메뉴 건너뛰기




Volumn 19, Issue 8, 1999, Pages 2974-2986

Overexpression of α-internexin causes abnormal neurofilamentous accumulations and motor coordination deficits in transgenic mice

Author keywords

Cytoskeleton; Intermediate filament; Motor deficits; Neurodegeneration; Neurofilament; Transgenic mice; internexin

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; INTERMEDIATE FILAMENT; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOUSE; MUSCLE WEAKNESS; NERVE DEGENERATION; NEUROFILAMENT; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PURKINJE CELL; PYRAMIDAL NERVE CELL;

EID: 0033561167     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-08-02974.1999     Document Type: Article
Times cited : (89)

References (50)
  • 1
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 2
    • 0026097837 scopus 로고
    • Tau in Alzheimer neurofibrillary tangles. N- And C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site
    • Brion JP, Hanger DP, Bruce MT, Couck AM. Flament-Durand J. Anderton BH (1991) Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site. Biochem J 273:127-133.
    • (1991) Biochem J , vol.273 , pp. 127-133
    • Brion, J.P.1    Hanger, D.P.2    Bruce, M.T.3    Couck, A.M.4    Flament-Durand, J.5    Anderton, B.H.6
  • 3
    • 0023515543 scopus 로고
    • Twostage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns
    • Carden MJ, Trojanowski JQ, Schlaepfer WW, Lee VM (1987) Twostage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns. J Neurosci 7:3489-3504.
    • (1987) J Neurosci , vol.7 , pp. 3489-3504
    • Carden, M.J.1    Trojanowski, J.Q.2    Schlaepfer, W.W.3    Lee, V.M.4
  • 4
    • 0028029567 scopus 로고
    • Characterization of the mouse gene encoding the neuronal intermediate filament protein α-internexin
    • Chien CL, Liem RK (1994) Characterization of the mouse gene encoding the neuronal intermediate filament protein α-internexin. Gene 149:289-292.
    • (1994) Gene , vol.149 , pp. 289-292
    • Chien, C.L.1    Liem, R.K.2
  • 5
    • 0025985501 scopus 로고
    • Structure of the gene for the neuronal intermediate filament protein α-internexin and functional analysis of its promoter
    • Ching GY, Liem RK (1991) Structure of the gene for the neuronal intermediate filament protein α-internexin and functional analysis of its promoter. J Biol Chem 266:19459-19468.
    • (1991) J Biol Chem , vol.266 , pp. 19459-19468
    • Ching, G.Y.1    Liem, R.K.2
  • 6
    • 0027220073 scopus 로고
    • Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments
    • Ching GY, Liem RK (1993) Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments. J Cell Biol 122:1323-1335.
    • (1993) J Cell Biol , vol.122 , pp. 1323-1335
    • Ching, G.Y.1    Liem, R.K.2
  • 7
    • 0031883774 scopus 로고    scopus 로고
    • Roles of head and tail domains in α-internexin's self-assembly and coassembly with the neurofilament triplet proteins
    • Ching GY, Liem RK (1998) Roles of head and tail domains in α-internexin's self-assembly and coassembly with the neurofilament triplet proteins. J Cell Sci 111:321-333.
    • (1998) J Cell Sci , vol.111 , pp. 321-333
    • Ching, G.Y.1    Liem, R.K.2
  • 9
    • 0029004898 scopus 로고
    • Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis
    • Collard JF, Cote F, Julien JP (1995) Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature 375:61-64.
    • (1995) Nature , vol.375 , pp. 61-64
    • Collard, J.F.1    Cote, F.2    Julien, J.P.3
  • 10
    • 0027465098 scopus 로고
    • Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis
    • Cote F. Collard JF, Julien JP (1993) Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Cell 73:35-46.
    • (1993) Cell , vol.73 , pp. 35-46
    • Cote, F.1    Collard, J.F.2    Julien, J.P.3
  • 11
    • 0001936444 scopus 로고
    • General pathology of neurons and neuroglia
    • (Hume A, Corsellis J, Duchen L, eds), London: Edward-Arnold.
