol.9 , pp. 660-671
    • Miyagaki, H.1
  • 80
    • 0027486263 scopus 로고
    • Interaction of the tail domain of high molecular weight subunits of neurofilaments with the COOH-terminal region of tubulin and its regulation of τ protein kinase II
    • Miyasaka H., Okabe S., Ishiguro K., Uchida T., Hirokawa N. Interaction of the tail domain of high molecular weight subunits of neurofilaments with the COOH-terminal region of tubulin and its regulation of τ protein kinase II. J. Biol. Chem. 268:1993;22695-22702
    • (1993) J. Biol. Chem. , vol.268 , pp. 22695-22702
    • Miyasaka, H.1    Okabe, S.2    Ishiguro, K.3    Uchida, T.4    Hirokawa, N.5
  • 81
    • 0021979211 scopus 로고
    • Giant axonal neuropathy. Acceleration of neurofilament transport in optic axons
    • Monaco S., Autilio-Gambetti L., Zabel D., Gambetti P. Giant axonal neuropathy. Acceleration of neurofilament transport in optic axons. Proc. Natl. Acad. Sci. 82:1985;920-924
    • (1985) Proc. Natl. Acad. Sci. , vol.82 , pp. 920-924
    • Monaco, S.1    Autilio-Gambetti, L.2    Zabel, D.3    Gambetti, P.4
  • 83
    • 0024499213 scopus 로고
    • Experimental increase of neurofilament transport rate: Decreases in neurofilament number and in axon diameter
    • Monaco S., Autilio-Gambetti L., Lasek R.J., Katz M.J., Gambetti P. Experimental increase of neurofilament transport rate: decreases in neurofilament number and in axon diameter. J. Neuropathol. Exp. Neurol. 48:1989;23-32
    • (1989) J. Neuropathol. Exp. Neurol. , vol.48 , pp. 23-32
    • Monaco, S.1    Autilio-Gambetti, L.2    Lasek, R.J.3    Katz, M.J.4    Gambetti, P.5
  • 84
    • 0024373687 scopus 로고
    • Axonal transport of neurofilament is accelerated in peripheral nerve during 2,5-hexanedione intoxication
    • Monaco S., Jacob J., Jenich H., Autilio-Gambetti L., Gambetti P. Axonal transport of neurofilament is accelerated in peripheral nerve during 2,5-hexanedione intoxication. Brain Res. 491:1989;328-334
    • (1989) Brain Res. , vol.491 , pp. 328-334
    • Monaco, S.1    Jacob, J.2    Jenich, H.3    Autilio-Gambetti, L.4    Gambetti, P.5
  • 86
    • 0025866194 scopus 로고
    • Cytoskeletal changes induced by 2,5-hexanedione on developing human neurons in vitro
    • Moretto G., Monaco S., Passarin M.G., Benedetti M.D., Rizzuto N. Cytoskeletal changes induced by 2,5-hexanedione on developing human neurons in vitro. Arch. Toxicol. 65:1991;409-413
    • (1991) Arch. Toxicol. , vol.65 , pp. 409-413
    • Moretto, G.1    Monaco, S.2    Passarin, M.G.3    Benedetti, M.D.4    Rizzuto, N.5
  • 87
    • 0027134558 scopus 로고
    • Neurofilaments are intrinsic determinants of axonal caliber
    • Muma N.A., Hoffman P.N. Neurofilaments are intrinsic determinants of axonal caliber. Micron. 24:1993;677-683
    • (1993) Micron , vol.24 , pp. 677-683
    • Muma, N.A.1    Hoffman, P.N.2
  • 88
    • 0019799305 scopus 로고
    • Biophysical and electrophysiological studies of hexanedione neurotoxicity
    • Nachtman J.P., Couri D. Biophysical and electrophysiological studies of hexanedione neurotoxicity. Neurotoxicology. 2:1981;541-556
    • (1981) Neurotoxicology , vol.2 , pp. 541-556
    • Nachtman, J.P.1    Couri, D.2
  • 89
    • 0028900588 scopus 로고
    • Two distinct functions of the carboxyl-terminal tail domain of NF-M upon neurofilament assembly: Cross-bridge formation and longitudinal elongation of filaments
    • Nakagawa T., Chen J., Zhang Z., Kanai Y., Hirokawa N. Two distinct functions of the carboxyl-terminal tail domain of NF-M upon neurofilament assembly: cross-bridge formation and longitudinal elongation of filaments. J. Cell Biol. 129:1995;411-429
    • (1995) J. Cell Biol. , vol.129 , pp. 411-429
    • Nakagawa, T.1    Chen, J.2    Zhang, Z.3    Kanai, Y.4    Hirokawa, N.5
  • 90
    • 0032192425 scopus 로고    scopus 로고
    • Dynamic behavior and organization of cytoskeletal proteins in neurons: Reconciling old and new findings
    • Nixon R.A. Dynamic behavior and organization of cytoskeletal proteins in neurons: reconciling old and new findings. BioEssays. 20:1998;798-807
    • (1998) BioEssays , vol.20 , pp. 798-807
    • Nixon, R.A.1
  • 91
    • 0022617701 scopus 로고
    • Multiple fates of newly synthesized neurofilament proteins: Evidence for a stationary neurofilament network distributed nonuniformly along axons of retinal ganglion cell neurons
    • Nixon R.A., Logvinenko K.B. Multiple fates of newly synthesized neurofilament proteins: evidence for a stationary neurofilament network distributed nonuniformly along axons of retinal ganglion cell neurons. J. Cell Biol. 102:1986;647-659
    • (1986) J. Cell Biol. , vol.102 , pp. 647-659
    • Nixon, R.A.1    Logvinenko, K.B.2
  • 92
    • 0023148301 scopus 로고
    • Posttranslational modification of neurofilament proteins by phosphate during axoplasmic transport in retinal ganglion cell neurons
    • Nixon R.A., Lewis S.E., Marotta C.A. Posttranslational modification of neurofilament proteins by phosphate during axoplasmic transport in retinal ganglion cell neurons. J. Neurosci. 7:1987;1145-1158
    • (1987) J. Neurosci. , vol.7 , pp. 1145-1158
    • Nixon, R.A.1    Lewis, S.E.2    Marotta, C.A.3
  • 93
    • 0027931132 scopus 로고
    • Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: Influences on regional neurofilament accumulation, interneurofilament spacing and axon caliber
    • Nixon R.A., Paskevich P.A., Sihag R.K., Thayer C.Y. Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing and axon caliber. J. Cell Biol. 126:1994;1031-1046
    • (1994) J. Cell Biol. , vol.126 , pp. 1031-1046
    • Nixon, R.A.1    Paskevich, P.A.2    Sihag, R.K.3    Thayer, C.Y.4
  • 94
    • 0030983861 scopus 로고    scopus 로고
    • The origin and nature of beading: A reversible transformation of the shape of nerve fibers
    • Ochs S., Pourmand R., Jersild R.A., Friedman R.N. The origin and nature of beading: a reversible transformation of the shape of nerve fibers. Prog. Neurobiol. 52:1997;391-426
    • (1997) Prog. Neurobiol. , vol.52 , pp. 391-426
    • Ochs, S.1    Pourmand, R.2    Jersild, R.A.3    Friedman, R.N.4
  • 95
    • 0027517095 scopus 로고
    • Neurotoxic effects of 2,5-hexanedione on rapidly growing unmyelinated peripheral nerve axons of a rat fetus: Dose-effect relationship
    • Ogawa Y., Komatsu T., Fujikake N., Fujii T., Tanaka J. Neurotoxic effects of 2,5-hexanedione on rapidly growing unmyelinated peripheral nerve axons of a rat fetus: dose-effect relationship. Environ. Res. 63:1993;287-295
    • (1993) Environ. Res. , vol.63 , pp. 287-295
    • Ogawa, Y.1    Komatsu, T.2    Fujikake, N.3    Fujii, T.4    Tanaka, J.5
  • 96
    • 0017164697 scopus 로고
    • Giant axonal swelling in "huffer's" neuropathy
    • Oh S.J., Kim J.M. Giant axonal swelling in "Huffer's" neuropathy. Arch. Neurol. 33:1976;583-586