    • Duchen L (1984) General pathology of neurons and neuroglia. In: Grccnficld's neuropathology, Ed 4 (Hume A, Corsellis J, Duchen L, eds), pp 1-52. London: Edward-Arnold.
    • (1984) Grccnficld's Neuropathology, Ed 4 , pp. 1-52
    • Duchen, L.1
  • 12
    • 0028261670 scopus 로고
    • Neurofilament-deficient axons and perikaryal aggregates in viable transgcnic mice expressing a neurofilament-β-galactosidase fusion protein
    • Eyer J, Peterson A (1994) Neurofilament-deficient axons and perikaryal aggregates in viable transgcnic mice expressing a neurofilament-β-galactosidase fusion protein. Neuron 12:389-405.
    • (1994) Neuron , vol.12 , pp. 389-405
    • Eyer, J.1    Peterson, A.2
  • 13
  • 14
    • 0026334107 scopus 로고
    • Cellular and molecular biology of neuronal intermediate filaments
    • Fliegner KH, Liem RK (1991) Cellular and molecular biology of neuronal intermediate filaments. Int Rev Cytol 131:109-167.
    • (1991) Int Rev Cytol , vol.131 , pp. 109-167
    • Fliegner, K.H.1    Liem, R.K.2
  • 15
    • 0028288886 scopus 로고
    • Expression of the gene for the neuronal intermediate filament protein α-internexin coincides with the onset of neuronal differentiation in the developing rat nervous system
    • Fliegner KH, Kaplan MP, Wood TL, Pintar JE, Liem RK (1994) Expression of the gene for the neuronal intermediate filament protein α-internexin coincides with the onset of neuronal differentiation in the developing rat nervous system. J Comp Neurol 342:161-173.
    • (1994) J Comp Neurol , vol.342 , pp. 161-173
    • Fliegner, K.H.1    Kaplan, M.P.2    Wood, T.L.3    Pintar, J.E.4    Liem, R.K.5
  • 16
    • 0026563548 scopus 로고
    • Filaments of Lewy bodies contain insoluble cytoskcletal elements
    • Galloway PG, Mulvihill P, Perry G (1992) Filaments of Lewy bodies contain insoluble cytoskcletal elements. Am J Pathol 140:809-822.
    • (1992) Am J Pathol , vol.140 , pp. 809-822
    • Galloway, P.G.1    Mulvihill, P.2    Perry, G.3
  • 17
    • 0027186458 scopus 로고
    • Female transgenic mice carrying multiple copies of the human gene for S100 β are hyperactive
    • Gerlai R, Friend W. Becker L, O'Hanlon D, Marks A, Roder J (1993) Female transgenic mice carrying multiple copies of the human gene for S100 β are hyperactive. Behav Brain Res 55:51-59.
    • (1993) Behav Brain Res , vol.55 , pp. 51-59
    • Gerlai, R.1    Friend, W.2    Becker, L.3    O'Hanlon, D.4    Marks, A.5    Roder, J.6
  • 18
    • 0024745894 scopus 로고
    • Multiple isoforms of human microtubule-associatcd protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
    • Goedert M, Spillantini MG, Jakes R. Rutherford D, Crowther RA (1989) Multiple isoforms of human microtubule-associatcd protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 3:519-526.
    • (1989) Neuron , vol.3 , pp. 519-526
    • Goedert, M.1    Spillantini, M.G.2    Jakes, R.3    Rutherford, D.4    Crowther, R.A.5
  • 21
    • 0030626046 scopus 로고    scopus 로고
    • Ccrebcllar timing systems
    • Ivry R (1997) Ccrebcllar timing systems. Int Rev Ncurohiol 41:555-573.