    • (1976) Arch. Neurol. , vol.33 , pp. 583-586
    • Oh, S.J.1    Kim, J.M.2
  • 97
    • 0022973745 scopus 로고
    • Comparison of central and peripheral nervous system lesions caused by high-dose short-term and low-dose subchronic acrylamide treatment in rats
    • O'Shaughnessy D.J., Losos G.J. Comparison of central and peripheral nervous system lesions caused by high-dose short-term and low-dose subchronic acrylamide treatment in rats. Toxicol. Pathol. 14:1986;389-394
    • (1986) Toxicol. Pathol. , vol.14 , pp. 389-394
    • O'Shaughnessy, D.J.1    Losos, G.J.2
  • 98
  • 99
    • 0023552130 scopus 로고
    • Carbon disulfide axonopathy. Another experimental model characterized by acceleration of neurofilament transport and distinct changes of axonal size
    • Pappolla M., Penton R., Weiss H.S., Miller C.H., Sahenk Z., Autilio-Gambetti L., Gambetti P. Carbon disulfide axonopathy. Another experimental model characterized by acceleration of neurofilament transport and distinct changes of axonal size. Brain Res. 424:1987;272-280
    • (1987) Brain Res. , vol.424 , pp. 272-280
    • Pappolla, M.1    Penton, R.2    Weiss, H.S.3    Miller, C.H.4    Sahenk, Z.5    Autilio-Gambetti, L.6    Gambetti, P.7
  • 100
    • 0026748428 scopus 로고
    • Alterations in neurofilament transport induced by 2,5-hexanedione and 3-acetyl-2,5-hexanedione
    • Pyle S.J., Amarnath V., Graham D.G., Anthony D.C. Alterations in neurofilament transport induced by 2,5-hexanedione and 3-acetyl-2,5-hexanedione. J. Neuropathol. Exp. Neurol. 51:1992;451-458
    • (1992) J. Neuropathol. Exp. Neurol. , vol.51 , pp. 451-458
    • Pyle, S.J.1    Amarnath, V.2    Graham, D.G.3    Anthony, D.C.4
  • 101
    • 0027379280 scopus 로고
    • Decreased levels of the high molecular weight subunit of neurofilaments and accelerated neurofilament transport during the recovery phase of 2,5-hexanedione
    • Pyle S.J., Amarnath V., Graham D.G., Anthony D.C. Decreased levels of the high molecular weight subunit of neurofilaments and accelerated neurofilament transport during the recovery phase of 2,5-hexanedione. Cell Motil. Cytoskeleton. 26:1993;133-143
    • (1993) Cell Motil. Cytoskeleton , vol.26 , pp. 133-143
    • Pyle, S.J.1    Amarnath, V.2    Graham, D.G.3    Anthony, D.C.4
  • 102
    • 0017356669 scopus 로고
    • Toxic polyneuropathies in Italy due to leather cement poisoning in shoe industries
    • Rizzuto N., Terzian H., Galiazzo-Rizzuto S. Toxic polyneuropathies in Italy due to leather cement poisoning in shoe industries. J. Neurol. Sci. 31:1977;343-354
    • (1977) J. Neurol. Sci. , vol.31 , pp. 343-354
    • Rizzuto, N.1    Terzian, H.2    Galiazzo-Rizzuto, S.3
  • 103
    • 0023154756 scopus 로고
    • D,l- versus meso-3,4-dimethyl-2,5-hexanedione: A morphometric study of the proximo-distal distribution of axonal swellings in the anterior root of the rat
    • Rosenberg C.K., Genter M.B., Szakal-Quin G., Anthony D.C., Graham D.G. d,l- versus meso-3,4-dimethyl-2,5-hexanedione: a morphometric study of the proximo-distal distribution of axonal swellings in the anterior root of the rat. Toxicol. Appl. Pharmacol. 87:1987;363-373
    • (1987) Toxicol. Appl. Pharmacol. , vol.87 , pp. 363-373
    • Rosenberg, C.K.1    Genter, M.B.2    Szakal-Quin, G.3    Anthony, D.C.4    Graham, D.G.5
  • 104
    • 0034599604 scopus 로고    scopus 로고
    • Dose and time as variables of toxicity
    • Rozman K.K., Doull J. Dose and time as variables of toxicity. Toxicology. 144:2000;169-178
    • (2000) Toxicology , vol.144 , pp. 169-178
    • Rozman, K.K.1    Doull, J.2
  • 105
    • 0027238901 scopus 로고
    • Reduced diameter and conduction velocity of myelinated fibers in the sciatic nerve of a neurofilament-deficient mutant quail
    • Sakaguchi T., Okada M., Kitamura T., Kawasaki K. Reduced diameter and conduction velocity of myelinated fibers in the sciatic nerve of a neurofilament-deficient mutant quail. Neurosci. Lett. 153:1993;65-68
    • (1993) Neurosci. Lett. , vol.153 , pp. 65-68
    • Sakaguchi, T.1    Okada, M.2    Kitamura, T.3    Kawasaki, K.4
  • 106
    • 0034722377 scopus 로고    scopus 로고
    • Local control of neurofilament accumulation during radial growth of myelinating axons in vivo: Selective role of site-specific phosphorylation
    • Sanchez I., Hassinger L., Sihag R.K., Cleveland D.W., Mohan P., Nixon R.A. Local control of neurofilament accumulation during radial growth of myelinating axons in vivo: selective role of site-specific phosphorylation. J. Cell Biol. 151:2000;1013-1024.2
    • (2000) J. Cell Biol. , vol.151 , pp. 1013-10242
    • Sanchez, I.1    Hassinger, L.2    Sihag, R.K.3    Cleveland, D.W.4    Mohan, P.5    Nixon, R.A.6
  • 107
    • 0022370229 scopus 로고
    • Pathogenesis of experimental giant neurofilamentous axonopathies: A unified hypothesis based on chemical modification of neurofilaments
    • Sayre L.M., Autilio-Gambetti L., Gambetti P. Pathogenesis of experimental giant neurofilamentous axonopathies: a unified hypothesis based on chemical modification of neurofilaments. Brain Res. Rev. 10:1985;69-83
    • (1985) Brain Res. Rev. , vol.10 , pp. 69-83
    • Sayre, L.M.1    Autilio-Gambetti, L.2    Gambetti, P.3
  • 108
    • 0022612263 scopus 로고
    • Structural basis of γ-diketone neurotoxicity: Non-neurotoxicity of 3,3-dimethyl-2,5-hexanedione, a γ-diketone incapable of pyrrole formation
    • Sayre L.M., Shearson C.M., Wongmongkolrit T., Medori R., Gambetti P. Structural basis of γ-diketone neurotoxicity: non-neurotoxicity of 3,3-dimethyl-2,5-hexanedione, a γ-diketone incapable of pyrrole formation. Toxicol. Appl. Pharmacol. 84:1986;36-44
    • (1986) Toxicol. Appl. Pharmacol. , vol.84 , pp. 36-44
    • Sayre, L.M.1    Shearson, C.M.2    Wongmongkolrit, T.3    Medori, R.4    Gambetti, P.5
  • 109
    • 0017075483 scopus 로고
    • Degeneration in central and peripheral nervous systems produced by pure n-hexane: An experimental study
    • Schaumburg H.H., Spencer P.S. Degeneration in central and peripheral nervous systems produced by pure n-hexane: an experimental study. Brain. 99:1976;183-192
    • (1976) Brain , vol.99 , pp. 183-192
    • Schaumburg, H.H.1    Spencer, P.S.2
  • 110
    • 0018200108 scopus 로고
    • Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract
    • Schaumburg H.H., Spencer P.S. Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract. Science. 199:1978;199-200
    • (1978) Science , vol.199 , pp. 199-200
    • Schaumburg, H.H.1    Spencer, P.S.2
  • 111
    • 0034433639 scopus 로고    scopus 로고
    • Microtubule motors, phosphorylation and axonal transport of neurofilaments
    • Shea T.B. Microtubule motors, phosphorylation and axonal transport of neurofilaments. J. Neurocytol. 29:2000;873-887