    • (1997) Int Rev Ncurohiol , vol.41 , pp. 555-573
    • Ivry, R.1
  • 22
    • 0021045186 scopus 로고
    • Motor performance achievements in rats of different ages
    • Janickc B, Schulze G. Coper H (1983) Motor performance achievements in rats of different ages. Exp Gerontol 18:393-407.
    • (1983) Exp Gerontol , vol.18 , pp. 393-407
    • Janickc, B.1    Schulze, G.2    Coper, H.3
  • 23
    • 0025469588 scopus 로고
    • α-internexin, a novel neuronal intermediate filament protein, precedes the low molecular weight neurofilament protein (NF-L) in the developing rat brain
    • Kaplan MP, Chin SS, Fliegner KH, Liem RK (1990) α-internexin, a novel neuronal intermediate filament protein, precedes the low molecular weight neurofilament protein (NF-L) in the developing rat brain. J Neurosci 10:2735-2748.
    • (1990) J Neurosci , vol.10 , pp. 2735-2748
    • Kaplan, M.P.1    Chin, S.S.2    Fliegner, K.H.3    Liem, R.K.4
  • 24
    • 0025334506 scopus 로고
    • Ubiquitin and phosphorylated neurofilament epitopes in ballooned neurons of the extraocular muscle nuclei in a case of Werdnig-Hoffmann disease
    • Kalo S, Hirano A (1990) Ubiquitin and phosphorylated neurofilament epitopes in ballooned neurons of the extraocular muscle nuclei in a case of Werdnig-Hoffmann disease. Acta Neuropathol (Berl) 80:334-337.
    • (1990) Acta Neuropathol (Berl) , vol.80 , pp. 334-337
    • Kalo, S.1    Hirano, A.2
  • 25
    • 0017135663 scopus 로고
    • Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion
    • Kohler G, Milstein C (1976) Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. Eur J Immunol 6:511-519.
    • (1976) Eur J Immunol , vol.6 , pp. 511-519
    • Kohler, G.1    Milstein, C.2
  • 27
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 28
    • 0027293898 scopus 로고
    • Neurofilaments are obligate heteropolymers in vivo
    • Lee MK, Xu Z, Wong PC, Cleveland DW (1993) Neurofilaments are obligate heteropolymers in vivo. J Cell Biol 122:1337-1350.
    • (1993) J Cell Biol , vol.122 , pp. 1337-1350
    • Lee, M.K.1    Xu, Z.2    Wong, P.C.3    Cleveland, D.W.4
  • 29
    • 0028116467 scopus 로고
    • A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease
    • Lee MK, Marszalek JR. Cleveland DW (1994) A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron 13:975-988.
    • (1994) Neuron , vol.13 , pp. 975-988
    • Lee, M.K.1    Marszalek, J.R.2    Cleveland, D.W.3
  • 30
    • 0027724598 scopus 로고
    • On the cerebellum and motor learning
    • Llinas R, Welsh JP (1993) On the cerebellum and motor learning. Curr Opin Neurobiol 3:958-965.
    • (1993) Curr Opin Neurobiol , vol.3 , pp. 958-965
    • Llinas, R.1    Welsh, J.P.2
  • 31
    • 0030026182 scopus 로고    scopus 로고
    • Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines
    • Luo L, Hensch TK, Ackerman L, Barbel S, Jan LY, Jan YN (1996) Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature 379:837-840.
    • (1996) Nature , vol.379 , pp. 837-840
    • Luo, L.1    Hensch, T.K.2    Ackerman, L.3    Barbel, S.4    Jan, L.Y.5    Jan, Y.N.6
  • 32
    • 0019189658 scopus 로고
    • The fine structure of the axonal torpedo in Purkinje cells of the human cerebellum
    • Mann DM, Stamp JE, Yates PO, Bannister CM (1980) The fine structure of the axonal torpedo in Purkinje cells of the human cerebellum. Neurol Res 1:369-378.