    • (2000) J. Neurocytol. , vol.29 , pp. 873-887
    • Shea, T.B.1
  • 112
    • 0026689889 scopus 로고
    • Neurotoxicity of acrylamide and 2,5-hexanedione in rats evaluated using a functional observational battery and pathological examination
    • Shell L., Rozum M., Jortner B.S., Ehrich M. Neurotoxicity of acrylamide and 2,5-hexanedione in rats evaluated using a functional observational battery and pathological examination. Neurotoxicol. Teratol. 14:1992;273-283
    • (1992) Neurotoxicol. Teratol. , vol.14 , pp. 273-283
    • Shell, L.1    Rozum, M.2    Jortner, B.S.3    Ehrich, M.4
  • 113
    • 0027995542 scopus 로고
    • Toxic axonal degeneration occurs independent of neurofilament accumulation
    • Sickles D.W., Pearson J.K., Beall A., Testino A. Toxic axonal degeneration occurs independent of neurofilament accumulation. J. Neurosci. Res. 39:1994;347-354
    • (1994) J. Neurosci. Res. , vol.39 , pp. 347-354
    • Sickles, D.W.1    Pearson, J.K.2    Beall, A.3    Testino, A.4
  • 114
    • 0016820609 scopus 로고
    • Experimental neuropathy produced by 2,5-hexanedione - A major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone
    • Spencer P.S., Schaumburg H.H. Experimental neuropathy produced by 2,5-hexanedione - A major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone. J. Neurol. Neurosurg. Psychiatry. 38:1975;771-775
    • (1975) J. Neurol. Neurosurg. Psychiatry , vol.38 , pp. 771-775
    • Spencer, P.S.1    Schaumburg, H.H.2
  • 115
    • 0000290933 scopus 로고
    • Central-peripheral distal axonopathy - The pathology of dying-back polyneuropathies
    • H.M. Zimmerman. NY: Grunne and Stratton
    • Spencer P.S., Schaumburg H.H. Central-peripheral distal axonopathy - The pathology of dying-back polyneuropathies. Zimmerman H.M. Progress in Neuropathology. 1976;253-295 Grunne and Stratton, NY
    • (1976) Progress in Neuropathology , pp. 253-295
    • Spencer, P.S.1    Schaumburg, H.H.2
  • 116
    • 0017341966 scopus 로고
    • Ultrastructural studies of the dying-back process: III. the evolution of experimental peripheral giant axonal degeneration
    • Spencer P.S., Schaumburg H.H. Ultrastructural studies of the dying-back process: III. The evolution of experimental peripheral giant axonal degeneration. J. Neuropathol. Exp. Neurol. 36:1977;276-299
    • (1977) J. Neuropathol. Exp. Neurol. , vol.36 , pp. 276-299
    • Spencer, P.S.1    Schaumburg, H.H.2
  • 117
    • 0017364389 scopus 로고
    • Ultrastructural studies of the dying-back process: IV. Differential vulnerability of PNS and CNS fibers in experimental central-peripheral distal axonopathies
    • Spencer P.S., Schaumburg H.H. Ultrastructural studies of the dying-back process: IV. Differential vulnerability of PNS and CNS fibers in experimental central-peripheral distal axonopathies. J. Neuropathol. Exp. Neurol. 36:1977;300-319
    • (1977) J. Neuropathol. Exp. Neurol. , vol.36 , pp. 300-319
    • Spencer, P.S.1    Schaumburg, H.H.2
  • 118
    • 0016612705 scopus 로고
    • Nervous system degeneration produced by the industrial solvent methyl n-butyl ketone
    • Spencer P.S., Schaumburg H.H., Raleigh R.L., Terhaar C.J. Nervous system degeneration produced by the industrial solvent methyl n-butyl ketone. Arch. Neurol. 32:1975;219-222
    • (1975) Arch. Neurol. , vol.32 , pp. 219-222
    • Spencer, P.S.1    Schaumburg, H.H.2    Raleigh, R.L.3    Terhaar, C.J.4
  • 120
    • 0002526528 scopus 로고
    • N-Hexane and methyl n-butyl ketone
    • P.S. Spencer, & H.H. Schaumburg. Baltimore, MD: Williams and Wilkins
    • Spencer P.S., Couri D., Schaumburg H.H. n-Hexane and methyl n-butyl ketone. Spencer P.S., Schaumburg H.H. Experimental and Clinical Neurotoxicology. 1980;456-475 Williams and Wilkins, Baltimore, MD
    • (1980) Experimental and Clinical Neurotoxicology , pp. 456-475
    • Spencer, P.S.1    Couri, D.2    Schaumburg, H.H.3
  • 121
    • 0020001543 scopus 로고
    • Cell body remodeling during dying-back axonopathy: DRG changes during advanced disease
    • Sterman A.B. Cell body remodeling during dying-back axonopathy: DRG changes during advanced disease. J. Neuropathol. Exp. Neurol. 41:1982;400-411
    • (1982) J. Neuropathol. Exp. Neurol. , vol.41 , pp. 400-411
    • Sterman, A.B.1
  • 122
    • 0021133892 scopus 로고
    • Hexacarbon neuropathy: Cell body changes are early, dynamic and specific
    • Sterman A.B. Hexacarbon neuropathy: cell body changes are early, dynamic and specific. Ann. Neurol. 16:1984;343-348
    • (1984) Ann. Neurol. , vol.16 , pp. 343-348
    • Sterman, A.B.1
  • 123
    • 0021876165 scopus 로고
    • Cell body responses to axonal injury: Traumatic axotomy versus toxic neuropathy
    • Sterman A.B., Delannoy M.R. Cell body responses to axonal injury: traumatic axotomy versus toxic neuropathy. Exp. Neurol. 89:1985;408-412
    • (1985) Exp. Neurol. , vol.89 , pp. 408-412
    • Sterman, A.B.1    Delannoy, M.R.2
  • 124
    • 0033571227 scopus 로고    scopus 로고
    • Axonal neurofilaments are nonessential elements of toxicant-induced reductions in fast axonal transport: Video-enhanced differential interference microscopy in peripheral nervous system axons
    • Stone J.D., Peterson A.P., Eyer J., Oblak J.G., Sickles D.W. Axonal neurofilaments are nonessential elements of toxicant-induced reductions in fast axonal transport: video-enhanced differential interference microscopy in peripheral nervous system axons. Toxicol. Appl. Pharmacol. 161:1999;50-58
    • (1999) Toxicol. Appl. Pharmacol. , vol.161 , pp. 50-58
    • Stone, J.D.1    Peterson, A.P.2    Eyer, J.3    Oblak, J.G.4    Sickles, D.W.5
  • 125
    • 0033794203 scopus 로고    scopus 로고
    • Neurofilaments are nonessential elements of toxicant-induced reductions in fast axonal transport: Pulse labeling in CNS neurons
    • Stone J.D., Peterson A.P., Eyer J., Sickles D.W. Neurofilaments are nonessential elements of toxicant-induced reductions in fast axonal transport: pulse labeling in CNS neurons. Neurotoxicology. 21:2000;447-458
    • (2000) Neurotoxicology , vol.21 , pp. 447-458
    • Stone, J.D.1    Peterson, A.P.2    Eyer, J.3    Sickles, D.W.4
  • 126
    • 0035313072 scopus 로고    scopus 로고
    • Neurofilaments are nonessential to the pathogenesis of toxicant-induced axonal degeneration
    • Stone J.D., Peterson A.P., Eyer J., Oblak T.G., Sickles D.W. Neurofilaments are nonessential to the pathogenesis of toxicant-induced axonal degeneration. J. Neurosci. 21:2001;2278-2287
    • (2001) J. Neurosci. , vol.21 , pp. 2278-2287
    • Stone, J.D.1    Peterson, A.P.2    Eyer, J.3    Oblak, T.G.4    Sickles, D.W.5
  • 127
    • 0029805514 scopus 로고    scopus 로고
    • Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton
    • Svitkina T.M., Verkhovsky A.B., Borisy G.G. Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton. J. Cell Biol. 135:1996;991-1007
    • (1996) J. Cell Biol. , vol.135 , pp. 991-1007
    • Svitkina, T.M.1    Verkhovsky, A.B.2    Borisy, G.G.3
  • 128
    • 0027529308 scopus 로고
    • Electrophysiological study of dorsal column function in streptozotocin-induced diabetic rats: Comparison with 2,5-hexanedione intoxication
    • Terada M., Yasuda H., Kikkawa R., Koyama N., Yokota T., Shigeta Y. Electrophysiological study of dorsal column function in streptozotocin-induced diabetic rats: comparison with 2,5-hexanedione intoxication. J. Neurol. Sci. 115:1993;58-66
    • (1993) J. Neurol. Sci. , vol.115 , pp. 58-66
    • Terada, M.1    Yasuda, H.2    Kikkawa, R.3    Koyama, N.4    Yokota, T.5    Shigeta, Y.6
  • 129
    • 0015900768 scopus 로고
    • Premiers resultats electrophysiologiques apres intoxications experimentales par l'hexne et par l'heptane techniques chez le rat blanc
    • Truhaut R., Laget P., Piat G., Phu-Lich N., Dutertre-Catella H., Huyen V.N. Premiers resultats electrophysiologiques apres intoxications experimentales par l'hexne et par l'heptane techniques chez le rat blanc. Arch. Mal. Prof. Med. Trav. Secur. Soc. 34:1973;417-426
    • (1973) Arch. Mal. Prof. Med. Trav. Secur. Soc. , vol.34 , pp. 417-426
    • Truhaut, R.1    Laget, P.2    Piat, G.3    Phu-Lich, N.4    Dutertre-Catella, H.5    Huyen, V.N.6
  • 130
    • 0027055112 scopus 로고
    • 2,5-Hexanedione-induced intermediate filament aggregates contain ubiquitin-protein conjugate immunoreactivity and resemble Rosenthal fibres
    • Tuckwell D.S., Laszlo L., Mayer R.J. 2,5-Hexanedione-induced intermediate filament aggregates contain ubiquitin-protein conjugate immunoreactivity and resemble Rosenthal fibres. Neuropathol. Appl. Neurobiol. 18:1992;593-609
    • (1992) Neuropathol. Appl. Neurobiol. , vol.18 , pp. 593-609
    • Tuckwell, D.S.1    Laszlo, L.2    Mayer, R.J.3
  • 131
    • 0032100631 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M
    • Veeranna, Amin N.D., Ahn N.G., Jaffe H., Winters C.A., Pant P., Pant H.C. Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M. J. Neurosci. 18:1998;4008-4021
    • (1998) J. Neurosci. , vol.18 , pp. 4008-4021
    • Veeranna1    Amin, N.D.2    Ahn, N.G.3    Jaffe, H.4    Winters, C.A.5    Pant, P.6    Pant, H.C.7
  • 132
    • 0034728574 scopus 로고    scopus 로고
    • Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain
    • Veeranna, Gu J., Shetty K.T., Takahashi M., Grant P., Pant H.C. Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain. Mol. Brain Res. 76:2000;229-236
    • (2000) Mol. Brain Res. , vol.76 , pp. 229-236
    • Veeranna1    Gu, J.2    Shetty, K.T.3    Takahashi, M.4    Grant, P.5    Pant, H.C.6
  • 133
    • 0026023073 scopus 로고
    • Phosphorylation-related immunoreactivity and the rate of transport of neurofilaments in chronic 2,5-hexanedione intoxication
    • Watson D.F., Fittro K.P., Hoffman P.N., Griffin J.W. Phosphorylation- related immunoreactivity and the rate of transport of neurofilaments in chronic 2,5-hexanedione intoxication. Brain Res. 539:1991;103-109
    • (1991) Brain Res. , vol.539 , pp. 103-109
    • Watson, D.F.1    Fittro, K.P.2    Hoffman, P.N.3    Griffin, J.W.4
  • 134
    • 0027410516 scopus 로고
    • Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