    • (1980) Neurol Res , vol.1 , pp. 369-378
    • Mann, D.M.1    Stamp, J.E.2    Yates, P.O.3    Bannister, C.M.4
  • 34
    • 0024462479 scopus 로고
    • Retardation in the slow axonal transport of cytoskeletal elements during maturation and aging
    • McQuarrie IG, Brady ST, Lasek RJ (1989) Retardation in the slow axonal transport of cytoskeletal elements during maturation and aging. Neurobiol Aging 10:359-365.
    • (1989) Neurobiol Aging , vol.10 , pp. 359-365
    • McQuarrie, I.G.1    Brady, S.T.2    Lasek, R.J.3
  • 35
    • 0023738527 scopus 로고
    • Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients
    • Munoz DG. Greene C, Perl DP, Selkoc DJ (1988) Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients. J Neuropathol Exp Neurol 47:9-18.
    • (1988) J Neuropathol Exp Neurol , vol.47 , pp. 9-18
    • Munoz, D.G.1    Greene, C.2    Perl, D.P.3    Selkoc, D.J.4
  • 36
    • 0025210663 scopus 로고
    • Swollen cortical neurons in Creutzfeldt-Jakob disease contain a phosphorylated neurofilament epitope
    • Nakazato Y, Hirato J, Ishida Y, Hoshi S, Hasegawa M, Fukuda T (1990) Swollen cortical neurons in Creutzfeldt-Jakob disease contain a phosphorylated neurofilament epitope. J Neuropathol Exp Neurol 49:197-205.
    • (1990) J Neuropathol Exp Neurol , vol.49 , pp. 197-205
    • Nakazato, Y.1    Hirato, J.2    Ishida, Y.3    Hoshi, S.4    Hasegawa, M.5    Fukuda, T.6
  • 38
    • 0023228210 scopus 로고
    • Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls
    • Schmidt ML, Carden MJ, Lee VM, Trojanowski JQ (1987) Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls, Lab Invest 56:282-294.
    • (1987) Lab Invest , vol.56 , pp. 282-294
    • Schmidt, M.L.1    Carden, M.J.2    Lee, V.M.3    Trojanowski, J.Q.4
  • 39
    • 0025165101 scopus 로고
    • Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells
    • Sohue G, Hashizume Y, Yasuda T, Mukai E, Kumagai T, Mitsuma T, Trojanowski JQ (1990) Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells. Acta Neuropathol (Berl) 79:402-408.
    • (1990) Acta Neuropathol (Berl) , vol.79 , pp. 402-408
    • Sohue, G.1    Hashizume, Y.2    Yasuda, T.3    Mukai, E.4    Kumagai, T.5    Mitsuma, T.6    Trojanowski, J.Q.7
  • 40
    • 0002918293 scopus 로고
    • Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ
    • Sternberger LA, Sternberger N H (1983) Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ. Proc Natl Acad Sci USA 80:6126-6130.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 6126-6130
    • Sternberger, L.A.1    Sternberger, N.H.2
  • 41
    • 0029833513 scopus 로고    scopus 로고
    • Alterations in neural intermediate filament organization: Functional implications and the induction of pathological changes related to motor neuron disease
    • Straube-West K, Loomis PA, Opal P, Goldman RD (1996) Alterations in neural intermediate filament organization: functional implications and the induction of pathological changes related to motor neuron disease. J Cell Sci 109:2319-2329.
    • (1996) J Cell Sci , vol.109 , pp. 2319-2329
    • Straube-West, K.1    Loomis, P.A.2    Opal, P.3    Goldman, R.D.4
  • 42
    • 17544370807 scopus 로고    scopus 로고
    • Phosphorylation of the high molecular weight neurofilament protein (NF- H) by Cdk5 and p35
    • Sun D, Leung CL, Liem RKH (1996) Phosphorylation of the high molecular weight neurofilament protein (NF- H) by Cdk5 and p35. J Biol Chem 271:14245-14251.