    • Xu Z., Cork L.C., Griffin J.W., Cleveland D.W. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell. 73:1993;23-33
    • (1993) Cell , vol.73 , pp. 23-33
    • Xu, Z.1    Cork, L.C.2    Griffin, J.W.3    Cleveland, D.W.4
  • 135
    • 0034030749 scopus 로고    scopus 로고
    • Phospho-dependent association of neurofilament proteins with kinesin in situ
    • Yabe J.T., Jung C., Chan W.K.-H., Shea T.B. Phospho-dependent association of neurofilament proteins with kinesin in situ. Cell Motil. Cytoskeleton. 45:2000;249-262
    • (2000) Cell Motil. Cytoskeleton , vol.45 , pp. 249-262
    • Yabe, J.T.1    Jung, C.2    Chan, W.K.-H.3    Shea, T.B.4
  • 136
    • 0035164218 scopus 로고    scopus 로고
    • The predominant form in which neurofilament subunits undergo axonal transport varies during axonal initiation, elongation and maturation
    • Yabe J.T., Chan W.K.-H., Chylinski T., Lee S., Pimenta A., Shea T.B. The predominant form in which neurofilament subunits undergo axonal transport varies during axonal initiation, elongation and maturation. Cell Motil. Cytoskeleton. 48:2000;61-83
    • (2000) Cell Motil. Cytoskeleton , vol.48 , pp. 61-83
    • Yabe, J.T.1    Chan, W.K.-H.2    Chylinski, T.3    Lee, S.4    Pimenta, A.5    Shea, T.B.6
  • 137
    • 0035313106 scopus 로고    scopus 로고
    • Neurofilaments consist of distinct population s that can be distinguished by C-terminal phosphorylation, bundling, and axonal transport rate in growing axonal neurites
    • Yabe J.T., Chylinski T., Wang F.-S., Pimenta A., Katter S.D., Linsley M.-D., Chan W.K.-H., Shea T.B. Neurofilaments consist of distinct population s that can be distinguished by C-terminal phosphorylation, bundling, and axonal transport rate in growing axonal neurites. J. Neurosci. 21:2001;2195-2205
    • (2001) J. Neurosci. , vol.21 , pp. 2195-2205
    • Yabe, J.T.1    Chylinski, T.2    Wang, F.-S.3    Pimenta, A.4    Katter, S.D.5    Linsley, M.-D.6    Chan, W.K.-H.7    Shea, T.B.8
  • 138
    • 0028287702 scopus 로고
    • Effects of 2,5-hexanedione on rat spinal pyramidal tract
    • Yagi Y. Effects of 2,5-hexanedione on rat spinal pyramidal tract. Jpn. J. Ind. Health. 36:1994;173-180
    • (1994) Jpn. J. Ind. Health , vol.36 , pp. 173-180
    • Yagi, Y.1
  • 141
    • 0026649311 scopus 로고
    • The same chemicals induce different neurotoxicity when administered in high doses for short term or low doses for long term to rats and dogs
    • Yoshimura S., Imai K., Saitoh Y., Yamaguchi H., Ohtaki S. The same chemicals induce different neurotoxicity when administered in high doses for short term or low doses for long term to rats and dogs. Mol. Chem. Neuropathol. 16:1992;59-83
    • (1992) Mol. Chem. Neuropathol. , vol.16 , pp. 59-83
    • Yoshimura, S.1    Imai, K.2    Saitoh, Y.3    Yamaguchi, H.4    Ohtaki, S.5
  • 142
    • 0028141716 scopus 로고
    • Formation and structure of cross-linking and monomeric pyrrole autooxidation products in 2,5-hexanedione-treated amino acids, peptides and proteins
    • Zhu M., Spink D.C., Yan B., Bank S., DeCaprio A.P. Formation and structure of cross-linking and monomeric pyrrole autooxidation products in 2,5-hexanedione-treated amino acids, peptides and proteins. Chem. Res. Toxicol. 7:1994;551-558
    • (1994) Chem. Res. Toxicol. , vol.7 , pp. 551-558
    • Zhu, M.1    Spink, D.C.2    Yan, B.3    Bank, S.4    Decaprio, A.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.