    • (1996) J Biol Chem , vol.271 , pp. 14245-14251
    • Sun, D.1    Leung, C.L.2    Liem, R.K.H.3
  • 43
    • 0026578604 scopus 로고
    • The cerebellum and the adaptive coordination of movement
    • Thach WT, Goodkin HP, Keating JG (1992) The cerebellum and the adaptive coordination of movement. Annu Rev Neurosci 15:403-442.
    • (1992) Annu Rev Neurosci , vol.15 , pp. 403-442
    • Thach, W.T.1    Goodkin, H.P.2    Keating, J.G.3
  • 44
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 45
    • 0028644131 scopus 로고
    • Phosphorylation of neuronal cytoskeletal proteins in Alzheimer's disease and Lewy body dementias
    • Trojanowski JQ, Lee VM (1994) Phosphorylation of neuronal cytoskeletal proteins in Alzheimer's disease and Lewy body dementias. Ann NY Acad Sci 747:92-109.
    • (1994) Ann NY Acad Sci , vol.747 , pp. 92-109
    • Trojanowski, J.Q.1    Lee, V.M.2
  • 46
    • 0030614372 scopus 로고    scopus 로고
    • Selective degeneration of Purkinje cells with Lewy body-like inclusions in aged NFHLACZ transgenic mice
    • Tu PH, Robinson KA, de Snoo F, Eyer J, Peterson A, Lee VM, Trojanowski JQ (1997) Selective degeneration of Purkinje cells with Lewy body-like inclusions in aged NFHLACZ transgenic mice. J Neurosci 17:1064-1074.
    • (1997) J Neurosci , vol.17 , pp. 1064-1074
    • Tu, P.H.1    Robinson, K.A.2    De Snoo, F.3    Eyer, J.4    Peterson, A.5    Lee, V.M.6    Trojanowski, J.Q.7
  • 47
    • 0028111812 scopus 로고
    • Age-associated and cell-type-specific neurofibrillary pathology in transgenic mice expressing the human midsized neurofilament subunit
    • Vickers JC, Morrison JH, Friedrich Jr VL, Elder GA, Perl DP, Katz RN, Lazzarini R A (1994) Age-associated and cell-type-specific neurofibrillary pathology in transgenic mice expressing the human midsized neurofilament subunit. J Neurosci 14:5603-5612.
    • (1994) J Neurosci , vol.14 , pp. 5603-5612
    • Vickers, J.C.1    Morrison, J.H.2    Friedrich Jr., V.L.3    Elder, G.A.4    Perl, D.P.5    Katz, R.N.6    Lazzarini, R.A.7
  • 48
    • 0021366281 scopus 로고
    • Identification of glial filament protein and vimentin in the same intermediate filament system in human glioma cells
    • Wang E, Cairncross JG, Liem RK (1984) Identification of glial filament protein and vimentin in the same intermediate filament system in human glioma cells. Proc Natl Acad Sci USA 81:2102-2106.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 2102-2106
    • Wang, E.1    Cairncross, J.G.2    Liem, R.K.3
  • 49
    • 0029124072 scopus 로고
    • Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons
    • Wong PC, Marszalek J, Crawford TO, Xu Z, Hsieh ST. Griffin JW, Cleveland DW (1995) Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons. J Cell Biol 130:1413-1422.
    • (1995) J Cell Biol , vol.130 , pp. 1413-1422
    • Wong, P.C.1    Marszalek, J.2    Crawford, T.O.3    Xu, Z.4    Hsieh, S.T.5    Griffin, J.W.6    Cleveland, D.W.7
  • 50
    • 0027410516 scopus 로고
    • Increased expression of neurofilament subunit N F-L produces morphological alterations that resemble the pathology of human motor neuron disease
    • Xu Z, Cork LC, Griffin JW, Cleveland DW (1993) Increased expression of neurofilament subunit N F-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell 73:23-33.
    • (1993) Cell , vol.73 , pp. 23-33
    • Xu, Z.1    Cork, L.C.2    Griffin, J.W.3    Cleveland, D.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.